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  1. Article ; Online: A thorny matter

    Ruchi Sharma / Carol J. Holman / Kyle E. Brown

    Annals of Hepatology, Vol 28, Iss 1, Pp 100771- (2023)

    Spur cell anemia

    1480  

    Abstract: Spur cell anemia (SCA) is an acquired form of non-autoimmune hemolytic anemia that occurs in advanced liver disease. It is characterized by the presence of acanthocytes or spur cells, spiculated erythrocytes whose shortened life span causes anemia that ... ...

    Abstract Spur cell anemia (SCA) is an acquired form of non-autoimmune hemolytic anemia that occurs in advanced liver disease. It is characterized by the presence of acanthocytes or spur cells, spiculated erythrocytes whose shortened life span causes anemia that is unresponsive to transfusion. SCA has been regarded as a rare condition with an ominous prognosis for which the only known cure is liver transplantation, but recent prospective studies have demonstrated the existence of a milder form of SCA in which there are smaller numbers of acanthocytes, but which is nevertheless associated with hemolysis and poor outcomes. This form of SCA appears to be considerably more common than the severe classical variant. The conventional understanding of the pathogenesis of SCA is that abnormalities of lipid metabolism are the primary event driving the formation of spur cells. However, the studies that underpin this theory are based on small numbers of patients with heterogeneous clinical features and inconsistent use of nomenclature for dysmorphic red blood cells. In this review, we discuss the evolution of the current understanding of SCA and therapeutic strategies that have been employed based on this understanding. Our goal is to raise awareness of this understudied condition that has significant implications for patient outcomes. Furthermore, we highlight the need for rigorous, contemporary research into the underlying cause or causes of SCA in order to develop an effective therapy for this disorder.
    Keywords Acanthocytes ; Hemolysis ; Anemia ; hemolytic ; End-stage liver disease ; Specialties of internal medicine ; RC581-951
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: A thorny matter: Spur cell anemia.

    Sharma, Ruchi / Holman, Carol J / Brown, Kyle E

    Annals of hepatology

    2022  Volume 28, Issue 1, Page(s) 100771

    Abstract: Spur cell anemia (SCA) is an acquired form of non-autoimmune hemolytic anemia that occurs in advanced liver disease. It is characterized by the presence of acanthocytes or spur cells, spiculated erythrocytes whose shortened life span causes anemia that ... ...

    Abstract Spur cell anemia (SCA) is an acquired form of non-autoimmune hemolytic anemia that occurs in advanced liver disease. It is characterized by the presence of acanthocytes or spur cells, spiculated erythrocytes whose shortened life span causes anemia that is unresponsive to transfusion. SCA has been regarded as a rare condition with an ominous prognosis for which the only known cure is liver transplantation, but recent prospective studies have demonstrated the existence of a milder form of SCA in which there are smaller numbers of acanthocytes, but which is nevertheless associated with hemolysis and poor outcomes. This form of SCA appears to be considerably more common than the severe classical variant. The conventional understanding of the pathogenesis of SCA is that abnormalities of lipid metabolism are the primary event driving the formation of spur cells. However, the studies that underpin this theory are based on small numbers of patients with heterogeneous clinical features and inconsistent use of nomenclature for dysmorphic red blood cells. In this review, we discuss the evolution of the current understanding of SCA and therapeutic strategies that have been employed based on this understanding. Our goal is to raise awareness of this understudied condition that has significant implications for patient outcomes. Furthermore, we highlight the need for rigorous, contemporary research into the underlying cause or causes of SCA in order to develop an effective therapy for this disorder.
    Language English
    Publishing date 2022-10-12
    Publishing country Mexico
    Document type Journal Article ; Review
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2022.100771
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  3. Article ; Online: Leveraging an Implementation Science Framework to Measure the Impact of Efforts to Scale Out a

    Tenney, Liliana / Huebschmann, Amy G / Brown, Carol E / Schwatka, Natalie V / Newman, Lee S

    International journal of environmental research and public health

    2022  Volume 19, Issue 3

    Abstract: The role of dissemination and implementation (D&I) science is critical to the translation ... ...

    Abstract The role of dissemination and implementation (D&I) science is critical to the translation of
    MeSH term(s) Adaptation, Physiological ; Humans ; Implementation Science ; Occupational Health ; Research Design ; Workplace
    Language English
    Publishing date 2022-01-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19031372
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  4. Article ; Online: A Novel Research Rotation for Residents Based on Serial Group Projects Using Existing Data Sets.

    Pershern, Lindsey S / Brenner, Adam / Kulikova, Alexandra / North, Carol S / Brown, E Sherwood

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2022  Volume 47, Issue 3, Page(s) 269–273

    MeSH term(s) Humans ; Rotation ; Internship and Residency ; Curriculum
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/s40596-022-01683-4
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    Zs.B 2043: Show issues Location:
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  5. Article ; Online: Performance of the Dexcom G7 Continuous Glucose Monitoring System in Pregnant Women with Diabetes.

    Polsky, Sarit / Valent, Amy M / Isganaitis, Elvira / Castorino, Kristin / O'Malley, Grenye / Beck, Stayce E / Gao, Peggy / Laffel, Lori M / Brown, Florence M / Levy, Carol J

    Diabetes technology & therapeutics

    2024  Volume 26, Issue 5, Page(s) 307–312

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Female ; Pregnancy ; Blood Glucose Self-Monitoring ; Adult ; Blood Glucose/analysis ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Pregnancy in Diabetics/blood ; Pregnancy in Diabetics/drug therapy ; Diabetes, Gestational/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/drug therapy ; Young Adult ; Continuous Glucose Monitoring
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452816-2
    ISSN 1557-8593 ; 1520-9156
    ISSN (online) 1557-8593
    ISSN 1520-9156
    DOI 10.1089/dia.2023.0516
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  6. Article ; Online: Evaluation of a Total Worker Health

    Schwatka, Natalie V / Brown, Carol E / Tenney, Liliana / Scott, Joshua G / Shore, Erin / Dally, Miranda / Newman, Lee S

    Occupational health science

    2023  Volume 5, Page(s) 163–188

    Abstract: Leaders play a critical role in the development and execution of Total Worker Health (TWH). Small businesses, in particular, can benefit from strong leadership support for TWH as the burden of work-related injury, illness and fatality, as well as poor ... ...

    Abstract Leaders play a critical role in the development and execution of Total Worker Health (TWH). Small businesses, in particular, can benefit from strong leadership support for TWH as the burden of work-related injury, illness and fatality, as well as poor health and well-being is high in this population. In the present study, we conducted a program evaluation of a TWH leadership development program for small business leaders using the RE-AIM framework. The goal of the program was to help change leaders' behaviors around health, safety and well-being practices following the theory of transformational leadership. Two leaders from each business participated in pre-training activities on their own, a 6-hour in-person training, and three months of access to virtual training transfer activities, including coaching and goal tracking. Our results suggest that the TWH leadership development program is effective at improving leaders' self-reported TWH leadership practices and that the in-person training was implemented successfully. However, leaders did not report improvements in their personal health and in fact reported increased levels of work stress after the program. We also observed some challenges when implementing our training transfer strategies. Our study suggests that leaders may benefit from attending TWH leadership trainings alongside other colleagues in their organization to facilitate a shared vision and goals for TWH in their organization. As a next step, it will be important to determine the program's effectiveness in changing business TWH policies and practices, employee perceptions of TWH and leadership, and employee health and safety outcomes.
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2892519-1
    ISSN 2367-0142 ; 2367-0134
    ISSN (online) 2367-0142
    ISSN 2367-0134
    DOI 10.1007/s41542-021-00086-5
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  7. Article ; Online: Interacting With Dermatology Patients Online: Private Practice vs Academic Institute Website Content.

    Patel, Jason / Jiminez, Victoria S / Braswell, Ann Carol / Oscherwitz, Max E / Brown, Michayla B / Patel, Om U / Mayo, Tiffany T

    Cutis

    2023  Volume 111, Issue 6, Page(s) 297–302

    Abstract: Although both private practices and academic institutions in dermatology treat the same variety of pathologies, private practices entice more patients. The purpose of this study was to examine the differences in website content between dermatology ... ...

    Abstract Although both private practices and academic institutions in dermatology treat the same variety of pathologies, private practices entice more patients. The purpose of this study was to examine the differences in website content between dermatology private practices and academic institutions. All 140 dermatology residency programs were first queried. Only websites that contained pertinent information for patients were used in this study (113 of 140 programs). A total of 113 private practice websites were then matched for location and reputation. These sites were assessed for 23 content criteria categorized as practice, physician, patient, or treatment/procedure. The results may be useful for optimizing both private practice and academic institution websites so that patients can better understand the institutions that provide their care.
    MeSH term(s) Humans ; Dermatology ; Physicians ; Private Practice ; Internet
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    DOI 10.12788/cutis.0784
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    Zs.B 1315: Show issues Location:
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  8. Article ; Online: Longitudinal Monitoring of Clinician-Patient Video Visits During the Peak of the COVID-19 Pandemic: Adoption and Sustained Challenges in an Integrated Health Care Delivery System.

    Palakshappa, Jessica A / Hale, Erica R / Brown, Joshua D / Kittel, Carol A / Dressler, Emily / Rosenthal, Gary E / Cutrona, Sarah L / Foley, Kristie L / Haines, Emily R / Houston Ii, Thomas K

    Journal of medical Internet research

    2024  Volume 26, Page(s) e54008

    Abstract: Background: Numerous prior opinion papers, administrative electronic health record data studies, and cross-sectional surveys of telehealth during the pandemic have been published, but none have combined assessments of video visit success monitoring with ...

    Abstract Background: Numerous prior opinion papers, administrative electronic health record data studies, and cross-sectional surveys of telehealth during the pandemic have been published, but none have combined assessments of video visit success monitoring with longitudinal assessments of perceived challenges to the rapid adoption of video visits during the pandemic.
    Objective: This study aims to quantify (1) the use of video visits (compared with in-person and telephone visits) over time during the pandemic, (2) video visit successful connection rates, and (3) changes in perceived video visit challenges.
    Methods: A web-based survey was developed for the dual purpose of monitoring and improving video visit implementation in our health care system during the COVID-19 pandemic. The survey included questions regarding rates of in-person, telephone, and video visits for clinician-patient encounters; the rate of successful connection for video visits; and perceived challenges to video visits (eg, software, hardware, bandwidth, and technology literacy). The survey was distributed via email to physicians, advanced practice professionals, and clinicians in May 2020. The survey was repeated in March 2021. Differences between the 2020 and 2021 responses were adjusted for within-respondent correlation across surveys and tested using generalized estimating equations.
    Results: A total of 1126 surveys were completed (511 surveys in 2020 and 615 surveys in 2021). In 2020, only 21.7% (73/336) of clinicians reported no difficulty connecting with patients during video visits and 28.6% (93/325) of clinicians reported no difficulty in 2021. The distribution of the percentage of successfully connected video visits ("Over the past two weeks of scheduled visits, what percentage did you successfully connect with patients by video?") was not significantly different between 2020 and 2021 (P=.74). Challenges in conducting video visits persisted over time. Poor connectivity was the most common challenge reported by clinicians. This response increased over time, with 30.5% (156/511) selecting it as a challenge in 2020 and 37.1% (228/615) in 2021 (P=.01). Patients not having access to their electronic health record portals was also a commonly reported challenge (109/511, 21.3% in 2020 and 137/615, 22.3% in 2021, P=.73).
    Conclusions: During the pandemic, our health care delivery system rapidly adopted synchronous patient-clinician communication using video visits. As experience with video visits increased, the reported failure rate did not significantly decline, and clinicians continued to report challenges related to general network connectivity and patient access to technology.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; Cross-Sectional Studies ; Communications Media ; Communication
    Language English
    Publishing date 2024-04-08
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1438-8871
    ISSN (online) 1438-8871
    ISSN 1438-8871
    DOI 10.2196/54008
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  9. Article ; Online: Relationship between chronic obstructive pulmonary disease and cognition in an aging population.

    Shea, Stephanie / Palka, Jayme M / Kulikova, Alexandra / North, Carol S / Brown, E Sherwood

    Journal of psychosomatic research

    2022  Volume 161, Page(s) 111000

    Abstract: Objectives: Chronic obstructive pulmonary disease (COPD) is a common and severe respiratory illness. Prior research suggests that COPD may be associated with depression as well as cognitive impairment and increased risk of dementia. Many studies to date ...

    Abstract Objectives: Chronic obstructive pulmonary disease (COPD) is a common and severe respiratory illness. Prior research suggests that COPD may be associated with depression as well as cognitive impairment and increased risk of dementia. Many studies to date have been relatively small, have largely relied on global screening measures to identify cognitive impairment, and have not examined the potential role of comorbid depression on cognition. This cross-sectional study examined the relationship between COPD and multiple cognitive domains at two time points using data from a large longitudinal population database.
    Methods: Linear multivariate analyses were conducted using secondary data from the Wisconsin Longitudinal Study to determine the effect of lifetime COPD and depressive symptom severity, assessed with the Center for Epidemiological Studies Depression Scale (CESD), on multiple cognitive outcomes.
    Results: In both 2004 (n = 1608) and 2011 (n = 1743), lifetime COPD was found to be a non-significant predictor of all cognitive outcomes, while depressive symptom severity predicted significantly lower scores on the immediate recall and digit ordering tasks in 2004 and on all outcomes in 2011. Exploratory analyses in only those with lifetime COPD revealed COPD severity to be a non-significant factor for all outcomes in 2004 and 2011.
    Conclusion: COPD was not significantly associated with cognition. Conversely, higher depressive symptom severity was significantly associated with poorer performance on additional cognitive tasks in 2011 compared to 2004, suggesting that depression may contribute to cognitive decline, dependent upon the context of aging.
    MeSH term(s) Aged ; Aging ; Cognition ; Cross-Sectional Studies ; Humans ; Longitudinal Studies ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80166-5
    ISSN 1879-1360 ; 0022-3999
    ISSN (online) 1879-1360
    ISSN 0022-3999
    DOI 10.1016/j.jpsychores.2022.111000
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    Ui I Zs.233: Show issues Location:
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  10. Article ; Online: Use of a Computerized Decisional Analysis Tool in Patients With Urgency Urinary Incontinence.

    Nguyen, Hoa / Brown, Oluwateniola / Bretschneider, Carol E / Mueller, Margaret / Geynisman-Tan, Julia / Lewicky-Gaupp, Christina / Kenton, Kimberly / Collins, Sarah

    Urogynecology (Philadelphia, Pa.)

    2023  Volume 29, Issue 9, Page(s) 757–762

    Abstract: Importance: Decision analysis tools (DAT) are shared decision making instruments that include patient input on treatment goals and values that have been shown to decrease decisional regret in women's health care.: Objective: We describe a novel, ... ...

    Abstract Importance: Decision analysis tools (DAT) are shared decision making instruments that include patient input on treatment goals and values that have been shown to decrease decisional regret in women's health care.
    Objective: We describe a novel, computerized DAT for patients with urinary incontinence (UI), and our primary aim was to assess the concordance between treatment fit as determined by the DAT and treatment selected after physician counseling in patients with urgency urinary incontinence and urgency predominant mixed urinary incontinence.
    Study design: We partnered with a health care startup to develop a computerized DAT incorporating evidence about UI and patient input about treatment goals and personal values. This is a retrospective cohort study examining the concordance of DAT-predicted treatments identified before consultation with the physician and those chosen after counseling. Electronic medical records were reviewed to abstract demographic, clinical data, and treatments chosen at the initial physician consultation. Because it was possible to pursue concurrent treatment options (ie, pelvic floor physical therapy and medications), the first 2 modalities identified in the treatment plan at consultation were abstracted. Descriptive statistics were conducted using SPSS®, we did not adjust for multiple comparisons.
    Results: Four hundred eighty-nine patients met the inclusion criteria for our study, and 65% of the cohort chose treatment options after counseling that were concordant with their DAT best treatment fit.
    Conclusion: Patients choosing treatment for urgency urinary incontinence and urgency predominant mixed urinary incontinence using a novel, computer-based DAT to prepare for shared decision making with their physicians often choose to proceed with their top DAT-determined treatment fit after counseling.
    MeSH term(s) Humans ; Female ; Retrospective Studies ; Urinary Incontinence/diagnosis ; Decision Making, Shared ; Electronic Health Records ; Emotions
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article
    ISSN 2771-1897
    ISSN (online) 2771-1897
    DOI 10.1097/SPV.0000000000001342
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