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Article: Comparison of Two Strategies for Hypercholesterolemia Detection through Point-of-Care Testing.

Arriaga-Cázares, Héctor Eliud / Vega-Morales, David / Moreno-Treviño, Carlos Alberto / Juarez-Juarez, Juana Lorena / Pérez-Arizmendi, Carlos Azael / Martagón-Rosado, Alexandro J

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 2

Abstract: Background: Childhood dyslipidemia is a common condition that can lead to atherosclerotic cardiovascular disease in adulthood. It is usually multifactorial. Screening for cholesterol disorders in children varies based on risk factors, with some ... ...

Abstract	Background: Childhood dyslipidemia is a common condition that can lead to atherosclerotic cardiovascular disease in adulthood. It is usually multifactorial. Screening for cholesterol disorders in children varies based on risk factors, with some guidelines recommending cascade screening for children with a clear family history of familial hypercholesterolemia, targeted screening for those with specific risk factors, and universal screening. Point-of-care testing (POCT) cholesterol tests offer potential advantages, including ease of use, portability, increased patient access, low cost, fewer medical or laboratory visits, and instant results. This study aimed to evaluate the effect of POCT cholesterol screening on the diagnosis of hypercholesterolemia in children in a family practice setting. Methods: We used a POCT cholesterol analyzer to perform two different (universal and targeted) screening approaches for dyslipidemia in children. We used the NCEP guidelines for the classification of the results. Results: We screened 183 children, 105 in the universal screening group and 78 in the targeted screening group. Eight patients in the targeted screening group had elevated cholesterol levels ( Conclusions: All participants received instant feedback and recommendations. Using a targeted screening approach, POCT could be a practical and effective tool for identifying at-risk children with hypercholesterolemia.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14020143
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Article ; Online: Structure, aggregation dynamics and crystallization of superfolder green fluorescent protein: Effect of long alkyl chain imidazolium ionic liquids.

Han, Qi / Darmanin, Connie / Rosado, Carlos J / Veríssimo, Nathalia Vieira / Pereira, Jorge F B / Bryant, Gary / Drummond, Calum J / Greaves, Tamar L

International journal of biological macromolecules

2023 Volume 253, Issue Pt 7, Page(s) 127456

Abstract: Green fluorescent protein (GFP) and its variants are widely used in medical and biological research, especially acting as indicators of protein structural integrity, protein-protein interactions and as biosensors. This study employs superfolder GFP ( ... ...

Abstract	Green fluorescent protein (GFP) and its variants are widely used in medical and biological research, especially acting as indicators of protein structural integrity, protein-protein interactions and as biosensors. This study employs superfolder GFP (sfGFP) to investigate the impact of varying alkyl chain length of 1-C
MeSH term(s)	Green Fluorescent Proteins/genetics ; Ionic Liquids/chemistry ; Crystallization ; Scattering, Small Angle ; X-Ray Diffraction
Chemical Substances	Green Fluorescent Proteins (147336-22-9) ; Ionic Liquids
Language	English
Publishing date	2023-10-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127456
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Article ; Online: Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms.

Le, John T / Ballester-Rosado, Carlos J / Frost, James D / Swann, John W

Epilepsia

2022 Volume 63, Issue 12, Page(s) 3078–3089

Abstract: Objective: Our goal was to determine whether animals with a history of epileptic spasms have learning and memory deficits. We also used continuous (24/7) long-term electroencephalographic (EEG) recordings to evaluate the evolution of epileptiform ... ...

Abstract	Objective: Our goal was to determine whether animals with a history of epileptic spasms have learning and memory deficits. We also used continuous (24/7) long-term electroencephalographic (EEG) recordings to evaluate the evolution of epileptiform activity in the same animals over time. Methods: Object recognition memory and object location memory tests were undertaken, as well as a matching to place water maze test that evaluated working memory. A retrospective analysis was undertaken of long-term video/EEG recordings from rats with epileptic spasms. The frequency and duration of the ictal events of spasms were quantified. Results: Rats with a history of epileptic spasms showed impairment on the three behavioral tests, and their scores on the object recognition memory and matching to place water maze tests indicated neocortical involvement in the observed impaired cognition. Analysis of EEG recordings unexpectedly showed that the ictal events of spasms and their accompanying behaviors progressively increased in duration over a 2-week period soon after onset, after which spasm duration plateaued. At the same time, spasm frequency remained unchanged. Soon after spasm onset, ictal events were variable in wave form but became more stereotyped as the syndrome evolved. Significance: Our EEG findings are the first to demonstrate progressive ictogenesis for epileptic spasms. Furthermore, in demonstrating cognitive deficits in the tetrodotoxin model, we have met a criterion for an animal model of West syndrome. Animal models will allow in-depth studies of spasm progression's potential role in cognitive regression and may elucidate why early treatment is considered essential for improved neurodevelopmental outcomes in children.
MeSH term(s)	Rats ; Animals ; Spasms, Infantile ; Retrospective Studies
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17428
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Zs.A 517: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Dicarbonyl-mediated AGEing and diabetic kidney disease.

Dimitropoulos, Alexandra / Rosado, Carlos J / Thomas, Merlin C

Journal of nephrology

2020 Volume 33, Issue 5, Page(s) 909–915

Abstract: Increased glycolytic flux into the diabetic kidney, combined with glycolytic inefficiencies introduced by oxidative stress, acts to increase the generation of triose-phosphate intermediates, which spontaneously degrade to form methylglyoxal. At the same ... ...

Abstract	Increased glycolytic flux into the diabetic kidney, combined with glycolytic inefficiencies introduced by oxidative stress, acts to increase the generation of triose-phosphate intermediates, which spontaneously degrade to form methylglyoxal. At the same time, the glyoxalase-catalysed pathway that degrades excess methylglyoxal is impaired. The resulting dicarbonyl stress increases the accumulation of Advanced Glycation End-products (AGEs), as highly reactive dicarbonyls modify proteins, DNA, phospholipids and even small molecules like glutathione and nitric oxide. The resulting molecular dysfunction, contributes to the development and progression of kidney disease in diabetes. The importance of the dicarbonyls in diabetic kidney disease is clearly demonstrated by the reno-protective benefits of structurally-disparate dicarbonyl scavengers in experimental studies. Equally, modulating the glyoxalase pathway is able to alter both dicarbonyl generation and renal dysfunction in the presence and absence of hyperglycaemia. However, beyond improving glycemia control and reducing oxidative stress, an effective way to attenuate dicarbonyl-mediated damage in patients with diabetic kidney disease remains an elusive goal.
MeSH term(s)	Aging ; Diabetes Mellitus ; Diabetic Nephropathies/etiology ; Glycation End Products, Advanced ; Humans ; Lactoylglutathione Lyase ; Pyruvaldehyde
Chemical Substances	Glycation End Products, Advanced ; Pyruvaldehyde (722KLD7415) ; Lactoylglutathione Lyase (EC 4.4.1.5)
Language	English
Publishing date	2020-03-13
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-020-00718-z
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Article: Correction: Sanchez-Collado et al. Orai2 Modulates Store-Operated Ca

Sanchez-Collado, Jose / Lopez, Jose J / Cantonero, Carlos / Jardin, Isaac / Regodón, Sergio / Redondo, Pedro C / Gordillo, Juan / Smani, Tarik / Salido, Gines M / Rosado, Juan A

Cancers

2023 Volume 15, Issue 4

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041290
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Article ; Online: Effect of ionic liquids on the fluorescence properties and aggregation of superfolder green fluorescence protein.

Han, Qi / Ryan, Timothy M / Rosado, Carlos J / Drummond, Calum J / Greaves, Tamar L

Journal of colloid and interface science

2021 Volume 591, Page(s) 96–105

Abstract: Proteins generally tend to aggregate with less desirable properties in numerous solvents, which is one of the major challenges in the development of solvents for functional proteins. This work aims to utilize fluorescence spectroscopy and small angle X- ... ...

Abstract	Proteins generally tend to aggregate with less desirable properties in numerous solvents, which is one of the major challenges in the development of solvents for functional proteins. This work aims to utilize fluorescence spectroscopy and small angle X-ray scattering (SAXS) to understand the effects of ionic liquids (ILs) on the fluorescence and aggregation behavior of superfolder green fluorescent protein (sfGFP). The studied ILs consisted of four different anions coupled with primary, tertiary and quaternary ammonium cations. The results show that the chromophore fluorescence was generally maintained in 1 mol% IL-water mixtures, then decreased with increasing IL concentration. We primarily employed the pseudo-radius of gyration (pseudo-R
MeSH term(s)	Anions ; Green Fluorescent Proteins ; Ionic Liquids ; Scattering, Small Angle ; X-Ray Diffraction
Chemical Substances	Anions ; Ionic Liquids ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2021.02.002
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Article: Circulating Soluble ACE2 Plays an Independent Role to Protect against Vascular Damage in Diabetic Mice.

Tikellis, Chris / Robinson, Gardner N / Rosado, Carlos J / Batu, Duygu / Zuniga-Gutierrez, Maria A / Pickering, Raelene J / Thomas, Merlin C

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 5

Abstract: Circulating levels of soluble ACE2 are increased by diabetes. Although this increase is associated with the presence and severity of cardiovascular disease, the specific role of soluble ACE2 in atherogenesis is unclear. Previous studies suggested that, ... ...

Abstract	Circulating levels of soluble ACE2 are increased by diabetes. Although this increase is associated with the presence and severity of cardiovascular disease, the specific role of soluble ACE2 in atherogenesis is unclear. Previous studies suggested that, like circulating ACE, soluble ACE2 plays a limited role in vascular homeostasis. To challenge this hypothesis, we aimed to selectively increase circulating ACE2 and measure its effects on angiotensin II dependent atherogenesis. Firstly, in
Language	English
Publishing date	2022-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11050987
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Article ; Online: Toxicity of Difenoconazole and Atrazine and Their Photodegradation Products on Aquatic Biota: Environmental Implications in Countries Lacking Good Agricultural Practices.

Mendieta Herrera, Julia / Iñiguez Armijos, Carlos / Rosado Alcarria, Daniel / Aguilar Ramírez, Silvio

Toxics

2023 Volume 11, Issue 3

Abstract: Agriculture is fundamental for human development, but it may also have a range of unwanted effects on ecosystems when pesticides inadvertently enter the environment. We determined the toxicity of difenoconazole and atrazine, as well as their ... ...

Abstract	Agriculture is fundamental for human development, but it may also have a range of unwanted effects on ecosystems when pesticides inadvertently enter the environment. We determined the toxicity of difenoconazole and atrazine, as well as their photodegradation products, on the bioindicators
Language	English
Publishing date	2023-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11030213
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Article ; Online: Small angle X-ray scattering investigation of ionic liquid effect on the aggregation behavior of globular proteins.

Han, Qi / El Mohamad, Mohamad / Brown, Stuart / Zhai, Jiali / Rosado, Carlos J / Shen, Yi / Blanch, Ewan W / Drummond, Calum J / Greaves, Tamar L

Journal of colloid and interface science

2023 Volume 648, Page(s) 376–388

Abstract: Globular proteins are well-folded model proteins, where ions can substantially influence their structure and aggregation. Ionic liquids (ILs) are salts in the liquid state with versatile ion combinations. Understanding the IL effect on protein behavior ... ...

Abstract	Globular proteins are well-folded model proteins, where ions can substantially influence their structure and aggregation. Ionic liquids (ILs) are salts in the liquid state with versatile ion combinations. Understanding the IL effect on protein behavior remains a major challenge. Here, we employed small angle X-ray scattering to investigate the effect of aqueous ILs on the structure and aggregation of globular proteins, namely, hen egg white lysozyme (Lys), human lysozyme (HLys), myoglobin (Mb), β-lactoglobulin (βLg), trypsin (Tryp) and superfolder green fluorescent protein (sfGFP). The ILs contain ammonium-based cations paired with the mesylate, acetate or nitrate anion. Results showed that only Lys was monomeric, whereas the other proteins formed small or large aggregates in buffer. Solutions with over 17 mol% IL resulted in significant changes in the protein structure and aggregation. The Lys structure was expanded at 1 mol% but compact at 17 mol% with structural changes in loop regions. HLys formed small aggregates, with the IL effect similar to Lys. Mb and βLg mostly had distinct monomer and dimer distributions depending on IL type and IL concentration. Complex aggregation was noted for Tryp and sfGFP. While the anion had the largest ion effect, changing the cation also induced the structural expansion and protein aggregation.
MeSH term(s)	Humans ; Muramidase/chemistry ; Ionic Liquids/chemistry ; X-Rays ; Anions ; Cations ; Green Fluorescent Proteins ; Scattering, Small Angle
Chemical Substances	Muramidase (EC 3.2.1.17) ; Ionic Liquids ; Anions ; Cations ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2023-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.05.130
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Article ; Online: Tick-associated diseases identified from hunting dogs during the COVID-19 pandemic in a Mayan community in Yucatan, Mexico.

Dzul-Rosado, Karla R / Arroyo-Solís, Karla A / Torres-Monroy, Adan J / Arias-León, Juan J / Peniche-Lara, Gaspar F / Puerto-Manzano, Fernando I / Landa-Flores, Magaly G / Del Mazo-López, Juan Carlos / Salceda-Sánchez, Beatriz

Open veterinary journal

2023 Volume 13, Issue 6, Page(s) 794–800

Abstract: Background: Hunting activity in the Mayan communities has increased due to COVID-19 and domestic dogs have gained more importance. Due to their proximity to humans, domestic dogs are a bridge between tick-borne diseases (TBDs) and humans and their peri- ... ...

Abstract	Background: Hunting activity in the Mayan communities has increased due to COVID-19 and domestic dogs have gained more importance. Due to their proximity to humans, domestic dogs are a bridge between tick-borne diseases (TBDs) and humans and their peri-domestic environment. In Mexico, and especially in rural regions, there were not adequate records of TBDs during the SARS-CoV-2 pandemic. Aim: Identify TBD of ticks collected during the COVID-19 pandemic in a rural community. Methods: Tick capture was carried out in March 2021, in Teabo, Yucatan. Ticks were removed using from domestic dogs and placed in ethanol. Collected ticks were morphologically identified and underwent DNA extraction and a partial segment of the mitochondrial 16S-rDNA gene was amplified to corroborate the tick species. The DNA was screened for the presence of Results: We collected 33 ectoparasites, Conclusion: We confirmed for the first time the presence of
MeSH term(s)	Animals ; Humans ; Dogs ; Working Dogs ; Mexico/epidemiology ; Pandemics ; COVID-19/epidemiology ; COVID-19/veterinary ; SARS-CoV-2 ; Tick-Borne Diseases/epidemiology ; Tick-Borne Diseases/veterinary ; Tick-Borne Diseases/microbiology ; Rickettsia/genetics ; Rhipicephalus sanguineus/microbiology ; Rhipicephalus sanguineus/parasitology ; Dog Diseases/microbiology
Language	English
Publishing date	2023-06-23
Publishing country	Libya
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2651664-0
ISSN	2218-6050 ; 2218-6050
ISSN (online)	2218-6050
ISSN	2218-6050
DOI	10.5455/OVJ.2023.v13.i6.14
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