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  1. Article ; Online: Treatment of glomerular diseases: pioneering clinical trials.

    Radhakrishnan, Jai

    Kidney international

    2020  Volume 97, Issue 3, Page(s) 433–436

    MeSH term(s) Glomerulonephritis ; Glomerulonephritis, Membranous ; Glomerulosclerosis, Focal Segmental ; Humans ; Kidney Diseases/therapy
    Language English
    Publishing date 2020-04-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Anticomplement therapies in "secondary thrombotic microangiopathies": ready for prime time?

    Radhakrishnan, Jai

    Kidney international

    2019  Volume 96, Issue 4, Page(s) 833–835

    MeSH term(s) Complement Inactivating Agents ; Complement Inactivator Proteins ; Hemolytic-Uremic Syndrome ; Humans ; Thrombotic Microangiopathies
    Chemical Substances Complement Inactivating Agents ; Complement Inactivator Proteins ; anticomplement
    Language English
    Publishing date 2019-08-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.08.005
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  3. Article ; Online: The Role of Anti-B Cell Activating Factor Therapy for Treating Lupus Nephritis.

    Wooden, Benjamin / Radhakrishnan, Jai

    Clinical journal of the American Society of Nephrology : CJASN

    2022  Volume 17, Issue 11, Page(s) 1583–1585

    MeSH term(s) Humans ; Lupus Nephritis/drug therapy ; Lupus Erythematosus, Systemic ; Immunosuppressive Agents/therapeutic use ; Treatment Outcome
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.11340922
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    Zs.A 6584: Show issues Location:
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  4. Article ; Online: Infection-Related Glomerulonephritis in Children and Adults.

    Iyengar, Arpana / Kamath, Nivedita / Radhakrishnan, Jai / Estebanez, Blanca Tarragon

    Seminars in nephrology

    2024  Volume 43, Issue 5, Page(s) 151469

    Abstract: Infection-related glomerulonephritis is an immunologically mediated glomerular injury after an infection. Glomerulonephritis may occur with the infection or after a variable latent period. Poststreptococcal glomerulonephritis (PSGN) is the prototype of ... ...

    Abstract Infection-related glomerulonephritis is an immunologically mediated glomerular injury after an infection. Glomerulonephritis may occur with the infection or after a variable latent period. Poststreptococcal glomerulonephritis (PSGN) is the prototype of infection-related glomerulonephritis. The streptococcal antigens, nephritis-associated plasmin-like receptor and streptococcal exotoxin B, have emerged as major players in the pathogenesis of PSGN. Although PSGN is the most common infection-related glomerulonephritis in children, in adults, glomerulonephritis is secondary to bacteria such as staphylococci, viruses such as hepatitis C, and human immunodeficiency virus, and, rarely, parasitic infections. Supportive therapy is the mainstay of treatment in most infection-related glomerulonephritis. Treatment of the underlying infection with specific antibiotics and antiviral medications is indicated in some infections. Parasitic infections, although rare, may be associated with significant morbidity. Poststreptococcal glomerulonephritis is a self-limiting condition with a good prognosis. However, bacterial, viral, and parasitic infections may be associated with significant morbidity and long-term consequences. Epidemiologic studies are required to assess the global burden of infection-related glomerulonephritis. A better understanding of the pathogenesis of infection-related glomerulonephritis may unravel more treatment options and preventive strategies.
    MeSH term(s) Child ; Adult ; Humans ; Streptococcal Infections/complications ; Streptococcal Infections/pathology ; Glomerulonephritis/complications ; Kidney Glomerulus ; Nephritis ; Parasitic Diseases/complications
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2023.151469
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  5. Article: The Launch of

    Radhakrishnan, Jai

    Kidney international reports

    2016  Volume 1, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2016-05-05
    Publishing country United States
    Document type Editorial
    ISSN 2468-0249
    ISSN 2468-0249
    DOI 10.1016/j.ekir.2016.04.004
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  6. Article ; Online: Age-related changes in nephrosclerosis in a multiethnic living kidney donor cohort.

    Emmons, Brendan R / Batal, Ibrahim / Radhakrishnan, Jai / Husain, S Ali

    Kidney international

    2023  Volume 104, Issue 2, Page(s) 394–397

    MeSH term(s) Humans ; Nephrosclerosis/etiology ; Kidney Transplantation/adverse effects ; Kidney ; Hypertension ; Living Donors
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.04.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Challenges in IgA Nephropathy Management: An Era of Complement Inhibition.

    Tesař, Vladimir / Radhakrishnan, Jai / Charu, Vivek / Barratt, Jonathan

    Kidney international reports

    2023  Volume 8, Issue 9, Page(s) 1730–1740

    Abstract: IgA nephropathy (IgAN) is the most common glomerular disease worldwide, with an estimated annual incidence of 25 per million adults. Despite optimized supportive care, some patients fail to achieve disease control and suffer progressive deterioration of ... ...

    Abstract IgA nephropathy (IgAN) is the most common glomerular disease worldwide, with an estimated annual incidence of 25 per million adults. Despite optimized supportive care, some patients fail to achieve disease control and suffer progressive deterioration of kidney function. In this subpopulation of patients, the Kidney Disease: Improving Global Outcomes 2021 guidelines recommend consideration of corticosteroids; however, their use is associated with significant side effects. Ongoing clinical trials are expected to identify corticosteroid-sparing therapies to help improve treatment and prognosis for patients with IgAN. It has been well-documented that the complement system plays a significant role in IgAN pathogenesis, and several complement inhibitors are now entering late-stage clinical development. This review evaluates what we know about the role of complement in the pathophysiology of IgAN and considers how the availability of targeted complement inhibitors may impact future clinical practice. Key knowledge gaps are evaluated, and research opportunities are recommended to help guide clinical decision-making and optimize patient outcomes. Such gaps include evaluating the relative contribution of the alternative and lectin pathways to disease pathogenesis, and the importance of determining the dominant pathway driving IgAN progression. Continued research into the staining of complement proteins in kidney biopsies and identifying targeted biomarkers to assess disease progression and treatment responses will also be needed to support the implementation of newer therapies in clinical practice. Considering the future horizons for enhancing the care of patients with IgAN, tackling the outstanding challenges now will help prepare for the best possible future outcomes.
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.06.010
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  8. Article ; Online: ANCA Vasculitis Treatment in the Dialysis Patient: Caution Needed!

    Hendren, Elizabeth / Radhakrishnan, Jai

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 11, Page(s) 1617–1619

    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Antibodies, Antineutrophil Cytoplasmic ; Humans ; Renal Dialysis/adverse effects
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.11960921
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    Zs.A 6584: Show issues Location:
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  9. Article ; Online: Kidney Replacement Therapy for Patients Requiring Cardiopulmonary Bypass Support during Cardiac Surgery.

    Stevens, Jacob S / Radhakrishnan, Jai

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 12, Page(s) 1898–1900

    MeSH term(s) Humans ; Cardiopulmonary Bypass/adverse effects ; Cardiac Surgical Procedures/adverse effects ; Renal Replacement Therapy ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Postoperative Complications/etiology
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.07150521
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  10. Article ; Online: Six Years of

    McLean, Radha / Mohan, Sumit / Radhakrishnan, Jai

    Kidney international reports

    2021  Volume 7, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.11.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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