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Article: Effect of Spironolactone and dbcAMP-Ca Combination Therapy on Clinical Outcomes and Left Ventricular Function in Chronic Heart Failure Patients Post Percutaneous Coronary Intervention.

Ye, Li / Tu, Sijia

Alternative therapies in health and medicine

2024

Abstract: Background: Improving treatment outcomes in chronic heart failure (CHF) patients post percutaneous coronary intervention (PCI) is of significant importance. CHF is a prevalent and severe chronic condition that negatively impacts patients' quality of ... ...

Abstract	Background: Improving treatment outcomes in chronic heart failure (CHF) patients post percutaneous coronary intervention (PCI) is of significant importance. CHF is a prevalent and severe chronic condition that negatively impacts patients' quality of life and increases the risks of hospitalization and mortality. Therefore, evaluating effective treatment strategies is crucial in improving the prognosis of CHF patients after PCI. Objective: The main objective of this study was to evaluate the clinical efficacy of combining spironolactone with dbcAMP-Ca in CHF patients following PCI. The study aimed to assess the impact of this combination therapy on both clinical outcomes and left ventricular function. Methodology: The study design involved the random assignment of 110 CHF subjects post-PCI into two groups: a combination group receiving spironolactone with dbcAMP-Ca and a spironolactone-only group. The subjects' clinical efficacy, left ventricular function, plasma brain natriuretic peptide (BNP), serum uric acid (UA), serum high-sensitivity C-reactive protein (hs-CRP) levels, autonomic nerve function, and postoperative adverse reactions were assessed. Results: The results demonstrated that the combination group, receiving spironolactone with dbcAMP-Ca, showed superior clinical efficacy, improved left ventricular function, and enhanced autonomic nerve function compared to the spironolactone-only group. Additionally, the combination group exhibited a lower incidence of adverse reactions and reduced levels of plasma BNP, UA, and hs-CRP. These findings indicate that spironolactone combined with dbcAMP-Ca has a favorable clinical effect in CHF patients post-PCI, effectively improving left ventricular and autonomic nerve function while maintaining high safety. Conclusions: The combination therapy of spironolactone and dbcAMP-Ca holds potential as an effective treatment strategy for CHF patients following PCI. This combination therapy demonstrated superior clinical efficacy, improved left ventricular function, and enhanced autonomic nerve function, with reduced adverse reactions and biomarker levels. Spironolactone combined with dbcAMP-Ca can be considered as a beneficial treatment strategy for CHF patients post-PCI. The demonstrated clinical efficacy, improvement in left ventricular function, and enhanced autonomic nerve function support the wider application of this combination therapy in the management of CHF patients in clinical settings.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fabrication and characterisation of collagen/pullulan ultra-thin fibers by electrospinning.

Chen, Junde / Li, Jianying / Li, Yushuang / Wu, Sijia

Food chemistry: X

2024 Volume 21, Page(s) 101138

Abstract: Collagen electrospun fibers are promising materials for food packaging and tissue engineering. The conventional electrospinning of collagen, however, is usually carried out by dissolving it in organic reagents, which are toxic. In this study, collagen/ ... ...

Abstract	Collagen electrospun fibers are promising materials for food packaging and tissue engineering. The conventional electrospinning of collagen, however, is usually carried out by dissolving it in organic reagents, which are toxic. In this study, collagen/pullulan (COL/PUL) ultra-thin fibers were prepared by electrospinning using acetic acid as a solvent. Compared to the conventional preparation method, the proposed method is safe and does not produce toxic solvent residues. The introduction of PUL increased the degree of molecular entanglement in the solution, so the viscosity of the COL/PUL electrospun solution increased from 0.50 ± 0.01 Pa∙s to 4.40 ± 0.08 Pa∙s, and the electrical conductivity decreased from 1954.00 ± 1.00 mS/cm to 1372.33 ± 0.58 mS/cm. Scanning electron microscopy analysis confirmed that PUL improved the spinnability of COL, and smooth, defect-free COL/PUL ultra-thin fibers with diameters of 215.32 ± 40.56 nm and 240.97 ± 53.93 nm were successfully prepared at a viscosity of greater than 1.18 Pa∙s. As the proportion of PUL increased, intramolecular hydrogen bonds became the dominant interaction between COL and PUL. The intermolecular hydrogen bonding content decreased from 52.05 % to 36.45 %, and the intramolecular hydrogen bonding content increased from 46.11 % to 62.95 %. The COL was gradually unfolded, the content of α-helices decreased from 33.57 % to 25.91 % and the random coils increased from 34.22 % to 40.09 %. More than 36 % of the triple helix fraction of COL was retained by the COL/PUL ultra-thin fibers, whereas only 16 % of the triple helix fraction of COL was retained by the COL nanofibers prepared with 2.2.2-trifluoroethanol. These results could serve as a reference for the development of green food COL-based fibers.
Language	English
Publishing date	2024-01-16
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1575
ISSN (online)	2590-1575
DOI	10.1016/j.fochx.2024.101138
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Seq-RBPPred: Predicting RNA-Binding Proteins from Sequence.

Yan, Yuyao / Li, Wenran / Wang, Sijia / Huang, Tao

ACS omega

2024 Volume 9, Issue 11, Page(s) 12734–12742

Abstract: RNA-binding proteins (RBPs) can interact with RNAs to regulate RNA translation, modification, splicing, and other important biological processes. The accurate identification of RBPs is of paramount importance for gaining insights into the intricate ... ...

Abstract	RNA-binding proteins (RBPs) can interact with RNAs to regulate RNA translation, modification, splicing, and other important biological processes. The accurate identification of RBPs is of paramount importance for gaining insights into the intricate mechanisms underlying organismal life activities. Traditional experimental methods to predict RBPs require a lot of time and money, so it is important to develop computational methods to predict RBPs. However, the existing approaches for RBP prediction still require further improvement due to unidentified RBPs in many species. In this study, we present Seq-RBPPred (predicting RBPs from sequence), a novel method that utilizes a comprehensive feature representation encompassing both biophysical properties and hidden-state features derived from protein sequences. In the results, comprehensive performance evaluations of Seq-RBPPred its superiority compare with state-of-the-art methods, yielding impressive performance including 0.922 for overall accuracy, 0.926 for sensitivity, 0.903 for specificity, and Matthew's correlation coefficient (MCC) of 0.757 as ascertained from the evaluation of the testing set. The data and code of Seq-RBPPred are available at https://github.com/yaoyao-11/Seq-RBPPred.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c08381
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fe-codoped carbon dots serving as a peroxidase mimic to generate in situ hydrogen peroxide for the visual detection of glucose.

Xie, Sijia / Zeng, Yating / Li, Jinfu / Lu, Xuemei / Xiong, Hai

Analytical and bioanalytical chemistry

2024

Abstract: Nanozyme technology has gained significant regard and been successfully implemented in various applications including chemical sensing, bio-medicine, and environmental monitoring. Fe-CDs were synthesized and characterized well in this study. As compared ... ...

Abstract	Nanozyme technology has gained significant regard and been successfully implemented in various applications including chemical sensing, bio-medicine, and environmental monitoring. Fe-CDs were synthesized and characterized well in this study. As compared to HRP (3.7 mM), the Fe-CDs exhibited a higher affinity towards H
Language	English
Publishing date	2024-02-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-024-05196-x
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Article ; Online: Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis.

Peng, Yue / Yang, Zhengshuang / Li, Jinling / Liu, Sijia

Drug delivery and translational research

2024 Volume 14, Issue 6, Page(s) 1517–1534

Abstract: Osteoarthritis (OA) is a prevalent chronic condition that primarily impacts the articular cartilage and surrounding bone tissue, resulting in joint inflammation and structural deterioration. The etiology of OA is multifaceted and intricately linked to ... ...

Abstract	Osteoarthritis (OA) is a prevalent chronic condition that primarily impacts the articular cartilage and surrounding bone tissue, resulting in joint inflammation and structural deterioration. The etiology of OA is multifaceted and intricately linked to the oxidative stress response of joint tissue. Oxidative stress (OS) in OA leads to the creation of reactive oxygen species (ROS) and other oxidizing agents, resulting in detrimental effects on chondrocytes. This oxidative damage diminishes the flexibility and robustness of cartilage, thereby expediting the progression of joint deterioration. Therefore, the antioxidant effect is crucial in the treatment of OA. Currently, a considerable number of components found in traditional Chinese medicine (TCM) have been scientifically demonstrated to exhibit remarkable antioxidant and anti-inflammatory properties. Nevertheless, the utilization of this program is considerably constrained as a result of intrinsic deficiencies, notably stability concerns. The successful amalgamation of TCM components with nanotechnology has properly tackled these concerns and enhanced the efficacy of therapeutic results. The objective of this study is to delineate the antioxidant characteristics of nano-TCM and assess the current inventory of literature pertaining to the application of nano-TCM in the treatment of OA. In conclusion, this paper will now turn to the constraints and potential avenues for the advancement of nano-TCM within the realm of OA therapy.
MeSH term(s)	Osteoarthritis/drug therapy ; Humans ; Medicine, Chinese Traditional ; Antioxidants/administration & dosage ; Antioxidants/therapeutic use ; Antioxidants/pharmacology ; Animals ; Nanotechnology ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/chemistry ; Oxidative Stress/drug effects
Chemical Substances	Antioxidants ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-024-01517-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Efficient Estimation under Data Fusion.

Li, Sijia / Luedtke, Alex

Biometrika

2023 Volume 110, Issue 4, Page(s) 1041–1054

Abstract: We aim to make inferences about a smooth, finite-dimensional parameter by fusing data from multiple sources together. Previous works have studied the estimation of a variety of parameters in similar data fusion settings, including in the estimation of ... ...

Abstract	We aim to make inferences about a smooth, finite-dimensional parameter by fusing data from multiple sources together. Previous works have studied the estimation of a variety of parameters in similar data fusion settings, including in the estimation of the average treatment effect and average reward under a policy, with the majority of them merging one historical data source with covariates, actions, and rewards and one data source of the same covariates. In this work, we consider the general case where one or more data sources align with each part of the distribution of the target population, for example, the conditional distribution of the reward given actions and covariates. We describe potential gains in efficiency that can arise from fusing these data sources together in a single analysis, which we characterize by a reduction in the semiparametric efficiency bound. We also provide a general means to construct estimators that achieve these bounds. In numerical simulations, we illustrate marked improvements in efficiency from using our proposed estimators rather than their natural alternatives. Finally, we illustrate the magnitude of efficiency gains that can be realized in vaccine immunogenicity studies by fusing data from two HIV vaccine trials.
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1119-8
ISSN	1464-3510 ; 0006-3444
ISSN (online)	1464-3510
ISSN	0006-3444
DOI	10.1093/biomet/asad007
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Article: Global trends and developments in mindfulness interventions for diabetes: a bibliometric study.

Jiang, Sijia / Pan, Xiaoli / Li, Hansen / Su, Yuqin

Diabetology & metabolic syndrome

2024 Volume 16, Issue 1, Page(s) 43

Abstract: Background: Diabetes is a metabolic disorder posing a global threat to health. Many scholars are dedicated to developing non-pharmacological therapies, and mindfulness intervention is among the potentially effective approaches. Due to the rapid increase ...

Abstract	Background: Diabetes is a metabolic disorder posing a global threat to health. Many scholars are dedicated to developing non-pharmacological therapies, and mindfulness intervention is among the potentially effective approaches. Due to the rapid increase in relevant research in recent years, along with the diverse focus and interventions used in studies, it has become challenging for practitioners to quickly comprehend the key features of this field and the directions worth paying attention to. Bibliometric analysis, in response, can help scholars understand this field and identify points of interest. Methods: Publications related to mindfulness intervention in diabetes from the establishment of the Web of Science Core Collection (WOSCC) to September 2023 were searched. We employed four bibliometric techniques: General Analysis of Publications, Collaborative Network Analysis, Co-citation Analysis, and Keyword Analysis. The CiteSpace 6.1.R was used to analyze the literature with the strongest citation bursts, while VOSviewer 1.6.13 was used to provide visualizations of publicly available data by analyzing co-citations or co-authorship affiliations. Results: We found a total of 387 articles. The results indicate that research on this topic has been steadily increasing over time. The United States is the top producer of relevant publications, with Tilburg University being the institution that publishes the most articles. The journal "Mindfulness" has the highest publication count. In the collaborative network analysis, the United States emerged as the main hub for global cooperation in this research field, contributing 182 articles with a total of 5872 citations. The journal "Diabetes Care" was frequently cited and played a central role. The keyword analysis revealed that researchers have shown a strong interest in how mindfulness interventions affect the mental health of diabetic individuals. Additionally, there is a focus on studying elderly diabetic groups and exploring how mindfulness interventions impact metabolic diseases. These areas are currently the main research priorities. Conclusion: Our findings demonstrate the current trend and hotspots in mindfulness intervention and offer some directions for future research.
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-024-01288-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of transcranial direct current stimulation on cognitive function in older adults with and without mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials.

Li, Sijia / Tang, Ying / Zhou, You / Ni, Yunxia

Gerontology

2024

Abstract: Introduction: Noninvasive brain stimulation (NIBS) has shown benefits for cognitive function in older adults. However, the effects of transcranial direct current stimulation (tDCS) on cognitive function in older adults are inconsistent across studies, ... ...

Abstract	Introduction: Noninvasive brain stimulation (NIBS) has shown benefits for cognitive function in older adults. However, the effects of transcranial direct current stimulation (tDCS) on cognitive function in older adults are inconsistent across studies, and the evidence for tDCS has limitations. We aim to explore whether tDCS can improve cognitive function and different cognitive domains (i.e., learning and memory and executive function) in adults aged 65 and older with and without mild cognitive impairment and to further analyze the influencing factors of tDCS. Methods: Five English databases (PubMed, Cochrane Library, EMBASE, Web of Science, the cumulative Index to Nursing and Allied Health Literature [CINAHL]) and four Chinese databases were searched from inception to 14 October 2023. Literature screening, data extraction, and quality assessment were completed independently by two reviewers. All statistical analyses were conducted using RevMan software (version 5.3). Standardized mean difference (SMD) along with a 95% confidence interval (CI) were used to express the effect size of the outcomes, and a random-effect model was also used. Results: A total of 10 RCTs and 1761 participants were included in the meta-analysis, and the risk of bias in those studies was relatively low. A significant effect favoring tDCS on immediate postintervention cognitive function (SMD=0.16, Z=2.36, P=0.02) was found. However, the effects on immediate postintervention learning and memory (SMD=0.20, Z=2.00, P=0.05) and executive function (SMD=0.10, Z=1.22, P=0.22), and 1-month postintervention cognitive function (SMD=0.12, Z=1.50, P=0.13), learning and memory (SMD=0.17, Z=1.39, P=0.16) and executive function (SMD=0.08, Z=0.67, P=0.51) were not statistically significant. Conclusion: TDCS can significantly improve the immediate postintervention cognitive function of healthy older adults and MCI elderly individuals. Additional longitudinal extensive sample studies are required to clarify the specific effects of tDCS on different cognitive domains, and the optimal tDCS parameters need to be explored to guide clinical practice.
Language	English
Publishing date	2024-03-07
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	193798-4
ISSN	1423-0003 ; 0304-324X
ISSN (online)	1423-0003
ISSN	0304-324X
DOI	10.1159/000537848
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Article ; Online: From Water to Water: Insight into the Translocation of Pesticides from Plant Rhizosphere Solution to Leaf Guttation and the Associated Ecological Risks.

Xia, Beiqi / Wang, Sijia / Li, Runan / Dong, Fengshou / Zheng, Yongquan / Li, Yuanbo

Environmental science & technology

2024

Abstract: Plant guttation is an important source of water/nutrients for many beneficial insects, while the presence of pesticides in guttation has been considered as a new exposure route for nontarget insects. This study aimed to elucidate how 15 diverse ... ...

Abstract	Plant guttation is an important source of water/nutrients for many beneficial insects, while the presence of pesticides in guttation has been considered as a new exposure route for nontarget insects. This study aimed to elucidate how 15 diverse pesticides are translocated from growth media to guttation by maize plants through a hydroponic experiment. All pesticides were effectively translocated from the growth solution to maize guttation and reached a steady state within 5 days. The strong positive correlation (
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c10925
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effect of Urban Agglomeration Expansion on PM2.5 Concentrations: Evidence from a Quasi-natural Experiment

Li, Sijia / Wu, Lihua

Chin. Geogr. Sci.. 2023 Apr., v. 33, no. 2 p.250-270

2023

Abstract: This study constructs a quasi-natural experiment based on the expansion of the Yangtze River Delta urban agglomeration (YRDUA) of China in 2010 to investigate the impact and inner mechanism of urban agglomeration expansion on fine particulate matter (PM₂. ...

Abstract	This study constructs a quasi-natural experiment based on the expansion of the Yangtze River Delta urban agglomeration (YRDUA) of China in 2010 to investigate the impact and inner mechanism of urban agglomeration expansion on fine particulate matter (PM₂.₅) concentrations through propensity scores in difference-in-differences models (PSM-DID) using panel data from 286 prefecture-level cities in China from 2003 to 2016. The results show that 1) urban agglomeration expansion contributes to an overall decrease in PM₂.₅ concentration, which is mainly achieved from the original cities. For the new cities, on the other hand, the expansion significantly increases the local PM₂.₅ concentration. 2) In the long term, the significant influence of urban agglomeration expansion on PM₂.₅ concentration lasts for three years and gradually decreases. A series of robustness tests confirm the applicability of the PSM-DID model. 3) Cities with weaker government regulation, a better educated population and higher per capita income present stronger PM₂.₅ reduction effects. 4) Urban agglomeration expansion affects the PM₂.₅ concentration mainly through industrial transfer and population migration, which cause a decrease in the PM₂.₅ concentration in the original cities and an increase in the PM₂.₅ concentration in the new cities. Corresponding policy suggestions are proposed based on the conclusions.
Keywords	income ; issues and policy ; models ; particulates ; river deltas ; China ; Yangtze River
Language	English
Dates of publication	2023-04
Size	p. 250-270.
Publishing place	Science Press
Document type	Article ; Online
ZDB-ID	2268241-7
ISSN	1993-064X ; 1002-0063
ISSN (online)	1993-064X
ISSN	1002-0063
DOI	10.1007/s11769-023-1342-4
Database	NAL-Catalogue (AGRICOLA)

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