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  1. Article: Editorial: Tumor metabolism: From molecular mechanisms to clinical application.

    Cheng, Chunming / Zhang, Si / Guan, Dongyin / Wang, Yi / Jyotsana, Nidhi

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1158467

    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1158467
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  2. Article ; Online: Editorial

    Chunming Cheng / Si Zhang / Dongyin Guan / Yi Wang / Nidhi Jyotsana

    Frontiers in Cell and Developmental Biology, Vol

    Tumor metabolism: From molecular mechanisms to clinical application

    2023  Volume 11

    Keywords tumor ; metabolism ; mechanism ; clinical application ; metabolic pathways ; therapeutic strategies ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer.

    Jyotsana, Nidhi / Ta, Kenny T / DelGiorno, Kathleen E

    Frontiers in oncology

    2022  Volume 12, Page(s) 858462

    Abstract: SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress and ...

    Abstract SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress and is, therefore, critical to cell growth, proliferation, and metabolism. SLC7A11 is expressed in different tissues and plays diverse functional roles in the pathophysiology of various diseases, including cancer, by regulating the processes of redox homeostasis, metabolic flexibility/nutrient dependency, immune system function, and ferroptosis. SLC7A11 expression is associated with poor prognosis and drug resistance in cancer and, therefore, represents an important therapeutic target. In this review, we discuss the molecular functions of SLC7A11 in normal
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.858462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Impact of COVID-19 on Cancer Risk and Treatment.

    Jyotsana, Nidhi / King, Michael R

    Cellular and molecular bioengineering

    2020  Volume 13, Issue 4, Page(s) 285–291

    Abstract: Millions of people are being infected with COVID-19 around the globe. Though the majority of them will recover, cancer patients remain at a higher risk to SARS-CoV-2 infection and its related severe outcomes. Understanding how viruses contribute to human ...

    Abstract Millions of people are being infected with COVID-19 around the globe. Though the majority of them will recover, cancer patients remain at a higher risk to SARS-CoV-2 infection and its related severe outcomes. Understanding how viruses contribute to human cancers provides us with new opportunities for preventing or treating virus-associated cancers. However, a limited amount of research has been done to date in the context of how viral infections impact cancer at the cellular level and
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2416037-4
    ISSN 1865-5033 ; 1865-5025
    ISSN (online) 1865-5033
    ISSN 1865-5025
    DOI 10.1007/s12195-020-00630-3
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  5. Article ; Online: The Impact of COVID-19 on Cancer Risk and Treatment

    Jyotsana, Nidhi / King, Michael R.

    Cellular and Molecular Bioengineering

    2020  Volume 13, Issue 4, Page(s) 285–291

    Keywords General Biochemistry, Genetics and Molecular Biology ; Modelling and Simulation ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2416037-4
    ISSN 1865-5033 ; 1865-5025
    ISSN (online) 1865-5033
    ISSN 1865-5025
    DOI 10.1007/s12195-020-00630-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The Impact of COVID-19 on Cancer Risk and Treatment

    Jyotsana, Nidhi / King, Michael R

    Cell Mol Bioeng

    Abstract: Millions of people are being infected with COVID-19 around the globe. Though the majority of them will recover, cancer patients remain at a higher risk to SARS-CoV-2 infection and its related severe outcomes. Understanding how viruses contribute to human ...

    Abstract Millions of people are being infected with COVID-19 around the globe. Though the majority of them will recover, cancer patients remain at a higher risk to SARS-CoV-2 infection and its related severe outcomes. Understanding how viruses contribute to human cancers provides us with new opportunities for preventing or treating virus-associated cancers. However, a limited amount of research has been done to date in the context of how viral infections impact cancer at the cellular level and vice versa. Therefore, in light of the COVID-19 global infection, this review highlights the need for better understanding of the biology of viral infections in cancer patients, to enable novel therapies to co-target viral infections and cancer.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #617312
    Database COVID19

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  7. Article ; Online: Overcoming TRAIL-resistance by sensitizing prostate cancer 3D spheroids with taxanes.

    Grayson, Korie A / Jyotsana, Nidhi / Ortiz-Otero, Nerymar / King, Michael R

    PloS one

    2021  Volume 16, Issue 3, Page(s) e0246733

    Abstract: Three-dimensional spheroid cultures have been shown to better physiologically mimic the cell-cell and cell-matrix interactions that occur in solid tumors more than traditional 2D cell cultures. One challenge in spheroid production is forming and ... ...

    Abstract Three-dimensional spheroid cultures have been shown to better physiologically mimic the cell-cell and cell-matrix interactions that occur in solid tumors more than traditional 2D cell cultures. One challenge in spheroid production is forming and maintaining spheroids of uniform size. Here, we developed uniform, high-throughput, multicellular spheroids that self-assemble using microwell plates. DU145 and PC3 cells were cultured as 2D monolayers and 3D spheroids to compare sensitization of TRAIL-resistance cancer cells to TRAIL mediated apoptosis via chemotherapy based on dimensionality. Monocultured monolayers and spheroids were treated with soluble TRAIL alone (24 hr), DTX or CBZ alone (24 hr), or a combination of taxane and TRAIL (24 + 24 hr) to determine the effectiveness of taxanes as TRAIL sensitizers. Upon treatment with soluble TRAIL or taxanes solely, monolayer cells and spheroids exhibited no significant reduction in cell viability compared to the control, indicating that both cell lines are resistant to TRAIL and taxane alone in 2D and 3D. Pretreatment with CBZ or DTX followed by TRAIL synergistically amplified apoptosis in 2D and 3D DU145 cell cultures. PC3 spheroids were more resistant to the combination therapy, displaying a more additive effect in the DTX + TRAIL group compared to 2D. There was a downregulation of DR4/5 expression in spheroid form compared to monolayers in each cell line. Additionally, normal fibroblasts (NFs) and cancer-associated fibroblasts (CAFs) were cocultured with both PCa cell lines as spheroids to determine if CAFs confer additional resistance to chemotherapy. We determined that co-cultured spheroids show similar drug resistance to monocultured spheroids when treated with taxane plus TRAIL treatment. Collectively, these findings suggest how the third dimension and cocultures of different cell types effect the sensitization of androgen-independent prostate cancer cells to TRAIL, suggesting therapeutic targets that could overcome TRAIL-resistance in metastatic castration-resistant prostate cancer (mCRPC).
    MeSH term(s) Apoptosis/drug effects ; Bridged-Ring Compounds/pharmacology ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; Humans ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/pathology ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; Taxoids/pharmacology
    Chemical Substances Bridged-Ring Compounds ; TNF-Related Apoptosis-Inducing Ligand ; Taxoids ; taxane (1605-68-1)
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0246733
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  8. Article ; Online: Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.

    Jyotsana, Nidhi / Heuser, Michael

    Expert opinion on therapeutic targets

    2017  Volume 22, Issue 2, Page(s) 107–121

    Abstract: Introduction: Mutations in genes associated with splicing have been found in hematologic malignancies, but also in solid cancers. Aberrant cancer specific RNA splicing either results from mutations or misexpression of the spliceosome genes directly, or ... ...

    Abstract Introduction: Mutations in genes associated with splicing have been found in hematologic malignancies, but also in solid cancers. Aberrant cancer specific RNA splicing either results from mutations or misexpression of the spliceosome genes directly, or from mutations in splice sites of oncogenes or tumor suppressors. Areas covered: In this review, we present molecular targets of aberrant splicing in various malignancies, information on existing and emerging therapeutics against such targets, and strategies for future drug development. Expert opinion: Alternative splicing is an important mechanism that controls gene expression, and hence pharmacologic and genetic control of aberrant alternative RNA splicing has been proposed as a potential therapy in cancer. To identify and validate aberrant RNA splicing patterns as therapeutic targets we need to (1) characterize the most common genetic aberrations of the spliceosome and of splice sites, (2) understand the dysregulated downstream pathways and (3) exploit in-vivo disease models of aberrant splicing. Antisense oligonucleotides show promising activity, but will benefit from improved delivery tools. Inhibitors of mutated splicing factors require improved specificity, as alternative and aberrant splicing are often intertwined like two sides of the same coin. In summary, targeting aberrant splicing is an early but emerging field in cancer treatment.
    MeSH term(s) Alternative Splicing/genetics ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Humans ; Molecular Targeted Therapy ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Oligonucleotides, Antisense/administration & dosage ; Oncogenes/genetics ; RNA Splicing/genetics
    Chemical Substances Antineoplastic Agents ; Oligonucleotides, Antisense
    Language English
    Publishing date 2017-12-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2018.1417390
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas.

    Wong, Jahg / Trinh, Vincent Q / Jyotsana, Nidhi / Baig, Jumanah F / Revetta, Frank / Shi, Chanjuan / Means, Anna L / DelGiorno, Kathleen E / Tan, Marcus

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20088

    Abstract: Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions. Alterations ... ...

    Abstract Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions. Alterations in HNF4α isoforms have been associated with tumorigenesis. However, the distribution of its isoforms during progression from dysplasia to malignancy has not been studied, nor has it yet been studied in intraductal papillary mucinous neoplasms, where both malignant and pre-malignant forms are routinely clinically identified. We examined the expression patterns of pan-promoter, P1-specific, and P2-specific isoform groups in normal pancreatic components and IPMNs. Pan-promoter, P1 and P2 nuclear expression were weakly positive in normal pancreatic components. Nuclear expression for all isoform groups was increased in low-grade IPMN, high-grade IPMN, and well-differentiated invasive adenocarcinoma. Poorly differentiated invasive components in IPMNs showed loss of all forms of HNF4α. Pan-promoter, and P1-specific HNF4α expression showed shifts in subnuclear and sub-anatomical distribution in IPMN, whereas P2 expression was consistently nuclear. Tumor cells with high-grade dysplasia at the basal interface with the stroma showed reduced expression of P1, while P2 was equally expressed in both components. Additional functional studies are warranted to further explore the mechanisms underlying the spatial and differential distribution of HNF4α isoforms in IPMNs.
    MeSH term(s) Humans ; Pancreatic Intraductal Neoplasms/pathology ; Pancreatic Neoplasms/pathology ; Pancreas/metabolism ; Adenocarcinoma/pathology ; Hyperplasia/pathology ; Protein Isoforms/metabolism ; Carcinoma, Pancreatic Ductal/pathology
    Chemical Substances Protein Isoforms
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-47238-x
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  10. Article: Oncogenic GNAS drives a gastric pylorus program in intraductal papillary mucinous neoplasms of the pancreas.

    Trinh, Vincent Quoc-Huy / Ankenbauer, Katherine E / Liu, Jiayue / Batardiere, Maelle / Maurer, H Carlo / Copeland, Celina / Wong, Jahg / Ben-Levy, Olivia / Torbit, Sabrina M / Jarvis, Brenda / Revetta, Frank / Ivanov, Sergey / Jyotsana, Nidhi / Makino, Yuki / Ruelas, Amanda M / Means, Anna L / Maitra, Anirban / Tan, Marcus C B / DelGiorno, Kathleen E

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Objective: Intraductal Papillary Mucinous Neoplasms (IPMNs) are cystic lesions and bona fide precursors for pancreatic ductal adenocarcinoma (PDAC). Recently, we showed that acinar to ductal metaplasia, an injury repair program, is characterized by a ... ...

    Abstract Objective: Intraductal Papillary Mucinous Neoplasms (IPMNs) are cystic lesions and bona fide precursors for pancreatic ductal adenocarcinoma (PDAC). Recently, we showed that acinar to ductal metaplasia, an injury repair program, is characterized by a transcriptomic program similar to gastric spasmolytic polypeptide expressing metaplasia (SPEM), suggesting common mechanisms of reprogramming between the stomach and pancreas. The aims of this study were to assay IPMN for pyloric markers and to identify molecular drivers of this program.
    Design: We analyzed RNA-seq studies of IPMN for pyloric markers, which were validated by immunostaining in patient samples. Cell lines expressing
    Results: Pyloric markers were identified in human IPMN.
    Conclusion: De novo
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.25.581948
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