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Article: COPD and glycopyrronium responsiveness assessment: An appraisal.

Bhattacharyya, Parthasarathi / Saha, Dipanjan / Chatterjee, Moumita / Sengupta, Sayoni / Dey, Debkanya / Banerjee, Rajat

Lung India : official organ of Indian Chest Society

2023 Volume 40, Issue 3, Page(s) 227–234

Abstract: Clinical trial registration: ECR/159/Inst/WB/2013/RR-20.: Background: Glycopyrronium bromide (a long-acting antimuscarinic agent: LAMA) appears pharmacokinetically suitable for testing bronchodilator responsiveness as salbutamol (short-acting β2- ... ...

Abstract	Clinical trial registration: ECR/159/Inst/WB/2013/RR-20. Background: Glycopyrronium bromide (a long-acting antimuscarinic agent: LAMA) appears pharmacokinetically suitable for testing bronchodilator responsiveness as salbutamol (short-acting β2-agonist: SABA). Exploring the feasibility, acceptability, degree of reversibility with glycopyrronium, and its comparison with that of salbutamol may be intriguing. Methods: New, consecutive, and willing outpatient attendees in the same season of the two consecutive years with chronic obstructive pulmonary disease (FEV1/FVC <0.07; FEV1 <80% of predicted) were subjected to serial responsiveness with inhalation of salbutamol first followed by 50 μg dry powder glycopyrronium [Salbutamol- Glycopyrronium] (phase-1) in the first year and glycopyrronium followed by salbutamol [Glycopyrronium- Salbutamol] (phase-2) in the following year. We looked for the acceptability, adverse reactions, and degree of changes in FEV1, FVC, FEV1/FVC, and FEF25-75 with comparison between the two groups. Results: The [Salbutamol- Glycopyrronium] group (n = 86) were similar in age, body mass index, and FEV1 to the [Glycopyrronium- Salbutamol] group (n = 88). Both the agents could make a significant (P <.0001) improvement in the parameters independently or as add-on when used serially in alternate orders. The intergroup difference at no stage was significant. The sensitive patients to salbutamol (n = 48), glycopyrronium (n = 44), and both (n = 12) have improvement of 165, 189, and 297 mL while a both-insensitive group (n = 70) had barely 44 mL of improvement. The protocol was universally accepted without any adverse events. Conclusion: Serial testing of salbutamol and glycopyrronium responsiveness in alternate orders provides an insight regarding the independent and the add-on effects of these two agents. About 40% of our chronic obstructive pulmonary disease patients had no clinically appreciable difference in FEV1 with the salbutamol + glycopyrronium combination inhalation.
Language	English
Publishing date	2023-04-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2410801-7
ISSN	0974-598X ; 0970-2113
ISSN (online)	0974-598X
ISSN	0970-2113
DOI	10.4103/lungindia.lungindia_376_22
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Article: The management of combined ACL and MCL injuries: A systematic review.

Rao, Raunak / Bhattacharyya, Rahul / Andrews, Barry / Varma, Rajat / Chen, Alvin

Journal of orthopaedics

2022 Volume 34, Page(s) 21–30

Abstract: Background: The management of combined anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries remains contentious. Clinical outcomes of surgical, conservative, and combined approaches have been described in a range of prospective ...

Abstract	Background: The management of combined anterior cruciate ligament (ACL) and medial collateral ligament (MCL) injuries remains contentious. Clinical outcomes of surgical, conservative, and combined approaches have been described in a range of prospective and retrospective studies. The aim of the current systematic review was to evaluate these outcomes and assess the study methodologies. Methods: A comprehensive literature search of the following databases was performed: PubMed, OVID, Cochrane Database of Systematic Reviews and Google Scholar. Studies were assessed using the Coleman Methodology Score. Results: 52 articles were included (3 randomised controlled trials, 8 prospective comparative studies, 17 retrospective comparative studies and 24 case series). Outcome measures were heterogeneous amongst articles. The most common outcomes assessed were AP laxity, Lysholm score and medial/valgus laxity. Complications at varying follow-up times with differing grades of MCL injury were reported in 25 (48%) studies. Evidence was conflicting, with no consensus from the available published literature regarding the best method of treatment for a combined ACL and MCL injury. Conclusions: Heterogeneous outcome measures and limited randomised controlled trials prevent advocacy of a single treatment option. Good outcomes have been reported from repair, reconstruction and conservative management of the MCL together with ACL reconstruction. Further prospective comparative data is required to evaluate MCL management choice and prognostic signs for successful nonsurgical MCL treatment.
Language	English
Publishing date	2022-08-04
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2022.07.024
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Article ; Online: An apparent case of non-accidental injury.

Tan, Guan Hao / Bhattacharyya, Rajat

Archives of disease in childhood. Education and practice edition

2017 Volume 103, Issue 5, Page(s) 247–248

MeSH term(s)	Blood Platelet Disorders/diagnosis ; Child Abuse/diagnosis ; Child, Preschool ; Contusions/etiology ; Diagnosis, Differential ; Eosinophilia/diagnosis ; Female ; Humans ; Platelet Function Tests
Language	English
Publishing date	2017-08-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2148818-6
ISSN	1743-0593 ; 1743-0585
ISSN (online)	1743-0593
ISSN	1743-0585
DOI	10.1136/archdischild-2017-313068
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Article ; Online: Treatment and mortality of hemophagocytic lymphohistiocytosis in critically ill children: A systematic review and meta-analysis.

Tan, Claire Jing-Wen / Ng, Zheng Qin / Bhattacharyya, Rajat / Sultana, Rehena / Lee, Jan Hau

Pediatric blood & cancer

2022 Volume 70, Issue 3, Page(s) e30122

Abstract: Objective: Risk factors of mortality in critically ill children with hemophagocytic lymphohistiocytosis (HLH) are not well described. This systematic review aims to determine overall mortality of critically ill children with HLH, and describes ... ...

Abstract	Objective: Risk factors of mortality in critically ill children with hemophagocytic lymphohistiocytosis (HLH) are not well described. This systematic review aims to determine overall mortality of critically ill children with HLH, and describes etiologies, treatment, and pediatric intensive care unit (PICU) support employed. Data sources: PubMed, Embase, Web of Science, CINAHL, and Cochrane Library from inception until February 28, 2022. Study selection: Observational studies and randomized controlled trials reporting children aged 18 years or below, diagnosed with HLH and admitted to the PICU. Data extraction: Etiologies, treatment modalities, PICU therapies, and mortality outcomes were summarized. Random-effects meta-analysis was performed. Data synthesis: Total 36 studies (total patients = 493, mean age: 49.5 months [95% confidence interval (CI): 30.9-79.5]) were included. Pooled mortality rate was 32.6% (95% CI: 23.4-42.4). The most frequent etiologies for HLH were infections (53.3%) and primary HLH (12.8%), while the remaining cases were due to other causes of secondary HLH, including autoimmune diseases, malignancy, and drug-induced and idiopathic HLH. Pooled mortality rate was higher in primary than secondary HLH (72.2%, 95% CI: 57.8-84.5 vs. 23.9%, 95% CI: 14.4-35.02; p < .01). Univariate analysis found that treatment with etoposide was associated with higher mortality, while intravenous immunoglobulins (IVIGs) were associated with lower mortality. Conversely, multivariable analysis adjusted for etiology demonstrated no association between etoposide and IVIG use, and mortality. Twenty-one studies (total patients = 278) had detailed information on PICU therapies. Mechanical ventilation (MV), continuous renal replacement therapy, and inotropes were used in 107 (38.5%), 66 (23.7%), and 51 patients (18.3%), respectively. Need for MV was associated with increased risk of mortality (mean difference = 28%, 95% CI: 9-47). Conclusion: Critically ill children with HLH have high mortality rates and require substantial PICU support. Collaborative work between multiple centers with standardized data collection can potentially provide more robust data.
MeSH term(s)	Humans ; Child ; Child, Preschool ; Lymphohistiocytosis, Hemophagocytic/complications ; Etoposide ; Critical Illness ; Retrospective Studies ; Intensive Care Units, Pediatric ; Immunoglobulins, Intravenous/therapeutic use
Chemical Substances	Etoposide (6PLQ3CP4P3) ; Immunoglobulins, Intravenous
Language	English
Publishing date	2022-12-29
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30122
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Article ; Conference proceedings: An Efficient Diagnosis of Diffuse Parenchymal Lung Disease from Spirometry Exploring the Novel Role of FEF25–75

Dey, Debkanya / Paul, Mintu / Saha, Gourab / Sengupta, Sayoni / Saha, Dipanjan / Banerjee, Rajat / Bhattacharyya, Parthasarathi

Indian Journal of Medical and Paediatric Oncology

2022 Volume 43, Issue S 01

Event/congress	National Research Scholars' Meet 2021 - Abstracts, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, 2021-12-09
Language	English
Publishing date	2022-08-01
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2181724-8
ISSN	0975-2129 ; 0971-5851 ; 0975-2129
ISSN (online)	0975-2129
ISSN	0971-5851 ; 0975-2129
DOI	10.1055/s-0042-1755481
Database	Thieme publisher's database

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Article ; Online: X-linked Sideroblastic Anemia in a Malay Boy With ALAS2 S568G Mutation.

Susanto, Thomas A K / Bhattacharyya, Rajat

Journal of pediatric hematology/oncology

2017 Volume 39, Issue 5, Page(s) 408–409

Abstract: Dimorphism in peripheral blood film was noted in a 16 year old Malay boy with anemia who was eventually diagnosed with X-linked sideroblastic anemia. A mutation in ALAS2 S568G was identified which has not been described previously in a Malay ethnic group. ...

Abstract	Dimorphism in peripheral blood film was noted in a 16 year old Malay boy with anemia who was eventually diagnosed with X-linked sideroblastic anemia. A mutation in ALAS2 S568G was identified which has not been described previously in a Malay ethnic group.
MeSH term(s)	5-Aminolevulinate Synthetase/genetics ; Adolescent ; Anemia, Sideroblastic/diagnosis ; Anemia, Sideroblastic/drug therapy ; Anemia, Sideroblastic/ethnology ; Anemia, Sideroblastic/genetics ; Genetic Diseases, X-Linked/diagnosis ; Genetic Diseases, X-Linked/drug therapy ; Genetic Diseases, X-Linked/ethnology ; Genetic Diseases, X-Linked/genetics ; Hemoglobins/analysis ; Humans ; Malaysia ; Male ; Mutation ; Pyridoxine/therapeutic use ; Sex Characteristics
Chemical Substances	Hemoglobins ; 5-Aminolevulinate Synthetase (EC 2.3.1.37) ; ALAS2 protein, human (EC 2.3.1.37) ; Pyridoxine (KV2JZ1BI6Z)
Language	English
Publishing date	2017-06-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000000814
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Article ; Online: Bleeder With a Clot: Thrombosis Following Treatment of Bleeding in a Child With Severe Hemophilia B.

Goh, Mei Ching / Lam, Joyce Ching Mei / Tan, Ah Moy / Bhattacharyya, Rajat

Journal of pediatric hematology/oncology

2020 Volume 43, Issue 4, Page(s) e561–e563

Abstract: A 16-year-old boy with severe hemophilia B and minimal bleeding manifestations in his early childhood presented with gastrointestinal bleeding at 11 years of age. Following administration of prothrombin complex concentrate, he developed peripheral venous ...

Abstract	A 16-year-old boy with severe hemophilia B and minimal bleeding manifestations in his early childhood presented with gastrointestinal bleeding at 11 years of age. Following administration of prothrombin complex concentrate, he developed peripheral venous thrombosis and cerebral sinovenous thrombosis, posing a management dilemma. His cerebral sinovenous thrombosis resolved spontaneously, proving watchful waiting to be a useful strategy. He developed spontaneous intracranial bleed at 14 years of age for which he was treated with factor IX concentrate and commenced on prophylaxis. We discuss the factors contributing to genotype-phenotype dissonance in severe hemophilia and considerations before commencing prophylaxis in such cases.
MeSH term(s)	Adolescent ; Blood Coagulation Factors/adverse effects ; Blood Coagulation Factors/therapeutic use ; Factor IX/therapeutic use ; Hemophilia B/therapy ; Hemorrhage/therapy ; Humans ; Male ; Thrombosis/etiology
Chemical Substances	Blood Coagulation Factors ; prothrombin complex concentrates (37224-63-8) ; Factor IX (9001-28-9)
Language	English
Publishing date	2020-07-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1231152-2
ISSN	1536-3678 ; 1077-4114 ; 0192-8562
ISSN (online)	1536-3678
ISSN	1077-4114 ; 0192-8562
DOI	10.1097/MPH.0000000000001904
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Article: Influence of continental rifting on sedimentation and its provenance and geodynamic implications: An example from late Paleoproterozoic Chandil Formation, eastern India

Chatterjee, Priyanka / De, Shuvabrata / Mazumder, Rajat / Ohta, Tohru / Chiarenzelli, Jeff / Bhattacharyya, Tapas

Earth-science reviews. 2022 Feb., v. 225

2022

Abstract: The Paleoproterozoic-Mesoproterozoic boundary is associated with onset of supercontinental cycle and global thermal perturbation. In the Singhbhum cratonic province, the 1600 Ma felsic volcanics and metasedimentary successions of the Chandil Formation ... ...

Abstract	The Paleoproterozoic-Mesoproterozoic boundary is associated with onset of supercontinental cycle and global thermal perturbation. In the Singhbhum cratonic province, the 1600 Ma felsic volcanics and metasedimentary successions of the Chandil Formation conformably overlies the mafic volcanic and volcaniclastic successions of the Dalma Formation. Unlike the Dalma Formation and the underlying Singhbhum Group of rocks, the sedimentary facies and provenance characterization of the Chandil Formation has been long overdue. Herein we present sedimentary facies and geochemical characterization of the Chandil Formation. The Chandil Formation has been divided into three distinct sedimentary facies associations: the bottommost trough cross-stratified, poorly sorted and texturally immature, coarse- to medium-grained sandstone-shale facies association formed in a fluvial setting. The overlying fine-grained, well-sorted and well-rounded sandstones of the sandstone-siltstone-mudstone (volcanic ash) facies association is characterized by aeolian dunes and pinstripe laminations, and thus formed in an aeolian environment. The medium-grained, moderately sorted, cross-bedded sandstones of the topmost facies association bear alternate thick-thin sandy foresets that are bounded by mudstone drapes and hummocky-cross stratification, indicating a marine depositional setting.The Chandil sedimentation pattern is remarkably similar to the very well-known and 1000 million years younger Potsdam Group clastics, USA that formed in an intracratonic rift setting with similar sedimentary facies characteristics. Comparative provenance studies of the clastic rocks of the Chandil Formation and the lowermost Potsdam Group reveal that the protoliths of both rock successions were arkosic to litharenitic composition. Trace element studies of the sedimentary units of both rock successions confirm the provenance interpretation and indicate reworking of early rift and/or granitic basement rocks. The similarities between these sedimentary successions including sedimentary facies, basin development, and geochemical trends, although differing in age by ca. 1 billion years, indicate overwhelming influence of provenance on sediment generation, transportation and deposition that muted other controlling factors of sedimentation like paleoclimate, changes to Earth magmatism and consequent changes in tectonic regime etc. Sedimentological and geochemical analysis, following the methodology adopted in this paper, from other sedimentary successions will help to infer the interplay between contemporary basin tectonics and consequent sedimentation. Our analyses further indicate major terrestrial sedimentation, higher continental freeboard and felsic magmatism around 1600 million years in the Singhbhum craton similar to the adjoining Cuddapah basin (Dharwar), Pranhita-Godavari basin (Bastar) in the southern Indian block, in the Central Indian Tectonic Zone, and in the Vindhyan basin of the north Indian block.
Keywords	Paleoproterozoic era ; Ursidae ; basins ; mudstone ; paleoclimatology ; provenance ; tectonics ; trace elements ; transportation ; volcanic ash ; India
Language	English
Dates of publication	2022-02
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1792-9
ISSN	0012-8252
ISSN	0012-8252
DOI	10.1016/j.earscirev.2021.103868
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Interplay Between Coagulation and Inflammation Pathways in COVID-19-Associated Respiratory Failure: A Narrative Review.

Bhattacharyya, Rajat / Iyer, Prasad / Phua, Ghee Chee / Lee, Jan Hau

Pulmonary therapy

2020 Volume 6, Issue 2, Page(s) 215–231

Abstract: The novel coronavirus disease (COVID-19) pandemic has caused an unprecedented worldwide socio-economic and health impact. There is increasing evidence that a combination of inflammation and hypercoagulable state are the main mechanisms of respiratory ... ...

Abstract	The novel coronavirus disease (COVID-19) pandemic has caused an unprecedented worldwide socio-economic and health impact. There is increasing evidence that a combination of inflammation and hypercoagulable state are the main mechanisms of respiratory failure in these patients. This narrative review aims to summarize currently available evidence on the complex interplay of immune dysregulation, hypercoagulability, and thrombosis in the pathogenesis of respiratory failure in COVID-19 disease. In addition, we will describe the experience of anticoagulation and anti-inflammatory strategies that have been tested. Profound suppression of the adaptive and hyperactivity of innate immune systems with macrophage activation appears to be a prominent feature in this infection. Immune dysregulation together with endotheliitis and severe hypercoagulability results in thromboinflammation and microvascular thrombosis in the pulmonary vasculature leading to severe respiratory distress. Currently, some guidelines recommend the use of prophylactic low molecular weight heparin in all hospitalized patients, with intermediate dose prophylaxis in those needing intensive care, and the use of therapeutic anticoagulation in patients with proven or suspected thrombosis. Strong recommendations cannot be made until this approach is validated by trial results. To target the inflammatory cascade, low-dose dexamethasone appears to be helpful in moderate to severe cases and trials with anti-interleukin agents (e.g., tocilizumab, anakinra, siltuximab) and non-steroidal anti-inflammatory drugs are showing early promising results. Potential newer agents (e.g., Janus kinase inhibitor such as ruxolitinib, baricitinib, fedratinib) are likely to be investigated in clinical trials. Unfortunately, current trials are mostly examining these agents in isolation and there may be a significant delay before evidence-based practice can be implemented. It is plausible that a combination of anti-viral drugs together with anti-inflammatory and anti-coagulation medicines will be the most successful strategy in managing severely affected patients with COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-08-25
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2364-1746
ISSN (online)	2364-1746
DOI	10.1007/s41030-020-00126-5
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Article ; Online: Residue and soil dissipation kinetics of chloroacetanilide herbicides on rice (Oryzae sativa L.) and assessing the impact on soil microbial parameters and enzyme activity.

Mahanta, Kaberi / Bhattacharyya, Pranaba Nanda / Sharma, Anjan Kumar / Rajkhowa, Dipjyoti / Lesueur, Didier / Verma, Harendra / Parit, Rajat / Deka, Jayanta / Medhi, Binoy Kumar / Kohli, Anshuman

Environmental monitoring and assessment

2023 Volume 195, Issue 7, Page(s) 910

Abstract: The present investigation determines the persistence of herbicides like butachlor and pretilachlor in Indian soil, and their impact on soil biological properties including microbial biomass carbon (MBC), total microbial population numbers, and enzyme ... ...

Abstract	The present investigation determines the persistence of herbicides like butachlor and pretilachlor in Indian soil, and their impact on soil biological properties including microbial biomass carbon (MBC), total microbial population numbers, and enzyme activities. Butachlor was degraded faster in autumn rice soil (t
MeSH term(s)	Kinetics ; Oryza ; Soil Microbiology ; Environmental Monitoring ; Carbon ; Herbicides
Chemical Substances	pretilachlor (617K7LM10D) ; 4-nitrophenol (Y92ZL45L4R) ; butachlor (94NU90OO5K) ; 2-chloro-N-(ethoxymethyl)-N-(2-methyl-6-(trifluoromethyl)phenyl)acetamide (78194-29-3) ; Carbon (7440-44-0) ; Herbicides
Language	English
Publishing date	2023-07-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-023-11513-1
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