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  1. Article ; Online: Author's reply to the Letter to the Editor on the original article "Lack of changes in preterm delivery and stillbirths during COVID-19 lockdown in a European region" by Juan Arnaez.

    Arnaez, Juan / Ochoa-Sangrador, Carlos / Garcia-Alix, Alfredo

    European journal of pediatrics

    2021  Volume 180, Issue 6, Page(s) 2005–2006

    MeSH term(s) COVID-19 ; Communicable Disease Control ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Premature Birth ; SARS-CoV-2 ; Stillbirth
    Language English
    Publishing date 2021-04-12
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-021-04072-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.75: Show issues Location:
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  2. Article ; Online: Value of brain damage biomarkers in cerebrospinal fluid in neonates with hypoxic-ischemic brain injury.

    Garcia-Alix, Alfredo / Arnaez, Juan

    Biomarkers in medicine

    2022  

    Abstract: Hypoxic-ischemic encephalopathy is one of the leading causes of death and neurological disability worldwide. A key issue in neonates with hypoxic-ischemic encephalopathy is accurately establishing the occurrence and severity of brain lesions soon after a ...

    Abstract Hypoxic-ischemic encephalopathy is one of the leading causes of death and neurological disability worldwide. A key issue in neonates with hypoxic-ischemic encephalopathy is accurately establishing the occurrence and severity of brain lesions soon after a perinatal hypoxic-ischemic event. This is crucial to help with prognosis; guide clinical decision-making, including the use of other therapies; and improve family counseling. Neurobiochemical markers may offer a quantitative approximation for estimating the severity of brain damage and identifying infants who have a high risk of further neurological disability. In addition, they should help identify those neonates who would benefit most from the implementation of other neuroprotective and neuroreparative interventions. Despite considerable progress in this area, relatively few studies have been aimed at examining the clinical utility of brain-specific proteins in cerebrospinal fluid, an important opening to characterizing pathological phenomena associated with hypoxic-ischemic brain injury.
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2021-0381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6985: Show issues Location:
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  3. Article ; Online: Hypoxic-ischaemic encephalopathy code: A systematic review for resource-limited settings.

    Garcia-Alix, Alfredo / Arnaez, Juan / Arca, Gemma / Martinez-Biarge, Miriam

    Anales de pediatria

    2024  Volume 100, Issue 4, Page(s) 275–286

    Abstract: It is estimated that 96% of infants with hypoxic-ischaemic encephalopathy (HIE) are born in resource-limited settings with no capacity to provide the standard of care that has been established for nearly 15 years in high-resource countries, which ... ...

    Abstract It is estimated that 96% of infants with hypoxic-ischaemic encephalopathy (HIE) are born in resource-limited settings with no capacity to provide the standard of care that has been established for nearly 15 years in high-resource countries, which includes therapeutic hypothermia (TH), continuous electroencephalographic monitoring and magnetic resonance imaging (MRI) in addition to close vital signs and haemodynamic monitoring. This situation does not seem to be changing; however, even with these limitations, currently available knowledge can help improve the care of HIE patients in resource-limited settings. The purpose of this systematic review was to provide, under the term "HIE Code", evidence-based recommendations for feasible care practices to optimise the care of infants with HIE and potentially help reduce the risks associated with comorbidity and improve neurodevelopmental outcomes. The content of the HIE code was grouped under 9 headings: (1) prevention of HIE, (2) resuscitation, (3) first 6h post birth, (4) identification and grading of encephalopathy, (5) seizure management, (6) other therapeutic interventions, (7) multiple organ dysfunction, (8) diagnostic tests and (9) family care.
    MeSH term(s) Humans ; Hypoxia-Ischemia, Brain/therapy ; Hypoxia-Ischemia, Brain/diagnosis ; Infant, Newborn ; Developing Countries ; Hypothermia, Induced/methods ; Health Resources ; Electroencephalography ; Resource-Limited Settings
    Language English
    Publishing date 2024-04-12
    Publishing country Spain
    Document type Systematic Review ; Journal Article
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2024.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neuromonitorización en el neonato prematuro extremo.

    Arnaez, Juan / García-Alix, Alfredo

    Anales de pediatria

    2021  

    Title translation Neuromonitoring of the extremely preterm infant.
    Language Spanish
    Publishing date 2021-07-30
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpedi.2021.07.005
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  5. Article: Neuron-specific enolase in cerebrospinal fluid as a biomarker of brain damage in infants with hypoxic-ischemic encephalopathy.

    Garcia-Alix, Alfredo / Arnaez, Juan

    Neural regeneration research

    2021  Volume 17, Issue 2, Page(s) 318–319

    Language English
    Publishing date 2021-07-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.317972
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  6. Article ; Online: Neuromonitoring of the extremely preterm infant.

    Arnaez, Juan / Garcia-Alix, Alfredo

    Anales de pediatria

    2021  Volume 95, Issue 6, Page(s) 395–396

    MeSH term(s) Gestational Age ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Intensive Care Units, Neonatal
    Language English
    Publishing date 2021-10-09
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2021.07.003
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  7. Article ; Online: Eligible neonatal donors after circulatory determination of death (Maastricht type III): A national survey of level III NICUs.

    Caserío, Sonia / Arnaez, Juan

    Pediatric transplantation

    2021  Volume 26, Issue 1, Page(s) e14129

    Abstract: Background: Organ donation continues to increase worldwide, but in general paediatric patients remain less likely to receive a transplant. The inclusion of neonates as donors after cDCD should be considered in an effort to increase donation rates.: ... ...

    Abstract Background: Organ donation continues to increase worldwide, but in general paediatric patients remain less likely to receive a transplant. The inclusion of neonates as donors after cDCD should be considered in an effort to increase donation rates.
    Methods: The survey for a cross-sectional national study of potential cDCD neonatal donors (Maastricht type III) was sent to all 90 level III Spanish neonatal units to explore: 1) protocols, education, and specific opinions on donation and 2) potential cDCD that could have been eligible over a 2-year period (2014-2015).
    Results: Forty-five centers (50%) completed the survey, and 38/45 gave information about potential eligible donors. In 16% of the centers specific protocols on neonatal donation exist. All hospitals demanded more specific training, and 65% noted that the donation process could be a problem in the family's dismissal of the child. During the study period 46 805 neonates were admitted in the 38 centers, and 625 neonates died. Ninety-five born at a gestational age ≥34 weeks and above 2000 gr died after an EoL decision, 38 (40%) and 13 (14%) of them due to neonatal encephalopathy and multiple congenital anomalies, respectively. There were 31 (33%) elegible infants who died in less than 120 min due to pathologies that did not contraindicate donation.
    Conclusions: Neonatal cDCD could help to reduce the gap between the supply of and demand for organs according to the potentially eligible patients emerging from this study. Training in EoL and donation processes should be provided to healthcare professionals.
    MeSH term(s) Attitude of Health Personnel ; Clinical Competence ; Clinical Decision-Making/methods ; Clinical Protocols ; Donor Selection/methods ; Donor Selection/standards ; Female ; Health Care Surveys ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Male ; Perinatal Death ; Retrospective Studies ; Spain ; Terminal Care/methods ; Terminal Care/standards
    Language English
    Publishing date 2021-09-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14129
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4947: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Motor, cognitive and behavioural outcomes after neonatal hypoxic-ischaemic encephalopathy.

    Hortigüela, María Montesclaros / Martínez-Biarge, Miriam / Conejo, David / Vega-Del-Val, Cristina / Arnaez, Juan

    Anales de pediatria

    2024  Volume 100, Issue 2, Page(s) 104–114

    Abstract: Introduction: The current neurodevelopmental status of patients with neonatal hypoxic-ischaemic encephalopathy (HIE) in Spain is unknown. Recent European studies highlight a shift of severe pathology towards mild motor disorders and emotional problems. ... ...

    Abstract Introduction: The current neurodevelopmental status of patients with neonatal hypoxic-ischaemic encephalopathy (HIE) in Spain is unknown. Recent European studies highlight a shift of severe pathology towards mild motor disorders and emotional problems. The aim of this study was to analyse neurodevelopmental outcomes in a cohort of neonates with HIE at age 3 years.
    Patients and method: Multicentre observational study of neonates born at 35 or more weeks of gestation with moderate to severe HIE in 2011-2013 in 12 hospitals in a large Spanish region (91 217 m
    Results: Sixty-three patients were recruited, of whom 5 (7.9%) were excluded due to other pathology and 14 (24%) died. Of the 44 survivors, 42 (95.5%) were evaluated. Of these 42, 10 (24%) had adverse outcomes (visual or hearing impairment, epilepsy, cerebral palsy or developmental delay). Other detected problems were minor neurological signs in 6 of the 42 (14%) and a higher incidence of emotional problems compared to controls: introversion (10.5% vs. 1.3%), anxiety (34.2% vs. 11.7%) and depression (28.9% vs. 7.8%) (P < .05). The severity of the lesions on neuroimaging was significantly higher in patients with motor impairment (P = .004) or who died or had an adverse outcome (P = .027).
    Conclusion: In addition to classical sequelae, the followup of patients with neonatal HIE should include the diagnosis and treatment of minor motor disorders and social and emotional problems.
    MeSH term(s) Child, Preschool ; Humans ; Infant, Newborn ; Asphyxia Neonatorum ; Cognition ; Cognitive Dysfunction ; Hypoxia-Ischemia, Brain/therapy ; Parturition
    Language English
    Publishing date 2024-02-07
    Publishing country Spain
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpede.2024.01.009
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  9. Article ; Online: Neonatal neurology, a crucial discipline to enhance neurologic care of the newborn.

    Garcia-Alix, Alfredo / Arnaez, Juan

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 109, Issue 12, Page(s) 2451–2453

    MeSH term(s) Humans ; Infant, Newborn ; Neurology
    Language English
    Publishing date 2020-04-16
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15258
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  10. Article ; Online: Morphine infusor pump switch to oral methadone.

    Santos Suárez, Juan / Del Valle Arnáez, Gema

    BMJ supportive & palliative care

    2019  Volume 10, Issue 1, Page(s) 1–3

    Abstract: Between 2014 and 2017, four patients with widespread cancer were referred to a home palliative care team from a hospital in Oviedo (Spain) with subcutaneous elastomeric infusion pump containing 180-260 mg/day of morphine for previously uncontrolled pain. ...

    Abstract Between 2014 and 2017, four patients with widespread cancer were referred to a home palliative care team from a hospital in Oviedo (Spain) with subcutaneous elastomeric infusion pump containing 180-260 mg/day of morphine for previously uncontrolled pain. 3-4 rotations were performed over 5-11 days, gradually substituting morphine for oral methadone (three times a day) to minimise the risks of rapid conversion, with a highly variable final subcutaneous morphine:oral methadone ratio (5:1 to 17:1), guided by the absence of pain, and to enhance the patient's functional capacity avoiding device dependence. The final methadone dose varied between 15 and 39 mg/day. There was daily telephone supervision and visits every 2-4 days. Patient demise occurred 56, 111, 168 and 350 days following the opioid conversion, and methadone was maintained until then. In all cases and prior to concluding the rotation, pain was controlled and sleepiness had subsided.
    MeSH term(s) Administration, Oral ; Aged ; Analgesics, Opioid/administration & dosage ; Cancer Pain/drug therapy ; Dose-Response Relationship, Drug ; Drug Substitution/methods ; Fatal Outcome ; Female ; Humans ; Infusion Pumps ; Infusions, Subcutaneous ; Male ; Methadone/administration & dosage ; Middle Aged ; Morphine/administration & dosage ; Palliative Care/methods ; Spain
    Chemical Substances Analgesics, Opioid ; Morphine (76I7G6D29C) ; Methadone (UC6VBE7V1Z)
    Language English
    Publishing date 2019-04-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/bmjspcare-2018-001760
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