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  1. Book ; Online: Selbststudium im digitalen Wandel

    Küstermann, Roland / Kunkel, Matthias / Mersch, André / Schreiber, Anne

    2021  

    Keywords Mathematics ; Education (General) ; Mathematik ; Selbststudium ; E-Learning ; ILIAS
    Subject Reine Mathematik ; Learning on demand ; Telelearning ; Teleteaching ; Electronic Learning ; Virtuelles Lernen ; Digitales Lernen
    Size 1 electronic resource (351 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT020676427
    ISBN 9783658312794 ; 3658312793
    DOI 10.1007/978-3-658-31279-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Selbststudium im digitalen Wandel

    Küstermann, Roland / Kunkel, Matthias / Mersch, André / Schreiber, Anne

    Digitales, begleitetes Selbststudium in der Mathematik – MINT meistern mit optes

    2021  

    Author's details herausgegeben von Roland Küstermann, Matthias Kunkel, André Mersch, Anne Schreiber
    Keywords Mathematics ; Education ; Mathematics—Study and teaching  ; Mathematik ; Selbststudium ; E-Learning ; ILIAS
    Subject Learning on demand ; Telelearning ; Teleteaching ; Electronic Learning ; Virtuelles Lernen ; Digitales Lernen ; Reine Mathematik
    Subject code 510
    Language German
    Size 1 Online-Ressource (XXVI, 351 S. 69 Abb., 59 Abb. in Farbe)
    Edition 1st ed. 2021
    Publisher Springer Fachmedien Wiesbaden ; Imprint: Springer Spektrum
    Publishing place Wiesbaden
    Document type Book ; Online
    HBZ-ID HT020567718
    ISBN 978-3-658-31279-4 ; 9783658312787 ; 3-658-31279-3 ; 3658312785
    DOI 10.1007/978-3-658-31279-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Die unsichtbaren Veteranen

    Kiesewetter, Roderich / Obermeier, Julia / Wüstner, André / Robbe, Reinhold / Bohnert, Marcel / Schreiber, Björn

    Kriegsheimkehrer in der deutschen Gesellschaft

    2016  

    Author's details Marcel Bohnert & Björn Schreiber (Hrsg.) ; mit Geleitworten von Roderich Kiesewetter, Julia Obermeier und André Wüstner ; sowie einem Epilog von Reinhold Robbe
    Keywords Afghanistan ; Bundeswehr ; Einsatz ; PTBS ; Soldaten ; Deutschland ; Militärischer Einsatz ; Heimkehr ; Veteran ; Posttraumatisches Stresssyndrom
    Subject Posttraumatisch-psychoreaktives Stresssyndrom ; Posttraumatic psychoreactive stress syndrome ; Posttraumatische Belastungsreaktion ; Posttraumatic stress disorder ; Posttraumatische Belastungsstörung ; PTSD ; PTB ; PTBS ; Trauma ; Kriegsveteran ; Militäreinsatz ; Einsatz
    Subject code 355.0094308697
    Language German
    Size 318 Seiten, Illustrationen, 22 cm
    Publisher Carola Hartmann Miles-Verlag
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT018936410
    ISBN 978-3-945861-27-1 ; 3-945861-27-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1596 available for loan (reading room) Lesesaal EG

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  4. Book ; Online: Theorie und Praxis der Unternehmerfamilie und des Familienunternehmens - Theory and Practice of Business Families and Family Businesses : Festschrift für Arist von Schlippe - Commemorative Publication for Arist von Schlippe (Edition 1)

    Rüsen, Tom A. / Hack, Andreas / Thomas, Adrian / Simon, Fritz B. / von Hertel, Anita / Astrachan Binz, Claudia / Brundin, Ethel / Spitzley, Dinah / Pieper, Torsten / Kriz, Jürgen / Rauschendorfer, Natalie / Mittelsten Scheid, Jörg / Frank, Hermann / Schreiber, Christoph / Wimmer, Rudolf / Groth, Torsten / Sharma, Pramodita / Scheffler, Marc André / Rau, Sabine /
    Steinhübel, Andreas / Zellweger, Thomas / Kirchdörfer, Rainer / Gimeno, Alberto / Plate, Markus / Prügl, Reinhard

    2021  

    Keywords Biography: general ; Biography & Autobiography ; Social Scientists & Psychologists
    Size 1 Online-Ressource
    Publisher Vandenhoeck and Ruprecht
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT021047144
    ISBN 9783666454196 ; 3666454194
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: Cold Atmospheric Plasma Is a Promising Alternative Treatment Option in Case of Split Skin Graft Failure.

    Khabipov, Aydar / Schreiber, Andre / Kersting, Stephan / Hummel, Richard / Höhn, Johannes / Partecke, Lars-Ivo / Bekeschus, Sander / Glitsch, Anne / Keßler, Wolfram

    Case reports in surgery

    2024  Volume 2024, Page(s) 1013445

    Abstract: Cold atmospheric plasma (CAP) has shown promising potential in promoting wound healing. This case report presents the successful application of CAP in a 42-year-old female patient with extensive wound healing disorders and superinfections following the ... ...

    Abstract Cold atmospheric plasma (CAP) has shown promising potential in promoting wound healing. This case report presents the successful application of CAP in a 42-year-old female patient with extensive wound healing disorders and superinfections following the excision of an abscess in the left thoracic region. After several failed split skin graft attempts, the implementation of CAP led to significant improvements in wound healing. This report highlights the wound healing-promoting effects of CAP and discusses its potential mechanisms of action.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2657697-1
    ISSN 2090-6919 ; 2090-6900
    ISSN (online) 2090-6919
    ISSN 2090-6900
    DOI 10.1155/2024/1013445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance.

    Schreiber, André / Rodner, Franziska / Oberberg, Nicole / Anhlan, Darisuren / Bletz, Stefan / Mellmann, Alexander / Planz, Oliver / Ludwig, Stephan

    Antiviral research

    2024  Volume 225, Page(s) 105840

    Abstract: Host targeting antiviral drugs (HTA) are directed against cellular mechanisms which can be exploited by viruses. These mechanisms are essential for viral replication, because missing functions cannot be compensated by the virus. However, this assumption ... ...

    Abstract Host targeting antiviral drugs (HTA) are directed against cellular mechanisms which can be exploited by viruses. These mechanisms are essential for viral replication, because missing functions cannot be compensated by the virus. However, this assumption needs experimental proof. Here we compared the HTA Zapnometinib (ZMN), with direct acting antivirals (DAA) (Remdesivir (RDV), Molnupiravir (MPV), Nirmatrelvir (NTV), Ritonavir (RTV), Paxlovid PAX)), in terms of their potency to induce reduced drug susceptibilities in SARS-CoV-2. During serial passage of δ-B1.617.2 adaptation to all DAAs occurred, while the inhibitory capacity of ZMN was not altered. Known single nucleotide polymorphisms (SNPs) responsible for partial resistances were found for RDV, NTV and PAX. Additionally, the high mutagenic potential of MPV was confirmed and decreased drug efficacies were found for the first time. Reduced DAA efficacy did not alter the inhibitory potential of ZMN. These results show that ZMN confers a high barrier towards the development of viral resistance and has the potential to act against partially DAA-insensitive viruses.
    MeSH term(s) Humans ; Antiviral Agents ; SARS-CoV-2 ; COVID-19 ; Hepatitis C, Chronic ; Ritonavir ; Cytidine/analogs & derivatives ; Hydroxylamines
    Chemical Substances Antiviral Agents ; Ritonavir (O3J8G9O825) ; molnupiravir (YA84KI1VEW) ; Cytidine (5CSZ8459RP) ; Hydroxylamines
    Language English
    Publishing date 2024-03-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2024.105840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus.

    Nacken, Wolfgang / Schreiber, André / Masemann, Dörthe / Ludwig, Stephan

    mBio

    2021  Volume 12, Issue 5, Page(s) e0219621

    Abstract: Host shutoff in influenza A virus (IAV) infection is a key process contributing to viral takeover of the cellular machinery and resulting in the downregulation of host gene expression. Analysis of nascently transcribed RNA in a cellular model that allows ...

    Abstract Host shutoff in influenza A virus (IAV) infection is a key process contributing to viral takeover of the cellular machinery and resulting in the downregulation of host gene expression. Analysis of nascently transcribed RNA in a cellular model that allows the functional induction of NS1 demonstrates that NS1 suppresses host transcription. NS1 inhibits the expression of genes driven by RNA polymerase II as well as RNA polymerase I-driven promoters, but not by the noneukaryotic T7 polymerase. Additionally, transcriptional termination is deregulated in cells infected with wild-type IAV. The NS1 effector domain alone is able to mediate both effects, whereas NS1 mutant GLEWN184-188RFKRY (184-188) is not. Overexpression of CPSF30 counteracts NS1-mediated inhibition of RNA polymerase II-driven reporter gene expression, but knockdown of CPSF30 expression does not attenuate gene expression. Although NS1 is associated with nuclear chromatin, superresolution microscopy demonstrates that NS1 does not colocalize with genomic DNA. Moreover, NS1 mutants and NS1 fusion proteins, unable to associate with nuclear chromatin and displaying an altered subcellular distribution are still able to attenuate reporter gene expression. However, tethering NS1 artificially to the cytoskeleton results in the loss of reporter gene inhibition. A NS1 deficient in both native nuclear localization signals (NLS) is able to inhibit gene expression as effective as wild-type NS1 when a synthetic NLS relocates it to specific structures of the nucleus. Colocalization experiments and reporter gene cotransfection experiments with a NS1 fusion guiding it to nuclear speckles suggest that the presence of NS1 in nuclear speckles seems to be essential for host shutoff.
    MeSH term(s) Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Cell Nucleus/virology ; Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage And Polyadenylation Specificity Factor/metabolism ; Host-Pathogen Interactions ; Humans ; Influenza A Virus, H7N7 Subtype/genetics ; Influenza A Virus, H7N7 Subtype/metabolism ; Influenza, Human/genetics ; Influenza, Human/metabolism ; Influenza, Human/virology ; Protein Domains ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Transcription, Genetic ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism
    Chemical Substances CPSF4 protein, human ; Cleavage And Polyadenylation Specificity Factor ; INS1 protein, influenza virus ; Viral Nonstructural Proteins ; RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2021-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02196-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: VR Facial Animation for Immersive Telepresence Avatars

    Rochow, Andre / Schwarz, Max / Schreiber, Michael / Behnke, Sven

    2023  

    Abstract: VR Facial Animation is necessary in applications requiring clear view of the face, even though a VR headset is worn. In our case, we aim to animate the face of an operator who is controlling our robotic avatar system. We propose a real-time capable ... ...

    Abstract VR Facial Animation is necessary in applications requiring clear view of the face, even though a VR headset is worn. In our case, we aim to animate the face of an operator who is controlling our robotic avatar system. We propose a real-time capable pipeline with very fast adaptation for specific operators. In a quick enrollment step, we capture a sequence of source images from the operator without the VR headset which contain all the important operator-specific appearance information. During inference, we then use the operator keypoint information extracted from a mouth camera and two eye cameras to estimate the target expression and head pose, to which we map the appearance of a source still image. In order to enhance the mouth expression accuracy, we dynamically select an auxiliary expression frame from the captured sequence. This selection is done by learning to transform the current mouth keypoints into the source camera space, where the alignment can be determined accurately. We, furthermore, demonstrate an eye tracking pipeline that can be trained in less than a minute, a time efficient way to train the whole pipeline given a dataset that includes only complete faces, show exemplary results generated by our method, and discuss performance at the ANA Avatar XPRIZE semifinals.

    Comment: Published in IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) 2022
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Robotics
    Subject code 004
    Publishing date 2023-04-24
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Sustainability performance of small and medium dairy enterprises in Brazil

    Feil, Alexandre André / Constantin do Amaral, Caroline / Schreiber, Dusan / Maehler, Alisson Eduardo

    Sustainable Production and Consumption 2023 Jul., v. 39, p. 301-310

    2023  , Page(s) 301–310

    Abstract: The sustainability performance of dairy enterprises can be improved using specific assessments indicators and indices. However, selecting a set of indicators and creating a specific sustainability index for dairy enterprises is challenging. This study ... ...

    Abstract The sustainability performance of dairy enterprises can be improved using specific assessments indicators and indices. However, selecting a set of indicators and creating a specific sustainability index for dairy enterprises is challenging. This study aimed to assess the sustainability performance of small and medium dairy enterprises using an indicator set and indices encompassing the three dimensions of the triple bottom line approach. Hence, a specific indicator set was selected based on the literature, and a sustainability index was structured based on the process of normalisation, mean weight, aggregation, and sensitivity analysis. Empirical validation was carried out with 32 small and medium dairy enterprises in Brazil using a questionnaire to evaluate sustainability performance. The results demonstrate that the indicator set, sub-indices (environmental, social, and economic), and index are adequate and consistent for diagnosing and identifying areas of improvement in the sustainable performance of small and medium dairy enterprises. In our sample, the highest efficiency regarding sustainability performance was related to economic sub-index indicators, whereas the lowest efficiency appeared in environmental and social sub-index indicators. The application of the sustainability index delivered essential information to consultants and managers of dairy enterprises to improve resource use and minimise the environmental and social impacts of their companies. The study posits that the specific sustainability index for small and medium dairy enterprises is a powerful management resource that can diagnose positive and negative points in a company related to the triple bottom line dimensions. Furthermore, the study provides suggestions for the use of the sustainability index, contributions to sustainability performance improvement, and limitations.
    Keywords area ; consultants ; dairies ; economic indicators ; environmental impact ; managers ; questionnaires ; resource management ; sampling ; small and medium enterprises ; social factors ; social impact ; Brazil ; Triple bottom line ; Set of indicators ; Sustainability index
    Language English
    Dates of publication 2023-07
    Size p. 301-310
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ISSN 2352-5509
    DOI 10.1016/j.spc.2023.05.024
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Pathogenic Relationships in Cystic Fibrosis and Renal Diseases: CFTR, SLC26A9 and Anoctamins.

    Kunzelmann, Karl / Ousingsawat, Jiraporn / Kraus, Andre / Park, Julien H / Marquardt, Thorsten / Schreiber, Rainer / Buchholz, Björn

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: ... The ... ...

    Abstract The Cl
    MeSH term(s) Humans ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Polycystic Kidney, Autosomal Dominant ; Polycystic Kidney Diseases ; Anoctamins ; Membrane Transport Proteins ; Sulfate Transporters/genetics ; Antiporters
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Anoctamins ; Membrane Transport Proteins ; SLC26A9 protein, human ; Sulfate Transporters ; Antiporters ; CFTR protein, human
    Language English
    Publishing date 2023-08-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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