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  1. Article ; Online: SARS-CoV-2 antibody titers at the time of hospital admission and risk for mortality.

    Ljunggren, Hans-Gustaf

    Journal of internal medicine

    2023  Volume 293, Issue 6, Page(s) 664–665

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Hospitalization ; Hospitals
    Language English
    Publishing date 2023-02-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13608
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  2. Article ; Online: Paths taken towards NK cell-mediated immunotherapy of human cancer-a personal reflection.

    Ljunggren, Hans-Gustaf

    Scandinavian journal of immunology

    2020  Volume 93, Issue 1, Page(s) e12993

    Abstract: The discovery that NK cells are able to specifically recognize cells lacking the expression of self-MHC class I molecules provided the first insight into NK cell recognition of tumour cells. It started a flourishing field of NK cell research aimed at ... ...

    Abstract The discovery that NK cells are able to specifically recognize cells lacking the expression of self-MHC class I molecules provided the first insight into NK cell recognition of tumour cells. It started a flourishing field of NK cell research aimed at exploring the molecular nature of NK cell receptors involved in tumour cell recognition. While much of the important early work was conducted in murine experimental model systems, studies of human NK cells rapidly followed. Over the years, human NK cell research has swiftly progressed, aided by new detailed molecular information on human NK cell development, differentiation, molecular specificity, tissue heterogeneity and functional capacity. NK cells have also been studied in many different diseases aside from cancer, including viral diseases, autoimmunity, allergy and primary immunodeficiencies. These fields of research have all, indirectly or directly, provided further insights into NK cell-mediated recognition of target cells and paved the way for the development of NK cell-based immunotherapies for human cancer. Excitingly, NK cell-based immunotherapy now opens up for novel strategies aimed towards treating malignant diseases, either alone or in combination with other drugs. Reviewed here are some personal reflections of select contributions leading up to the current state-of-the-art in the field, with a particular emphasis on contributions from our own laboratory. This review is part of a series of articles on immunology in Scandinavia, published in conjunction with the 50th anniversary of the Scandinavian Society for Immunology.
    MeSH term(s) Animals ; Antigens, Neoplasm/immunology ; Cell Differentiation/immunology ; Disease Models, Animal ; Disease Susceptibility/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Host-Pathogen Interactions ; Humans ; Immunotherapy/adverse effects ; Immunotherapy/methods ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Lymphocyte Activation/genetics ; Lymphocyte Activation/immunology ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Organ Specificity/immunology ; Receptors, Antigen, T-Cell/metabolism ; Treatment Outcome
    Chemical Substances Antigens, Neoplasm ; Histocompatibility Antigens Class I ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2020-11-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.12993
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  3. Article ; Online: Activated Natural Killer Cells Hit Neurogenesis in the Aging Brain.

    Cuapio, Angelica / Ljunggren, Hans-Gustaf

    Neuroscience bulletin

    2021  Volume 37, Issue 7, Page(s) 1072–1074

    MeSH term(s) Brain ; Killer Cells, Natural ; Neurogenesis
    Language English
    Publishing date 2021-03-29
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-021-00654-3
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  4. Article ; Online: Viral escape from NK-cell-mediated immunosurveillance: A lesson for cancer immunotherapy?

    Momayyezi, Pouria / Bilev, Eleni / Ljunggren, Hans-Gustaf / Hammer, Quirin

    European journal of immunology

    2023  Volume 53, Issue 11, Page(s) e2350465

    Abstract: Natural killer (NK) cells are innate lymphocytes that participate in immune responses against virus-infected cells and tumors. As a countermeasure, viruses and tumors employ strategies to evade NK-cell-mediated immunosurveillance. In this review, we ... ...

    Abstract Natural killer (NK) cells are innate lymphocytes that participate in immune responses against virus-infected cells and tumors. As a countermeasure, viruses and tumors employ strategies to evade NK-cell-mediated immunosurveillance. In this review, we examine immune evasion strategies employed by viruses, focusing on examples from human CMV and severe acute respiratory syndrome coronavirus 2. We explore selected viral evasion mechanisms categorized into three classes: (1) providing ligands for the inhibitory receptor NKG2A, (2) downregulating ligands for the activating receptor NKG2D, and (3) inducing the immunosuppressive cytokine transforming growth factor (TGF)-β. For each class, we draw parallels between immune evasion by viruses and tumors, reviewing potential opportunities for overcoming evasion in cancer therapy. We suggest that in-depth investigations of host-pathogen interactions between viruses and NK cells will not only deepen our understanding of viral immune evasion but also shed light on how NK cells counter such evasion attempts. Thus, due to the parallels of immune evasion by viruses and tumors, we propose that insights gained from antiviral NK-cell responses may serve as valuable lessons that can be leveraged for designing future cancer immunotherapies.
    MeSH term(s) Humans ; Monitoring, Immunologic ; Killer Cells, Natural ; Immune Evasion ; Neoplasms/therapy ; Neoplasms/metabolism ; Immunotherapy
    Language English
    Publishing date 2023-08-12
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202350465
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  5. Article ; Online: NK cells in COVID-19-from disease to vaccination.

    Hammer, Quirin / Cuapio, Angelica / Bister, Jonna / Björkström, Niklas K / Ljunggren, Hans-Gustaf

    Journal of leukocyte biology

    2023  Volume 114, Issue 5, Page(s) 507–512

    Abstract: Natural killer cells participate in the host innate immune response to viral infection. Conversely, natural killer cell dysfunction and hyperactivation can contribute to tissue damage and immunopathology. Here, we review recent studies with respect to ... ...

    Abstract Natural killer cells participate in the host innate immune response to viral infection. Conversely, natural killer cell dysfunction and hyperactivation can contribute to tissue damage and immunopathology. Here, we review recent studies with respect to natural killer cell activity during infection with SARS-CoV-2. Discussed are initial reports of patients hospitalized with COVID-19, which revealed prompt natural killer cell activation during the acute disease state. Another hallmark of COVID-19, early on observed, was a decrease in numbers of natural killer cells in the circulation. Data from patients with acute SARS-CoV-2 infection as well as from in vitro models demonstrated strong anti-SARS-CoV-2 activity by natural killer cells, likely through direct cytotoxicity as well as indirectly by secreting cytokines. Additionally, we describe the molecular mechanisms underlying natural killer cell recognition of SARS-CoV-2-infected cells, which involve triggering of multiple activating receptors, including NKG2D, as well as loss of inhibition through NKG2A. Discussed is also the ability of natural killer cells to respond to SARS-CoV-2 infection via antibody-dependent cellular cytotoxicity. With respect to natural killer cells in the pathogenesis of COVID-19, we review studies demonstrating how hyperactivation and misdirected NK cell responses could contribute to disease course. Finally, while knowledge is still rather limited, we discuss current insights suggesting a contribution of an early natural killer cell activation response in the generation of immunity against SARS-CoV-2 following vaccination with anti-SARS-CoV-2 mRNA vaccines.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Killer Cells, Natural ; Cytokines ; Vaccination
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad031
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  6. Article ; Online: Natural killer cells in antiviral immunity.

    Björkström, Niklas K / Strunz, Benedikt / Ljunggren, Hans-Gustaf

    Nature reviews. Immunology

    2021  Volume 22, Issue 2, Page(s) 112–123

    Abstract: Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies. We first discuss NK cells in the ... ...

    Abstract Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies. We first discuss NK cells in the context of acute viral infections, with flavivirus and influenza virus infections as examples. Questions related to activation of NK cells, homing to infected tissues and the role of tissue-resident NK cells in acute viral infections are also addressed. Next, we discuss NK cells in the context of chronic viral infections with hepatitis C virus and HIV-1. Also covered is the role of adaptive-like NK cell expansions as well as the appearance of CD56
    MeSH term(s) COVID-19/immunology ; Humans ; Immunity, Innate ; Killer Cells, Natural/immunology ; SARS-CoV-2 ; Virus Diseases/immunology
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-021-00558-3
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  7. Article ; Online: Covid-19, SSI 50 years and Nobel: Three immunological reasons to remember 2020.

    Höglund, Petter / Ljunggren, Hans-Gustaf / Jonsson, Roland

    Scandinavian journal of immunology

    2020  Volume 92, Issue 6, Page(s) e12997

    Language English
    Publishing date 2020-11-26
    Publishing country England
    Document type Editorial
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.12997
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  8. Article ; Online: Academia and big pharma United.

    Ljunggren, Hans-Gustaf

    Science translational medicine

    2014  Volume 6, Issue 217, Page(s) 217ed1

    MeSH term(s) Academic Medical Centers/organization & administration ; Drug Industry/organization & administration ; Sweden
    Language English
    Publishing date 2014-01-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.3007459
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  9. Book ; Thesis: Immunological defence against MHC class I deficient cells

    Ljunggren, Hans-Gustaf

    1990  

    Author's details Hans-Gustaf Ljunggren
    Size Getr. Zählung : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Stockholm, Karolinska Inst., Diss., 1990
    HBZ-ID HT003967729
    ISBN 91-7900-979-4 ; 978-91-7900-979-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    92 E 45 order for loan Magazin

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  10. Article ; Online: Dendritic cells, dendritic cell-based vaccines and Ralph Steinman.

    Ljunggren, Hans-Gustaf

    Journal of internal medicine

    2012  Volume 271, Issue 2, Page(s) 174–176

    MeSH term(s) Allergy and Immunology/history ; Dendritic Cells/immunology ; History, 20th Century ; History, 21st Century ; New York ; Nobel Prize ; Vaccines/history ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2012-02
    Publishing country England
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/j.1365-2796.2011.02495.x
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