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  1. Article ; Online: Implementing and Maintaining a SARS-CoV-2 Exposure Notification Application for Mobile Phones: The Finnish Experience.

    Pihlajamäki, Mika / Wickström, Sara / Puranen, Kaija / Helve, Otto / Yrttiaho, Aleksi / Siira, Lotta

    JMIR public health and surveillance

    2023  Volume 9, Page(s) e46563

    Abstract: Exposure notification applications (ENAs) or digital proximity tracing apps were used in several countries during the COVID-19 pandemic. In this viewpoint, we share our experience of implementing and running the Finnish ENA (Koronavilkku), one of the ... ...

    Abstract Exposure notification applications (ENAs) or digital proximity tracing apps were used in several countries during the COVID-19 pandemic. In this viewpoint, we share our experience of implementing and running the Finnish ENA (Koronavilkku), one of the national ENAs with the highest proportion of users during the pandemic. With the aim of strengthening public trust and increasing app uptake, there was a strong prioritization of privacy and data security for the end user throughout the ENA development. This, in turn, limited the use of the app as a tool for health care professionals and deeper insight into its potential effectiveness. The ENA was designed to supplement conventional contact tracing, rather than replace it, and to serve as an early warning system and a trigger for action for the user in case of potential exposure. The predefined target of 40% uptake in the population was achieved within 3 months of the ENA launch. We consider easy-to-understand information produced together with communication experts crucial during the changing pandemic situation. This information educated people about the app as one component in mitigating the pandemic. As the pandemic and its mitigation evolved, the ENA also needed adapting and updating. A few months after its launch, Finland joined European interoperability, which allowed the ENA to share information with ENAs of other countries. We added automatic token issuing to the ENA as of mid-2021. If added earlier and more comprehensively, automatization could have more effectively saved resources in health care services and prevented overburdening contact tracing teams, while also notifying potentially exposed individuals quicker and more reliably. In the spring of 2021, the number of active apps started to gradually decline. Quarantine and testing practices for asymptomatic vaccinated individuals following exposure to the virus were eased and home tests became more common, eventually replacing laboratory testing for much of the population. Taken together, this led to decreased token issuance, which weakened the potential public health usefulness of the app. A self-service option for token issuance would likely have prolonged the lifespan of the app. The ENA was discontinued in mid-2022. Regularly conducted surveys would have helped gain timely knowledge on the use and effectiveness of the app for better responding to the changing needs during the pandemic.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Finland/epidemiology ; Pandemics/prevention & control ; Disease Notification ; Mobile Applications ; Cell Phone
    Language English
    Publishing date 2023-07-13
    Publishing country Canada
    Document type Journal Article
    ISSN 2369-2960
    ISSN (online) 2369-2960
    DOI 10.2196/46563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mechanical state transitions in the regulation of tissue form and function.

    Mao, Yanlan / Wickström, Sara A

    Nature reviews. Molecular cell biology

    2024  

    Abstract: From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues undergo constant changes in genome activity, cell fate, proliferation, movement, metabolism and growth. Importantly, these biological ... ...

    Abstract From embryonic development, postnatal growth and adult homeostasis to reparative and disease states, cells and tissues undergo constant changes in genome activity, cell fate, proliferation, movement, metabolism and growth. Importantly, these biological state transitions are coupled to changes in the mechanical and material properties of cells and tissues, termed mechanical state transitions. These mechanical states share features with physical states of matter, liquids and solids. Tissues can switch between mechanical states by changing behavioural dynamics or connectivity between cells. Conversely, these changes in tissue mechanical properties are known to control cell and tissue function, most importantly the ability of cells to move or tissues to deform. Thus, tissue mechanical state transitions are implicated in transmitting information across biological length and time scales, especially during processes of early development, wound healing and diseases such as cancer. This Review will focus on the biological basis of tissue-scale mechanical state transitions, how they emerge from molecular and cellular interactions, and their roles in organismal development, homeostasis, regeneration and disease.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-024-00719-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Stretched skin cells divide without DNA replication.

    Stubb, Aki / Wickström, Sara A

    Nature

    2022  Volume 605, Issue 7908, Page(s) 31–32

    MeSH term(s) Animals ; Cell Division ; DNA Replication ; Skin/cytology ; Zebrafish
    Language English
    Publishing date 2022-04-27
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-00790-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mechanical Forces in Nuclear Organization.

    Miroshnikova, Yekaterina A / Wickström, Sara A

    Cold Spring Harbor perspectives in biology

    2022  Volume 14, Issue 1

    Abstract: Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular responses that control cell fate changes. Mechanical forces also physically distort neighboring cells and the surrounding connective tissue, which propagate ... ...

    Abstract Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular responses that control cell fate changes. Mechanical forces also physically distort neighboring cells and the surrounding connective tissue, which propagate mechanochemical signals over long distances to guide tissue patterning, organogenesis, and adult tissue homeostasis. As the largest and stiffest organelle, the nucleus is particularly sensitive to mechanical force and deformation. Nuclear responses to mechanical force include adaptations in chromatin architecture and transcriptional activity that trigger changes in cell state. These force-driven changes also influence the mechanical properties of chromatin and nuclei themselves to prevent aberrant alterations in nuclear shape and help maintain genome integrity. This review will discuss principles of nuclear mechanotransduction and chromatin mechanics and their role in DNA damage and cell fate regulation.
    MeSH term(s) Cell Differentiation ; Cell Nucleus ; Chromatin ; Genome ; Mechanotransduction, Cellular/physiology
    Chemical Substances Chromatin
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a039685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanical regulation of chromatin and transcription.

    Dupont, Sirio / Wickström, Sara A

    Nature reviews. Genetics

    2022  Volume 23, Issue 10, Page(s) 624–643

    Abstract: Cells and tissues generate and are exposed to various mechanical forces that act across a range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform cell behaviour during development and adult tissue homeostasis, and ... ...

    Abstract Cells and tissues generate and are exposed to various mechanical forces that act across a range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform cell behaviour during development and adult tissue homeostasis, and alterations in forces and in their downstream mechanotransduction pathways can influence disease progression. Recent advances have been made in our understanding of the mechanisms by which forces regulate chromatin organization and state, and of the mechanosensitive transcription factors that respond to the physical properties of the cell microenvironment to coordinate gene expression, cell states and behaviours. These insights highlight the relevance of mechanosensitive transcriptional regulation to physiology, disease and emerging therapies.
    MeSH term(s) Chromatin/genetics ; Gene Expression Regulation ; Homeostasis ; Mechanotransduction, Cellular/physiology ; Transcription Factors
    Chemical Substances Chromatin ; Transcription Factors
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2035157-4
    ISSN 1471-0064 ; 1471-0056
    ISSN (online) 1471-0064
    ISSN 1471-0056
    DOI 10.1038/s41576-022-00493-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Seizures in hospitalised paediatric patients with SARS-CoV-2 and comparison of severity with seizures in hospitalised paediatric patients with other respiratory viruses during the COVID-19 pandemic: a population-based cohort study.

    Anastasopoulou, Stavroula / Svensson, Eva / Wickström, Ronny / Hertting, Olof / Rinder, Malin Ryd / Bennet, Rutger / Eriksson, Margareta

    Archives of disease in childhood

    2024  Volume 109, Issue 2, Page(s) 152–157

    Abstract: Objective: To study seizures in patients hospitalised due to SARS-CoV-2 infection, and compare ... Patients aged 1 month-18 years hospitalised due to SARS-CoV-2 with and without seizures, and patients ... Main outcome measures: The prevalence of seizures in hospitalised patients due to SARS-CoV-2 ...

    Abstract Objective: To study seizures in patients hospitalised due to SARS-CoV-2 infection, and compare their severity with seizures in patients hospitalised due to other viral respiratory tract infections (RTIs).
    Design: Observational population-based cohort study.
    Setting: Northern Stockholm.
    Patients: Patients aged 1 month-18 years hospitalised due to SARS-CoV-2 with and without seizures, and patients of the same age hospitalised due to other viral RTIs with seizures, between 1 March 2020 and 30 June 2022.
    Main outcome measures: The prevalence of seizures in hospitalised patients due to SARS-CoV-2, the evaluation of assumed predictors of seizures and the comparison of severity markers in patients with SARS-CoV-2 versus other RTIs.
    Results: 32 of 239 included patients (13.4%) admitted due to SARS-CoV-2 infection had seizures. Central nervous system (CNS) disease and the omicron period had significantly increased OR for seizures (OR: 5.12; CI: 2.06 to 12.72 and OR: 3.01; CI: 1.15 to 7.88, respectively). Seizures in patients with SARS-CoV-2 were more common in children older than 5 years (p=0.001), even in the absence of fever (p=0.007), as compared with other viral RTIs. The duration of hospitalisation was longer in patients with seizures due to other viral RTIs (p=0.023). There was no significant difference regarding severity markers of seizures between the two groups.
    Conclusions: CNS disease and the omicron period were risk factors for seizures in patients with SARS-CoV-2, who were older than patients with other RTIs. The severity of seizures was comparable between the two groups; hospitalisation was however longer in patients with other RTIs.
    MeSH term(s) Humans ; Child ; Child, Preschool ; SARS-CoV-2 ; COVID-19/complications ; COVID-19/epidemiology ; Cohort Studies ; Pandemics ; Seizures/epidemiology ; Seizures/etiology ; Respiratory Tract Infections
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-325974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Shaping the stem cell field.

    Villeneuve, Clémentine / Wickström, Sara A

    Nature reviews. Molecular cell biology

    2021  Volume 22, Issue 5, Page(s) 305

    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-021-00347-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: BETting against wound healing.

    Ylivinkka, Irene / Wickström, Sara A

    Nature chemical biology

    2021  Volume 17, Issue 3, Page(s) 233–235

    MeSH term(s) Gambling ; Humans ; Keratinocytes ; Wound Healing
    Language English
    Publishing date 2021-01-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-020-00709-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Niche Above: A Novel Modality of Stem Cell Regulation in Mammalian Skin Epidermis.

    Coulombe, Pierre A / Wickström, Sara A

    Cell stem cell

    2021  Volume 28, Issue 3, Page(s) 365–366

    Abstract: In this issue of Cell Stem Cell, Ning et al. (2021) demonstrate that contractility in differentiating, suprabasally located keratinocytes acts non-cell-autonomously to regulate the replication and differentiation of the stem/progenitor keratinocytes in ... ...

    Abstract In this issue of Cell Stem Cell, Ning et al. (2021) demonstrate that contractility in differentiating, suprabasally located keratinocytes acts non-cell-autonomously to regulate the replication and differentiation of the stem/progenitor keratinocytes in the basal layer of epidermis. This finding expands our understanding of the niche that regulates stem/progenitor cells in skin.
    MeSH term(s) Animals ; Cell Differentiation ; Epidermal Cells ; Epidermis ; Epigenomics ; Keratinocytes ; Stem Cells ; Transcription Factors
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2021.02.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: What doesn't kill you makes you differentiate.

    Peters, Franziska / Wickström, Sara A

    Developmental cell

    2021  Volume 56, Issue 24, Page(s) 3303–3304

    Abstract: Tissues need strategies to cope with genomic insults to maintain their integrity. In this issue of Developmental Cell, Kato et al. use in vivo fate tracing to observe selective elimination of epidermal stem cells (EpiSCs) harboring severe genomic lesions ...

    Abstract Tissues need strategies to cope with genomic insults to maintain their integrity. In this issue of Developmental Cell, Kato et al. use in vivo fate tracing to observe selective elimination of epidermal stem cells (EpiSCs) harboring severe genomic lesions through their differentiation and compensatory expansion of surrounding intact cells.
    Language English
    Publishing date 2021-12-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2021.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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