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Article ; Online: The NHS fails to care for its own employees.

Khan, Shujhat / Iqbal, Noreena

2022 Volume 379, Page(s) o2575

MeSH term(s)	Humans ; State Medicine ; Surveys and Questionnaires
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.o2575
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Macklin effect in COVID-19.

Iqbal, Noreena / Malik, Ayesha / Chaudhry, Manahil

Clinical medicine (London, England)

2022 Volume 22, Issue Suppl 4, Page(s) 56–57

MeSH term(s)	COVID-19 ; Humans ; Mediastinal Emphysema ; Wounds, Nonpenetrating
Language	English
Publishing date	2022-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmed.22-4-s56
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acute Cholecystitis Masking a Gastric Bezoar.

Chaudhry, Manahil / Iqbal, Noreena / Malik, Ayesha

Cureus

2022 Volume 14, Issue 2, Page(s) e22673

Abstract: A bezoar is a solid mass of indigestible material that usually forms in the gastrointestinal (GI) tract. Gastric bezoars, located in the stomach, can present variably. They can be asymptomatic or present with GI symptoms like nausea, vomiting, abdominal ... ...

Abstract	A bezoar is a solid mass of indigestible material that usually forms in the gastrointestinal (GI) tract. Gastric bezoars, located in the stomach, can present variably. They can be asymptomatic or present with GI symptoms like nausea, vomiting, abdominal pain, or more serious complications, such as GI obstruction or perforation. Diagnostic modalities are mainly radiological, and treatment may either be conservative or interventional. Herein, we disclose the case of a 47-year-old female who presented with a two-week history of abdominal pain with an incidental finding of a possible gastric phytobezoar, co-existing with gallbladder disease. Although not previously reported, this study highlights the possibility of an association between gallbladder disease and the formation of a bezoar.
Language	English
Publishing date	2022-02-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.22673
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Macklin Effect in COVID-19.

Iqbal, Noreena / Malik, Ayesha / Chaudhry, Manahil

Cureus

2021 Volume 13, Issue 8, Page(s) e16949

Abstract: From the mere outlook of the ongoing pandemic, coronavirus (severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) seems to target mainly the respiratory system, but more evolving evidence has advocated its multi-organ involvement. While various ... ...

Abstract	From the mere outlook of the ongoing pandemic, coronavirus (severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) seems to target mainly the respiratory system, but more evolving evidence has advocated its multi-organ involvement. While various complications have been reported in coronavirus disease 2019 (COVID-19) patients, spontaneous pneumomediastinum (SP) remains an uncommon complication.
Language	English
Publishing date	2021-08-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.16949
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Essential Palatal Tremor Following an Upper Respiratory Tract Infection: A Case Report.

Azam, Khalid / Kanwal, Ayesha / Chaudhry, Manahil / Iqbal, Noreena / Malik, Ayesha

Cureus

2021 Volume 13, Issue 1, Page(s) e12543

Abstract: Bilateral objective tinnitus is a rare accompanying manifestation of an underlying palatal tremor (PT). PT can either be secondary to a lesion in the triangle of Guillain and Mollaret, or it can present without a causal organic lesion. In this report, we ...

Abstract	Bilateral objective tinnitus is a rare accompanying manifestation of an underlying palatal tremor (PT). PT can either be secondary to a lesion in the triangle of Guillain and Mollaret, or it can present without a causal organic lesion. In this report, we present an unusual case of a young female with objective tinnitus revealing a PT.
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.12543
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antioxidant, carbonic anhydrase inhibition and diuretic activity of

Masood, Noreena / Jamil, QurratUlAin / Aslam, Muhammad Irfan / Masood, Muhammad Irfan / Shirazi, Jafir Hussain / Jamil, Qazi Adnan / Jan, Muhammad Saeed / Alsuwayt, Bader / Ahmad, Ashfaq / Abdullah Alnasser, Sulaiman Mohammed / Aufy, Mohammed / Iqbal, Shahid Muhammad

Heliyon

2023 Volume 9, Issue 12, Page(s) e22485

Abstract: Background: Leptadenia pyrotechnica: Methods: The 70 % methanolic : Results: Lp.Cr. indicated high phenolic and flavonoid contents which correlated with good antioxidant activity. GC-MS analysis showed the presence of 104 compounds from different ... ...

Abstract	Background: Leptadenia pyrotechnica Methods: The 70 % methanolic Results: Lp.Cr. indicated high phenolic and flavonoid contents which correlated with good antioxidant activity. GC-MS analysis showed the presence of 104 compounds from different phytochemical classes. Diuretic activity was performed at 10-300 mg/kg concentrations where the dose of 100 and 300 mg/kg showed good diuretic and saluretic activity comparable to furosemide. Lp.Cr exhibited diuresis both in acute and prolonged study protocols which can be attributed to carbonic anhydrase inhibition, effect on prostaglandins and cholinergic pathways. Conclusion: L. pyrotechnica
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e22485
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Idiopathic Dilatation of Inferior Vena Cava: A Case Report.

Malik, Ayesha / Chaudhry, Manahil / Abdullah, Mohammad / Inam, Syed Hashim Ali / Iqbal, Noreena

Cureus

2020 Volume 12, Issue 9, Page(s) e10313

Abstract: Inferior vena cava (IVC) is a large collapsible vein whose diameter and extent of inspiratory collapse are known to correlate with right atrial (RA) pressures; hence, IVC dilatation represents a cardiac pathology. IVC dilatation in the absence of any ... ...

Abstract	Inferior vena cava (IVC) is a large collapsible vein whose diameter and extent of inspiratory collapse are known to correlate with right atrial (RA) pressures; hence, IVC dilatation represents a cardiac pathology. IVC dilatation in the absence of any cardiac involvement is termed as idiopathic. We report a case of a 39-year-old male who presented with abdominal pain and had an incidental finding of isolated IVC dilatation with diminished inspiratory collapsibility and normal RA pressures. This case report emphasizes that IVC dilatation may not always have an underlying cardiac pathology.
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.10313
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prevalence of Microalbuminuria in Type 2 Diabetes Mellitus.

Sana, Muhammad Ahsan / Chaudhry, Manahil / Malik, Ayesha / Iqbal, Noreena / Zakiuddin, Ayesha / Abdullah, Mohammad

Cureus

2020 Volume 12, Issue 12, Page(s) e12318

Abstract: Objective: The presence of albumin in the urine is a marker of glomerular involvement in type 2 diabetes mellitus (T2DM), depicting diabetic nephropathy. Strict glycemic control can prevent and delay the occurrence of microalbuminuria and other diabetic ...

Abstract	Objective: The presence of albumin in the urine is a marker of glomerular involvement in type 2 diabetes mellitus (T2DM), depicting diabetic nephropathy. Strict glycemic control can prevent and delay the occurrence of microalbuminuria and other diabetic complications. Therefore, we conducted a study to report the prevalence of microalbuminuria in type 2 diabetics along with its association with diabetic control. Methods: A total of 133 patients with T2DM were consecutively included and their co-morbidities, body mass index, mode of treatment of diabetes (oral hypoglycemic drugs and/or insulin), duration since diagnosis of T2DM, and hemoglobin A1c (HbA1c) levels were recorded. A morning, mid-stream urine sample was collected and a urine spot for albumin:creatinine ratio (UACR) was assessed. Descriptive and analytic statistics were drawn with different variables and UACR values. Results: The mean age of the participants was 54.5 ± 10.3 years which included 60.9% males and 39.1% females. The overall incidence of diabetic nephropathy was 30.1%, with 25.6% having microalbuminuria and 4.5% having macroalbuminuria. Pearson correlation test was used to compare UACR and duration of diabetes (p=0.034) and HbA1c (p=0.001). Conclusion: UACR was higher in patients with uncontrolled T2DM (in terms of higher HbA1c value) and with a longer duration since diagnosis. We recommend that UACR should be inculcated in routine practice, annually, for all patients with T2DM for gauging the development of underlying renal involvement and prompt management.
Language	English
Publishing date	2020-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.12318
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparison Between Menstrual Migraine and Menstrual-Unrelated Migraine in Women Attending Gynecology Clinics.

Abdullah, Mohammad / Qaiser, Sara / Malik, Ayesha / Chaudhry, Manahil / Fatima, Tehreem / Iqbal, Noreena

Cureus

2020 Volume 12, Issue 10, Page(s) e10976

Abstract: Background Migraine is amongst the top 10 most disabling conditions, and the disease burden is highest in young and middle-aged women. Another variant of the migraine headache, menstrual migraine (MM) is experienced by this cohort of patients. Former ... ...

Abstract	Background Migraine is amongst the top 10 most disabling conditions, and the disease burden is highest in young and middle-aged women. Another variant of the migraine headache, menstrual migraine (MM) is experienced by this cohort of patients. Former studies have done comparisons between various demographic and clinical features of MM versus menstrual-unrelated migraine (MUM) in patients presenting to various clinics with the primary complaint of headaches. We aimed to compare symptoms of migraine in women attending gynecology outpatient clinics, regardless of their presenting complaint. This would help lessen the selection bias and produce more generalizable results. Methods and materials A cross-sectional study was conducted in the outpatient gynecology clinics at a tertiary care hospital over six months. The clinic attendees were screened for sufferers of a primary headache of the migraine type. The migraineurs were then stratified into groups A, MM patients, and group B, MUM patients, using the International Headache Society (HIS) criteria. They were then questioned for the presence of various symptoms associated with their migraine attacks for comparison. Results One-hundred eighty-one women (between 12 years to 55 years) were found to have primary headaches; amongst these, 126 patients met the inclusion criteria and consented to participate; from these, 62 (49.2%) patients had MM and 64 (50.8%) patients had MUM. The symptoms of nausea (p=0.00269), photophobia (p=0.000088), and phonophobia (p=0.0281) were statistically higher in MM patients while vomiting was not a significant feature. Both groups had a predominantly unilateral headache. The average days of the attack had a significant difference between the two groups (p=0.000019), where the duration was longer for MM patients. Conclusions It was observed that patients with MM tend to experience more features associated with migraine headaches, including a longer duration of attacks, and have a worse experience overall.
Language	English
Publishing date	2020-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.10976
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Antioxidant, carbonic anhydrase inhibition and diuretic activity of Leptadenia pyrotechnica Forssk. Decne

Noreena Masood / QurratUlAin Jamil / Muhammad Irfan Aslam / Muhammad Irfan Masood / Jafir Hussain Shirazi / Qazi Adnan Jamil / Muhammad Saeed Jan / Bader Alsuwayt / Ashfaq Ahmad / Sulaiman Mohammed Abdullah Alnasser / Mohammed Aufy / Shahid Muhammad Iqbal

Heliyon, Vol 9, Iss 12, Pp e22485- (2023)

2023

Abstract: Background: Leptadenia pyrotechnica Forssk. Decne is a member of family Apocynaceae and locally known as ‘Khipp’. It is found in dry, sandy habitat of Pakistan and in several other regions around the world including Asia, Tropical Africa, Western Gulf ... ...

Abstract	Background: Leptadenia pyrotechnica Forssk. Decne is a member of family Apocynaceae and locally known as ‘Khipp’. It is found in dry, sandy habitat of Pakistan and in several other regions around the world including Asia, Tropical Africa, Western Gulf and Mediterranean countries. It has nutritional value, containing 4 % lipids, 23 % proteins, 28 % carbohydrates, 4 % fibers, vitamin E and several minerals. Traditionally, this plant has been used by several communities for pain, different inflammatory and kidney disorders. Ethno-botanical studies have reported the use of L. pyrotechnica in nephrolithiasis, kidney disorders and induction of diuresis, which requires a detailed pharmacological study to validate the folkloric use of L. pyrotechnica as diuretic. Methods: The 70 % methanolic L. pyrotechnica (Lp.Cr) extract was prepared and qualitatively checked for the presence of various phytochemicals. Phenolic, flavonoid, tannin and saponin contents were quantified. GC-MS analysis of Lp.Cr was also performed. Antioxidant potential of Lp.Cr was evaluated by DPPH, ABTS and nitrite radical scavenging assays. CUPRAC and FRAP assay described the reducing potential of Lp.Cr. Diuretic activity was performed in both acute and prolonged models at different doses followed by the estimation of electrolytes, urea and creatinine levels. The mechanism of diuresis was described by pre-treatment with atropine, l-NAME, indomethacin and carbonic anhydrase inhibition. Results: Lp.Cr. indicated high phenolic and flavonoid contents which correlated with good antioxidant activity. GC-MS analysis showed the presence of 104 compounds from different phytochemical classes. Diuretic activity was performed at 10–300 mg/kg concentrations where the dose of 100 and 300 mg/kg showed good diuretic and saluretic activity comparable to furosemide. Lp.Cr exhibited diuresis both in acute and prolonged study protocols which can be attributed to carbonic anhydrase inhibition, effect on prostaglandins and cholinergic pathways. Conclusion: L. pyrotechnica ...
Keywords	Leptadenia pyrotechnica ; GC-MS ; Antioxidant ; Diuretic ; Saluretic ; Carbonic anhydrase ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	500
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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