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  1. Article ; Online: Disease Relapse Rate from Long-Term Follow-Up Data in Löfgren's Syndrome.

    Karakaya, Bekir / Veltkamp, Marcel / van Moorsel, Coline H M / Grutters, Jan C

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 8, Page(s) 1026–1028

    MeSH term(s) Humans ; Follow-Up Studies ; Sarcoidosis, Pulmonary ; Sarcoidosis ; Chronic Disease
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202307-1291LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Desmoplakin: An Important Player in Aging Lung Disease.

    van Moorsel, Coline H M

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 9, Page(s) 1201–1202

    MeSH term(s) Aging ; Desmoplakins/genetics ; Epithelial Cells ; Genome-Wide Association Study ; Humans ; Lung Diseases
    Chemical Substances Desmoplakins
    Language English
    Publishing date 2020-09-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202006-2457ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Comprehensive Family Health History and Genetic Analyses Are Complementary in the Detection of Risk for Progressive Pulmonary Fibrosis.

    Terwiel, Michelle / van Moorsel, Coline H M

    Chest

    2021  Volume 159, Issue 5, Page(s) 1709–1710

    MeSH term(s) Genetic Testing ; Humans ; Pulmonary Fibrosis/diagnosis ; Pulmonary Fibrosis/genetics
    Language English
    Publishing date 2021-05-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.02.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Putting Genetics Into Practice: Challenges Associated With the Genetics of Short Telomere Syndromes.

    van Moorsel, Coline H M

    Chest

    2020  Volume 158, Issue 6, Page(s) 2249–2250

    MeSH term(s) Cell Cycle Proteins ; Humans ; Nuclear Proteins ; Pulmonary Fibrosis ; RNA ; Silent Mutation ; Syndrome ; Telomerase/genetics ; Telomere/genetics
    Chemical Substances Cell Cycle Proteins ; DKC1 protein, human ; Nuclear Proteins ; telomerase RNA ; RNA (63231-63-0) ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.09.071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Optimizing Screening for Early Disease Detection in Familial Pulmonary Fibrosis (FLORIS): A Prospective Cohort Study Design.

    Maus, Martijn T K / Groen, Karlijn / van der Vis, Joanne J / Grutters, Jan C / van Moorsel, Coline H M

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Decreased Survival and Lung Function in Progressive Pulmonary Fibrosis.

    Platenburg, Mark G J P / van der Vis, Joanne J / Grutters, Jan C / van Moorsel, Coline H M

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Kaplan-Meier Estimate ; Risk Factors ; Lung ; Netherlands
    Language English
    Publishing date 2023-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis.

    Kraaijvanger, Raisa / Janssen Bonás, Montse / Grutters, Jan C / Paspali, Ioanna / Veltkamp, Marcel / de Kleijn, Dominique P V / van Moorsel, Coline H M

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 166

    Abstract: Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, prednisone and methotrexate (MTX) ... ...

    Abstract Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, prednisone and methotrexate (MTX) are the most common anti-inflammatory therapies. However, there is large inter-patient variability in response to treatment, and predictive response markers are currently lacking.
    Objective: In this study, we investigated the predictive potential of biomarkers in extracellular vesicles (EVs) isolated from biobanked serum of patients with pulmonary sarcoidosis stored prior to start of therapy.
    Methods: Protein concentrations of a four-protein test panel of inflammatory proteins were measured in a discovery (n = 16) and replication (n = 129) cohort of patients with sarcoidosis and 47 healthy controls. Response to therapy was defined as an improvement of the absolute score of > 5% forced vital capacity (FVC) and/or > 10% diffusion lung of carbon monoxide (DLCO) after 24 weeks compared to baseline (before treatment).
    Results: Serum protein levels differed between EV fractions and serum, and between sarcoidosis cases and controls. Serpin C1 concentrations in the low density lipid particle EV fraction were lower at baseline in the group of patients with a good response to MTX treatment in both the discovery cohort (p = 0.059) and in the replication cohort (p = 0.032). EV Serpin C1 showed to be a significant predictor for response to treatment with MTX (OR 0.4; p = 0.032).
    Conclusion: This study shows that proteins isolated from EVs harbor a distinct signal and have potential as new predictive therapy response biomarkers in sarcoidosis.
    MeSH term(s) Humans ; Sarcoidosis, Pulmonary/diagnosis ; Sarcoidosis, Pulmonary/drug therapy ; Methotrexate/therapeutic use ; Antithrombin III ; Sarcoidosis ; Biomarkers ; Extracellular Vesicles
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; Antithrombin III (9000-94-6) ; Biomarkers
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-024-02809-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correspondence for "Clinical epidemiology of familial sarcoidosis: A systematic literature review".

    Terwiel, Michelle / van Moorsel, Coline H M

    Respiratory medicine

    2019  Volume 160, Page(s) 105753

    MeSH term(s) Humans ; Pedigree ; Publications ; Sarcoidosis
    Language English
    Publishing date 2019-07-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2019.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clustering of lung diseases in the family of interstitial lung disease patients.

    Terwiel, Michelle / Grutters, Jan C / van Moorsel, Coline H M

    BMC pulmonary medicine

    2022  Volume 22, Issue 1, Page(s) 134

    Abstract: Background: The presence of familial interstitial lung disease (ILD) has been found to predict development of progressive pulmonary fibrosis. However, the role of non-ILD lung diseases in ILD patients' families has not yet been investigated. We aimed to ...

    Abstract Background: The presence of familial interstitial lung disease (ILD) has been found to predict development of progressive pulmonary fibrosis. However, the role of non-ILD lung diseases in ILD patients' families has not yet been investigated. We aimed to identify associations between ILDs and non-ILD lung diseases from ILD patients' self-reported family health history.
    Methods: We analysed questionnaires on family health history of 1164 ILD patients for the occurrence of ILD and non-ILD lung disease in relatives. Logistic regression analysis was used to study associations with diagnosis groups.
    Results: Familial pulmonary fibrosis was reported by 20% of patients with idiopathic pulmonary fibrosis (IPF; OR 9.2, 95% CI 4.7-17.9), and 15% of patients with unclassifiable pulmonary fibrosis (OR 4.1, 95% CI 2.0-8.2). Familial occurrence was reported by 14% of patients with sarcoidosis (OR 3.3, 95% CI 1.9-5.8). Regarding non-ILD lung disease, significantly more patients with IPF (36%) reported lung cancer in their family (OR 2.3, 95% CI 1.4-3.5), and patients with hypersensitivity pneumonitis (18%) mostly reported COPD (OR 2.3, 95% CI 1.3-4.2). Comparison of sporadic and familial ILD patients' reports showed that emphysema (OR 4.6, 95% CI 1.8-11.6), and lung cancer (OR 2.4, 95% CI 1.2-4.9) were predictive for familial pulmonary fibrosis, particularly when reported both in a family (OR 16.7, 95% CI 3.2-86.6; p < 0.001).
    Conclusions: Our findings provide evidence for clustering of ILD and non-ILD lung diseases in families and show that self-reported emphysema and lung cancer of relatives in this population predicts familial pulmonary fibrosis.
    MeSH term(s) Cluster Analysis ; Emphysema ; Humans ; Idiopathic Pulmonary Fibrosis/epidemiology ; Lung Diseases, Interstitial/epidemiology ; Lung Neoplasms
    Language English
    Publishing date 2022-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-022-01927-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: To progress understanding of disease triggers and modifiers in sarcoidosis, stratification is the key.

    van Moorsel, Coline H M

    The European respiratory journal

    2017  Volume 50, Issue 6

    MeSH term(s) Genetic Predisposition to Disease ; Humans ; Sarcoidosis
    Language English
    Publishing date 2017-12-14
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02002-2017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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