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  1. Article ; Online: Implementation of remote monitoring strategies to improve chronic heart failure management.

    Chau, Vinh Q / Imamura, Teruhiko / Narang, Nikhil

    Current opinion in cardiology

    2024  Volume 39, Issue 3, Page(s) 210–217

    Abstract: Purpose of review: The goal of this review is to describe the current evidence available for remote monitoring devices available for patients with chronic heart failure, and also detail practical clinical recommendations for implementing these tools in ... ...

    Abstract Purpose of review: The goal of this review is to describe the current evidence available for remote monitoring devices available for patients with chronic heart failure, and also detail practical clinical recommendations for implementing these tools in daily clinical practice.
    Recent findings: Several devices ranging from sophisticated multiparametric algorithms in defibrillators, implantable pulmonary artery pressure sensors, and wearable devices to measure thoracic impedance can be utilized as important adjunctive tools to reduce the risk of heart failure hospitalization in patients with chronic heart failure. Pulmonary artery pressure sensors provide the most granular data regarding hemodynamic status, while alerts from wearable devices for thoracic impedance and defibrillator-based algorithms increase the likelihood of worsening clinical status while also having high negative predictive value when values are within normal range.
    Summary: Multiple device-based monitoring strategies are available to reduce longitudinal risk in patients with chronic heart failure. Further studies are needed to best understand a practical pathway to integrate multiple signals of data for early clinical decompensation risk predictionVideo abstract: http://links.lww.com/HCO/A95.
    MeSH term(s) Humans ; Defibrillators, Implantable ; Chronic Disease ; Predictive Value of Tests ; Heart Failure/therapy ; Algorithms
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000001119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Osteopontin in HFpEF: More Than Just a Remodeling-Specific Biomarker.

    Salloum, Fadi N / Chau, Vinh Q

    Journal of the American College of Cardiology

    2019  Volume 73, Issue 21, Page(s) 2719–2721

    MeSH term(s) Biomarkers ; Heart Failure ; Humans ; Osteopontin ; Stroke Volume ; Ventricular Dysfunction, Left
    Chemical Substances Biomarkers ; Osteopontin (106441-73-0)
    Language English
    Publishing date 2019-05-31
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2019.03.477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Response to Muller et al. Regarding "Impact of COVID-19 on Patients Supported with a Left Ventricular Assist Device".

    Zakrzewski, Jack / Coyle, Laura / Aicher, Tracy / Gallagher, Colleen / Kuper, Katelyn / Sciamanna, Christopher / Chau, Vinh Q / Tatooles, Antone

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2022  Volume 68, Issue 9, Page(s) e157

    MeSH term(s) COVID-19 ; Heart Transplantation ; Heart-Assist Devices ; Humans ; Ventricular Function, Left
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of COVID-19 on Patients Supported with a Left Ventricular Assist Device.

    Zakrzewski, Jack / Coyle, Laura / Aicher, Tracy / Chickerillo, Krystina / Gallagher, Colleen / Kuper, Katelyn / Sciamanna, Chris / Chau, Vinh Q / Tatooles, Antone

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2022  Volume 67, Issue 11, Page(s) 1189–1195

    Abstract: Patients on left ventricular assist device (LVAD) support may be susceptible to severe disease and complications from coronavirus disease-19 (COVID-19). The purpose of this study was to describe the clinical course of COVID-19 in LVAD patients. A ... ...

    Abstract Patients on left ventricular assist device (LVAD) support may be susceptible to severe disease and complications from coronavirus disease-19 (COVID-19). The purpose of this study was to describe the clinical course of COVID-19 in LVAD patients. A retrospective review was performed at our center; 28 LVAD patients who developed COVID-19 between March 2020 and March 2021, and six patients with a prior COVID-19 infection who underwent LVAD implantation, were identified and examined. Of the 28 patients, nine (32%) died during the study period, five (18%) during their index hospitalization for COVID-19. Two patients (7%) presented with suspected pump thrombosis. In a nonadjusted binary regression logistic analysis, admission to the intensive care unit (unadjusted odds ratio, 7.6 [CI, 1.2-48], P = 0.03), and the need for mechanical ventilation (unadjusted odds ratio 14 [CI, 1.3-159], P = 0.03) were associated with mortality. The six patients who previously had COVID-19 and subsequently received a LVAD were on intra-aortic balloon pump and inotropic support at time of surgery. All six experienced a complicated and prolonged postoperative course. Three patients (50%) suffered from ischemic stroke, and there was one (17%) 30 day mortality. We observed an increased risk of morbidity and mortality in LVAD patients with COVID-19.
    MeSH term(s) COVID-19 ; Heart Failure/surgery ; Heart-Assist Devices/adverse effects ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001578
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Troubleshooting Total Artificial Heart: Novel Use of Implantable Hemodynamic Monitor.

    Chau, Vinh Q / Oliveros, Estefania / Mahmood, Kiran / Surach, Cristina / Roldan, Julie / Al-Najjar, Neveen / Lala, Anuradha / Anyanwu, Anelechi / Moss, Noah / Mitter, Sumeet S

    JACC. Case reports

    2021  Volume 3, Issue 7, Page(s) 1024–1028

    Abstract: Accurate device optimization of the Syncardia temporary total artificial heart is difficult while waiting for heart transplantation. In this challenging clinical cohort, using an implantable hemodynamic monitor (CardioMEMS HF system) can assist in volume ...

    Abstract Accurate device optimization of the Syncardia temporary total artificial heart is difficult while waiting for heart transplantation. In this challenging clinical cohort, using an implantable hemodynamic monitor (CardioMEMS HF system) can assist in volume and hemodynamic assessments. (
    Language English
    Publishing date 2021-06-02
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2021.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: De novo human leukocyte antigen allosensitization patterns in patients bridged to heart transplantation using left ventricular assist devices.

    Chau, Vinh Q / Feinman, Jason / Fullin, Kerianne / Mahmood, Kiran / Oliveros, Estefania / Mitter, Sumeet S / Pinney, Sean P / Mancini, Donna M / Lala, Anuradha / Moss, Noah

    Transplant immunology

    2022  Volume 72, Page(s) 101567

    Abstract: Introduction: We examined the impact and time course of de novo human leukocyte antigen (HLA) allosensitization following left ventricular assist device (LVAD) implantation.: Methods and results: Forty patients had a calculated panel reactive ... ...

    Abstract Introduction: We examined the impact and time course of de novo human leukocyte antigen (HLA) allosensitization following left ventricular assist device (LVAD) implantation.
    Methods and results: Forty patients had a calculated panel reactive antibody (cPRA) prior to LVAD surgery between January 2014 and December 2018. Of these patients, we retrospectively studied 33 patients who had pre-LVAD cPRA <10%. De novo allosensitization was defined as cPRA ≥10% within 3 months following LVAD surgery, and "persistent allosensitization" was defined as cPRA ≥10% at time of heart transplant or death. One-third (11/33) of our cohort developed de novo allosensitization within 3-months post-LVAD. Median duration of follow-up during LVAD support was 588 days (IQR 337-1071 days), or approximately 19 months. In an adjusted, multivariable analysis, female sex remained associated with de novo allosensitization (adjusted odds ratio [95%CI]: 11 (1.4-85), P = 0.026). De novo allosensitization was subsequently associated with persistent allosensitization (P = 0.024). Both axial-flow and centrifugal-flow LVADs had similar rates of allosensitization. Compared to those with no allosensitization, patients with de novo allosensitization did not appear to have inferior post-transplant outcomes of death or treated rejection.
    Conclusion: In our single-center experience, one-third of patients developed de novo allosensitization which did not appear to associate with inferior post-transplant outcomes. Female sex was associated with de novo allosensitization.
    MeSH term(s) Antibodies ; Female ; HLA Antigens ; Heart Transplantation ; Heart-Assist Devices ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; Humans ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Antibodies ; HLA Antigens ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II
    Language English
    Publishing date 2022-03-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2022.101567
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  7. Article ; Online: Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction.

    Nguyen, Khoa / Chau, Vinh Q / Mauro, Adolfo G / Durrant, David / Toldo, Stefano / Abbate, Antonio / Das, Anindita / Salloum, Fadi N

    Journal of cardiovascular pharmacology and therapeutics

    2020  Volume 25, Issue 5, Page(s) 472–483

    Abstract: Aims: Hydrogen sulfide (H: Methods and results: Adult male mice underwent myocardial infarction (MI) by coronary artery ligation after baseline echocardiography. Following MI, mice were treated with Na: Conclusion: ... ...

    Abstract Aims: Hydrogen sulfide (H
    Methods and results: Adult male mice underwent myocardial infarction (MI) by coronary artery ligation after baseline echocardiography. Following MI, mice were treated with Na
    Conclusion: Na
    MeSH term(s) Animals ; Apoptosis/drug effects ; Cofilin 2/metabolism ; Disease Models, Animal ; Down-Regulation ; Heart Failure/metabolism ; Heart Failure/pathology ; Heart Failure/physiopathology ; Heart Failure/prevention & control ; Hydrogen Sulfide/pharmacology ; Inflammasomes/metabolism ; Male ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocardium/metabolism ; Myocardium/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Sulfides/pharmacology ; Ventricular Function, Left/drug effects ; Ventricular Remodeling/drug effects
    Chemical Substances Cfl2 protein, mouse ; Cofilin 2 ; Inflammasomes ; MIRN21 microRNA, mouse ; MicroRNAs ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Sulfides ; sodium sulfide (YGR27ZW0Y7) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1329372-2
    ISSN 1940-4034 ; 1074-2484
    ISSN (online) 1940-4034
    ISSN 1074-2484
    DOI 10.1177/1074248420923542
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  8. Article ; Online: The Imperfect Cytokine Storm: Severe COVID-19 With ARDS in a Patient on Durable LVAD Support.

    Chau, Vinh Q / Oliveros, Estefania / Mahmood, Kiran / Singhvi, Aditi / Lala, Anuradha / Moss, Noah / Gidwani, Umesh / Mancini, Donna M / Pinney, Sean P / Parikh, Aditya

    JACC. Case reports

    2020  Volume 2, Issue 9, Page(s) 1315–1320

    Abstract: As health systems worldwide grapple with the coronavirus disease-2019 (COVID-19) pandemic, patients with durable LVAD support represent a unique population at risk for the disease. This paper outlines the case of such a patient who developed COVID-19 ... ...

    Abstract As health systems worldwide grapple with the coronavirus disease-2019 (COVID-19) pandemic, patients with durable LVAD support represent a unique population at risk for the disease. This paper outlines the case of such a patient who developed COVID-19 complicated by a "cytokine storm" with severe acute respiratory distress syndrome and myocardial injury and describes the challenges that arose during management.
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2020.04.001
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  9. Article ; Online: Mitochondrial H

    Li, Zhen / Xia, Huijing / Sharp, Thomas E / LaPenna, Kyle B / Elrod, John W / Casin, Kevin M / Liu, Ken / Calvert, John W / Chau, Vinh Q / Salloum, Fadi N / Xu, Shi / Xian, Ming / Nagahara, Noriyuki / Goodchild, Traci T / Lefer, David J

    Circulation research

    2022  Volume 131, Issue 3, Page(s) 222–235

    Abstract: Background: Hydrogen sulfide (H: Methods: Human myocardial samples obtained from patients with heart failure undergoing cardiac surgeries were probed for 3-MST protein expression. 3-MST knockout mice and C57BL/6J wild-type mice were subjected to ... ...

    Abstract Background: Hydrogen sulfide (H
    Methods: Human myocardial samples obtained from patients with heart failure undergoing cardiac surgeries were probed for 3-MST protein expression. 3-MST knockout mice and C57BL/6J wild-type mice were subjected to transverse aortic constriction to induce pressure overload heart failure with reduced ejection fraction. Cardiac structure and function, vascular reactivity, exercise performance, mitochondrial respiration, and ATP synthesis efficiency were assessed. In addition, untargeted metabolomics were utilized to identify key pathways altered by 3-MST deficiency.
    Results: Myocardial 3-MST was significantly reduced in patients with heart failure compared with nonfailing controls. 3-MST KO mice exhibited increased accumulation of branched-chain amino acids in the myocardium, which was associated with reduced mitochondrial respiration and ATP synthesis, exacerbated cardiac and vascular dysfunction, and worsened exercise performance following transverse aortic constriction. Restoring myocardial branched-chain amino acid catabolism with 3,6-dichlorobenzo1[b]thiophene-2-carboxylic acid (BT2) and administration of a potent H
    Conclusions: Our data suggest that 3-MST derived mitochondrial H
    MeSH term(s) Adenosine Triphosphate/metabolism ; Amino Acids, Branched-Chain/metabolism ; Animals ; Heart Failure/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Myocardium/metabolism ; Ventricular Dysfunction, Left/metabolism
    Chemical Substances Amino Acids, Branched-Chain ; Adenosine Triphosphate (8L70Q75FXE) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.121.319817
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  10. Article ; Online: Application of machine learning in screening for congenital heart diseases using fetal echocardiography.

    Truong, Vien T / Nguyen, Binh P / Nguyen-Vo, Thanh-Hoang / Mazur, Wojciech / Chung, Eugene S / Palmer, Cassady / Tretter, Justin T / Alsaied, Tarek / Pham, Vy T / Do, Huan Q / Do, Phuong T N / Pham, Vinh N / Ha, Ban N / Chau, Hoa N / Le, Tuyen K

    The international journal of cardiovascular imaging

    2022  

    Abstract: There is a growing body of literature supporting the utilization of machine learning (ML) to improve diagnosis and prognosis tools of cardiovascular disease. The current study was to investigate the impact that the ML framework may have on the ... ...

    Abstract There is a growing body of literature supporting the utilization of machine learning (ML) to improve diagnosis and prognosis tools of cardiovascular disease. The current study was to investigate the impact that the ML framework may have on the sensitivity of predicting the presence or absence of congenital heart disease (CHD) using fetal echocardiography. A comprehensive fetal echocardiogram including 2D cardiac chamber quantification, valvar assessments, assessment of great vessel morphology, and Doppler-derived blood flow interrogation was recorded. The postnatal echocardiogram was used to ascertain the diagnosis of CHD. A random forest (RF) algorithm with a nested tenfold cross-validation was used to train models for assessing the presence of CHD. The study population was derived from a database of 3910 singleton fetuses with maternal age of 28.8 ± 5.2 years and gestational age at the time of fetal echocardiography of 22.0 weeks (IQR 21-24). The proportion of CHD was 14.1% for the studied cohort confirmed by post-natal echocardiograms. Our proposed RF-based framework provided a sensitivity of 0.85, a specificity of 0.88, a positive predictive value of 0.55 and a negative predictive value of 0.97 to detect the CHD with the mean of mean ROC curves of 0.94 and the mean of mean PR curves of 0.84. Additionally, six first features, including cardiac axis, peak velocity of blood flow across the pulmonic valve, cardiothoracic ratio, pulmonary valvar annulus diameter, right ventricular end-diastolic diameter, and aortic valvar annulus diameter, are essential features that play crucial roles in adding more predictive values to the model in detecting patients with CHD. ML using RF can provide increased sensitivity in prenatal CHD screening with very good performance. The incorporation of ML algorithms into fetal echocardiography may further standardize the assessment for CHD.
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-022-02566-3
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