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  1. Book ; Online: Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation

    Reijmers, Rogier M. / Petrey, Aaron C. / Troeberg, Linda / Lord, Megan S.

    2020  

    Keywords Medicine ; Immunology ; glycosaminoglycan (GAG) ; proteoglycans (PG) ; immune response ; inflammation ; heparan sulfate (HS) ; chondroitin sulfate (CS) ; dermatan sulfate (DS) ; hyaluronan
    Size 1 electronic resource (234 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230927
    ISBN 9782889662531 ; 2889662535
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts.

    Jiang, Shouyuan / Wise, Steven G / Kovacic, Jason C / Rnjak-Kovacina, Jelena / Lord, Megan S

    Trends in biotechnology

    2023  Volume 42, Issue 3, Page(s) 369–381

    Abstract: The performance of synthetic biomaterial vascular grafts for the bypass of stenotic and dysfunctional blood vessels remains an intractable challenge in small-diameter applications. The functionalization of biomaterials with extracellular matrix (ECM) ... ...

    Abstract The performance of synthetic biomaterial vascular grafts for the bypass of stenotic and dysfunctional blood vessels remains an intractable challenge in small-diameter applications. The functionalization of biomaterials with extracellular matrix (ECM) molecules is a promising approach because these molecules can regulate multiple biological processes in vascular tissues. In this review, we critically examine emerging approaches to ECM-containing vascular graft biomaterials and explore opportunities for future research and development toward clinical use.
    MeSH term(s) Biocompatible Materials ; Biomimetics ; Blood Vessel Prosthesis ; Extracellular Matrix ; Tissue Engineering
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2023.09.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Tuning the intentional corona of cerium oxide nanoparticles to promote angiogenesis via fibroblast growth factor 2 signalling.

    Fu, Lu / Li, Rupeng / Whitelock, John M / Lord, Megan S

    Regenerative biomaterials

    2022  Volume 9, Page(s) rbac081

    Abstract: Inadequate angiogenesis is a hallmark of conditions including cardiovascular diseases, stroke and chronic diabetic wounds, which exhibit tissue ischaemia ensuring that therapeutic strategies to promote angiogenesis are of great interest. However, many ... ...

    Abstract Inadequate angiogenesis is a hallmark of conditions including cardiovascular diseases, stroke and chronic diabetic wounds, which exhibit tissue ischaemia ensuring that therapeutic strategies to promote angiogenesis are of great interest. However, many angiogenic treatments involve the delivery of growth factors which have limited clinical success due to poor stability, high manufacturing cost and poor efficacy. Cerium oxide nanoparticles (nanoceria) can either promote or inhibit angiogenesis depending on their surface corona chemistry. Here, nanoceria were functionalized with an intentional heparin corona, a polysaccharide which binds and signals growth factors, of different chain lengths and surface grafting density to establish their effect on angiogenesis. These nanoparticles promoted angiogenesis
    Language English
    Publishing date 2022-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2799042-4
    ISSN 2056-3426 ; 2056-3418
    ISSN (online) 2056-3426
    ISSN 2056-3418
    DOI 10.1093/rb/rbac081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial: Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation.

    Reijmers, Rogier M / Troeberg, Linda / Lord, Megan S / Petrey, Aaron C

    Frontiers in immunology

    2020  Volume 11, Page(s) 595867

    Language English
    Publishing date 2020-10-15
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.595867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The role of the cell surface glycocalyx in drug delivery to and through the endothelium.

    Fu, Lu / Kim, Ha Na / Sterling, James D / Baker, Shenda M / Lord, Megan S

    Advanced drug delivery reviews

    2022  Volume 184, Page(s) 114195

    Abstract: Cell membranes are key interfaces where materials engineering meets biology. Traditionally regarded as just the location of receptors regulating the uptake of molecules, we now know that all mammalian cell membranes are 'sugar coated'. These sugars, or ... ...

    Abstract Cell membranes are key interfaces where materials engineering meets biology. Traditionally regarded as just the location of receptors regulating the uptake of molecules, we now know that all mammalian cell membranes are 'sugar coated'. These sugars, or glycans, form a matrix bound at the cell membrane via proteins and lipids, referred to as the glycocalyx, which modulate access to cell membrane receptors crucial for interactions with drug delivery systems (DDS). Focusing on the key blood-tissue barrier faced by most DDS to enable transport from the place of administration to target sites via the circulation, we critically assess the design of carriers for interactions at the endothelial cell surface. We also discuss the current challenges for this area and provide opportunities for future research efforts to more fully engineer DDS for controlled, efficient, and targeted interactions with the endothelium for therapeutic application.
    MeSH term(s) Animals ; Biological Transport ; Drug Delivery Systems ; Endothelial Cells ; Endothelium, Vascular ; Glycocalyx/metabolism ; Humans ; Mammals
    Language English
    Publishing date 2022-03-12
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2022.114195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2241: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Recombinant perlecan domain V covalently immobilized on silk biomaterials via plasma immersion ion implantation supports the formation of functional endothelium.

    Lau, Kieran / Fu, Lu / Zhang, Anyu / Akhavan, Behnam / Whitelock, John / Bilek, Marcela M / Lord, Megan S / Rnjak-Kovacina, Jelena

    Journal of biomedical materials research. Part A

    2023  Volume 111, Issue 6, Page(s) 825–839

    Abstract: Strategies to promote rapid formation of functional endothelium are required to maintain blood fluidity and regulate smooth muscle cell proliferation in synthetic vascular conduits. In this work, we explored the biofunctionalization of silk biomaterials ... ...

    Abstract Strategies to promote rapid formation of functional endothelium are required to maintain blood fluidity and regulate smooth muscle cell proliferation in synthetic vascular conduits. In this work, we explored the biofunctionalization of silk biomaterials with recombinantly expressed domain V of human perlecan (rDV) to promote endothelial cell interactions and the formation of functional endothelium. Perlecan is essential in vascular development and homeostasis and rDV has been shown to uniquely support endothelial cell, while inhibiting smooth muscle cell and platelet interactions, both key contributors of vascular graft failure. rDV was covalently immobilized on silk using plasma immersion ion implantation (PIII), a simple one-step surface treatment process which enables strong immobilization in the absence of chemical cross-linkers. rDV immobilization on surface-modified silk was assessed for amount, orientation, and bio-functionality in terms of endothelial cell interactions and functional endothelial layer formation. rDV immobilized on PIII-treated silk (rDV-PIII-silk) supported rapid endothelial cell adhesion, spreading, and proliferation to form functional endothelium, as evidenced by the expression of vinculin and VE-cadherin markers. Taken together, the results provide evidence for the potential of rDV-PIII-silk as a biomimetic vascular graft material.
    MeSH term(s) Humans ; Silk/chemistry ; Biocompatible Materials ; Immersion ; Cell Adhesion ; Blood Vessel Prosthesis ; Extracellular Matrix Proteins ; Endothelium
    Chemical Substances Silk ; Biocompatible Materials ; perlecan (143972-95-6) ; Extracellular Matrix Proteins
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: ROS-Mediated Anti-Angiogenic Activity of Cerium Oxide Nanoparticles in Melanoma Cells.

    Yong, Joel M / Fu, Lu / Tang, Fengying / Yu, Peimin / Kuchel, Rhiannon P / Whitelock, John M / Lord, Megan S

    ACS biomaterials science & engineering

    2022  Volume 8, Issue 2, Page(s) 512–525

    Abstract: Angiogenesis plays a key role in cancer progression, including transition to the metastatic ... ...

    Abstract Angiogenesis plays a key role in cancer progression, including transition to the metastatic phase
    MeSH term(s) Cerium/pharmacology ; Humans ; Melanoma/drug therapy ; Nanoparticles ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species ; Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.1c01268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis.

    Emig, Alyssa A / Hansen, Megan / Grimm, Sandra / Coarfa, Cristian / Lord, Nathan D / Williams, Margot Kossmann

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Anteroposterior (AP) elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both the mesoderm and neuroectoderm, but how or whether molecular regulation of C&E differs between tissues remains an open ...

    Abstract Anteroposterior (AP) elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both the mesoderm and neuroectoderm, but how or whether molecular regulation of C&E differs between tissues remains an open question. Using a zebrafish explant model of AP axis extension, we show that C&E of the neuroectoderm and mesoderm can be uncoupled
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.06.579243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Redox Active Cerium Oxide Nanoparticles: Current Status and Burning Issues.

    Lord, Megan S / Berret, Jean Francois / Singh, Sanjay / Vinu, Ajayan / Karakoti, Ajay S

    Small (Weinheim an der Bergstrasse, Germany)

    2021  Volume 17, Issue 51, Page(s) e2102342

    Abstract: Research on cerium oxide nanoparticles (nanoceria) has captivated the scientific community due to their unique physical and chemical properties, such as redox activity and oxygen buffering capacity, which made them available for many technical ... ...

    Abstract Research on cerium oxide nanoparticles (nanoceria) has captivated the scientific community due to their unique physical and chemical properties, such as redox activity and oxygen buffering capacity, which made them available for many technical applications, including biomedical applications. The redox mimetic antioxidant properties of nanoceria have been effective in the treatment of many diseases caused by reactive oxygen species (ROS) and reactive nitrogen species. The mechanism of ROS scavenging activity of nanoceria is still elusive, and its redox activity is controversial due to mixed reports in the literature showing pro-oxidant and antioxidant activity. In light of its current research interest, it is critical to understand the behavior of nanoceria in the biological environment and provide answers to some of the critical and open issues. This review critically analyzes the status of research on the application of nanoceria to treat diseases caused by ROS. It reviews the proposed mechanism of action and shows the effect of surface coatings on its redox activity. It also discusses some of the crucial issues in deciphering the mechanism and redox activity of nanoceria and suggests areas of future research.
    MeSH term(s) Cerium ; Nanoparticles ; Oxidation-Reduction ; Reactive Oxygen Species
    Chemical Substances Reactive Oxygen Species ; Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
    Language English
    Publishing date 2021-08-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202102342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: De Novo Engineering of Metal-Organic Framework-Printed In Vitro Diagnostic Devices for Specific Capture and Release of Tumor Cells.

    Liang, Jieying / Liu, Jian / Lord, Megan S / Wang, Yu / Liang, Kang

    Small (Weinheim an der Bergstrasse, Germany)

    2021  Volume 17, Issue 44, Page(s) e2103590

    Abstract: Herein, a paper-based in vitro diagnostic device (IVD) is developed via inkjet printing of de novo engineered, boronic acid-rich metal-organic frameworks (BMOFs). The newly developed BMOFs simultaneously possess crystalline and amorphous structure, ... ...

    Abstract Herein, a paper-based in vitro diagnostic device (IVD) is developed via inkjet printing of de novo engineered, boronic acid-rich metal-organic frameworks (BMOFs). The newly developed BMOFs simultaneously possess crystalline and amorphous structure, mesopore size, large surface area, and retain a high level of boronic acid integration. After printing the BMOFs on the filter paper, the BMOF-printed paper IVD shows a rapid response time (40 min) towards cancer cell capture and its maximum cell capture capacity reaches approximately (4.5 ±1.1) ×10
    MeSH term(s) Boronic Acids ; Cell Survival ; Metal-Organic Frameworks ; Reagent Kits, Diagnostic ; Silicon
    Chemical Substances Boronic Acids ; Metal-Organic Frameworks ; Reagent Kits, Diagnostic ; Silicon (Z4152N8IUI)
    Language English
    Publishing date 2021-09-29
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202103590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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