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  1. Article ; Online: H-index and Hemolysis Associated with ECMO: Is This So Simple?

    Dufour, Nicolas

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2021  Volume 67, Issue 11, Page(s) e202–e203

    MeSH term(s) Extracorporeal Membrane Oxygenation/adverse effects ; Hematologic Tests ; Hemolysis ; Humans
    Language English
    Publishing date 2021-05-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: High-Throughput Bacteriophage Testing with Potency Determination: Validation of an Automated Pipetting and Phage Drop-Off Method.

    Dufour, Nicolas / Delattre, Raphaëlle / Debarbieux, Laurent

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: The development of bacteriophages (phages) as active pharmaceutical ingredients for the treatment of patients is on its way and regulatory agencies are calling for reliable methods to assess phage potency. As the number of phage banks is increasing, so ... ...

    Abstract The development of bacteriophages (phages) as active pharmaceutical ingredients for the treatment of patients is on its way and regulatory agencies are calling for reliable methods to assess phage potency. As the number of phage banks is increasing, so is the number of phages that need to be tested to identify therapeutic candidates. Currently, assessment of phage potency on a semi-solid medium to observe plaque-forming units is unavoidable and proves to be labor intensive when considering dozens of phage candidates. Here, we present a method based on automated pipetting and phage drop-off performed by a liquid-handling robot, allowing high-throughput testing and phage potency determination (based on phage titer and efficiency of plaquing). Ten phages were tested, individually and assembled into one cocktail, against 126
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pituitary tumor prognostication: WHO is really the best?

    Sahakian, Nicolas / Dufour, Henry / Brue, Thierry / Cuny, Thomas

    European journal of endocrinology

    2023  Volume 189, Issue 1, Page(s) R1–R3

    MeSH term(s) Humans ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/pathology ; Biomarkers, Tumor ; Ki-67 Antigen/metabolism ; World Health Organization ; Tumor Suppressor Protein p53 ; Prognosis
    Chemical Substances Biomarkers, Tumor ; Ki-67 Antigen ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-07-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1093/ejendo/lvad080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Vocal complexity in a socially complex corvid: gradation, diversity and lack of common call repertoire in male rooks.

    Martin, Killian / Cornero, Francesca M / Clayton, Nicola S / Adam, Olivier / Obin, Nicolas / Dufour, Valérie

    Royal Society open science

    2024  Volume 11, Issue 1, Page(s) 231713

    Abstract: Vocal communication is widespread in animals, with vocal repertoires of varying complexity. The social complexity hypothesis predicts that species may need high vocal complexity to deal with complex social organization (e.g. have a variety of different ... ...

    Abstract Vocal communication is widespread in animals, with vocal repertoires of varying complexity. The social complexity hypothesis predicts that species may need high vocal complexity to deal with complex social organization (e.g. have a variety of different interindividual relations). We quantified the vocal complexity of two geographically distant captive colonies of rooks, a corvid species with complex social organization and cognitive performances, but understudied vocal abilities. We quantified the diversity and gradation of their repertoire, as well as the inter-individual similarity at the vocal unit level. We found that males produced call units with lower diversity and gradation than females, while song units did not differ between sexes. Surprisingly, while females produced highly similar call repertoires, even between colonies, each individual male produced almost completely different call repertoires from any other individual. These findings question the way male rooks communicate with their social partners. We suggest that each male may actively seek to remain vocally distinct, which could be an asset in their frequently changing social environment. We conclude that inter-individual similarity, an understudied aspect of vocal repertoires, should also be considered as a measure of vocal complexity.
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.231713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Danger signals in traumatic hemorrhagic shock and new lines for clinical applications.

    Dufour-Gaume, Frédérique / Frescaline, Nadira / Cardona, Venetia / Prat, Nicolas J

    Frontiers in physiology

    2023  Volume 13, Page(s) 999011

    Abstract: Hemorrhage is the leading cause of death in severe trauma injuries. When organs or tissues are subjected to prolonged hypoxia, danger signals-known as damage-associated molecular patterns (DAMPs)-are released into the intercellular environment. The ... ...

    Abstract Hemorrhage is the leading cause of death in severe trauma injuries. When organs or tissues are subjected to prolonged hypoxia, danger signals-known as damage-associated molecular patterns (DAMPs)-are released into the intercellular environment. The endothelium is both the target and a major provider of damage-associated molecular patterns, which are directly involved in immuno-inflammatory dysregulation and the associated tissue suffering. Although damage-associated molecular patterns release begins very early after trauma, this release and its consequences continue beyond the initial treatment. Here we review a few examples of damage-associated molecular patterns to illustrate their pathophysiological roles, with emphasis on emerging therapeutic interventions in the context of severe trauma. Therapeutic intervention administered at precise points during damage-associated molecular patterns release may have beneficial effects by calming the inflammatory storm triggered by traumatic hemorrhagic shock.
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.999011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Plus de 30% des médecins en Suisse viennent de l'etranger.

    Dufour, Nicolas

    Revue medicale suisse

    2015  Volume 11, Issue 468, Page(s) 795

    Title translation More than 30% of doctors in Switzerland come from abroad.
    MeSH term(s) Female ; Foreign Medical Graduates/statistics & numerical data ; Humans ; Male ; Physicians/statistics & numerical data ; Switzerland
    Language French
    Publishing date 2015-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The multifaceted nature of HIV latency.

    Dufour, Caroline / Gantner, Pierre / Fromentin, Rémi / Chomont, Nicolas

    The Journal of clinical investigation

    2021  Volume 131, Issue 11

    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI151380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Vocal complexity in a socially complex corvid

    Killian Martin / Francesca M. Cornero / Nicola S. Clayton / Olivier Adam / Nicolas Obin / Valérie Dufour

    Royal Society Open Science, Vol 11, Iss

    gradation, diversity and lack of common call repertoire in male rooks

    2024  Volume 1

    Abstract: Vocal communication is widespread in animals, with vocal repertoires of varying complexity. The social complexity hypothesis predicts that species may need high vocal complexity to deal with complex social organization (e.g. have a variety of different ... ...

    Abstract Vocal communication is widespread in animals, with vocal repertoires of varying complexity. The social complexity hypothesis predicts that species may need high vocal complexity to deal with complex social organization (e.g. have a variety of different interindividual relations). We quantified the vocal complexity of two geographically distant captive colonies of rooks, a corvid species with complex social organization and cognitive performances, but understudied vocal abilities. We quantified the diversity and gradation of their repertoire, as well as the inter-individual similarity at the vocal unit level. We found that males produced call units with lower diversity and gradation than females, while song units did not differ between sexes. Surprisingly, while females produced highly similar call repertoires, even between colonies, each individual male produced almost completely different call repertoires from any other individual. These findings question the way male rooks communicate with their social partners. We suggest that each male may actively seek to remain vocally distinct, which could be an asset in their frequently changing social environment. We conclude that inter-individual similarity, an understudied aspect of vocal repertoires, should also be considered as a measure of vocal complexity.
    Keywords bioacoustics ; bird ; repertoire ; heterogeneity ; clustering ; Science ; Q
    Subject code 590
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher The Royal Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Text revision in Scientific Writing Assistance

    Jourdan, Léane / Boudin, Florian / Dufour, Richard / Hernandez, Nicolas

    An Overview

    2023  

    Abstract: Writing a scientific article is a challenging task as it is a highly codified genre. Good writing skills are essential to properly convey ideas and results of research work. Since the majority of scientific articles are currently written in English, this ...

    Abstract Writing a scientific article is a challenging task as it is a highly codified genre. Good writing skills are essential to properly convey ideas and results of research work. Since the majority of scientific articles are currently written in English, this exercise is all the more difficult for non-native English speakers as they additionally have to face language issues. This article aims to provide an overview of text revision in writing assistance in the scientific domain. We will examine the specificities of scientific writing, including the format and conventions commonly used in research articles. Additionally, this overview will explore the various types of writing assistance tools available for text revision. Despite the evolution of the technology behind these tools through the years, from rule-based approaches to deep neural-based ones, challenges still exist (tools' accessibility, limited consideration of the context, inexplicit use of discursive information, etc.)

    Comment: Published at 13th International Workshop on Bibliometric-enhanced Information Retrieval 12 pages
    Keywords Computer Science - Computation and Language
    Subject code 420
    Publishing date 2023-03-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Screening for Psychological Distress in Healthcare Workers Using Machine Learning: A Proof of Concept.

    Geoffrion, Steve / Morse, Catherine / Dufour, Marie-Michèle / Bergeron, Nicolas / Guay, Stéphane / Lanovaz, Marc J

    Journal of medical systems

    2023  Volume 47, Issue 1, Page(s) 120

    Abstract: The purpose of this study was to train and test preliminary models using two machine learning algorithms to identify healthcare workers at risk of developing anxiety, depression, and post-traumatic stress disorder. The study included data from a ... ...

    Abstract The purpose of this study was to train and test preliminary models using two machine learning algorithms to identify healthcare workers at risk of developing anxiety, depression, and post-traumatic stress disorder. The study included data from a prospective cohort study of 816 healthcare workers collected using a mobile application during the first two waves of COVID-19. Each week, the participants responded to 11 questions and completed three screening questionnaires (one for anxiety, one for depression, and one for post-traumatic stress disorder). Then, the research team selected two questions (out of the 11), which were used with biological sex to identify whether scores on each screening questionnaire would be positive or negative. The analyses involved a fivefold cross-validation to test the accuracy of models based on logistic regression and support vector machines using cross-sectional and cumulative measures. The findings indicated that the models derived from the two questions and biological sex accurately identified screening scores for anxiety, depression, and post-traumatic stress disorders in 70% to 80% of cases. However, the positive predictive value never exceeded 50%, underlining the importance of collecting more data to train better models. Our proof of concept demonstrates the feasibility of using machine learning to develop novel models to screen for psychological distress in at-risk healthcare workers. Developing models with fewer questions may reduce burdens of active monitoring in practical settings by decreasing the weekly assessment duration.
    MeSH term(s) Humans ; Prospective Studies ; Cross-Sectional Studies ; Anxiety/diagnosis ; Health Personnel ; Psychological Distress ; Depression/diagnosis
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-023-02011-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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