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  1. Article: Comparison of Long-Term Postoperative Outcomes of the Subtypes of Chronic Rhinosinusitis with Nasal Polyps.

    Lee, Sang-Min / Yoo, Shin-Hyuk / Mo, Ji-Hun

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: 1) ...

    Abstract (1)
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061699
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  2. Article ; Online: Systematic omics analysis identifies CCR6 as a therapeutic target to overcome cancer resistance to EGFR inhibitors.

    Kwon, Eun-Ji / Cha, Hyuk-Jin / Lee, Haeseung

    iScience

    2024  Volume 27, Issue 4, Page(s) 109448

    Abstract: Epidermal growth factor receptor inhibitors (EGFRi) have exhibited promising clinical outcomes in the treatment of various cancers. However, their widespread application has been limited by low patient eligibility and the emergence of resistance. ... ...

    Abstract Epidermal growth factor receptor inhibitors (EGFRi) have exhibited promising clinical outcomes in the treatment of various cancers. However, their widespread application has been limited by low patient eligibility and the emergence of resistance. Leveraging a multi-omics approach (>1000 cancer cell lines), we explored molecular signatures linked to EGFRi responsiveness and found that expression signatures involved in the estrogen response could recapitulate cancer cell dependency on EGFR, a phenomenon not solely attributable to EGFR-activating mutations. By correlating genome-wide function screening data with EGFRi responses, we identified chemokine receptor 6 (CCR6) as a potential druggable target to mitigate EGFRi resistance. In isogenic cell models, pharmacological inhibition of CCR6 effectively reversed acquired EGFRi resistance, disrupting mitochondrial oxidative phosphorylation, a cellular process commonly associated with therapy resistance. Our data-driven strategy unveils drug-response biomarkers and therapeutic targets for resistance, thus potentially expanding EGFRi applicability and efficacy.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109448
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  3. Article ; Online: Erratum to: Predictive factors associated with trajectory of job satisfaction of workers with physical disabilities: A latent growth curve analysis.

    Do, Ji-Hye / Yoo, Eun-Young / Jung, Min-Ye / Park, Ji-Hyuk / Hong, Ickpyo / Lee, Seohyun

    Work (Reading, Mass.)

    2023  Volume 76, Issue 1, Page(s) 411

    Language English
    Publishing date 2023-08-07
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-236016
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    Zs.A 4810: Show issues Location:
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  4. Article ; Online: Metabolic Obesity Phenotypes and Incident Cardiovascular Outcomes in Middle-Aged and Older Korean Adults: A Longitudinal 10-Year Analysis of the Korean Genome and Epidemiology Study.

    Park, Jae-Min / Lee, Hye Sun / Yang, Juyeon / Jung, Dong-Hyuk / Lee, Ji-Won

    Metabolic syndrome and related disorders

    2024  Volume 22, Issue 3, Page(s) 232–239

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Middle Aged ; Humans ; Aged ; Risk Factors ; Coronary Artery Disease/epidemiology ; Prospective Studies ; Obesity/complications ; Obesity/epidemiology ; Obesity/genetics ; Phenotype ; Stroke/epidemiology ; Republic of Korea/epidemiology ; Body Mass Index ; Metabolic Syndrome
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2023.0170
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  5. Article: A Novel NADP-Dependent Formate Dehydrogenase From the Hyperthermophilic Archaeon

    Yang, Ji-In / Lee, Seong Hyuk / Ryu, Ji-Young / Lee, Hyun Sook / Kang, Sung Gyun

    Frontiers in microbiology

    2022  Volume 13, Page(s) 844735

    Abstract: The genome of the hyperthermophilic ... ...

    Abstract The genome of the hyperthermophilic archaeon
    Language English
    Publishing date 2022-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.844735
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  6. Article: A comparative study of ammonia solubility in imidazolium-based ionic liquids with different structural compositions.

    Salman, Muhammad / Lee, Ji Won / Lee, Sang Hyuk / Lee, Min Ho / Pham, Van Duc / Kim, Min-Sik / Cho, Daeheum / Lee, Hye Jin

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24305

    Abstract: Four imidazolium-based ionic liquids (ILs) with two cations 1-pentyl-3-butylimidazolium [PBIM] ...

    Abstract Four imidazolium-based ionic liquids (ILs) with two cations 1-pentyl-3-butylimidazolium [PBIM]
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24305
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  7. Article: Proposed Etiotypes for COPD: Controversial issues.

    Kim, Sang Hyuk / Moon, Ji-Yong / Min, Kyung Hoon / Lee, Hyun

    Tuberculosis and respiratory diseases

    2024  

    Abstract: The 2023 Global Initiative for Chronic Obstructive Lung Disease (GOLD) revised the definition of chronic obstructive pulmonary disease (COPD) to broadly include a variety of etiologies. A new taxonomy, composed of etiotypes, aims to highlight the ... ...

    Abstract The 2023 Global Initiative for Chronic Obstructive Lung Disease (GOLD) revised the definition of chronic obstructive pulmonary disease (COPD) to broadly include a variety of etiologies. A new taxonomy, composed of etiotypes, aims to highlight the heterogeneity in causes and pathogenesis of COPD, allowing more personalized management strategies and emphasizing the need for targeted research to understand and manage COPD better. However, controversy arises with including some diseases under the umbrella term of COPD, as their clinical presentations and treatments differ from classical COPD, which is smoking-related. COPD due to infection (COPD-I) and COPD due to environmental exposure (COPD-P) are classifications within the new taxonomy. Some disease entities in these categories show distinct clinical features and may not benefit from conventional COPD treatments, raising questions about their classification as COPD subtypes. There is also controversy regarding whether bronchiectasis with airflow limitations should be classified as an etiotype of COPD. This article discusses controversial issues associated with the proposed etiotypes for COPD in terms of COPD-I, COPD-P, and bronchiectasis. While the updated COPD definition by GOLD 2023 is a major step towards recognizing the disease's complexity, it also raises questions about the classification of related respiratory conditions. This highlights the need for further research to improve our understanding and approach to COPD management.
    Language English
    Publishing date 2024-02-06
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2023.0194
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    Zs.A 5937: Show issues Location:
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  8. Article: Longitudinal trajectories of atherogenic index of plasma and risks of cardiovascular diseases: results from the Korean genome and epidemiology study.

    Chun, Dong-Wook / Lee, Yae-Ji / Lee, Jun-Hyuk / Lee, Ji-Won

    Thrombosis journal

    2023  Volume 21, Issue 1, Page(s) 99

    Abstract: Background: Although the atherogenic index of plasma (AIP) based on a single measurement is a known risk factor for cardiovascular disease (CVD), little is known about whether changes in AIP over time are related to incident CVD. We aimed to determine ... ...

    Abstract Background: Although the atherogenic index of plasma (AIP) based on a single measurement is a known risk factor for cardiovascular disease (CVD), little is known about whether changes in AIP over time are related to incident CVD. We aimed to determine whether AIP trajectory, which reflects homogenous AIP trends for a particular period, is associated with CVD risk.
    Methods: Data from 5,843 participants of the Korean Genome and Epidemiology Study (KoGES) were analyzed. The KoGES had been conducted biennially from the baseline survey (2001-2002) to the eighth follow-up survey (2017-2018). The research design specifies the exposure period from baseline to the third follow-up, designates the latent period at the fourth follow-up, and establishes the event accrual period from the fifth to the eighth follow-up. During the exposure period, we identified two trajectories: a decreasing (n = 3,036) and an increasing group (n = 2,807) using latent variable mixture modeling. Information on CVD was collected initially through the self-reporting, followed by in depth person-to-person interview conducted by a well-trained examiner. During the event accrual period, the cumulative incidence rates of CVD between the two AIP trajectory groups were estimated using Kaplan-Meier analysis with the log-rank test. Multiple Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
    Results: The increasing AIP trajectory group had a significantly higher cumulative incidence rate of CVD than the decreasing AIP trajectory group. Compared to the decreasing AIP trajectory group, the increasing AIP trajectory group had a higher risk of incident CVD (HR: 1.31, 95% CI: 1.02-1.69) after adjusting for confounders.
    Conclusions: The risk of incident CVD increased when the AIP level showed an increasing trend and remained high over a long period. This suggests that checking and managing the trajectory of the AIP can be a preventive strategy for incident CVD.
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118392-2
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-023-00542-y
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  9. Article ; Online: Association between body fat decrease during the first year after diagnosis and the prognosis of idiopathic pulmonary fibrosis: CT-based body composition analysis.

    Lee, Ji Young / Yoon, Soon Ho / Goo, Jin Mo / Park, Jimyung / Lee, Jong Hyuk

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 103

    Abstract: Background: The prognostic role of changes in body fat in patients with idiopathic pulmonary fibrosis (IPF) remains underexplored. We investigated the association between changes in body fat during the first year post-diagnosis and outcomes in patients ... ...

    Abstract Background: The prognostic role of changes in body fat in patients with idiopathic pulmonary fibrosis (IPF) remains underexplored. We investigated the association between changes in body fat during the first year post-diagnosis and outcomes in patients with IPF.
    Methods: This single-center, retrospective study included IPF patients with chest CT scan and pulmonary function test (PFT) at diagnosis and a one-year follow-up between January 2010 and December 2020. The fat area (cm
    Results: In total, 307 IPF patients (69.3 ± 8.1 years; 238 men) were included. During the first year post-diagnosis, fat area, muscle area, and body mass index (BMI) changed by -15.4 cm
    Conclusion: A ≥ 52.3 cm
    MeSH term(s) Male ; Humans ; Retrospective Studies ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Prognosis ; Adipose Tissue ; Body Composition ; Tomography, X-Ray Computed
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-024-02712-6
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  10. Article ; Online: Risk of non-thyroidal autoimmune diseases in patients with Graves' disease: a nationwide retrospective cohort study.

    Sohn, Seo Young / Ahn, Ji Yeon / Lee, Min Kyung / Lee, Jae Hyuk / Kwon, Ji-Won / Kweon, Ji-Min / Lee, Ju-Yeun

    Rheumatology (Oxford, England)

    2024  

    Abstract: Objective: Graves' disease (GD) is a major autoimmune thyroid disorder and associated with non-thyroidal autoimmune disease (NTAD). We aimed to investigate the risk of NTAD in patients with GD compared with age- and sex-matched controls and to evaluate ... ...

    Abstract Objective: Graves' disease (GD) is a major autoimmune thyroid disorder and associated with non-thyroidal autoimmune disease (NTAD). We aimed to investigate the risk of NTAD in patients with GD compared with age- and sex-matched controls and to evaluate whether the risk differs between individuals with or without Graves' ophthalmopathy (GO).
    Methods: This was a retrospective cohort study using data from the Korean National Health Claims database. We included 77 401 patients with GD (2,310 with GO) and 77 401 age- and sex-matched controls. Risk of NTAD were compared between the entire cohort and within the GD cohort.
    Results: During a mean follow-up period of 9 years, NTAD developed in 12 341 (16.1%) patients in the GD cohort. Risk for systemic lupus erythematosus (SLE) [adjusted hazard ratio (aHR):1.15, 95% confidence interval (CI): 1.02-1.29], vitiligo (aHR: 1.24, 95% CI: 1.10-1.40), and alopecia areata (aHR: 1.11, 95% CI: 1.10-1.40) were higher in the GD cohort than in the control cohort. In the GD cohort, risk for SLE (aHR: 1.60, 95% CI: 1.11-2.33), Sjogren's syndrome (aHR: 1.89, 95% CI: 1.30-2.74), and ankylosing spondylitis (aHR: 1.53, 95% CI: 1.08-2.17) were higher in the GO group than in the non-GO group.
    Conclusion: This study demonstrated an increased risk of SLE, vitiligo and alopecia areata in patient with GD. In the GD cohort, patients with GO had an increased risk of SLE, Sjogren's syndrome and ankylosing spondylitis. These findings suggest that importance of implementing a strategy for early detection of NTAD based on the presence of GO.
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead708
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