LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 231

Search options

  1. Book: Notch from neurodevelopment to neurodegeneration

    Israël, Alain

    keeping the fate ; with 1 table

    (Research and perspectives in Alzheimer's disease)

    2002  

    Author's details A. Israël ... (ed.)
    Series title Research and perspectives in Alzheimer's disease
    Keywords Alzheimerkrankheit ; Nervendegeneration ; Preseniline ; Signaltransduktion ; Amyloid ; Präkursor
    Subject Signalübertragung ; Signalvermittlung ; Precursor ; Vorläufermolekül ; Alzheimer-Krankheit ; Alzheimersche Krankheit ; Alzheimer-Demenz ; Morbus Alzheimer ; Greisenblödsinn ; Alzheimer's Disease ; Neurodegenerative Krankheit ; Neurodegenerative Erkrankung
    Language English
    Size XVI, 155 S. : Ill.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT013379973
    ISBN 3-540-43073-3 ; 978-3-540-43073-5
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 2804 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The IKK complex, a central regulator of NF-kappaB activation.

    Israël, Alain

    Cold Spring Harbor perspectives in biology

    2010  Volume 2, Issue 3, Page(s) a000158

    Abstract: The IKK kinase complex is the core element of the NF-kappaB cascade. It is essentially made of two kinases (IKKalpha and IKKbeta) and a regulatory subunit, NEMO/IKKgamma. Additional components may exist, transiently or permanently, but their ... ...

    Abstract The IKK kinase complex is the core element of the NF-kappaB cascade. It is essentially made of two kinases (IKKalpha and IKKbeta) and a regulatory subunit, NEMO/IKKgamma. Additional components may exist, transiently or permanently, but their characterization is still unsure. In addition, it has been shown that two separate NF-kappaB pathways exist, depending on the activating signal and the cell type, the canonical (depending on IKKbeta and NEMO) and the noncanonical pathway (depending solely on IKKalpha). The main question, which is still only partially answered, is to understand how an NF-kappaB activating signal leads to the activation of the kinase subunits, allowing them to phosphorylate their targets and eventually induce nuclear translocation of the NF-kappaB dimers. I will review here the genetic, biochemical, and structural data accumulated during the last 10 yr regarding the function of the three IKK subunits.
    MeSH term(s) Animals ; Dimerization ; Gene Expression Regulation ; Humans ; I-kappa B Kinase/metabolism ; Mice ; Models, Biological ; Models, Genetic ; Mutation ; NF-kappa B/metabolism ; Phenotype ; Protein Structure, Tertiary ; Time Factors ; Zinc Fingers
    Chemical Substances NF-kappa B ; I-kappa B Kinase (EC 2.7.11.10)
    Language English
    Publishing date 2010-02-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a000158
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Filters: When, Why, and How (Not) to Use Them.

    de Cheveigné, Alain / Nelken, Israel

    Neuron

    2019  Volume 102, Issue 2, Page(s) 280–293

    Abstract: Filters are commonly used to reduce noise and improve data quality. Filter theory is part of a scientist's training, yet the impact of filters on interpreting data is not always fully appreciated. This paper reviews the issue and explains what a filter ... ...

    Abstract Filters are commonly used to reduce noise and improve data quality. Filter theory is part of a scientist's training, yet the impact of filters on interpreting data is not always fully appreciated. This paper reviews the issue and explains what a filter is, what problems are to be expected when using them, how to choose the right filter, and how to avoid filtering by using alternative tools. Time-frequency analysis shares some of the same problems that filters have, particularly in the case of wavelet transforms. We recommend reporting filter characteristics with sufficient details, including a plot of the impulse or step response as an inset.
    MeSH term(s) Artifacts ; Causality ; Data Accuracy ; Fourier Analysis ; Humans ; Neurosciences ; Signal Processing, Computer-Assisted ; Signal-To-Noise Ratio ; Wavelet Analysis
    Language English
    Publishing date 2019-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2019.02.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Correspondence for "clinical epidemiology of familial sarcoidosis: A systematic literature review".

    Calender, Alain / Valeyre, Dominique / Israel-Biet, Dominique / Pacheco, Yves

    Respiratory medicine

    2019  Volume 160, Page(s) 105717

    MeSH term(s) Genetic Predisposition to Disease ; Humans ; Publications ; Sarcoidosis
    Language English
    Publishing date 2019-06-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2019.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.

    Israël, Alain

    Trends in immunology

    2006  Volume 27, Issue 9, Page(s) 395–397

    Abstract: Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the IkappaB kinase (IKK) complex, the central component of the nuclear factor (NF)-kappaB signaling cascade. Two new papers demonstrate that NF- ... ...

    Abstract Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the IkappaB kinase (IKK) complex, the central component of the nuclear factor (NF)-kappaB signaling cascade. Two new papers demonstrate that NF-kappaB essential modulator (NEMO)-IKKgamma, the structural and regulatory component of the IKK complex, specifically recognizes Lys63 polyubiquitin chains attached to the receptor-interacting protein (RIP)1 kinase following tumor necrosis factor treatment, and that this recognition is a requirement for IKK activation.
    MeSH term(s) Enzyme Activation ; I-kappa B Kinase/immunology ; I-kappa B Kinase/metabolism ; NF-kappa B/immunology ; NF-kappa B/metabolism ; Ubiquitins/immunology ; Ubiquitins/metabolism
    Chemical Substances NF-kappa B ; Ubiquitins ; I-kappa B Kinase (EC 2.7.11.10)
    Language English
    Publishing date 2006-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2006.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 2: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Modeling Potential Autophagy Pathways in COVID-19 and Sarcoidosis.

    Calender, Alain / Israel-Biet, Dominique / Valeyre, Dominique / Pacheco, Yves

    Trends in immunology

    2020  Volume 41, Issue 10, Page(s) 856–859

    Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mainly affects the lungs. Sarcoidosis is an autoinflammatory disease characterized by the diffusion of granulomas in the lungs and other ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mainly affects the lungs. Sarcoidosis is an autoinflammatory disease characterized by the diffusion of granulomas in the lungs and other organs. Here, we discuss how the two diseases might involve some common mechanistic cellular pathways around the regulation of autophagy.
    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Autophagy/drug effects ; Autophagy/genetics ; Azithromycin/therapeutic use ; Betacoronavirus/growth & development ; Betacoronavirus/pathogenicity ; COVID-19 ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/genetics ; Coronavirus Infections/virology ; Host-Pathogen Interactions/drug effects ; Humans ; Isoniazid/therapeutic use ; Lung/drug effects ; Lung/pathology ; Lung/virology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/genetics ; Pneumonia, Viral/virology ; Pulmonary Edema/drug therapy ; Pulmonary Edema/epidemiology ; Pulmonary Edema/genetics ; Pulmonary Edema/virology ; Rifampin/therapeutic use ; SARS-CoV-2 ; Sarcoidosis/drug therapy ; Sarcoidosis/epidemiology ; Sarcoidosis/genetics ; Sarcoidosis/virology ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/genetics ; Severe Acute Respiratory Syndrome/virology ; Severity of Illness Index
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Azithromycin (83905-01-5) ; Chloroquine (886U3H6UFF) ; Isoniazid (V83O1VOZ8L) ; Rifampin (VJT6J7R4TR)
    Keywords covid19
    Language English
    Publishing date 2020-08-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2020.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 2: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: State-Specific Prevalence of Depression Among Adults With and Without Diabetes - United States, 2011-2019.

    Koyama, Alain K / Hora, Israel A / Bullard, Kai McKeever / Benoit, Stephen R / Tang, Shichao / Cho, Pyone

    Preventing chronic disease

    2023  Volume 20, Page(s) E70

    Abstract: Introduction: In 2019 among US adults, 1 in 9 had diagnosed diabetes and 1 in 5 had diagnosed depression. Since these conditions frequently coexist, compounding their health and economic burden, we examined state-specific trends in depression prevalence ...

    Abstract Introduction: In 2019 among US adults, 1 in 9 had diagnosed diabetes and 1 in 5 had diagnosed depression. Since these conditions frequently coexist, compounding their health and economic burden, we examined state-specific trends in depression prevalence among US adults with and without diagnosed diabetes.
    Methods: We used data from the 2011 through 2019 Behavioral Risk Factor Surveillance System to evaluate self-reported diabetes and depression prevalence. Joinpoint regression estimated state-level trends in depression prevalence by diabetes status.
    Results: In 2019, the overall prevalence of depression in US adults with and without diabetes was 29.2% (95% CI, 27.8%-30.6%) and 17.9% (95% CI, 17.6%-18.1%), respectively. From 2011 to 2019, the depression prevalence was relatively stable for adults with diabetes (28.6% versus 29.2%) but increased for those without diabetes from 15.5% to 17.9% (average annual percent change [APC] over the 9-year period = 1.6%, P = .015). The prevalence of depression was consistently more than 10 percentage points higher among adults with diabetes than those without diabetes. The APC showed a significant increase in some states (Illinois: 5.9%, Kansas: 3.5%) and a significant decrease in others (Arizona: -5.1%, Florida: -4.0%, Colorado: -3.4%, Washington: -0.9%). In 2019, although it varied by state, the depression prevalence among adults with diabetes was highest in states with a higher diabetes burden such as Kentucky (47.9%), West Virginia (47.0%), and Maine (41.5%).
    Conclusion: US adults with diabetes are more likely to report prevalent depression compared with adults without diabetes. These findings highlight the importance of screening and monitoring for depression as a potential complication among adults with diabetes.
    MeSH term(s) United States/epidemiology ; Adult ; Humans ; Prevalence ; Depression/epidemiology ; Arizona ; Colorado ; Diabetes Mellitus/epidemiology
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2135684-1
    ISSN 1545-1151 ; 1545-1151
    ISSN (online) 1545-1151
    ISSN 1545-1151
    DOI 10.5888/pcd20.220407
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Modeling Potential Autophagy Pathways in COVID-19 and Sarcoidosis

    Calender, Alain / Israel-Biet, Dominique / Valeyre, Dominique / Pacheco, Yves

    Trends in Immunology

    2020  Volume 41, Issue 10, Page(s) 856–859

    Keywords Immunology ; Immunology and Allergy ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2020.08.001
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1601: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 2: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Extracorporeal life support allows lung transplant in anti-MDA5+ rapidly progressive interstitial lung disease.

    Bay, Pierre / Pineton de Chambrun, Marc / Roux, Antoine / Bunel, Vincent / Combes, Alain / Israël-Biet, Dominique / Zuber, Benjamin / Nunes, Hilario / Allenbach, Yves / Uzunhan, Yurdagül

    The European respiratory journal

    2022  Volume 59, Issue 5

    MeSH term(s) Autoantibodies ; Extracorporeal Membrane Oxygenation ; Humans ; Lung Diseases, Interstitial/therapy ; Lung Transplantation
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02968-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Small molecule anion carriers facilitate lactate transport in model liposomes and cells.

    Alonso-Carrillo, Daniel / Arias-Betancur, Alain / Carreira-Barral, Israel / Fontova, Pere / Soto-Cerrato, Vanessa / García-Valverde, María / Pérez-Tomás, Ricardo / Quesada, Roberto

    iScience

    2023  Volume 26, Issue 10, Page(s) 107898

    Abstract: An excessive production of lactate by cancer cells fosters tumor growth and metastasis. Therefore, targeting lactate metabolism and transport offers a new therapeutic strategy against cancer, based on dependency of some cancer cells for lactate as energy ...

    Abstract An excessive production of lactate by cancer cells fosters tumor growth and metastasis. Therefore, targeting lactate metabolism and transport offers a new therapeutic strategy against cancer, based on dependency of some cancer cells for lactate as energy fuel or as oncogenic signal. Herein we present a family of anionophores based on the structure of click-tambjamines that have proved to be extremely active lactate carriers across phospholipid membranes. Compound 1, the most potent lactate transmembrane carrier, was studied in HeLa cells. The use of a monocarboxylate transporters (MCTs) inhibitor proved that
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107898
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top