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  1. Article ; Online: Comment: Comparison of 2-Bag Versus 3-Bag

    Wong, Anselm

    The Annals of pharmacotherapy

    2022  Volume 57, Issue 4, Page(s) 505

    MeSH term(s) Humans ; Child ; Acetaminophen/adverse effects ; Acetylcysteine/therapeutic use ; Analgesics, Non-Narcotic/adverse effects ; Drug Overdose ; Chemical and Drug Induced Liver Injury/etiology
    Chemical Substances Acetaminophen (362O9ITL9D) ; Acetylcysteine (WYQ7N0BPYC) ; Analgesics, Non-Narcotic
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/10600280221117323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 900: Show issues Location:
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  2. Article ; Online: The presence of abdominal pain associated with acetaminophen overdose does not predict severity of liver injury.

    Wang, Chen / Wong, Anselm

    The American journal of emergency medicine

    2024  Volume 79, Page(s) 52–57

    Abstract: Aim: Whilst it is known that abdominal pain is a common symptom in patients with acetaminophen overdose, its association with severity of liver injury has not been clearly defined. This study investigates the association between the symptom of abdominal ...

    Abstract Aim: Whilst it is known that abdominal pain is a common symptom in patients with acetaminophen overdose, its association with severity of liver injury has not been clearly defined. This study investigates the association between the symptom of abdominal pain on presentation to hospital and the degree of liver injury post-acetaminophen overdose.
    Methods: Admissions with acetaminophen poisoning, requiring treatment with acetylcysteine were identified and reviewed from a search of a large Australian tertiary hospital network from February 20th, 2014, to August 30th, 2018. Parameters such as presence of abdominal pain, time post-ingestion and peak ALT were collected. Single acute ingestions, staggered and repeated supratherapeutic ingestions were analysed.
    Results: 539 cases were identified in the study period, 79% female, with mean age 25 (17-43) years. Patients presenting to the emergency department with abdominal pain post-acetaminophen overdose had a similar risk of developing hepatotoxicity or acute liver injury compared to patients without abdominal pain regardless of time to presentation. Patients presenting <8-h post-overdose with abdominal pain were as likely to develop hepatotoxicity (1/46, 2.2%) compared to those without abdominal pain (1/54 [1.9%]; OR = 1.18 [0.07 to 19.4]). Those presenting >8-h post-overdose with abdominal pain were as likely to develop hepatotoxicity (13/92, 14.1%) compared to those without abdominal pain (4/35 [11.4%]; OR = 1.28 [0.39 to 4.21]).
    Conclusions: The presence of abdominal pain after acetaminophen overdose was not predictive of the development of liver injury in patients receiving acetylcysteine treatment. Further prospective studies are required to confirm this finding. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
    MeSH term(s) Humans ; Female ; Adult ; Male ; Acetaminophen/therapeutic use ; Analgesics, Non-Narcotic/therapeutic use ; Acetylcysteine/therapeutic use ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/complications ; Retrospective Studies ; Australia ; Drug Overdose/complications ; Drug Overdose/drug therapy
    Chemical Substances Acetaminophen (362O9ITL9D) ; Analgesics, Non-Narcotic ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2024.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2005: Show issues Location:
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  3. Article ; Online: Comment on Truncated IV acetylcysteine treatment duration has potential to safely preserve resources during the COVID-19 pandemic.

    Wong, Anselm

    Clinical toxicology (Philadelphia, Pa.)

    2020  Volume 59, Issue 1, Page(s) 77–78

    MeSH term(s) Acetylcysteine/therapeutic use ; COVID-19 ; Duration of Therapy ; Humans ; Pandemics ; SARS-CoV-2
    Chemical Substances Acetylcysteine (WYQ7N0BPYC)
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2020.1809667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 and toxicity from potential treatments: Panacea or poison.

    Wong, Anselm

    Emergency medicine Australasia : EMA

    2020  Volume 32, Issue 4, Page(s) 697–699

    Abstract: Since December 2019, coronavirus disease (COVID-19) has been increasingly spreading from its origin in Wuhan, China to many countries around the world eventuating in morbidity and mortality affecting millions of people. This pandemic has proven to be a ... ...

    Abstract Since December 2019, coronavirus disease (COVID-19) has been increasingly spreading from its origin in Wuhan, China to many countries around the world eventuating in morbidity and mortality affecting millions of people. This pandemic has proven to be a challenge given that there is no immediate cure, no vaccine is currently available and medications or treatments being used are still undergoing clinical trials. There have already been examples of self-medication and overdose. Clearly, there is a need to further define the efficacy of treatments used in the management of COVID-19. This evidence needs to be backed by large randomised-controlled clinical trials. In the meantime, there will no doubt be further off-label use of these medications by patients and practitioners and possibly related toxicity.
    MeSH term(s) Antiviral Agents/therapeutic use ; Antiviral Agents/toxicity ; Azithromycin/therapeutic use ; Azithromycin/toxicity ; Betacoronavirus/drug effects ; Chloroquine/therapeutic use ; Chloroquine/toxicity ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine/therapeutic use ; Hydroxychloroquine/toxicity ; Pandemics ; Pneumonia, Viral/drug therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2161824-0
    ISSN 1742-6723 ; 1742-6731 ; 1035-6851
    ISSN (online) 1742-6723
    ISSN 1742-6731 ; 1035-6851
    DOI 10.1111/1742-6723.13537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5940: Show issues Location:
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  5. Article ; Online: Utility of NT-proBNP monitoring in prolonged coma following massive baclofen exposure.

    Hodgson, Sarah E / Wong, Anselm

    Emergency medicine Australasia : EMA

    2022  Volume 35, Issue 2, Page(s) 359–361

    MeSH term(s) Humans ; Coma/chemically induced ; Baclofen/adverse effects ; Natriuretic Peptide, Brain ; Peptide Fragments ; Biomarkers ; Heart Failure ; Prognosis
    Chemical Substances pro-brain natriuretic peptide (1-76) ; Baclofen (H789N3FKE8) ; Natriuretic Peptide, Brain (114471-18-0) ; Peptide Fragments ; Biomarkers
    Language English
    Publishing date 2022-12-18
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 2161824-0
    ISSN 1742-6723 ; 1742-6731 ; 1035-6851
    ISSN (online) 1742-6723
    ISSN 1742-6731 ; 1035-6851
    DOI 10.1111/1742-6723.14154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID ‐19 and toxicity from potential treatments

    Wong, Anselm

    Emergency Medicine Australasia

    Panacea or poison

    2020  Volume 32, Issue 4, Page(s) 697–699

    Keywords Emergency Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2161824-0
    ISSN 1742-6731 ; 1035-6851
    ISSN 1742-6731 ; 1035-6851
    DOI 10.1111/1742-6723.13537
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 5940: Show issues Location:
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  7. Article: CD137L, a driver of harmful inflammation in the nervous system.

    Wong, Hiu Yi / Chan, Amanda C Y / Mak, Anselm / Schwarz, Herbert

    Neural regeneration research

    2023  Volume 18, Issue 11, Page(s) 2387–2388

    Language English
    Publishing date 2023-06-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.371357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comment on “Truncated IV acetylcysteine treatment duration has potential to safely preserve resources during the COVID-19 pandemic.”

    Wong, Anselm

    Clinical Toxicology

    2020  , Page(s) 1–1

    Keywords Toxicology ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2020.1809667
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  10. Article ; Online: Efficacy of sustained low-efficiency dialysis in the management of sodium valproate overdose.

    Wong, Anselm / Graudins, Andis

    Internal medicine journal

    2021  Volume 51, Issue 2, Page(s) 295–296

    MeSH term(s) Anticonvulsants ; Drug Overdose/therapy ; Humans ; Hybrid Renal Replacement Therapy ; Valproic Acid
    Chemical Substances Anticonvulsants ; Valproic Acid (614OI1Z5WI)
    Language English
    Publishing date 2021-02-18
    Publishing country Australia
    Document type Letter
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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