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  1. Article: Identification of Prominent Genes between 3D Glioblastoma Models and Clinical Samples via GEO/TCGA/CGGA Data Analysis.

    Phon, Brandon Wee Siang / Bhuvanendran, Saatheeyavaane / Ayub, Qasim / Radhakrishnan, Ammu Kutty / Kamarudin, Muhamad Noor Alfarizal

    Biology

    2023  Volume 12, Issue 5

    Abstract: A paradigm shift in preclinical evaluations of new anticancer GBM drugs should occur in favour of 3D cultures. This study leveraged the vast genomic data banks to investigate the suitability of 3D cultures as cell-based models for GBM. We hypothesised ... ...

    Abstract A paradigm shift in preclinical evaluations of new anticancer GBM drugs should occur in favour of 3D cultures. This study leveraged the vast genomic data banks to investigate the suitability of 3D cultures as cell-based models for GBM. We hypothesised that correlating genes that are highly upregulated in 3D GBM models will have an impact in GBM patients, which will support 3D cultures as more reliable preclinical models for GBM. Using clinical samples of brain tissue from healthy individuals and GBM patients from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Chinese Glioma Genome Atlas (CGGA), and Genotype-Tissue Expression (GTEx) databases, several genes related to pathways such as epithelial-to-mesenchymal transition (EMT)-related genes (
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12050648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Male lineages in the Himalayan foothills: a commentary on Y-chromosome haplogroup diversity in the sub-Himalayan Terai and Duars populations of East India.

    Ayub, Qasim

    Journal of human genetics

    2011  Volume 56, Issue 12, Page(s) 813–814

    MeSH term(s) Chromosomes, Human, Y ; Genetic Variation ; Haplotypes ; Humans
    Language English
    Publishing date 2011-12
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1425192-9
    ISSN 1435-232X ; 1434-5161
    ISSN (online) 1435-232X
    ISSN 1434-5161
    DOI 10.1038/jhg.2011.114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 201: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-Resistant

    Al-Trad, Esra'a I / Che Hamzah, Ainal Mardziah / Puah, Suat Moi / Chua, Kek Heng / Hanifah, Muhamad Zarul / Ayub, Qasim / Palittapongarnpim, Prasit / Kwong, Stephen M / Chew, Ching Hoong / Yeo, Chew Chieng

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Methicillin- ... ...

    Abstract Methicillin-resistant
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular characterization and comparative genomic analysis of

    Muzahid, Nazmul Hasan / Hussain, Md Hamed / Huët, Marie Andrea Laetitia / Dwiyanto, Jacky / Su, Tin Tin / Reidpath, Daniel / Mustapha, Faizah / Ayub, Qasim / Tan, Hock Siew / Rahman, Sadequr

    Microbial genomics

    2023  Volume 9, Issue 4

    Abstract: Acinetobacter ... ...

    Abstract Acinetobacter baumannii
    MeSH term(s) Humans ; Acinetobacter baumannii/genetics ; Malaysia ; Phylogeny ; Prospective Studies ; Hospitals ; Genomics
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of Prominent Genes between 3D Glioblastoma Models and Clinical Samples via GEO/TCGA/CGGA Data Analysis

    Phon, Brandon Wee Siang / Bhuvanendran, Saatheeyavaane / Ayub, Qasim / Radhakrishnan, Ammu Kutty / Kamarudin, Muhamad Noor Alfarizal

    Biology (Basel). 2023 Apr. 25, v. 12, no. 5

    2023  

    Abstract: A paradigm shift in preclinical evaluations of new anticancer GBM drugs should occur in favour of 3D cultures. This study leveraged the vast genomic data banks to investigate the suitability of 3D cultures as cell-based models for GBM. We hypothesised ... ...

    Abstract A paradigm shift in preclinical evaluations of new anticancer GBM drugs should occur in favour of 3D cultures. This study leveraged the vast genomic data banks to investigate the suitability of 3D cultures as cell-based models for GBM. We hypothesised that correlating genes that are highly upregulated in 3D GBM models will have an impact in GBM patients, which will support 3D cultures as more reliable preclinical models for GBM. Using clinical samples of brain tissue from healthy individuals and GBM patients from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Chinese Glioma Genome Atlas (CGGA), and Genotype-Tissue Expression (GTEx) databases, several genes related to pathways such as epithelial-to-mesenchymal transition (EMT)-related genes (CD44, TWIST1, SNAI1, CDH2, FN1, VIM), angiogenesis/migration-related genes (MMP1, MMP2, MMP9, VEGFA), hypoxia-related genes (HIF1A, PLAT), stemness-related genes (SOX2, PROM1, NES, FOS), and genes involved in the Wnt signalling pathway (DKK1, FZD7) were found to be upregulated in brain samples from GBM patients, and the expression of these genes were also enhanced in 3D GBM cells. Additionally, EMT-related genes were upregulated in GBM archetypes (wild-type IDH1ᴿ¹³²) that historically have poorer treatment responses, with said genes being significant predictors of poorer survival in the TCGA cohort. These findings reinforced the hypothesis that 3D GBM cultures can be used as reliable models to study increased epithelial-to-mesenchymal transitions in clinical GBM samples.
    Keywords brain ; gene expression ; genome ; genomics ; glioblastoma
    Language English
    Dates of publication 2023-0425
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12050648
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Determining Soil Microbial Communities and Their Influence on

    Goh, Yit Kheng / Zoqratt, Muhammad Zarul Hanifah Md / Goh, You Keng / Ayub, Qasim / Ting, Adeline Su Yien

    Biology

    2020  Volume 9, Issue 12

    Abstract: Basal stem rot (BSR), caused ... ...

    Abstract Basal stem rot (BSR), caused by
    Language English
    Publishing date 2020-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology9120424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Geographical separation and ethnic origin influence the human gut microbial composition: a meta-analysis from a Malaysian perspective.

    Dwiyanto, Jacky / Ayub, Qasim / Lee, Sui Mae / Foo, Su Chern / Chong, Chun Wie / Rahman, Sadequr

    Microbial genomics

    2021  Volume 7, Issue 8

    Abstract: Ethnicity is consistently reported as a strong determinant of human gut microbiota. However, the bulk of these studies are from Western countries, where microbiota variations are mainly driven by relatively recent migration events. Malaysia is a ... ...

    Abstract Ethnicity is consistently reported as a strong determinant of human gut microbiota. However, the bulk of these studies are from Western countries, where microbiota variations are mainly driven by relatively recent migration events. Malaysia is a multicultural society, but differences in gut microbiota persist across ethnicities. We hypothesized that migrant ethnic groups continue to share fundamental gut traits with the population in the country of origin due to shared cultural practices despite subsequent geographical separation. To test this hypothesis, the 16S rRNA gene amplicons from 16 studies comprising three major ethnic groups in Malaysia were analysed, covering 636 Chinese, 248 Indian and 123 Malay individuals from four countries (China, India, Indonesia and Malaysia). A confounder-adjusted permutational multivariate analysis of variance (PERMANOVA) detected a significant association between ethnicity and the gut microbiota (PERMANOVA
    MeSH term(s) China ; Ethnicity ; Gastrointestinal Microbiome/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; India ; Indonesia ; Malaysia ; RNA, Ribosomal, 16S
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Oral, Gut Microbiota and Cardiometabolic Health of Indigenous Orang Asli Communities.

    Yeo, Li-Fang / Lee, Soo Ching / Palanisamy, Uma Devi / Khalid, Bak / Ayub, Qasim / Lim, Shu Yong / Lim, Yvonne Al / Phipps, Maude Elvira

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 812345

    Abstract: The Orang Asli (OA) of Malaysia have been relatively understudied where little is known about their oral and gut microbiomes. As human health is closely intertwined with the human microbiome, this study first assessed the cardiometabolic health in four ... ...

    Abstract The Orang Asli (OA) of Malaysia have been relatively understudied where little is known about their oral and gut microbiomes. As human health is closely intertwined with the human microbiome, this study first assessed the cardiometabolic health in four OA communities ranging from urban, rural to semi-nomadic hunter-gatherers. The urban Temuan suffered from poorer cardiometabolic health while rural OA communities were undergoing epidemiological transition. The oral microbiota of the OA were characterised by sequencing the V4 region of the 16S rRNA gene. The OA oral microbiota were unexpectedly homogenous, with comparably low alpha diversity across all four communities. The rural Jehai and Temiar PP oral microbiota were enriched for uncharacterised bacteria, exhibiting potential for discoveries. This finding also highlights the importance of including under-represented populations in large cohort studies. The Temuan oral microbiota were also elevated in opportunistic pathogens such as
    MeSH term(s) Bacteria/genetics ; Cardiovascular Diseases ; Gastrointestinal Microbiome/genetics ; Humans ; Microbiota ; RNA, Ribosomal, 16S/genetics
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-04-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.812345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Biomonitoring of heavy metals in the feathers of House crow (Corvus splendens) from some metropolitans of Asia and Africa.

    Iqbal, Farheena / Wilson, Robyn / Ayub, Qasim / Song, Beng Kah / Krzeminska-Ahmedzai, Urszula / Talei, Amin / Hermawan, Andreas Aditya / Rahman, Sadequr

    Environmental science and pollution research international

    2022  Volume 30, Issue 13, Page(s) 35715–35726

    Abstract: Urban-dwelling birds can be useful biomonitors to assess the impact of the urbanisation on both public and wildlife health. Widely distributed urban bird species, the House crow, was studied for heavy metal accumulation levels from nine cities of South ... ...

    Abstract Urban-dwelling birds can be useful biomonitors to assess the impact of the urbanisation on both public and wildlife health. Widely distributed urban bird species, the House crow, was studied for heavy metal accumulation levels from nine cities of South Asia, Southeast Asia and Africa that border the Indian Ocean. Feathers were spectroscopically investigated for the deposition of ten heavy metals, i.e. As, Zn, Pb, Cd, Ni, iron Fe, Mn, Cr, Cu and Li. Fe and Zn were found to be the most prevalent metals in all sites. Measured concentrations of Pb (4.38-14.77 mg kg
    MeSH term(s) Animals ; Crows ; Biological Monitoring ; Cadmium/analysis ; Environmental Pollutants/analysis ; Feathers/chemistry ; Lead/analysis ; Environmental Monitoring ; Metals, Heavy/analysis ; Asia ; Birds ; Africa
    Chemical Substances Cadmium (00BH33GNGH) ; Environmental Pollutants ; Lead (2P299V784P) ; Metals, Heavy
    Language English
    Publishing date 2022-12-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-24712-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  10. Article ; Online: Dataset of knowledge, attitude, practices and psychological implications of healthcare workers in Pakistan during COVID-19 pandemic.

    Qasim, Muhammad / Awan, Usman Ayub / Afzal, Muhammad Sohail / Saqib, Muhammad Arif Nadeem / Siddiqui, Shajee / Ahmed, Haroon

    Data in brief

    2020  Volume 32, Page(s) 106234

    Abstract: The COVID-19 pandemic has created a global health emergency and has a huge impact on the health care workers, especially on their mental health. The dataset presented was an assessment of COVID-19 related knowledge, attitude, practices and its effects on ...

    Abstract The COVID-19 pandemic has created a global health emergency and has a huge impact on the health care workers, especially on their mental health. The dataset presented was an assessment of COVID-19 related knowledge, attitude, practices and its effects on the mental health of frontline healthcare workers in Pakistan. The data were collected using a snowball sampling technique. A questionnaire was developed assessing sociodemographic characteristics (6 items), knowledge (11 items), attitude (5 items), practices (6 items), information sources (1 item) and psychological implications (12 items) and distributed using online tools. The dataset includes 476 healthcare workers in Pakistan. The dataset will help to prevent and curb the spread of COVID-19 among health workers and contribute to policymakers. Furthermore, our dataset provides detailed insights into different risk factors of psychological problems, and it may be served as the reference for various in-depth surveys.
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2020.106234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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