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  1. Article ; Online: Next-Generation Sequencing for Identifying Unknown Pathogens in Sentinel Immunocompromised Hosts.

    Fishman, Jay A

    Emerging infectious diseases

    2023  Volume 29, Issue 2, Page(s) 431–432

    MeSH term(s) High-Throughput Nucleotide Sequencing ; Immunocompromised Host
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2902.221829
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
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  2. Article ; Online: The epidemiology of community-acquired respiratory viruses during the SARS-CoV-2 pandemic.

    Fishman, Jay A

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2021  Volume 20, Issue 12, Page(s) 3680

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Coinfection/epidemiology ; Coinfection/prevention & control ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/prevention & control ; Global Health ; Humans ; Pandemics ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control ; Virus Diseases/epidemiology ; Virus Diseases/prevention & control
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.16382
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    Zs.A 5542: Show issues Location:
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  3. Article ; Online: The Pathogenesis and Diagnosis of

    Apostolopoulou, Anna / Fishman, Jay A

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 11

    Abstract: Pneumocystis ... ...

    Abstract Pneumocystis jiroveci
    Language English
    Publishing date 2022-11-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8111167
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  4. Article ; Online: The Immunocompromised Transplant Recipient and SARS-CoV-2 Infection.

    Fishman, Jay A

    Journal of the American Society of Nephrology : JASN

    2020  Volume 31, Issue 6, Page(s) 1147–1149

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Kidney Transplantation ; New York ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Transplant Recipients
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2020040416
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    Zs.A 3344: Show issues Location:
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  5. Article ; Online: Pneumocystis jiroveci.

    Fishman, Jay A

    Seminars in respiratory and critical care medicine

    2020  Volume 41, Issue 1, Page(s) 141–157

    Abstract: Pneumocystis ... ...

    Abstract Pneumocystis jiroveci
    MeSH term(s) Humans ; Immunocompromised Host ; Organ Transplantation/adverse effects ; Pneumocystis carinii ; Pneumonia, Pneumocystis/diagnosis ; Pneumonia, Pneumocystis/drug therapy ; Radiography ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
    Chemical Substances Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2020-01-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0039-3399559
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    Zs.A 1555: Show issues Location:
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  6. Article ; Online: Prevention of infection in xenotransplantation: Designated pathogen-free swine in the safety equation.

    Fishman, Jay A

    Xenotransplantation

    2020  Volume 27, Issue 3, Page(s) e12595

    Abstract: Post-transplantation infections are common. In immunosuppressed human xenograft recipients, infection is most likely to be due to the same pathogens seen in human allotransplantation. However, organisms derived from swine and transmitted with xenografts ... ...

    Abstract Post-transplantation infections are common. In immunosuppressed human xenograft recipients, infection is most likely to be due to the same pathogens seen in human allotransplantation. However, organisms derived from swine and transmitted with xenografts have the potential to cause novel infections in xenograft recipients. The specific organisms likely to cause infection or "xenosis" are unknown but are postulated to be like those causing infection in allograft recipients. On this basis, theoretical exclusion criteria have been developed to guide the development of source animal herds. Herds developed based on the exclusion of potential human pathogens have been termed "designated pathogen-free" (DPF). Lists of potential pathogens will require revision with changing epidemiology of infection in swine worldwide and clinical experience. Development of new microbiological assays is required both for animal screening and in clinical diagnosis should infections occur. Genetic modifications of swine have the potential to eliminate certain infectious agents such as the porcine endogenous retrovirus; infectious complications of such modifications have not been observed. Unexpected, off target effects of genetic modifications require further study. Monitoring for infection in asymptomatic recipients is important to define infectious risks which are unknown in the absence of clinical trials data. Advanced microbiological techniques may be applied to diagnose and prevent infection in xenograft recipients.
    MeSH term(s) Animals ; Endogenous Retroviruses/immunology ; Heterografts/immunology ; Humans ; Immunocompromised Host/immunology ; Infections/immunology ; Specific Pathogen-Free Organisms/immunology ; Swine ; Transplantation, Heterologous/adverse effects
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1236298-0
    ISSN 1399-3089 ; 0908-665X
    ISSN (online) 1399-3089
    ISSN 0908-665X
    DOI 10.1111/xen.12595
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    Zs.A 4514: Show issues Location:
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  7. Article ; Online: Humoral immune responses against SARS-CoV-2 in transplantation: Actionable biomarker or misplaced trust?

    Fishman, Jay A / Alter, Galit

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2022  Volume 22, Issue 5, Page(s) 1291–1292

    MeSH term(s) Antibodies, Viral ; Biomarkers ; COVID-19 ; Humans ; Immunity, Humoral ; SARS-CoV-2 ; Trust ; Vaccination
    Chemical Substances Antibodies, Viral ; Biomarkers
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.17018
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    Zs.A 5542: Show issues Location:
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  8. Article ; Online: Mycobacterium tuberculosis in transplantation: Immunity sufficient to perpetuate disease?

    Fishman, Jay A

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2019  Volume 19, Issue 5, Page(s) 1262–1263

    MeSH term(s) Humans ; Immunosuppressive Agents ; Kidney Transplantation ; Mycobacterium tuberculosis ; Retrospective Studies ; Tuberculosis
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2019-01-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.15254
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  9. Article ; Online: Donor-Derived Infections: Monitoring of Posttransplant Infections and Safety Lessons From the Opioid Epidemic.

    Fishman, Jay A / Irwin, Linda

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2022  Volume 20, Issue Suppl 4, Page(s) 20–23

    Abstract: Objectives: The inadequate supply of transplantable organs necessitates new approaches to donor screening while avoiding transmission of infections. Donor-derived infections are well described. Multiple changes have occurred in donor management and ... ...

    Abstract Objectives: The inadequate supply of transplantable organs necessitates new approaches to donor screening while avoiding transmission of infections. Donor-derived infections are well described. Multiple changes have occurred in donor management and organ utilization, including increased recognition of and therapies for viral infections, the emergence of multidrug antimicrobial-resistant organisms, and identification of some uncommon viral infections transmitted with allografts to clusters of recipients. Donor evaluation has been impacted by substance use-associated deaths and routine use of serologies and nucleic acid testing for hepatitis C virus, hepatitis B virus, and human immunodeficiency virus. Improved assays are needed to prevent infectious transmissions.
    Materials and methods: The MGH Transplant Center reviewed experience with recipients of organs from donors meeting donor risk criteria and tracked all recipients for possible exposures to hepatitis C virus, hepatitis B virus, and human immunodeficiency virus. This required development of an electronic database to document microbiologic testing data.
    Results: Database enhancements allowed tracking of serologic testing. Among our organ recipients, no transmissions of the studied viruses were identified by nucleic acid testing or clinically. Multiple patients had positive serologic assays for tested viruses; all recipients were retested, and appropriate interventions were introduced if the test was confirmed. Some false-positive serologies resulted from recent hepatitis B virus vaccination, receipt of blood products, or transmission of donor B cells with tissues.
    Conclusions: Organ transplant from donors meeting donor risk criteria for disease transmission can be performed safely with appropriate informed consent and rigorous pre- and posttransplant microbiological testing. Enhanced compliance with vaccination for hepatitis B virus should be tracked. New sequencing technologies developed for investigation of undiagnosed infections and in xenotransplantation may inform future directions for donor screening. Such tools may increase the safe utilization of organs from donors who have potential risk for transmission of infection to recipients.
    MeSH term(s) Analgesics, Opioid ; HIV Infections ; Hepacivirus ; Hepatitis B virus ; Hepatitis C ; Humans ; Nucleic Acids ; Opioid Epidemic ; Tissue Donors ; Treatment Outcome
    Chemical Substances Analgesics, Opioid ; Nucleic Acids
    Language English
    Publishing date 2022-08-26
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.DonorSymp.2022.L17
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  10. Article ; Online: Mentorship in academic medicine

    Jay A. Fishman

    Health Sciences Review, Vol 1, Iss , Pp 100004- (2021)

    Competitive advantage while reducing burnout?

    2021  

    Abstract: Increased regulatory oversight, mandated use of electronic medical records, and economic constraints on healthcare and research confront academic medical institutions while the core requirements for productivity in research, teaching and excellence and ... ...

    Abstract Increased regulatory oversight, mandated use of electronic medical records, and economic constraints on healthcare and research confront academic medical institutions while the core requirements for productivity in research, teaching and excellence and equity in clinical care remain. “Burnout” is an important challenge to healthcare and reflects the alienation, cynicism and decreased productivity of responsibilities in medicine that may detract from individual career engagement. Mentorship is advantageous in the successful navigation of careers in academic medicine, notably for individuals in need of specialized knowledge, skills or psychological support to accelerate their development. A formalized mentorship program provides individuals with the guidance and support needed for career development and may alleviate some of the alienation associated with burnout. The interdisciplinary nature of biomedicine supports the use of multiple mentors to provide diverse perspectives for trainees and junior faculty. Mentorship programs require institutional engagement with clear articulation of institutional goals and values as well as financial and political support. Such programs will identify and train potential leaders throughout an organizational hierarchy, support innovation and flexibility within the organization, increase job satisfaction and retention, and, as a result, enhance the institution's competitive position. Notably, relationships developed within a supportive environment may also mitigate the development of professional burnout.
    Keywords Burnout ; leadership ; promotion ; mentorship program ; research ; innovation ; Medicine ; R
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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