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  1. Article: Genetic Information to Share with Parents when Newborn Screening Reveals the Presence of Sickle Cell Trait.

    Elenga, Narcisse

    International journal of pediatrics

    2024  Volume 2024, Page(s) 8910397

    Abstract: The primary purpose of newborn screening for sickle cell disease is to diagnose the disease before the appearance of symptoms and to initiate early treatment. To answer the question "What genetic information needs to be communicated to parents when ... ...

    Abstract The primary purpose of newborn screening for sickle cell disease is to diagnose the disease before the appearance of symptoms and to initiate early treatment. To answer the question "What genetic information needs to be communicated to parents when newborn screening reveals the presence of a sickle cell trait," we conducted a survey using a self-administered online questionnaire. We received responses from 122 healthcare workers and members of sickle cell disease associations, in France and French overseas departments. Our results showed similar positions on this issue. The information conveyed is not consistent and is the result of grassroots initiatives. The negative consequences generated by this information could be reduced when this information is delivered by a multidisciplinary team, within the framework of a dedicated consultation. This information on sickle cell trait status should be given in at least three key periods: the neonatal period, early adolescence, and later adolescence, when reproductive implications become important. Neonatal screening programs should develop systems that allow referring physicians to easily access the results of neonatal screening electronically. Harmonization of practices should allow a better analysis of the consequences of this counselling on family projects.
    Language English
    Publishing date 2024-02-22
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2495026-9
    ISSN 1687-9759 ; 1687-9740
    ISSN (online) 1687-9759
    ISSN 1687-9740
    DOI 10.1155/2024/8910397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A new generation of physicians-The Generation Z. Are you ready to deal with it?

    Elenga, Narcisse / Krishnaswamy, Guha

    Frontiers in public health

    2023  Volume 10, Page(s) 1015584

    MeSH term(s) Humans ; Physicians/trends
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1015584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Imperative of Early Treatment for Children With COVID-19 Infection.

    Elenga, Narcisse

    Indian pediatrics

    2020  Volume 57, Issue 6, Page(s) 587–588

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Time-to-Treatment
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country India
    Document type Letter
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 859: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Real-world observational study on the long-term effect of L-glutamine treatment on renal parameters of adult and pediatric patients with sickle cell disease.

    Elenga, Narcisse / Yassin, Mohamed A

    Frontiers in medicine

    2023  Volume 10, Page(s) 1243870

    Abstract: Background: Sickle cell disease (SCD) is a rare genetic blood condition affecting millions worldwide. Oxidative stress is a key player in the pathogenesis of SCD and its comorbid consequences. Renal function impairment is a common complication of SCD in ...

    Abstract Background: Sickle cell disease (SCD) is a rare genetic blood condition affecting millions worldwide. Oxidative stress is a key player in the pathogenesis of SCD and its comorbid consequences. Renal function impairment is a common complication of SCD in both pediatric and adult patients with serious consequences leading to increased risk of mortality. In this observational real-world study, we are reporting the long-term (120 weeks) renal function in 10 patients treated with L-glutamine.
    Methods: Ten patients (4 pediatric and 6 adults), with confirmed diagnoses of SCD (HbSS genotype), were enrolled, these included four patients from Qatar with Arab Indian haplotype and six patients from French Guiana with African haplotype. All patients were treated with L-glutamine oral powder (~0.3 g/kg body weight, Endari
    Results: The study showed that with L-glutamine treatment there were improvements in renal and hematological parameters with no vaso-occlusive crisis at both 48-and 120-week follow-up time points in all 10 patients. Improvements were seen in the albumin creatinine ratio (ACR) from baseline to 48 weeks (mean [Standard deviation SD] ACR: -4.19 [9.81] mg/g) and 120 weeks (mean [SD] ACR: -12.31 [21.09] mg/g). Mean (SD) increase in hemoglobin concentrations from baseline to 48 weeks and 120 weeks was 0.72 (1) g/dL and 1.41 (0.79) g/dL, respectively. Mean (SD) reticulocyte counts and LDH levels decreased from baseline to 48 weeks (mean [SD] change from baseline to 48 weeks, reticulocyte counts: -40.30 [101.58] × 10
    Conclusion: This is one of the first studies that assessed the long-term renal outcomes in SCD using L-glutamine. L-glutamine improved the renal function in patients with SCD along with improvements in clinical outcomes and hemolysis, from 48 weeks and sustained through 120 weeks of treatment.
    Language English
    Publishing date 2023-12-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1243870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Real-world observational study on the long-term effect of L-glutamine treatment on renal parameters of adult and pediatric patients with sickle cell disease

    Narcisse Elenga / Mohamed A. Yassin

    Frontiers in Medicine, Vol

    2023  Volume 10

    Abstract: BackgroundSickle cell disease (SCD) is a rare genetic blood condition affecting millions worldwide. Oxidative stress is a key player in the pathogenesis of SCD and its comorbid consequences. Renal function impairment is a common complication of SCD in ... ...

    Abstract BackgroundSickle cell disease (SCD) is a rare genetic blood condition affecting millions worldwide. Oxidative stress is a key player in the pathogenesis of SCD and its comorbid consequences. Renal function impairment is a common complication of SCD in both pediatric and adult patients with serious consequences leading to increased risk of mortality. In this observational real-world study, we are reporting the long-term (120 weeks) renal function in 10 patients treated with L-glutamine.MethodsTen patients (4 pediatric and 6 adults), with confirmed diagnoses of SCD (HbSS genotype), were enrolled, these included four patients from Qatar with Arab Indian haplotype and six patients from French Guiana with African haplotype. All patients were treated with L-glutamine oral powder (~0.3 g/kg body weight, Endari®) twice daily for 120 weeks. Clinical events and laboratory parameters (renal function, hemoglobin, reticulocytes, and lactate dehydrogenase [LDH]) were measured at baseline, 48, and 120 weeks.ResultsThe study showed that with L-glutamine treatment there were improvements in renal and hematological parameters with no vaso-occlusive crisis at both 48-and 120-week follow-up time points in all 10 patients. Improvements were seen in the albumin creatinine ratio (ACR) from baseline to 48 weeks (mean [Standard deviation SD] ACR: −4.19 [9.81] mg/g) and 120 weeks (mean [SD] ACR: −12.31 [21.09] mg/g). Mean (SD) increase in hemoglobin concentrations from baseline to 48 weeks and 120 weeks was 0.72 (1) g/dL and 1.41 (0.79) g/dL, respectively. Mean (SD) reticulocyte counts and LDH levels decreased from baseline to 48 weeks (mean [SD] change from baseline to 48 weeks, reticulocyte counts: −40.30 [101.58] × 109 cells/L; LDH levels: −259 [154.93] U/L) and 120 weeks (mean [SD] change from baseline to 120 weeks, reticulocyte counts: −58.30 [128.38] × 109 cells/L; LDH levels: −344.80 [274.63] U/L).ConclusionThis is one of the first studies that assessed the long-term renal outcomes in SCD using L-glutamine. L-glutamine improved ...
    Keywords L-glutamine ; sickle cell disease ; clinical outcomes ; hemolysis parameters ; renal parameters ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The Imperative of Early Treatment for Children With COVID-19 Infection

    Elenga, Narcisse

    Indian Pediatrics

    2020  Volume 57, Issue 6, Page(s) 587–588

    Keywords Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 402594-5
    ISSN 0019-6061
    ISSN 0019-6061
    DOI 10.1007/s13312-020-1871-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 859: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Discriminating Malaria from Dengue Fever and Chikungunya Infection in Children Living in Endemic Areas.

    Elenga, Narcisse

    Indian journal of pediatrics

    2017  Volume 84, Issue 8, Page(s) 649–650

    MeSH term(s) Adolescent ; Chikungunya Fever/diagnosis ; Chikungunya Fever/pathology ; Child ; Child, Preschool ; Coinfection/diagnosis ; Dengue/diagnosis ; Dengue/pathology ; Diagnosis, Differential ; French Guiana/epidemiology ; Humans ; Infant ; Malaria, Falciparum/diagnosis ; Malaria, Falciparum/pathology ; Malaria, Vivax/diagnosis ; Malaria, Vivax/pathology ; Retrospective Studies
    Language English
    Publishing date 2017-04-21
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-017-2341-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Community-Acquired Pneumonia Requiring Hospitalization among French Guianese Children.

    Cannesson, Alexandre / Elenga, Narcisse

    International journal of pediatrics

    2021  Volume 2021, Page(s) 4358818

    Abstract: Community-acquired pneumonia remains a leading cause of hospitalizations among children worldwide. The diagnosis is based on the history, the physical examination results in children with fever plus respiratory signs and symptoms, and chest radiography. ... ...

    Abstract Community-acquired pneumonia remains a leading cause of hospitalizations among children worldwide. The diagnosis is based on the history, the physical examination results in children with fever plus respiratory signs and symptoms, and chest radiography. The microbiological etiology is confirmed by viral testing and hemocultures. The most likely etiology depends on the age of the child. The features of childhood pneumonia vary between countries and territories. The purpose of this study was to describe the epidemiological characteristics and current microbial ecology of community-acquired pneumonia in children in French Guiana. We performed a retrospective, descriptive, and monocentric study between January 1, 2015, and December 31, 2017, in the pediatric ward of the Cayenne Hospital in French Guiana. The studied population was aged from 0 to 15 years and 3 months and hospitalized for acute community-acquired pneumonia. A total of 415 patients (mean age 3.62 years) were included. A pathogen was identifiable in 22.4% of cases, including bacteria in 61.3%, viruses in 43%, and coinfections in 14%. The main pathogens were respiratory syncytial virus (31.2%),
    Language English
    Publishing date 2021-12-22
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2495026-9
    ISSN 1687-9759 ; 1687-9740
    ISSN (online) 1687-9759
    ISSN 1687-9740
    DOI 10.1155/2021/4358818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: What's childhood asthma in French Guiana? A cohort study based on children referred for allergology consultations at the Cayenne hospital center.

    Maniassom, Chiméne / Defo, Antoine / De Blay, Frédéric / Elenga, Narcisse

    Frontiers in public health

    2023  Volume 11, Page(s) 1198937

    Abstract: Background: Asthma is a multifactorial chronic disease, whose most frequent etiology is allergy, especially to : Methods: A retrospective cohort study focused on children from 0 to 18 years of age, followed for asthma at the Department of Pediatrics ... ...

    Abstract Background: Asthma is a multifactorial chronic disease, whose most frequent etiology is allergy, especially to
    Methods: A retrospective cohort study focused on children from 0 to 18 years of age, followed for asthma at the Department of Pediatrics of the Cayenne Hospital Center in French Guiana. All asthmatic children followed by the same paediatric allergist were systematically skin-tested with Bt total extract, and Bt-specific IgE tests were additionally performed to confirm specific sensitization. All follow-up variables were collected from medical records. The outcome was sensitization to
    Results: 302 patients were followed: 177 cases of allergic rhinitis, 135 allergic conjunctivitis, 105 atopic dermatitis, 153 food allergy, and 14 cases of drug allergy. Poly-allergy (respiratory, food, skin, and medicinal) was present in 239 children. There were 158 children followed for asthma, of whom 103 (65%) were sensitized to
    Conclusion: In French Guiana, asthma is characterized by a high prevalence of Blomia tropicalis sensitization.
    Language English
    Publishing date 2023-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1198937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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