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  1. Article: Cutaneous toxicities from targeted therapies used in oncology: Literature review of clinical presentation and management.

    Huynh Dagher, Solène / Blom, Astrid / Chabanol, Hedi / Funck-Brentano, Elisa

    International journal of women's dermatology

    2021  Volume 7, Issue 5Part A, Page(s) 615–624

    Abstract: With the development of molecular targeted therapies, a wide array of dermatologic toxicities is appearing. Their prevention, recognition, and management by dermatologists is critical to ensure antineoplastic treatment continuation. The objective of this ...

    Abstract With the development of molecular targeted therapies, a wide array of dermatologic toxicities is appearing. Their prevention, recognition, and management by dermatologists is critical to ensure antineoplastic treatment continuation. The objective of this study was to provide a literature review of the most common dermatologic toxicities due to targeted therapies in oncologic patients, including their clinical presentation, prevention, and management.
    Language English
    Publishing date 2021-09-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2832233-2
    ISSN 2352-6475
    ISSN 2352-6475
    DOI 10.1016/j.ijwd.2021.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Influence of Media Coverage and Governmental Policies on Google Queries Related to COVID-19 Cutaneous Symptoms: Infodemiology Study.

    Huynh Dagher, Solene / Lamé, Guillaume / Hubiche, Thomas / Ezzedine, Khaled / Duong, Tu Anh

    JMIR public health and surveillance

    2021  Volume 7, Issue 2, Page(s) e25651

    Abstract: Background: During COVID-19, studies have reported the appearance of internet searches for disease symptoms before their validation by the World Health Organization. This suggested that monitoring of these searches with tools including Google Trends may ...

    Abstract Background: During COVID-19, studies have reported the appearance of internet searches for disease symptoms before their validation by the World Health Organization. This suggested that monitoring of these searches with tools including Google Trends may help monitor the pandemic itself. In Europe and North America, dermatologists reported an unexpected outbreak of cutaneous acral lesions (eg, chilblain-like lesions) in April 2020. However, external factors such as public communications may also hinder the use of Google Trends as an infodemiology tool.
    Objective: The study aimed to assess the impact of media announcements and lockdown enforcement on internet searches related to cutaneous acral lesions during the COVID-19 outbreak in 2020.
    Methods: Two searches on Google Trends, including daily relative search volumes for (1) "toe" or "chilblains" and (2) "coronavirus," were performed from January 1 to May 16, 2020, with the United States, the United Kingdom, France, Italy, Spain, and Germany as the countries of choice. The ratio of interest over time in "chilblains" and "coronavirus" was plotted. To assess the impact of lockdown enforcement and media coverage on these internet searches, we performed an interrupted time-series analysis for each country.
    Results: The ratio of interest over time in "chilblains" to "coronavirus" showed a constant upward trend. In France, Italy, and the United Kingdom, lockdown enforcement was associated with a significant slope change for "chilblain" searches with a variation coefficient of 1.06 (SE 0.42) (P=0.01), 1.04 (SE 0.28) (P<.01), and 1.21 (SE 0.44) (P=0.01), respectively. After media announcements, these ratios significantly increased in France, Spain, Italy, and the United States with variation coefficients of 18.95 (SE 5.77) (P=.001), 31.31 (SE 6.31) (P<.001), 14.57 (SE 6.33) (P=.02), and 11.24 (SE 4.93) (P=.02), respectively, followed by a significant downward trend in France (-1.82 [SE 0.45]), Spain (-1.10 [SE 0.38]), and Italy (-0.93 [SE 0.33]) (P<.001, P=0.004, and P<.001, respectively). The adjusted R
    Conclusions: To date, the association between chilblain-like lesions and COVID-19 remains controversial; however, our results indicate that Google queries of "chilblain" were highly influenced by media coverage and government policies, indicating that caution should be exercised when using Google Trends as a monitoring tool for emerging diseases.
    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Europe/epidemiology ; Humans ; Internet ; Mass Media/statistics & numerical data ; Public Health Surveillance/methods ; Public Policy ; Search Engine/trends ; Skin Diseases/virology ; United States/epidemiology
    Language English
    Publishing date 2021-02-25
    Publishing country Canada
    Document type Journal Article
    ISSN 2369-2960
    ISSN (online) 2369-2960
    DOI 10.2196/25651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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