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Article: The Limits of Power: Wind Energy, Orkney, and the Post-war British State.

Dudley, Marianna

2019

Abstract: This article identifies the environmental components of the limits of industrial nationalization between 1945 and 1956, and with it the spatial dimensions of state power, through a case study of wind power experiments on the Orkney islands. Technocratic ... ...

Abstract	This article identifies the environmental components of the limits of industrial nationalization between 1945 and 1956, and with it the spatial dimensions of state power, through a case study of wind power experiments on the Orkney islands. Technocratic and socialist principles drove efforts to supply electricity to all corners of the nation, but material and environmental factors limited success, especially in remote regions. The article considers the materiality of islandness and its effects on the application of national-scale energy policy and emergence of 'alternative' energy solutions, in light of James C. Scott's theory of high modernism as an ideology which emanated from centres of power to rural peripheries. It argues that an environmental lens produces new thinking on the spatial constructions of state in post-war Britain that recognizes the influence of geographical edges as materially and imaginatively capable of disrupting a narrative of one-way power emanating from the centre. Wind joins other natural forces able to exert agency in narratives of technological development and modernism, which augment our understanding of energy, nature, and nation.
Language	English
Publishing date	2019-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2077480-1
ISSN	1477-4674 ; 0955-2359
ISSN (online)	1477-4674
ISSN	0955-2359
DOI	10.1093/tcbh/hwz024
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Book ; Online: An environmental history of the UK Defence Estate, 1945 to the present

Dudley, Marianna

2012

Abstract: This book explores the environmental history of the British military through a comparative framework of five key sites in England and Wales. The military presence at these places, it is claimed, has protected them from more damaging land uses such as ... ...

Institution	Great Britain / Defence Estate Organisation (Works) ebrary, Inc
Author's details	Marianna Dudley
Abstract	This book explores the environmental history of the British military through a comparative framework of five key sites in England and Wales. The military presence at these places, it is claimed, has protected them from more damaging land uses such as intensive agriculture, urban sprawl and industrial development. The book examines such claims and explores how and why the military has embraced nature conservation policies. The greening of the MOD and khaki conservation are critically examined in an historical context. The emergence of the training landscapes as protected spaces is contrasted wi
Keywords	Armed Forces/Environmental aspects ; Great Britain
Language	English
Size	Online-Ressource (252 p), ill
Publisher	Continuum
Publishing place	London
Document type	Book ; Online
Note	Includes bibliographical references and index
ISBN	1280577533 ; 128057755X ; 9781280577550 ; 9781441192424 ; 9781280577536 ; 1441192425
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Enhanced Thermal Conductivity of Free-Standing Double-Walled Carbon Nanotube Networks.

Mehew, Jake Dudley / Timmermans, Marina Y / Saleta Reig, David / Sergeant, Stefanie / Sledzinska, Marianna / Chávez-Ángel, Emigdio / Gallagher, Emily / Sotomayor Torres, Clivia M / Huyghebaert, Cedric / Tielrooij, Klaas-Jan

ACS applied materials & interfaces

2023

Abstract: Nanomaterials are driving advances in technology due to their oftentimes superior properties over bulk materials. In particular, their thermal properties become increasingly important as efficient heat dissipation is required to realize high-performance ... ...

Abstract	Nanomaterials are driving advances in technology due to their oftentimes superior properties over bulk materials. In particular, their thermal properties become increasingly important as efficient heat dissipation is required to realize high-performance electronic devices, reduce energy consumption, and prevent thermal damage. One application where nanomaterials can play a crucial role is extreme ultraviolet (EUV) lithography, where pellicles that protect the photomask from particle contamination have to be transparent to EUV light, mechanically strong, and thermally conductive in order to withstand the heat associated with high-power EUV radiation. Free-standing carbon nanotube (CNT) films have emerged as candidates due to their high EUV transparency and ability to withstand heat. However, the thermal transport properties of these films are not well understood beyond bulk emissivity measurements. Here, we measure the thermal conductivity of free-standing CNT films using all-optical Raman thermometry at temperatures between 300 and 700 K. We find thermal conductivities up to 50 W m
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c09210
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Article ; Online: A Novel Approach to Safer Glucocorticoid Receptor-Targeted Anti-lymphoma Therapy via REDD1 (Regulated in Development and DNA Damage 1) Inhibition.

Lesovaya, Ekaterina A / Savinkova, Alena V / Morozova, Olga V / Lylova, Evgeniya S / Zhidkova, Ekaterina M / Kulikov, Evgeny P / Kirsanov, Kirill I / Klopot, Anna / Baida, Gleb / Yakubovskaya, Marianna G / Gordon, Leo I / Readhead, Ben / Dudley, Joel T / Budunova, Irina

Molecular cancer therapeutics

2020 Volume 19, Issue 9, Page(s) 1898–1908

Abstract: Glucocorticoids are widely used for therapy of hematologic malignancies. Unfortunately, chronic treatment with glucocorticoids commonly leads to adverse effects including skin and muscle atrophy and osteoporosis. We found recently that REDD1 (regulated ... ...

Abstract	Glucocorticoids are widely used for therapy of hematologic malignancies. Unfortunately, chronic treatment with glucocorticoids commonly leads to adverse effects including skin and muscle atrophy and osteoporosis. We found recently that REDD1 (regulated in development and DNA damage 1) plays central role in steroid atrophy. Here, we tested whether REDD1 suppression makes glucocorticoid-based therapy of blood cancer safer. Unexpectedly, approximately 50% of top putative REDD1 inhibitors selected by bioinformatics screening of Library of Integrated Network-Based Cellular Signatures database (LINCS) were PI3K/Akt/mTOR inhibitors. We selected Wortmannin, LY294002, and AZD8055 for our studies and showed that they blocked basal and glucocorticoid-induced REDD1 expression. Moreover, all PI3K/mTOR/Akt inhibitors modified glucocorticoid receptor function shifting it toward therapeutically important transrepression. PI3K/Akt/mTOR inhibitors enhanced anti-lymphoma effects of Dexamethasone
MeSH term(s)	Animals ; Cell Line, Tumor ; Female ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Humans ; Lymphoma/drug therapy ; Mice ; Receptors, Glucocorticoid/metabolism ; Transcription Factors/antagonists & inhibitors
Chemical Substances	DDIT4 protein, human ; Glucocorticoids ; Receptors, Glucocorticoid ; Transcription Factors
Language	English
Publishing date	2020-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2063563-1
ISSN	1538-8514 ; 1535-7163
ISSN (online)	1538-8514
ISSN	1535-7163
DOI	10.1158/1535-7163.MCT-19-1111
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Article ; Online: Society for Cardiovascular Magnetic Resonance (SCMR) guidelines for reporting cardiovascular magnetic resonance examinations.

Hundley, W Gregory / Bluemke, David A / Bogaert, Jan / Flamm, Scott D / Fontana, Marianna / Friedrich, Matthias G / Grosse-Wortmann, Lars / Karamitsos, Theodoros D / Kramer, Christopher M / Kwong, Raymond Y / McConnell, Michael / Nagel, Eike / Neubauer, Stefan / Nijveldt, Robin / Pennell, Dudley J / Petersen, Steffen E / Raman, Subha V / van Rossum, Albert

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2022 Volume 24, Issue 1, Page(s) 29

MeSH term(s)	Cardiovascular System ; Heart ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Predictive Value of Tests
Language	English
Publishing date	2022-04-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/s12968-021-00827-z
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Article ; Online: Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy.

Lesovaya, Ekaterina / Agarwal, Shivani / Readhead, Ben / Vinokour, Elena / Baida, Gleb / Bhalla, Pankaj / Kirsanov, Kirill / Yakubovskaya, Marianna / Platanias, Leonidas C / Dudley, Joel T / Budunova, Irina

The Journal of investigative dermatology

2018 Volume 138, Issue 9, Page(s) 1935–1944

Abstract: Glucocorticoids have excellent therapeutic properties; however, they cause significant adverse atrophogenic effects. The mTORC1 inhibitor REDD1 has been recently identified as a key mediator of glucocorticoid-induced atrophy. We performed computational ... ...

Abstract	Glucocorticoids have excellent therapeutic properties; however, they cause significant adverse atrophogenic effects. The mTORC1 inhibitor REDD1 has been recently identified as a key mediator of glucocorticoid-induced atrophy. We performed computational screening of a connectivity map database to identify putative REDD1 inhibitors. The top selected candidates included rapamycin, which was unexpected because it inhibits pro-proliferative mTOR signaling. Indeed, rapamycin inhibited REDD1 induction by glucocorticoids dexamethasone, clobetasol propionate, and fluocinolone acetonide in keratinocytes, lymphoid cells, and mouse skin. We also showed blunting of glucocorticoid-induced REDD1 induction by either catalytic inhibitor of mTORC1/2 (OSI-027) or genetic inhibition of mTORC1, highlighting role of mTOR in glucocorticoid receptor signaling. Moreover, rapamycin inhibited glucocorticoid receptor phosphorylation, nuclear translocation, and loading on glucocorticoid-responsive elements in REDD1 promoter. Using microarrays, we quantified a global effect of rapamycin on gene expression regulation by fluocinolone acetonide in human keratinocytes. Rapamycin inhibited activation of glucocorticoid receptor target genes yet enhanced the repression of pro-proliferative and proinflammatory genes. Remarkably, rapamycin protected skin against glucocorticoid-induced atrophy but had no effect on the glucocorticoid anti-inflammatory activity in different in vivo models, suggesting the clinical potential of combining rapamycin with glucocorticoids for the treatment of inflammatory diseases.
MeSH term(s)	Animals ; Atrophy/chemically induced ; Atrophy/pathology ; Atrophy/prevention & control ; Disease Models, Animal ; Female ; Immunosuppressive Agents/pharmacology ; Keratinocytes/metabolism ; Mice ; Mice, Inbred C57BL ; Receptors, Glucocorticoid/drug effects ; Receptors, Glucocorticoid/metabolism ; Sirolimus/pharmacology ; Skin/drug effects ; Skin/pathology ; Steroids/toxicity ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism
Chemical Substances	Ddit4 protein, mouse ; Immunosuppressive Agents ; Receptors, Glucocorticoid ; Steroids ; Transcription Factors ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2018-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2018.02.045
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Article ; Online: Diffusion Tensor Cardiovascular Magnetic Resonance in Cardiac Amyloidosis.

Khalique, Zohya / Ferreira, Pedro F / Scott, Andrew D / Nielles-Vallespin, Sonia / Martinez-Naharro, Ana / Fontana, Marianna / Hawkins, Phillip / Firmin, David N / Pennell, Dudley J

Circulation. Cardiovascular imaging

2020 Volume 13, Issue 5, Page(s) e009901

Abstract: Background Cardiac amyloidosis (CA) is a disease of interstitial myocardial infiltration, usually by light chains or transthyretin. We used diffusion tensor cardiovascular magnetic resonance (DT-CMR) to noninvasively assess the effects of amyloid ... ...

Abstract	Background Cardiac amyloidosis (CA) is a disease of interstitial myocardial infiltration, usually by light chains or transthyretin. We used diffusion tensor cardiovascular magnetic resonance (DT-CMR) to noninvasively assess the effects of amyloid infiltration on the cardiac microstructure. Methods DT-CMR was performed at diastole and systole in 20 CA, 11 hypertrophic cardiomyopathy, and 10 control subjects with calculation of mean diffusivity, fractional anisotropy, and sheetlet orientation (secondary eigenvector angle). Results Mean diffusivity was elevated and fractional anisotropy reduced in CA compared with both controls and hypertrophic cardiomyopathy (
MeSH term(s)	Aged ; Amyloid Neuropathies, Familial/diagnostic imaging ; Amyloid Neuropathies, Familial/pathology ; Amyloid Neuropathies, Familial/physiopathology ; Cardiomyopathies/diagnostic imaging ; Cardiomyopathies/pathology ; Cardiomyopathies/physiopathology ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Cardiomyopathy, Hypertrophic/pathology ; Cardiomyopathy, Hypertrophic/physiopathology ; Case-Control Studies ; Diagnosis, Differential ; Diffusion Tensor Imaging ; Female ; Humans ; Immunoglobulin Light-chain Amyloidosis/diagnostic imaging ; Immunoglobulin Light-chain Amyloidosis/pathology ; Immunoglobulin Light-chain Amyloidosis/physiopathology ; Male ; Middle Aged ; Myocardium/pathology ; Predictive Value of Tests
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2435045-X
ISSN	1942-0080 ; 1941-9651
ISSN (online)	1942-0080
ISSN	1941-9651
DOI	10.1161/CIRCIMAGING.119.009901
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Article ; Online: Metagenomic characterization of the maternal prenatal gastrointestinal microbiome by pregravid BMI.

Dreisbach, Caitlin / Alhusen, Jeanne / Prescott, Stephanie / Dudley, Donald / Trinchieri, Giorgio / Siega-Riz, Anna Maria

Obesity (Silver Spring, Md.)

2022 Volume 31, Issue 2, Page(s) 412–422

Abstract: Objective: The incidence of women entering into pregnancy with BMI indicating overweight or obesity is rising with concurrent increases in adverse complications such as gestational diabetes. Although several studies have examined the compositional ... ...

Abstract	Objective: The incidence of women entering into pregnancy with BMI indicating overweight or obesity is rising with concurrent increases in adverse complications such as gestational diabetes. Although several studies have examined the compositional changes to the microbiome across BMI classifications, there has been no investigation regarding changes in microbial function during pregnancy. Methods: A total of 105 gastrointestinal microbiome biospecimens were used in this analysis. Biospecimens were sequenced by using the Illumina NovaSeq 6000 shotgun metagenomics platform. Results: Findings indicate an enrichment in microbiota from the phylum Firmicutes across all pregravid BMI groups with a decrease in α diversity in groups with BMI indicating obesity or overweight compared with a group with BMI indicating normal weight (p = 0.02). More specifically, women with BMI indicating obesity or overweight had enrichment in Bifidobacterium bifidum and B. adolescentis. Women with BMI > 25 kg/m Conclusions: Our analysis suggests that there are differences in microbial composition and function between BMI groups. Future research should consider how these changes contribute to specific clinical outcomes during pregnancy.
MeSH term(s)	Pregnancy ; Humans ; Female ; Overweight/complications ; Body Mass Index ; Gastrointestinal Microbiome ; Obesity/epidemiology ; Diabetes, Gestational
Language	English
Publishing date	2022-12-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23659
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Healthcare Providers' Perceived Communication Barriers to Offering Palliative Care to Patients With Heart Failure: An Integrative Review.

Schallmo, Marianne K / Dudley-Brown, Sharon / Davidson, Patricia M

The Journal of cardiovascular nursing

2018 Volume 34, Issue 2, Page(s) E9–E18

Abstract: Context: Heart failure is a chronic complex syndrome that is common and burdensome. International clinical practice guidelines recommend that healthcare providers communicate palliative care options with patients with heart failure.: Objectives: The ... ...

Abstract	Context: Heart failure is a chronic complex syndrome that is common and burdensome. International clinical practice guidelines recommend that healthcare providers communicate palliative care options with patients with heart failure. Objectives: The aim of this study was to conduct an integrative review to evaluate how healthcare providers perceived communication barriers to offering information to individuals in the palliative phase of heart failure. Methods: Four databases and the gray literature were searched from January 1987 to February 2017. Inclusion and exclusion criteria were applied. Studies were graded for strength and quality using a critical appraisal tool, and key themes were extracted and synthesized. Results: Ten articles met the full inclusion criteria. Most studies were qualitative or nonexperimental studies of good quality. Authors of several studies found that healthcare providers lacked basic knowledge about palliative care or did not possess sufficient knowledge to effectively provide care. Poor knowledge of palliative care created a barrier between the provider and the patient. Inadequate education or inexperience in palliative care led to the resistance of health providers to implementing a palliative approach. Conclusions: The results of this review emphasize a lack of knowledge as a barrier to delivering palliative care. Healthcare providers caring for individuals with heart failure need palliative care knowledge, skills, and competencies to ensure that this vulnerable population receives holistic patient-centered care.
MeSH term(s)	Attitude of Health Personnel ; Communication Barriers ; Heart Failure/therapy ; Humans ; Palliative Care
Language	English
Publishing date	2018-12-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639335-4
ISSN	1550-5049 ; 0889-4655
ISSN (online)	1550-5049
ISSN	0889-4655
DOI	10.1097/JCN.0000000000000556
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Article ; Online: REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids.

Baida, Gleb / Bhalla, Pankaj / Kirsanov, Kirill / Lesovaya, Ekaterina / Yakubovskaya, Marianna / Yuen, Kit / Guo, Shuchi / Lavker, Robert M / Readhead, Ben / Dudley, Joel T / Budunova, Irina

EMBO molecular medicine

2015 Volume 7, Issue 1, Page(s) 42–58

Abstract: Cutaneous atrophy is the major adverse effect of topical glucocorticoids; however, its molecular mechanisms are poorly understood. Here, we identify stress-inducible mTOR inhibitor REDD1 (regulated in development and DNA damage response 1) as a major ... ...

Abstract	Cutaneous atrophy is the major adverse effect of topical glucocorticoids; however, its molecular mechanisms are poorly understood. Here, we identify stress-inducible mTOR inhibitor REDD1 (regulated in development and DNA damage response 1) as a major molecular target of glucocorticoids, which mediates cutaneous atrophy. In REDD1 knockout (KO) mice, all skin compartments (epidermis, dermis, subcutaneous fat), epidermal stem, and progenitor cells were protected from atrophic effects of glucocorticoids. Moreover, REDD1 knockdown resulted in similar consequences in organotypic raft cultures of primary human keratinocytes. Expression profiling revealed that gene activation by glucocorticoids was strongly altered in REDD1 KO epidermis. In contrast, the down-regulation of genes involved in anti-inflammatory glucocorticoid response was strikingly similar in wild-type and REDD1 KO mice. Integrative bioinformatics analysis of our and published gene array data revealed similar changes of gene expression in epidermis and in muscle undergoing glucocorticoid-dependent and glucocorticoid-independent atrophy. Importantly, the lack of REDD1 did not diminish the anti-inflammatory effects of glucocorticoids in preclinical model. Our findings suggest that combining steroids with REDD1 inhibitors may yield a novel, safer glucocorticoid-based therapies.
MeSH term(s)	Adult ; Aged ; Animals ; Atrophy/etiology ; Atrophy/genetics ; Atrophy/metabolism ; Atrophy/pathology ; Female ; Glucocorticoids/adverse effects ; Glucocorticoids/metabolism ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mice, Knockout ; Middle Aged ; Skin Diseases/drug therapy ; Skin Diseases/genetics ; Skin Diseases/metabolism ; Skin Diseases/pathology ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	DDIT4 protein, human ; Ddit4 protein, mouse ; Glucocorticoids ; Transcription Factors
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2467145-9
ISSN	1757-4684 ; 1757-4676
ISSN (online)	1757-4684
ISSN	1757-4676
DOI	10.15252/emmm.201404601
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