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Article ; Online: Quantum spin driven Yu-Shiba-Rusinov multiplets and fermion-parity-preserving phase transition in K

Wang, Shu-Ze / Yu, Xue-Qing / Wei, Li-Xuan / Wang, Li / Cheng, Qiang-Jun / Peng, Kun / Cheng, Fang-Jun / Liu, Yu / Li, Fang-Sen / Ma, Xu-Cun / Xue, Qi-Kun / Song, Can-Li

Science bulletin

2024

Abstract: Magnetic impurities in superconductors are of increasing interest due to emergent Yu-Shiba-Rusinov ...

Abstract	Magnetic impurities in superconductors are of increasing interest due to emergent Yu-Shiba-Rusinov (YSR) states and Majorana zero modes for fault-tolerant quantum computation. However, a direct relationship between the YSR multiple states and magnetic anisotropy splitting of quantum impurity spins remains poorly characterized. By using scanning tunneling microscopy, we systematically resolve individual transition-metal (Fe, Cr, and Ni) impurities induced YSR multiplets as well as their Zeeman effects in the K
Language	English
Publishing date	2024-03-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2816140-3
ISSN	2095-9281 ; 2095-9273
ISSN (online)	2095-9281
ISSN	2095-9273
DOI	10.1016/j.scib.2024.03.052
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Article ; Online: Yu-Ping-Feng-San alleviates inflammation in atopic dermatitis mice by TLR4/MyD88/NF-κB pathway.

Nie, Jing / Jiang, Xiaoyuan / Wang, Guomi / Xu, Yanan / Pan, Rui / Yu, Wantao / Li, Yuanwen / Wang, Jingxiao

Journal of ethnopharmacology

2024 Volume 329, Page(s) 118092

Abstract: Ethnopharmacological relevance: Yu-Ping-Feng-San (YPF) is a traditional Chinese medicine formula ...

Abstract	Ethnopharmacological relevance: Yu-Ping-Feng-San (YPF) is a traditional Chinese medicine formula that has therapeutic effects on allergic diseases such as allergic rhinitis and asthma. However, its potential efficacy and mechanism in the treatment of atopic dermatitis (AD) has not been extensively illustrated. Aim of the study: The purpose of this study was to investigate the efficacy and possible mechanisms of YPF in AD pathogenesis. Methods: Network pharmacology and GEO data mining were adopted to firstly identify the potential mechanisms of YPF on AD. Then DNCB induced-AD murine model was established to test the efficacy of YPF and verify its effects on inflammatory cytokines and NF-κB pathway. In addition, molecular docking was performed to detect the binding affinity of YPF's active components with NF-κB pathway related molecules. Results: Network pharmacology and human data mining suggested that YPF may act on the NF-κB pathway in AD pathogenesis. With DNCB mice model, we found that YPF significantly improved AD symptoms, reduced SCORAD scores, and alleviated skin tissue inflammation in mice. At the same time, the expression of inflammatory cytokines, TNF-α, sPLA2-IIA and IL-6, was down-regulated. Moreover, YPF suppressed TLR4/MyD88/NF-κB pathway in situ in a dose-dependent manner. Molecular docking further confirmed that seven compounds in YPF had exceptional binding properties with TNF-α, IL-6 and TLR4. Conclusion: YPF may help the recovery of AD by inhibiting the TLR4/MyD88/NF-κB pathway, which provides novel insights for the treatment of AD by YPF.
Language	English
Publishing date	2024-04-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118092
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Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 9110704

Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

Abstract	Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW. Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms. Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/9110704
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Zs.A 5995: Show issues

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Article ; Online: Correction: Yu et al. Comparison of Physical and Biochemical Characterizations of SARS-CoV-2 Inactivated by Different Treatments.

Yu, Shouzhi / Wei, Yangyang / Liang, Hongyang / Ji, Wenheng / Chang, Zhen / Xie, Siman / Wang, Yichuan / Li, Wanli / Liu, Yingwei / Wu, Hao / Li, Jie / Wang, Hui / Yang, Xiaoming

Viruses

2023 Volume 15, Issue 5

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2023-04-23
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15051035
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Article ; Online: Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.

Xie, Linbi / Song, Xu / Lei, Ling / Chen, Chu / Zhao, Huan / Hu, Jingyi / Yu, Yue / Bai, Xiaolu / Wu, Xia / Li, Xiangfeng / Yang, Xiao / Yuan, Bo / Li, Dongxiao / Zhu, Xiangdong / Zhang, Xingdong

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117480

Abstract: Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula ...

Abstract	Ethnopharmacological relevance: Heng-Gu-Gu-Shang-Yu-He-Ji (Osteoking, OK) is a well-known formula for fracture therapy. In clinic, OK is effective in treating fractures while alleviating osteoporosis (OP) symptoms. However, active components of OK and the associated molecular mechanisms remain not fully elucidated. Aim of the study: This study aims to systematically evaluate the anti-osteoporosis efficacy of OK and for the first time combine network pharmacology with high-throughput whole gene transcriptome sequencing to study its underlying mechanism. Materials and methods: In this study, the osteoporosis model was established by the castration of both ovaries. The level of serum bone turnover factor was detected by enzyme-linked immunosorbent assay. Micro-CT and HE staining were used to observe the changes of bone histopathology, and nano-indentation technique was used to detect the biomechanical properties of rat bone. The main active Chemical components of OK were identified using UPLC-DAD. Efficacy verification and mechanism exploration were conducted by network pharmacology, molecular docking, whole gene transcriptomics and in vivo experiments. Results: In our study, OK significantly improved bone microarchitecture and bone biomechanical parameters in OVX rats, reduced osteoclast indexes such as C-telopeptide of type I collage (CTX-I) and increased Osteoprotegerin (OPG)/Receptor activator of NF-κB ligand (RANKL) levels. Mechanistically, PI3K/AKT pathway was a common pathway for genome enrichment analysis (KEGG) of both network pharmacology and RNA-seq studies. G protein-β-like protein (GβL), Ribosomal-protein S6 kinase homolog 2 (S6K2), and Phosphoinositide 3-kinase (PI3K) appeared differentially expression in the PI3K-AKT signaling pathway. These results were also confirmed by qRT-PCR and immunohistochemistry. Conclusions: OK may be used to treat osteoporosis, at least partly by activating PI3K/AKT/mTORC1 signaling pathway.
MeSH term(s)	Rats ; Animals ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Network Pharmacology ; Molecular Docking Simulation ; Rats, Sprague-Dawley ; Osteoprotegerin/genetics ; Osteoprotegerin/metabolism ; Osteoporosis/metabolism ; Gene Expression Profiling ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Osteoprotegerin ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-11-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117480
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Zs.A 1494: Show issues

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Article ; Online: How does Mei-yu precipitation respond to climate change?

Sun, Bo / Xue, Rufan / Li, Wanling / Zhou, Siyu / Li, Huixin / Zhou, Botao / Wang, Huijun

National science review

2023 Volume 10, Issue 12, Page(s) nwad246

Abstract: Mei-yu is an important weather phenomenon in the middle-lower Yangtze River valley (YRV) region ... This study investigates the changes in the characteristics of Mei-yu under global warming and the potential ... the frequency and intensity of extreme precipitation events (EPEs) in the YRV region during the Mei-yu period ...

Abstract	Mei-yu is an important weather phenomenon in the middle-lower Yangtze River valley (YRV) region. This study investigates the changes in the characteristics of Mei-yu under global warming and the potential reasons based on observation and reanalysis data during 1961-2022. Notable increasing long-term trends are detected in the number of days without rainfall (NDWOR), the intensity of rainfall events, and the frequency and intensity of extreme precipitation events (EPEs) in the YRV region during the Mei-yu period (15 June-10 July) over past decades. The increasing trend in NDWOR is attributed to decreased relative humidity over land surface and a longer time for the air to be replenished with moisture after rainfall events in a warming climate. The increasing trends in the intensity of rainfall events and frequency/intensity of EPEs are attributed to the strengthened transient water vapor convergence and convection in the atmosphere under global warming. Furthermore, the response of Mei-yu to 2°C of global warming with respect to the pre-industrial climate is analysed using CMIP6 models. The results suggest that the NDWOR, intensity of rainfall events and frequency of EPEs will increase in the YRV region during the Mei-yu period under the 2°C warming scenario, which implies a more challenging climate risk management in the future. Overall, the intensity of rainfall events during the Mei-yu period has the most significant response to climate change in observations and projections. The model results have a relatively large uncertainty.
Language	English
Publishing date	2023-09-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwad246
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Article ; Online: Seasonal variations, source apportionment and dry deposition of chemical species of total suspended particulate in Pengjia Yu Island, East China Sea.

Yu-Xiao, Li / Shu-Han, Liu / Li, Luo / Shu-Di, Yang / Bin-Yu, Lu / Chen, Wang / Shih-Chieh, Hsu / Shuh-Ji, Kao

Marine pollution bulletin

2023 Volume 187, Page(s) 114608

Abstract: ... and analyzed from January to December 2010 in Pengjia Yu Island, an open region in East China Sea (ECS ...

Abstract	Total of 172 total suspended particulate (TSP) samples and its chemical compositions were collected and analyzed from January to December 2010 in Pengjia Yu Island, an open region in East China Sea (ECS). Despite the predominance of sea-salt major ions (Na
MeSH term(s)	Particulate Matter/analysis ; Air Pollutants/analysis ; Seasons ; Dust/analysis ; China ; Ions/analysis ; Minerals ; Coal/analysis ; Environmental Monitoring ; Aerosols/analysis
Chemical Substances	Particulate Matter ; Air Pollutants ; Dust ; Ions ; Minerals ; Coal ; Aerosols
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.114608
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Article ; Online: Obstructive sleep-disordered breathing and orthodontics. An interview with Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang and Kasey Li

Guilleminault, Christian / Hervy-Auboiron, Michèle / Huang, Yu-Shu / Li, Kasey / Amat, Philippe

L' Orthodontie francaise

2023 Volume 93, Issue Suppl 1, Page(s) 5–33

Title translation	Obstructive sleep-disordered breathing and orthodontics. An interview with Christian Guilleminault, Michèle Hervy-Auboiron, Yu-Shu Huang and Kasey Li.
MeSH term(s)	Humans ; Orthodontics ; Sleep Apnea, Obstructive/therapy ; Ethnicity ; Dental Care
Language	English
Publishing date	2023-01-26
Publishing country	France
Document type	Interview
ZDB-ID	417383-1
ISSN	1954-3395 ; 0078-6608 ; 1966-5202
ISSN (online)	1954-3395
ISSN	0078-6608 ; 1966-5202
DOI	10.1684/orthodfr.2022.96
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Article ; Online: A mini review of Yu-Ping-Feng polysaccharides

Yang Liu / Binbin Tong / Shuangxing Wang / Gen Li / Yuansheng Tan / Hui Yu / Kelin Yang / Yingying Yu

Aquaculture Reports, Vol 20, Iss , Pp 100697- (2021)

Their biological activities and potential applications in aquaculture

2021

Abstract: ... become a focus of attention in many fields, particularly in medical research industry. Yu-Ping-Feng (YPF ... not studied. Under the guidance of the Pharmacological Efficacy Index, we have extracted Yu-Ping-Feng ...

Abstract	Polysaccharides, one of the important active ingredients of traditional Chinese herbal medicine, become a focus of attention in many fields, particularly in medical research industry. Yu-Ping-Feng (YPF) is a primary component of many traditional Chinese medicine prescriptions, and it’s proven to be significantly beneficial to human health. In recent years, polysaccharides from YPF have been well documented after successful isolation and purification, but the polysaccharides from YPF post-processing wastes are not studied. Under the guidance of the Pharmacological Efficacy Index, we have extracted Yu-Ping-Feng polysaccharides (YPF-P) from the wastes of YPF in our previous work. Our previous findings showed that YPF-P promote the growth, enhance immunity and organ structure or function of cultured fish northern snakehead fish (Channa argus) and grass carp (Ctenopharyngodon idellus), and significantly improve the intestinal microflora of fish. This paper reviews the current status of YPF-P and their application in aquaculture, including the development of green feed for aquatic animals and the re-utilization of the YPF wastes. This series of work is a way to have the best of both worlds, not only to realize the rational treatment of medical wastes, but also to effectively use the wastes, to find a green raw material for aquatic feed.
Keywords	Traditional Chinese medicine ; Yu-Ping-Feng polysaccharides ; Feed additive ; Aquaculture. Fisheries. Angling ; SH1-691
Subject code	540
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction for Yu et al., "A Mouse

Yu, Zhenbao / Chen, Taiping / Hébert, Josée / Li, En / Richard, Stéphane

Molecular and cellular biology

2017 Volume 37, Issue 17

Language	English
Publishing date	2017-09-01
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00298-17
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