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Article ; Online: An unusual complication of arteriovenous fistula.

Béland, Marc-Antoine / Bergeron, Nicolas A D / Béland, Mathieu / Haydock, Ludwig / Isenring, Paul

2024 Volume 105, Issue 4, Page(s) 893

MeSH term(s)	Humans ; Arteriovenous Fistula/diagnostic imaging ; Arteriovenous Fistula/etiology ; Arteriovenous Fistula/therapy
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.09.023
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Article ; Online: X-linked Alport syndrome presenting in mother and son with the same unique histopathological features.

Bergeron, Nicolas A D / Garneau, Alexandre P / Rousseau-Gagnon, Mathieu / Riopel, Julie / Isenring, Paul

Journal of nephrology

2024

Abstract: Alport syndrome has been linked to three different genes, that is, COL4A3, COL4A4 and COL4A5. It is characterized by progressive and non-specific glomerulosclerosis with irregular thickening of the glomerular basement membrane (GBM). At times, the ... ...

Abstract	Alport syndrome has been linked to three different genes, that is, COL4A3, COL4A4 and COL4A5. It is characterized by progressive and non-specific glomerulosclerosis with irregular thickening of the glomerular basement membrane (GBM). At times, the histopathologic picture is dominated by lesions that are consistent with focal and segmental glomerulosclerosis or IgA nephropathy. Here, we report the cases of two related individuals (mother and son) who were diagnosed with COL4A5-related Alport syndrome due to a missense variant (p.Gly1170Ser) in a G-X-Y repeat and found to present the same highly unusual histopathological abnormalities on their kidney biopsies. One of the abnormalities shared, which does not appear to have been reported, was reduced COL4A5 immunolabeling that was limited to Bowman's capsule even though the ultrastructure of the GBM was distorted. The other abnormality was superimposed segmental IgA deposition in both individuals, accompanied by mesangial changes in the mother. We feel that these findings provide novel insight into the mechanisms of disease manifestation in Alport syndrome. They suggest, in particular, that collagen expression and/or assemblies in Bowman's capsule is more vulnerable to missense mutations in COL4A5 than elsewhere in the kidney. Our findings also suggest that certain coinherited gene polymorphisms act as unexpectedly important phenotypic determinants in COL4A-related disorders.
Language	English
Publishing date	2024-04-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-024-01942-7
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Article ; Online: Persistent Obstructive Sleep Apnea Burden on Family Finances and Quality of Life.

Bergeron, Mathieu / Ishman, Stacey L

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2021 Volume 165, Issue 3, Page(s) 483–489

Abstract: Objective: We previously found that financial concerns negatively affect the quality of life of families of children with persistent obstructive sleep apnea (OSA) after tonsillectomy. The goal is to quantify the financial impact on families of children ... ...

Abstract	Objective: We previously found that financial concerns negatively affect the quality of life of families of children with persistent obstructive sleep apnea (OSA) after tonsillectomy. The goal is to quantify the financial impact on families of children with persistent OSA and assess contributing factors. Study design: Cross-sectional survey study with comparison group. Setting: Upper airway center at a tertiary pediatric hospital. Methods: Participants included consecutive children with persistent OSA from September to October 2017. Healthy children seen in a general otolaryngology clinic served as controls. Families of both groups completed the Family Impact Questionnaire and the modified Comprehensive Score for Financial Toxicity (COST). Results: Families of the 50 patients (25 study and 25 control) completed the surveys: the mean age was 6.4 years (95% CI, 5.0-7.8), and 19 (38%) were female. There were no differences in age, sex, race, or insurance status between groups ( Conclusion: Families of children with persistent OSA reported a high financial burden related to their children's disease and were more likely to report financial toxicity than families of controls. Concern regarding missed work and school associated with appointments and treatment was a significant factor.
MeSH term(s)	Case-Control Studies ; Child ; Down Syndrome/complications ; Female ; Financing, Personal/economics ; Humans ; Male ; Quality of Life ; Sleep Apnea, Obstructive/economics ; Sleep Apnea, Obstructive/physiopathology ; Surveys and Questionnaires
Language	English
Publishing date	2021-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599820986566
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Article ; Online: Navigating the Multifaceted Intricacies of the Na

Rioux, Alexis V / Nsimba-Batomene, Thy-Rene / Slimani, Samira / Bergeron, Nicolas Ad / Gravel, Mathieu Am / Schreiber, Simon V / Fiola, Marie-Jeanne / Haydock, Ludwig / Garneau, Alexandre P / Isenring, Paul

Physiological reviews

2024

Abstract: ... The ... ...

Abstract	The Na
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209902-0
ISSN	1522-1210 ; 0031-9333
ISSN (online)	1522-1210
ISSN	0031-9333
DOI	10.1152/physrev.00027.2023
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Article ; Online: Comparison of Tympanostomy Tubes Under Local Anesthesia Versus General Anesthesia for Children.

Fournier, Isabelle / Caron, Camille / McMurtry, C Meghan / Lapointe, Annie / Giguere, Chantal / Doré-Bergeron, Marie-Joëlle / Bergeron, Mathieu

The Laryngoscope

2023 Volume 134, Issue 5, Page(s) 2422–2429

Abstract: Objective: Tympanostomy tube insertion (TTI) is typically accomplished under general anesthesia (GA) in the operating room. We aimed to compare pain between GA and local anesthesia (LA) in surgically naïve children undergoing TTI. Secondary objectives ... ...

Abstract	Objective: Tympanostomy tube insertion (TTI) is typically accomplished under general anesthesia (GA) in the operating room. We aimed to compare pain between GA and local anesthesia (LA) in surgically naïve children undergoing TTI. Secondary objectives examined patient's quality of life (QoL) and parent's satisfaction. Study design: Prospective single-center study. Setting: Tertiary pediatric academic center. Methods: Consecutive children who underwent TTI under GA were compared to patients under LA. Pain standardized observational pain scales (Face, Legs, Activity, Cry, Consolability Scale [FLACC], Children's hospital of Eastern Ontario Pain Scale [CHEOPS]) were completed pre-procedure, during the first tympanostomy and second tympanostomy, and post-procedure, as well as 1 week postoperatively. General health-related QoL (PedsQL) and QoL specific to otitis media (OM-6) were measured before insertion and 1 month postoperatively. Parental satisfaction was also evaluated using a qualitative scale. Results: LA group had statistically significant higher pain levels at the beginning (7.3 vs. 0), during the first tympanostomy (7.8 vs. 0), during the second tympanostomy (7.7 vs. 0), and at end of the procedure (6.9 vs. 0) with the FLACC scale (all p < 0.01). Results were similar with the CHEOPS scale. No pain was noted 1 week after surgery in either group. Both groups had similar improvement in their QoL (p > 0.05). Minor complication occurred at a similar rate (p > 0.05). Parents were equally satisfied with their choice of anesthesia in both groups when initially questioned after the procedure (p > 0.05). Conclusions: Children experienced significantly less pain under GA than LA. If LA is to be used, pain and distress-reducing strategies are critical. Shared decision-making with families is essential. Level of evidence: 3 Laryngoscope, 134:2422-2429, 2024.
MeSH term(s)	Child ; Humans ; Anesthesia, General/adverse effects ; Anesthesia, Local/methods ; Middle Ear Ventilation/methods ; Pain ; Prospective Studies ; Quality of Life
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.31095
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Article ; Online: Evaluating the Need for Intensive Care Admission After Supraglottoplasty for Severe Laryngomalacia.

Gagnon, Carolanne / Bérubé, Simon / Sauthier, Michaël / Rouillard-Bazinet, Noémie / Bergeron, Mathieu

The Laryngoscope

2023 Volume 134, Issue 1, Page(s) 466–470

Abstract: Objective: Postoperative airway concerns persist despite a low rate of post-supraglottoplasty complications for children with laryngomalacia. The objective of this study is to determine the factors associated with the need for intensive care unit (ICU) ... ...

Abstract	Objective: Postoperative airway concerns persist despite a low rate of post-supraglottoplasty complications for children with laryngomalacia. The objective of this study is to determine the factors associated with the need for intensive care unit (ICU) admission following supraglottoplasty. Methods: A 7-year retrospective cohort analysis was conducted between 2014 and 2021. A patient requiring ICU level of care was defined as the use of respiratory support such as intubation, positive pressure ventilation, high-flow nasal cannula, or multiple doses of nebulized epinephrine. Results: About 134 medical charts were reviewed; 12 patients were excluded because of concurrent surgery. Age at the time of surgery was 2.8 (4.3) months (median [interquartile range]). About 33 (27.0%) ultimately required ICU-level care. Prematurity (odds ratio [OR] 13.8), neurological condition (OR ∞), American Society of Anesthesiology class 3-4 (OR 6.5), and younger age (OR 1.8) were more likely to require ICU admission. No patient above 10 months of age needed ICU monitoring. The use of respiratory support justifying ICU was known within the first 4 h after surgery for almost all (32/33, 97%) of these patients. 4/33 (12.1%) were kept intubated and the remaining needed non-invasive ventilation. Only one patient (1/122, 0.8%) was reintubated 12 h after surgery for progressive respiratory distress. Conclusion: Approximately a quarter of patients required ICU-level care after supraglottoplasty. For nearly all patients without comorbidities requiring ICU, this can be safely predicted within the first 4 h after surgery. Our data suggest that selected patients undergoing supraglottoplasty may be safely monitored outside of an ICU setting after an observation period in the post-anesthesia care unit. Level of evidence: 4 Laryngoscope, 134:466-470, 2024.
MeSH term(s)	Child ; Humans ; Infant ; Laryngomalacia/surgery ; Laryngomalacia/complications ; Retrospective Studies ; Hospitalization ; Critical Care ; Intensive Care Units ; Treatment Outcome
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30813
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Article: The effects of the COVID-19 pandemic on French-Canadian adolescents' academic motivation: A follow-up study.

Smith, Jonathan / Guimond, Fanny-Alexandra / St-Amand, Jérôme / Fitzpatrick, Caroline / Bergeron, Julie / Gagnon, Mathieu

Clinical case reports

2022 Volume 10, Issue 9, Page(s) e6376

Abstract: We previously shared results suggesting that the academic motivation of a sample of French-Canadian adolescents remained stable from few weeks before the first wave to the second wave of the COVID-19 pandemic. We here examine if this pattern persisted ... ...

Abstract	We previously shared results suggesting that the academic motivation of a sample of French-Canadian adolescents remained stable from few weeks before the first wave to the second wave of the COVID-19 pandemic. We here examine if this pattern persisted using data collected at a third time point.
Language	English
Publishing date	2022-09-22
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.6376
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Article: Single points of access to fill the "GAP" for unattached patients in primary care: what makes paediatric users more likely to require a medical appointment?

Bergeron, Sebastien J / Lamoureux-Lamarche, Catherine / Milot, David-Martin / Lanthier-Veilleux, Mathieu / Berbiche, Djamal / Breton, Mylaine

Healthcare management forum

2023 , Page(s) 8404704231215698

Abstract: Unattachment to a regular primary care professional can affect children's and adolescents' well-being, considering their unique health needs. Having no alternative, many turn to emergency departments for non-urgent conditions. To help unattached patients ...

Abstract	Unattachment to a regular primary care professional can affect children's and adolescents' well-being, considering their unique health needs. Having no alternative, many turn to emergency departments for non-urgent conditions. To help unattached patients access healthcare services while on waitlists, Quebec's government implemented single access points in each administrative region across the province. Our study aimed to describe the paediatric population using single access points and identify associations between their characteristics and need for a medical appointment. Clinical-administrative data of 1,323 paediatric access point users in the Montérégie region from November 2022 to March 2023 were utilized to conduct bivariate and multivariable regression analyses. Our study showed that young age, assessment trajectory, and specific reasons for calling were more likely to necessitate a medical appointment. While access points improve accessibility to doctors, questions remain regarding the relevance of medical consultations, inequities, and possible security issues resulting from the overall process.
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2140831-2
ISSN	2352-3883 ; 0840-4704
ISSN (online)	2352-3883
ISSN	0840-4704
DOI	10.1177/08404704231215698
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Article ; Online: Vocal Fold Injection Augmentation for Post-Airway Reconstruction Dysphonia: A Case Series.

Bergeron, Mathieu / Giliberto, John Paul / Tabangin, Meredith E / de Alarcon, Alessandro

The Annals of otology, rhinology, and laryngology

2021 Volume 131, Issue 2, Page(s) 134–139

Abstract: Objectives: Post airway reconstruction dysphonia (PARD) is common and has a significant effect on the quality of life of patients. Vocal fold injection augmentation (VFIA) is one treatment that can be used to improve glottic insufficiency in some ... ...

Abstract	Objectives: Post airway reconstruction dysphonia (PARD) is common and has a significant effect on the quality of life of patients. Vocal fold injection augmentation (VFIA) is one treatment that can be used to improve glottic insufficiency in some patients. The goal of this study was to characterize the use and outcomes of VFIA for PARD. Methods: Retrospective chart review from January 2007 to July 2018 at a tertiary pediatric care center. Consecutive patients with PARD who underwent VFIA, who had a preoperative voice evaluation and a follow-up evaluation within 3 months after VFIA (fat, carboxymethylcellulose gel, hyaluronic acid). Results: Thirty-four patients (20 female) underwent VFIA. The mean age at the time of the injection was 13.6 years (SD 6.1). Twenty patients (58.8%) had a history of prematurity and a mean of 1.8 open airway surgeries. After injection, 29/34 patients (85.3%) noted a subjective voice improvement. The baseline Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) overall severity score decreased by a mean of 5.7 (SD = 19.6) points, Conclusion: Patients with PARD represent a complex subset of patients. VFIA is a straightforward intervention that may improve voice perception. Many patients reported subjective improvement despite minimal objective measurement. Further work is warranted to elucidate the role of injection in management of PARD.
Language	English
Publishing date	2021-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/00034894211012594
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Article ; Online: Contrasting life-history traits of black spruce and jack pine influence their physiological response to drought and growth recovery in northeastern boreal Canada.

Marchand, William / Girardin, Martin P / Hartmann, Henrik / Lévesque, Mathieu / Gauthier, Sylvie / Bergeron, Yves

The Science of the total environment

2021 Volume 794, Page(s) 148514

Abstract: An increase in frequency, intensity and duration of drought events affects forested ecosystems. Trees react to these changes by adjusting stomatal conductance to maximize the trade-off between carbon gains and water losses. A better understanding of the ... ...

Abstract	An increase in frequency, intensity and duration of drought events affects forested ecosystems. Trees react to these changes by adjusting stomatal conductance to maximize the trade-off between carbon gains and water losses. A better understanding of the consequences of these drought-induced physiological adjustments for tree growth could help inferring future productivity potentials of boreal forests. Here, we used samples from a forest inventory network in Canada where a decline in growth rates of black spruce (Picea mariana (Mill.) B.S.P.) and jack pine (Pinus banksiana Lamb.) occurred in 1988-1992, an exceptionally dry period, to verify if this growth decline resulted from physiological adjustments of trees to drought. We measured carbon and oxygen isotope ratios in growth rings of 95 spruces and 49 pines spanning 1985-1993. We used
MeSH term(s)	Canada ; Droughts ; Ecosystem ; Picea ; Pinus ; Trees
Language	English
Publishing date	2021-06-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.148514
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