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Article: Phylogenomics of

Migliaccio, Antonella / Bray, James / Intoccia, Michele / Stabile, Maria / Scala, Giovanni / Jolley, Keith A / Brisse, Sylvain / Zarrilli, Raffaele

Frontiers in microbiology

2023 Volume 14, Page(s) 1264030

Abstract: Introduction: Non-: Methods: Phylogenies were performed on Pasteur Multilocus Sequence Typing (MLST) or ribosomal Multilocus Sequence Typing (rMLST) concatenated alleles, or SNPs extracted from core genome alignment.: Results: The Pasteur MLST ... ...

Abstract	Introduction: Non- Methods: Phylogenies were performed on Pasteur Multilocus Sequence Typing (MLST) or ribosomal Multilocus Sequence Typing (rMLST) concatenated alleles, or SNPs extracted from core genome alignment. Results: The Pasteur MLST scheme was able to identify and genotype 72 species in the Conclusion: In conclusion, Pasteur MLST phylogeny of non-
Language	English
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1264030
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Article ; Online: PI3K/PTEN/mTOR pathway dynamic tracking and prognostic value in HR+/HER2- BC patients with residual disease after neoadjuvant chemotherapy: a cohort study.

Miglietta, Federica / Carraro, Valentina / Amato, Ottavia / Griguolo, Gaia / Bottosso, Michele / Munari, Giada / Zarrilli, Giovanni / Lo Mele, Marcello / Barbieri, Caterina / Dei Tos, Angelo Paolo / Guarneri, Valentina / Dieci, Maria Vittoria / Fassan, Matteo

Journal of clinical pathology

2023

Abstract: Aims: Hormone receptor-positive (HR)+/HER2- breast cancer (BC) is highly heterogeneous, with PI3K/PTEN/mTOR pathway alterations emerging as possible players within this complexity. We longitudinally tracked PI3K/PTEN/mTOR pathway dynamics from baseline ... ...

Abstract	Aims: Hormone receptor-positive (HR)+/HER2- breast cancer (BC) is highly heterogeneous, with PI3K/PTEN/mTOR pathway alterations emerging as possible players within this complexity. We longitudinally tracked PI3K/PTEN/mTOR pathway dynamics from baseline biopsy to residual disease (RD)-and to metastases in case of relapse-in HR+/HER2- BC patients receiving neoadjuvant chemotherapy (NACT). Methods: HR+/HER2- BC patients with RD after NACT were identified. We assessed Results: 92 patient were included. The conversion rate of Conclusions: We observed that PI3K/PTEN/mTOR pathway is highly dynamic under NACT exposure and the assessment of
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jcp-2023-208856
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Article ; Online: miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma.

Zarrilli, Giovanni / Galuppini, Francesca / Angerilli, Valentina / Munari, Giada / Sabbadin, Marianna / Lazzarin, Vanni / Nicolè, Lorenzo / Biancotti, Rachele / Fassan, Matteo

International journal of molecular sciences

2021 Volume 22, Issue 7

Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that play a pivotal role in many aspects of cell biology, including cancer development. Within esophageal cancer, miRNAs have been proved to be involved in all phases of carcinogenesis, from initiation to ... ...

Abstract	MicroRNAs (miRNAs) are small non-coding RNAs that play a pivotal role in many aspects of cell biology, including cancer development. Within esophageal cancer, miRNAs have been proved to be involved in all phases of carcinogenesis, from initiation to metastatic spread. Several miRNAs have been found to be dysregulated in esophageal premalignant lesions, namely Barrett's esophagus, Barrett's dysplasia, and squamous dysplasia. Furthermore, numerous studies have investigated the alteration in the expression levels of many oncomiRNAs and tumor suppressor miRNAs in esophageal squamous cell carcinoma and esophageal adenocarcinoma, thus proving how miRNAs are able modulate crucial regulatory pathways of cancer development. Considering these findings, miRNAs may have a role not only as a diagnostic and prognostic tool, but also as predictive biomarker of response to anti-cancer therapies and as potential therapeutic targets. This review aims to summarize several studies on the matter, focusing on the possible diagnostic-therapeutic implications.
MeSH term(s)	Adenocarcinoma ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Disease Progression ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/metabolism ; Esophagus/pathology ; Gene Expression ; Gene Expression Profiling ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; MicroRNAs/therapeutic use ; Precancerous Conditions/genetics ; Precancerous Conditions/metabolism ; Precancerous Conditions/pathology ; Prognosis
Chemical Substances	Biomarkers, Tumor ; MicroRNAs
Language	English
Publishing date	2021-03-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22073640
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Article: Erratum: Epigenetics of oral and oropharyngeal cancers (Review).

Russo, Daniela / Merolla, Francesco / Varricchio, Silvia / Salzano, Giovanni / Zarrilli, Giovanni / Mascolo, Massimo / Strazzullo, Viviana / Crescenzo, Rosa Maria Di / Celetti, Angela / Ilardi, Gennaro

Biomedical reports

2020 Volume 12, Issue 5, Page(s) 290

Abstract: This corrects the article DOI: 10.3892/br.2018.1136.]. ...

Abstract	[This corrects the article DOI: 10.3892/br.2018.1136.].
Language	English
Publishing date	2020-03-06
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	2763624-0
ISSN	2049-9442 ; 2049-9434
ISSN (online)	2049-9442
ISSN	2049-9434
DOI	10.3892/br.2020.1290
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Article ; Online: miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma

Giovanni Zarrilli / Francesca Galuppini / Valentina Angerilli / Giada Munari / Marianna Sabbadin / Vanni Lazzarin / Lorenzo Nicolè / Rachele Biancotti / Matteo Fassan

International Journal of Molecular Sciences, Vol 22, Iss 3640, p

2021 Volume 3640

Abstract	MicroRNAs (miRNAs) are small non-coding RNAs that play a pivotal role in many aspects of cell biology, including cancer development. Within esophageal cancer, miRNAs have been proved to be involved in all phases of carcinogenesis, from initiation to metastatic spread. Several miRNAs have been found to be dysregulated in esophageal premalignant lesions, namely Barrett’s esophagus, Barrett’s dysplasia, and squamous dysplasia. Furthermore, numerous studies have investigated the alteration in the expression levels of many oncomiRNAs and tumor suppressor miRNAs in esophageal squamous cell carcinoma and esophageal adenocarcinoma, thus proving how miRNAs are able modulate crucial regulatory pathways of cancer development. Considering these findings, miRNAs may have a role not only as a diagnostic and prognostic tool, but also as predictive biomarker of response to anti-cancer therapies and as potential therapeutic targets. This review aims to summarize several studies on the matter, focusing on the possible diagnostic–therapeutic implications.
Keywords	microRNAs ; esophageal cancer ; carcinogenetic cascade ; predictive biomarker ; targeted therapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: A Prognostic Model Based on Residual Cancer Burden and Tumor-Infiltrating Lymphocytes on Residual Disease after Neoadjuvant Therapy in HER2+ Breast Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 17, Page(s) 3429–3437

Abstract: Purpose: We aim to evaluate the prognostic significance of tumor-infiltrating lymphocyte on residual disease (RD-TIL) in HER2+ patients with breast cancer who failed to achieve pathologic complete response (pCR) after anti-HER2+ chemotherapy (CT)-based ... ...

Abstract	Purpose: We aim to evaluate the prognostic significance of tumor-infiltrating lymphocyte on residual disease (RD-TIL) in HER2+ patients with breast cancer who failed to achieve pathologic complete response (pCR) after anti-HER2+ chemotherapy (CT)-based neoadjuvant treatment (NAT). We assessed the feasibility of combining the prognostic information provided by residual cancer burden (RCB) and RD-TILs into a composite score (RCB+TIL). Experimental design: HER2+ patients with breast cancer treated with CT+anti-HER2-based NAT at three institutions were retrospectively included. RCB and TIL levels were evaluated on hematoxylin and eosin-stained slides from surgical samples according to available recommendations. Overall survival (OS) was used as an outcome measure. Results: A total of 295 patients were included, of whom 195 had RD. RCB was significantly associated with OS. Higher RD-TILs were significantly associated with poorer OS as compared with lower RD-TILs (15% cutoff). In multivariate analysis, both RCB and RD-TIL maintained their independent prognostic value. A combined score, RCB+TIL, was calculated from the estimated coefficient of RD-TILs and the RCB index in a bivariate logistic model for OS. The RCB+TIL score was significantly associated with OS. The C-index for OS of the RCB+TIL score was numerically higher than that of RCB and significantly higher than that of RD-TILs. Conclusions: We have reported an independent prognostic impact of RD-TILs after anti-HER2+CT NAT, which might underlie an imbalance of the RD microenvironment towards immunosuppressive features. We provided a new composite prognostic score based on RCB+TIL, which was significantly associated with OS and proved to be more informative than the isolated evaluation of RCB and RD-TILs.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Prognosis ; Lymphocytes, Tumor-Infiltrating ; Neoplasm, Residual/pathology ; Neoadjuvant Therapy ; Retrospective Studies ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Tumor Microenvironment
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-23-0480
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Article ; Online: Gastric metastases of breast cancer: Histopathological and molecular characterization of a single Institution case series.

Zarrilli, Giovanni / Angerilli, Valentina / Cappellesso, Rocco / Galuppini, Francesca / Pennelli, Gianmaria / Farinati, Fabio / Nicolè, Lorenzo / Savarino, Edoardo / Realdon, Stefano / Griguolo, Gaia / Bottosso, Michele / Dieci, Maria Vittoria / Guarneri, Valentina / Dei Tos, Angelo Paolo / Lo Mele, Marcello / Fassan, Matteo

Pathology, research and practice

2022 Volume 233, Page(s) 153872

Abstract: The metastatic spread of breast carcinoma to the stomach is a rare event and often represents a diagnostic challenge. In the present study, 23 cases of gastric metastases from breast cancer were retrospectively identified dating back until 2007. ... ...

Abstract	The metastatic spread of breast carcinoma to the stomach is a rare event and often represents a diagnostic challenge. In the present study, 23 cases of gastric metastases from breast cancer were retrospectively identified dating back until 2007. Primitive histotype, localization, gross appearance, microscopic architecture were analyzed. Cytokeratins 7 and 20, sex hormones, HER2 and Ki67 expression was evaluated. According to the results, the series was characterized by an enrichment of lobular primitive histotype (43.7%). In most cases gastric metastases were described as parietal nodules, polypoid masses or ulcerated lesions, mainly involving the antro-angular region. In a relatively high rate (10.5%) of cases, endoscopic examinations resulted negative for macroscopic lesions. More than half of the cases (52.2%) microscopically resembled primitive poorly cohesive gastric cancer. Because gross and histological findings can be deceiving, immunohistochemistry may be essential for the diagnosis of gastric metastases from breast cancer. Accordingly with the results of our analysis and literature review, an immunohistochemical panel composed of cytokeratins 7 and 20, Estrogen and Progesteron Receptors would drastically improve diagnostic accuracy. Interaction among the clinician, endoscopist and the pathologist is also essential to provide the patient the best therapeutic option.
MeSH term(s)	Breast Neoplasms ; Estrogens ; Female ; Humans ; Keratin-7 ; Retrospective Studies ; Stomach
Chemical Substances	Estrogens ; Keratin-7
Language	English
Publishing date	2022-04-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2022.153872
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Article ; Online: The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury.

Zarrilli, Giovanni / Angerilli, Valentina / Businello, Gianluca / Sbaraglia, Marta / Traverso, Giulia / Fortarezza, Francesco / Rizzo, Stefania / De Gaspari, Monica / Basso, Cristina / Calabrese, Fiorella / Dei Tos, Angelo Paolo / Fassan, Matteo

International journal of molecular sciences

2021 Volume 22, Issue 2

Abstract: A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have ... ...

Abstract	A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as "cytokine storm".
MeSH term(s)	Angiotensin-Converting Enzyme 2/metabolism ; Autopsy ; COVID-19/diagnostic imaging ; COVID-19/immunology ; COVID-19/pathology ; Cytokine Release Syndrome ; Cytokines/blood ; Humans ; Lung Injury/diagnostic imaging ; Lung Injury/immunology ; Lung Injury/pathology ; Lung Injury/virology ; SARS-CoV-2/isolation & purification
Chemical Substances	Cytokines ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-01-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22020974
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Article ; Online: Correction: Incorporating weekly carboplatin in anthracycline and paclitaxel-containing neoadjuvant chemotherapy for triple-negative breast cancer: propensity-score matching analysis and TIL evaluation.

British journal of cancer

2022 Volume 128, Issue 2, Page(s) 398

Language	English
Publishing date	2022-12-02
Publishing country	England
Document type	Published Erratum
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-022-02087-9
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Article ; Online: The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury

Giovanni Zarrilli / Valentina Angerilli / Gianluca Businello / Marta Sbaraglia / Giulia Traverso / Francesco Fortarezza / Stefania Rizzo / Monica De Gaspari / Cristina Basso / Fiorella Calabrese / Angelo Paolo Dei Tos / Matteo Fassan

International Journal of Molecular Sciences, Vol 22, Iss 2, p

2021 Volume 974

Abstract	A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as “cytokine storm”.
Keywords	SARS-CoV-2 ; COVID19 ; pathology ; cytokine storm ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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