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  1. Book: Update on rupatadine in the management of allergic disorders

    Mullol, Joaquim

    (Allergy : Supplement ; 100)

    2015  

    Author's details [J. Mullol ...]
    Series title Allergy : Supplement ; 100
    Allergy
    Allergy ; Supplement
    Collection Allergy
    Allergy ; Supplement
    Language English
    Size 24 S. : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018538576
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Uh III Zs 150 -Suppl.100- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Chronic Rhinosinusitis: Forward!

    Rank, Matthew / Mullol, Joaquim

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 6, Page(s) 1472–1473

    MeSH term(s) Chronic Disease ; Humans ; Rhinitis/epidemiology ; Sinusitis/diagnosis
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Decade of Clinical Advances in Chronic Rhinosinusitis: 2012-2022.

    Naclerio, Robert / Mullol, Joaquim / Stevens, Whitney W

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 1, Page(s) 43–50

    Abstract: The field of chronic rhinosinusitis (CRS) is constantly evolving. In the past 10 years, key advancements in basic and translational research as well as clinical studies have improved our understanding and management of CRS. Notably, treatment options ... ...

    Abstract The field of chronic rhinosinusitis (CRS) is constantly evolving. In the past 10 years, key advancements in basic and translational research as well as clinical studies have improved our understanding and management of CRS. Notably, treatment options have expanded to include novel therapeutic drugs, devices, and surgical techniques. Assessments of patient symptoms and their impact on quality of life have become more standardized. Progress has also been made in both determining the true prevalence of CRS and recognizing comorbidities that can impact CRS severity. Practice guidelines have also shifted from expert opinion to more data-driven analyses. This review highlights major clinical advancements made in the field of CRS over the past 10 years as well as identifies current gaps in knowledge that can form the basis for new areas of study over the next decade.
    MeSH term(s) Humans ; Rhinitis/epidemiology ; Rhinitis/therapy ; Rhinitis/diagnosis ; Quality of Life ; Nasal Polyps/epidemiology ; Sinusitis/diagnosis ; Sinusitis/epidemiology ; Sinusitis/therapy ; Comorbidity ; Chronic Disease
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.10.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Type 2 and Non-type 2 Inflammation in the Upper Airways: Cellular and Molecular Alterations in Olfactory Neuroepithelium Cell Populations.

    Marin, Concepció / Alobid, Isam / López-Chacón, Mauricio / VanStrahlen, Camilo R / Mullol, Joaquim

    Current allergy and asthma reports

    2024  Volume 24, Issue 4, Page(s) 211–219

    Abstract: Purpose of review: Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfactory function, but is impaired during chronic type 2 and non-type 2 inflammation of the upper airways. In this ... ...

    Abstract Purpose of review: Neurogenesis occurring in the olfactory epithelium is critical to continuously replace olfactory neurons to maintain olfactory function, but is impaired during chronic type 2 and non-type 2 inflammation of the upper airways. In this review, we describe the neurobiology of olfaction and the olfactory alterations in chronic rhinosinusitis with nasal polyps (type 2 inflammation) and post-viral acute rhinosinusitis (non-type 2 inflammation), highlighting the role of immune response attenuating olfactory neurogenesis as a possibly mechanism for the loss of smell in these diseases.
    Recent findings: Several studies have provided relevant insights into the role of basal stem cells as direct participants in the progression of chronic inflammation identifying a functional switch away from a neuro-regenerative phenotype to one contributing to immune defense, a process that induces a deficient replacement of olfactory neurons. The interaction between olfactory stem cells and immune system might critically underlie ongoing loss of smell in type 2 and non-type 2 inflammatory upper airway diseases. In this review, we describe the neurobiology of olfaction and the olfactory alterations in type 2 and non-type 2 inflammatory upper airway diseases, highlighting the role of immune response attenuating olfactory neurogenesis, as a possibly mechanism for the lack of loss of smell recovery.
    MeSH term(s) Humans ; Smell/physiology ; Anosmia/metabolism ; Inflammation/metabolism ; Olfactory Mucosa/metabolism ; Sinusitis ; Olfaction Disorders ; Chronic Disease ; Rhinitis
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-024-01137-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5548: Show issues Location:
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  5. Article ; Online: Pheno-Endotyping Antrochoanal Nasal Polyposis.

    Garaycochea, Octavio / Van Strahlen, Camilo Rodríguez / Alobid, Isam / Mullol, Joaquim

    Current allergy and asthma reports

    2023  Volume 23, Issue 3, Page(s) 165–180

    Abstract: Purpose of review: Antrochoanal polyps (ACPs) are benign polypoid lesions arising from the inner wall of the maxillary sinus and extending into the choana. Although the diagnosis and treatment strategies of ACP have changed since this entity was first ... ...

    Abstract Purpose of review: Antrochoanal polyps (ACPs) are benign polypoid lesions arising from the inner wall of the maxillary sinus and extending into the choana. Although the diagnosis and treatment strategies of ACP have changed since this entity was first described, the underlying pathogenic mechanism of APC is poorly understood. This article reviews the current knowledge of the etiology, inflammatory parameters, and microscopic findings of ACP.
    Recent findings: The inflammatory pattern of ACP appears to center around a neutrophilic inflammation T1-dominant endotype. Apart from the inflammatory component of ACP, at the microscopic level, the presence of tissue remodeling, mostly fibrin deposition and edema, and cysts in the epithelium and lamina propria has been described. Although the origin of this T1-dominant endotype immune response of ACPs is not entirely clear, it could be related to a lymphatic obstruction mechanism. This review serves to define a phenotype of ACP with potential endotypes based on the characteristics of the inflammatory parameters, microscopic findings, and hypotheses about the pathogenesis of ACP.
    MeSH term(s) Humans ; Nasal Polyps/etiology ; Inflammation/pathology ; Maxillary Sinus/pathology
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-023-01066-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Current evaluation and management of patients with chronic rhinosinusitis and nasal polyps.

    Ceballos Cantu, Juan Carlos / Alobid, Isam / Mullol, Joaquim

    Expert review of clinical immunology

    2022  Volume 18, Issue 12, Page(s) 1253–1263

    Abstract: Introduction: A clear understanding of the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) and its close association with other airway pathologies, especially asthma, helps to comprehend the concept of the united airway and the ... ...

    Abstract Introduction: A clear understanding of the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP) and its close association with other airway pathologies, especially asthma, helps to comprehend the concept of the united airway and the importance of a multidisciplinary approach and the actual roll of biologic therapy.
    Areas covered: This expert review is the synthesis of a working group on the current state of the art of the evaluation and management of CRSwNP. A thorough analysis of the literature has been conducted for the latest studies and results, specially the European (EPOS 2020) and American (ICAR-RS 2021) guidelines.
    Expert opinion: The roles of optimal medical treatment and indications for surgery are becoming clearer, but much research is still needed regarding the extent and radicality when surgery is indicated. The main objectives of this review were to provide a clear and updated description of treatments, their indication, follow-up, and response criteria. These steps are considering the broad spectrum of inflammation endophenotypes and the biologic therapy available. Understanding the role and limitations of each specialty is key for providing greatest benefit to the patient.
    MeSH term(s) Humans ; Nasal Polyps/therapy ; Rhinitis/therapy ; Sinusitis/therapy ; Chronic Disease ; Asthma/complications
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2022.2128767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6661: Show issues Location:
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  7. Article ; Online: Mechanisms by which dupilumab normalizes eicosanoid metabolism and restores aspirin-tolerance in AERD: A hypothesis.

    Picado, César / Mullol, Joaquim / Roca-Ferrer, Jordi

    The Journal of allergy and clinical immunology

    2022  Volume 151, Issue 2, Page(s) 310–313

    Abstract: Aspirin-exacerbated respiratory disease (AERD) is associated with overproduction of proinflammatory cysteinyl leukotrienes (CysLTs), defective generation of anti-inflammatory prostaglandin ... ...

    Abstract Aspirin-exacerbated respiratory disease (AERD) is associated with overproduction of proinflammatory cysteinyl leukotrienes (CysLTs), defective generation of anti-inflammatory prostaglandin E
    MeSH term(s) Humans ; Aspirin/pharmacology ; Aspirin/therapeutic use ; Cyclooxygenase 2 ; Interleukin-4 ; Asthma, Aspirin-Induced/drug therapy ; Asthma, Aspirin-Induced/metabolism ; Leukotrienes ; Dinoprostone/metabolism ; Asthma/drug therapy ; Prostaglandin-E Synthases/genetics ; Receptors, Prostaglandin E, EP2 Subtype/metabolism ; Receptors, Interleukin-1
    Chemical Substances Aspirin (R16CO5Y76E) ; dupilumab (420K487FSG) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Interleukin-4 (207137-56-2) ; cysteinyl-leukotriene ; Leukotrienes ; Dinoprostone (K7Q1JQR04M) ; Prostaglandin-E Synthases (EC 5.3.99.3) ; Receptors, Prostaglandin E, EP2 Subtype ; Receptors, Interleukin-1
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.92: Show issues Location:
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  8. Article ; Online: Chronic Rhinosinusitis and COVID-19.

    Marin, Concepció / Hummel, Thomas / Liu, Zheng / Mullol, Joaquim

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 6, Page(s) 1423–1432

    Abstract: The COVID-19 pandemic has raised awareness about olfactory dysfunction, although a loss of smell was present in the general population before COVID-19. Chronic rhinosinusitis (CRS) is a common upper airway chronic inflammatory disease that is also one of ...

    Abstract The COVID-19 pandemic has raised awareness about olfactory dysfunction, although a loss of smell was present in the general population before COVID-19. Chronic rhinosinusitis (CRS) is a common upper airway chronic inflammatory disease that is also one of the most common causes of olfactory dysfunction. It can be classified into different phenotypes (ie, with and without nasal polyps) and endotypes (ie, type 2 and non-type 2 inflammation). However, scientific information regarding CRS within the context of COVID-19 is still scarce. This review focuses on (1) the potential effects of severe acute respiratory syndrome coronavirus 2 infection on CRS symptoms, including a loss of smell, and comorbidities; (2) the pathophysiologic mechanisms involved in the olfactory dysfunction; (3) CRS diagnosis in the context of COVID-19, including telemedicine; (4) the protective hypothesis of CRS in COVID-19; and (5) the efficacy and safety of therapeutic options for CRS within the context of COVID-19.
    MeSH term(s) Anosmia ; COVID-19 ; Chronic Disease ; Humans ; Nasal Polyps/complications ; Nasal Polyps/epidemiology ; Nasal Polyps/therapy ; Olfaction Disorders/epidemiology ; Pandemics ; Rhinitis/epidemiology ; Rhinitis/etiology ; Rhinitis/therapy ; Sinusitis/epidemiology ; Sinusitis/etiology ; Sinusitis/therapy
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7086: Show issues Location:
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  9. Article ; Online: Omalizumab improves sleep and health status for patients with chronic rhinosinusitis with nasal polyps: An analysis of randomized clinical trials.

    Meltzer, Eli O / Mullol, Joaquim / Ko, Jinnie / Saenz, Rebecca / Steinke, John W / Millette, Lauren A / Gevaert, Philippe

    International forum of allergy & rhinology

    2024  

    Abstract: Background: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have high incidence of sleep impairment. We evaluated the impact of omalizumab treatment on sleep characteristics and associated health status in patients with CRSwNP.: ... ...

    Abstract Background: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have high incidence of sleep impairment. We evaluated the impact of omalizumab treatment on sleep characteristics and associated health status in patients with CRSwNP.
    Methods: Prespecified exploratory analysis assessed outcomes from patients included in the POLYP 1 and POLYP 2 phase 3 clinical trials and the open-label extension. Sleep was assessed by the sleep domain of the Sino-Nasal Outcome Test-22 (SNOT-22; MCID > 4 in patients with CRS) and the Medical Outcomes Study Sleep Scale (MOS-Sleep). Health status was assessed by Healthy Days Core Module (HDCM) and sinonasal-specific Patient Global Impression of Change (PGIC).
    Results: Omalizumab improved sleep as assessed by the SNOT-22 sleep domain. At week 24, adjusted mean (95%CI) SNOT-22 sleep scores had reduced from baseline by -8.5 (-9.9 to -7.1) with omalizumab versus -2.7 (-4.1 to -1.3) with placebo. At week 52 (all patents on OMA), adjusted mean (95%CI) SNOT-22 sleep scores had reduced from baseline by -10.1 (-11.4 to -8.7) with omalizumab. Improvements were observed in all eight items of the SNOT-22 sleep domain: difficulty falling asleep, fatigue, frustration/restlessness/irritability, lack good night's sleep, reduced concentration, reduced productivity, wake up tired, and wake up at night. In addition, omalizumab improved six of eight sleep outcomes on the MOS-Sleep scale. There were concurrent improvements in HDCM and PGIC.
    Conclusion: Omalizumab improved sleep and self-reported health status in patients with CRSwNP. This contributes to evidence that omalizumab provides value for patients beyond the reduction of sinonasal symptoms.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6927: Show issues Location:
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  10. Article ; Online: Prevalence of atopic dermatitis in the adolescent population of Catalonia (Spain).

    Mora, Toni / Sánchez-Collado, Irene / Mullol, Joaquim / Muñoz-Cano, Rosa / Ribó, Paula / Valero, Antonio

    Allergologia et immunopathologia

    2023  Volume 51, Issue 4, Page(s) 101–109

    Abstract: Background: Studies on the prevalence of atopic dermatitis (AD) for the adolescent cohort in general-based large populations are scarce worldwide. We performed a retrospective population--based observational cohort study of 76,665 adolescent patients ... ...

    Abstract Background: Studies on the prevalence of atopic dermatitis (AD) for the adolescent cohort in general-based large populations are scarce worldwide. We performed a retrospective population--based observational cohort study of 76,665 adolescent patients diagnosed with AD in Catalonia (Spain). We studied the prevalence of AD by age, gender, disease severity, comorbidities, serum total immunoglobulin E (tIgE) and appropriate medical treatment (AMT) for the Catalan population.
    Methods: Adolescent individuals (12-17 years) diagnosed with AD by medical records at different health care levels (primary, hospital, emergency) from the Catalan Health System (CHS) were included. Statistical analyses evaluated sociodemographic characteristics, prevalence, comorbidities, serum tIgE and AMT.
    Results: The overall diagnosed AD prevalence in the adolescent Catalan population (76,665) was 16.9%, being higher for the non-severe (16.7%) than for the severe (0.2%) populations. Topical corticosteroids were the most prescribed drug (49.5%), and the use of all prescribed treatments was higher in severe AD patients, especially systemic corticosteroids (49.7%) and immunosuppressants (45.4%). AD patients had, on average, a serum tIgE of 163.6 KU/L, which was higher for severe than non-severe disease (155.5 KU/L vs 101.9 KU/L, respectively). Allergic rhinitis (15.0%) and asthma (13.5%) were among the most frequent comorbid respiratory and allergy diseases.
    Conclusions: This is the first Spanish study reporting the overall diagnosed prevalence for a large-scale adolescent cohort (12-17 years old) from Catalonia. It provides new and robust evidence of AD's prevalence and related characteristics in this region.
    MeSH term(s) Humans ; Adolescent ; Child ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/diagnosis ; Spain/epidemiology ; Retrospective Studies ; Prevalence ; Rhinitis, Allergic ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2023-07-01
    Publishing country Singapore
    Document type Observational Study ; Journal Article
    ZDB-ID 193144-1
    ISSN 1578-1267 ; 0301-0546
    ISSN (online) 1578-1267
    ISSN 0301-0546
    DOI 10.15586/aei.v51i4.893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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