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Article ; Online: Higher-order G-quadruplex structures and porphyrin ligands: Towards a non-ambiguous relationship.

Falanga, Andrea Patrizia / D'Urso, Alessandro / Travagliante, Gabriele / Gangemi, Chiara Maria Antonietta / Marzano, Maria / D'Errico, Stefano / Terracciano, Monica / Greco, Francesca / De Stefano, Luca / Dardano, Principia / Rea, Ilaria / Piccialli, Gennaro / Oliviero, Giorgia / Borbone, Nicola

International journal of biological macromolecules

2024 , Page(s) 131801

Abstract: Herein, we evaluated the interaction of the tetracationic porphyrin ... ...

Abstract	Herein, we evaluated the interaction of the tetracationic porphyrin H
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131801
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Article ; Online: The Hairpin Form of r(G

Wang, Zi-Fu / Ursu, Andrei / Childs-Disney, Jessica L / Guertler, Rea / Yang, Wang-Yong / Bernat, Viachaslau / Rzuczek, Suzanne G / Fuerst, Rita / Zhang, Yong-Jie / Gendron, Tania F / Yildirim, Ilyas / Dwyer, Brendan G / Rice, Joseph E / Petrucelli, Leonard / Disney, Matthew D

Cell chemical biology

2018 Volume 26, Issue 2, Page(s) 179–190.e12

Abstract: ... FTD) is an expanded G ...

Abstract	The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G
MeSH term(s)	Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Binding Sites ; C9orf72 Protein/genetics ; DNA Repeat Expansion/genetics ; Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/pathology ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Nuclear Magnetic Resonance, Biomolecular ; Nucleic Acid Conformation ; Polyribosomes/drug effects ; Polyribosomes/metabolism ; Protein Biosynthesis/drug effects ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/pharmacology ; Thermodynamics
Chemical Substances	C9orf72 Protein ; RNA-Binding Proteins ; Small Molecule Libraries
Language	English
Publishing date	2018-11-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2451-9448
ISSN (online)	2451-9448
DOI	10.1016/j.chembiol.2018.10.018
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Article ; Online: Pharmacological targeting of G protein-coupled receptor heteromers.

Moreno, Estefanía / Casajuana-Martin, Nil / Coyle, Michael / Campos, Baruc Campos / Galaj, Ewa / Del Torrent, Claudia Llinas / Seyedian, Arta / Rea, William / Cai, Ning-Sheng / Bonifazi, Alessandro / Florán, Benjamín / Xi, Zheng-Xiong / Guitart, Xavier / Casadó, Vicent / Newman, Amy H / Bishop, Christopher / Pardo, Leonardo / Ferré, Sergi

Pharmacological research

2022 Volume 185, Page(s) 106476

Abstract: A main rationale for the role of G protein-coupled receptor (GPCR) heteromers as targets for drug ...

Abstract	A main rationale for the role of G protein-coupled receptor (GPCR) heteromers as targets for drug development is the putative ability of selective ligands for specific GPCRs to change their pharmacological properties upon GPCR heteromerization. The present study provides a proof of concept for this rationale by demonstrating that heteromerization of dopamine D
MeSH term(s)	Animals ; Rats ; Mice ; Levodopa ; Receptors, Dopamine D3/agonists ; Receptors, Dopamine D1/agonists ; Dopamine ; Receptors, G-Protein-Coupled ; Ligands ; Dyskinesias
Chemical Substances	N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-3-yl)benzamide ; Levodopa (46627O600J) ; N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-pyridine-2-ylbenzamide ; Receptors, Dopamine D3 ; Receptors, Dopamine D1 ; Dopamine (VTD58H1Z2X) ; Receptors, G-Protein-Coupled ; Ligands
Language	English
Publishing date	2022-09-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2022.106476
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Article ; Online: Biased G Protein-Independent Signaling of Dopamine D

Guitart, Xavier / Moreno, Estefanía / Rea, William / Sánchez-Soto, Marta / Cai, Ning-Sheng / Quiroz, César / Kumar, Vivek / Bourque, Liam / Cortés, Antoni / Canela, Enric I / Bishop, Christopher / Newman, Amy H / Casadó, Vicent / Ferré, Sergi

Molecular neurobiology

2019 Volume 56, Issue 10, Page(s) 6756–6769

Abstract: Several studies found in vitro evidence for heteromerization of dopamine ... ...

Abstract	Several studies found in vitro evidence for heteromerization of dopamine D
MeSH term(s)	Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Drug Synergism ; GTP-Binding Proteins/metabolism ; HEK293 Cells ; Humans ; Isoquinolines/pharmacology ; Male ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; Models, Biological ; Motor Activity/drug effects ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Peptides/metabolism ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D3/antagonists & inhibitors ; Receptors, Dopamine D3/metabolism ; Salicylamides/pharmacology ; Signal Transduction ; Sulfonamides/pharmacology
Chemical Substances	Isoquinolines ; Peptides ; Receptors, Dopamine D1 ; Receptors, Dopamine D3 ; Salicylamides ; Sulfonamides ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; GTP-Binding Proteins (EC 3.6.1.-) ; eticlopride (J8M468HBH4) ; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide (M876330O56)
Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-019-1564-8
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Article: Self-Assembly of G-Rich Oligonucleotides Incorporating a 3'-3' Inversion of Polarity Site: A New Route Towards G-Wire DNA Nanostructures.

Oliviero, Giorgia / D'Errico, Stefano / Pinto, Brunella / Nici, Fabrizia / Dardano, Principia / Rea, Ilaria / De Stefano, Luca / Mayol, Luciano / Piccialli, Gennaro / Borbone, Nicola

ChemistryOpen

2017 Volume 6, Issue 4, Page(s) 599–605

Abstract: ... medical sciences. Herein, we report a novel strategy to obtain structurally homogeneous DNA G-wire nanostructures ... of known length, starting from the short unmodified G-rich oligonucleotide d(5'-CGGT-3'-3'-GGC-5') ( ...

Abstract	Obtaining DNA nanostructures with potential applications in drug discovery, diagnostics, and electronics in a simple and affordable way represents one of the hottest topics in nanotechnological and medical sciences. Herein, we report a novel strategy to obtain structurally homogeneous DNA G-wire nanostructures of known length, starting from the short unmodified G-rich oligonucleotide d(5'-CGGT-3'-3'-GGC-5') (
Language	English
Publishing date	2017-06-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2655605-4
ISSN	2191-1363
ISSN	2191-1363
DOI	10.1002/open.201700024
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Article ; Online: Impact of Resistance Exercise and Nutritional Endorsement on physical performance in patients with GvHD (IRENE-G study) - design and rational of a randomized controlled trial.

Bujan Rivera, Janina / Kühl, Rea / Zech, Ulrike / Hendricks, Anne / Luft, Thomas / Dreger, Peter / Friedmann-Bette, Birgit / Betz, Theresa-Maria / Wiskemann, Joachim

BMC cancer

2022 Volume 22, Issue 1, Page(s) 440

Abstract: ... Study (IRENE-G) is to evaluate the effects of resistance exercise in combination with nutritional ... endorsement on physical, nutritional and patient-reported outcomes in GvHD patients.: Methods: IRENE-G is ...

Abstract	Background: Graft-versus-host disease (GvHD) remains a major complication and limitation to successful allogeneic hematopoietic stem cell transplantation. Treatment of GvHD is challenging due to its heterogeneous nature of presentation, with steroids remaining the established first-line treatment. Long-term doses of systemic corticosteroids have many well-known side-effects including muscle atrophy. Despite the fact that reports in non-cancer clinical populations treated with glucocorticoids demonstrated that resistance training can reverse atrophy and weakness, no RCT has evaluated the potential of resistance training on preventing the disease- and treatment-induced loss of skeletal muscle mass and function in GvHD patients yet. In this context, ensuring adequate nutrition is important as protein deprivation may accelerate the wasting process. As GvHD patients are commonly found to be malnourished, nutritional medical care should be considered when investigating the effect of exercise in GvHD patients. Therefore, the aim of the present "Impact of Resistance Exercise and Nutritional Endorsement on physical performance in patients with GvHD" - Study (IRENE-G) is to evaluate the effects of resistance exercise in combination with nutritional endorsement on physical, nutritional and patient-reported outcomes in GvHD patients. Methods: IRENE-G is a 24-week prospective interventional RCT. One hundred twelve participants will be randomly allocated (1:1) to one of two arms: resistance exercise and nutritional optimization (experimental) vs. nutritional optimization only (control). Participants in the experimental group will engage in a supervised, progressive moderate-to-high intensity resistance training that is consistent with exercise guidelines for cancer patients, while additionally receiving nutritional support/therapy. Subjects of the control group solely receive nutritional support/therapy based on individual needs. Participants will be assessed at baseline, at 8, 16, 24 weeks for physical performance and various physiological, nutritional and patient-reported outcomes. Follow-up will be 6 months after intervention completion. Discussion: To our knowledge, this will be the first RCT to assess and compare the effects of a resistance intervention supplemented by nutritional support/therapy against nutritional support only on various health-related outcomes in GvHD patients. The study will contribute to our understanding of the value of exercise and nutritional endorsement in counteracting the negative consequences of GvHD and its treatment. Trial registration: ClinicalTrials.gov : NCT05111834 . Registered 8 November 2021 - Retrospectively registered.
MeSH term(s)	Exercise ; Graft vs Host Disease/etiology ; Graft vs Host Disease/therapy ; Humans ; Physical Functional Performance ; Prospective Studies ; Resistance Training
Language	English
Publishing date	2022-04-22
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-022-09497-1
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Article ; Online: Enhanced quantification of serum immunoglobulin G from a non-model wildlife species, the Steller sea lion (Eumetopias jubatus), using a protein A ELISA.

Kennedy, Stephanie N / Wilhite, Brittany / Margaret Castellini, J / Rea, Lorrie D / Kuhn, Thomas B / Ferrante, Andrea / O'Hara, Todd M

Journal of immunological methods

2018 Volume 462, Page(s) 42–47

Abstract: ... methodology utilizing the binding properties of Staphylococcus-derived Protein A (PrtA) to immunoglobulin G ...

Abstract	Immunoglobulins (Ig) are proteins that preserve immune homeostasis and are quantified to infer changes to the acquired humoral immune response in mammals. Measuring Ig in non-model wildlife for immune surveillance often requires ingenuity, and rigorous standardization of methodologies to provide reliable results especially when lacking species-specific reagents. We modified and optimized existing ELISA methodology utilizing the binding properties of Staphylococcus-derived Protein A (PrtA) to immunoglobulin G (IgG). We enhanced the assay for quantifying IgG in Steller sea lion (SSL) serum using critical quality control measures including dilution linearity, spike and percent recoveries, and internal controls. Of the modifications made, heat treatment of SSL serum enhanced accuracy and precision of IgG measurements by improving linearity and percent recovery in parallel dilutions and serum spikes. Purified canine IgG standard was not affected by heat inactivation. These results support that confounding serum proteins interfere with binding of PrtA with IgG demonstrating the need for heat treatment of serum to optimize IgG quantification using the PrtA-ELISA. Further, essential validation measures ensure proper assay performance. Consequently, the improved PrtA-ELISA provides species-independent IgG detection with validation criteria to enhance accuracy and precision for addressing future immunological questions in non-model wildlife in clinical, ecological, and conservation contexts.
MeSH term(s)	Animals ; Dogs ; Enzyme-Linked Immunosorbent Assay/methods ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Sea Lions
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2018-08-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2018.08.004
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Article: Enhanced quantification of serum immunoglobulin G from a non-model wildlife species, the Steller sea lion (Eumetopias jubatus), using a protein A ELISA

Kennedy, Stephanie N / Andrea Ferrante / Brittany Wilhite / J. Margaret Castellini / Lorrie D. Rea / Todd O'Hara / Tom Kuhn

Journal of immunological methods. 2018,

2018

Abstract: ... methodology utilizing the binding properties of Staphylococcus-derived Protein A (PrtA) to immunoglobulin G ...

Abstract	Immunoglobulins (Ig) are proteins that preserve immune homeostasis and are quantified to infer changes to the acquired humoral immune response in mammals. Measuring Ig in non-model wildlife for immune surveillance often requires ingenuity, and rigorous standardization of methodologies to provide reliable results especially when lacking species-specific reagents. We modified and optimized existing ELISA methodology utilizing the binding properties of Staphylococcus-derived Protein A (PrtA) to immunoglobulin G (IgG). We enhanced the assay for quantifying IgG in Steller sea lion (SSL) serum using critical quality control measures including dilution linearity, spike and percent recoveries, and internal controls. Of the modifications made, heat treatment of SSL serum enhanced accuracy and precision of IgG measurements by improving linearity and percent recovery in parallel dilutions and serum spikes. Purified canine IgG standard was not affected by heat inactivation. These results support that confounding serum proteins interfere with binding of PrtA with IgG demonstrating the need for heat treatment of serum to optimize IgG quantification using the PrtA-ELISA. Further, essential validation measures ensure proper assay performance. Consequently, the improved PrtA-ELISA provides species-independent IgG detection with validation criteria to enhance accuracy and precision for addressing future immunological questions in non-model wildlife in clinical, ecological, and conservation contexts.
Keywords	binding properties ; blood serum ; crystal proteins ; dogs ; enzyme-linked immunosorbent assay ; Eumetopias jubatus ; heat inactivation ; heat treatment ; homeostasis ; humoral immunity ; immunoglobulin G ; insecticidal proteins ; monitoring ; quality control ; wildlife
Language	English
Size	p. .
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2018.08.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: CARVALHO, E. J. G. . Políticas Públicas e Gestão da Educação no Brasil. 1. ed. Maringá

REA Editor

Revista Espaço Acadêmico, Vol 13, Iss

EDUEM, 2012. 317p

2013 Volume 144

Keywords	Social sciences (General) ; H1-99
Language	Portuguese
Publishing date	2013-05-01T00:00:00Z
Publisher	Universidade Estadual de Maringá
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Functional Nanomaterials for Healthcare

Terracciano, Monica / Rea, Ilaria / Borbone, Nicola / Tramontano, Chiara

2023

Keywords	Technology: general issues ; Biotechnology ; mitochondrial targeting ; gold nanoparticles ; cancer chemotherapy ; drug delivery ; betulinic acid ; laminin receptor ; zinc oxide nanoparticles ; organic surface deposit ; cytotoxicity assay ; photocatalytic activity ; ROS generation ; toxicity mechanism ; MDA-MB-231 ; HT-29 ; ebselen ; cerium ; ERK1/2 ; STAT-6 ; IL-4 ; STAT-1 ; antimicrobial activity ; carbon nanotubes ; human SP-D ; cancer cells ; apoptosis ; immunotherapy ; Alhydrogel® ; silica nanoparticles ; Bet v 1 ; BM4 ; SiO2 ; allergen ; structural integrity ; alum ; nanoparticles ; antimicrobial resistance ; bacteria ; resistance mechanism ; hyaluronic acid ; adipic acid dihydrazide ; silver nanoparticles ; polymer molecular weight ; antimicrobial ; SARS-CoV-2 ; protein nanoparticles ; vaccines ; nanovaccine ; nanomedicine ; protein-based nanotechnology ; graphene oxide ; biopolymer blends ; biomineralization ; ectopic bone formation ; osteoinduction ; ex vivo analysis ; nanotechnology ; cosmetic ; chitosan ; essential oils ; preservative agents ; metal-organic framework ; cardiovascular diseases ; graphene ; G+ ; PLA ; Grafylon ; scaffold ; neuronal differentiation ; stem cells ; 3D printing ; regenerative medicine ; Curcumin ; Paclitaxel ; triple-negative breast cancer cell lines (4T1 and MDA MB 231) ; metastasis ; capsaicin ; human ; pruritogens ; desensitization ; itch ; polymers ; compartments ; biomedical ; mesoporous silica nanoparticles ; MSN ; porous materials ; functionalisation ; NMR ; HR-MAS NMR ; surface ; COVID-19 ; cationic surfactants ; virucidal activity ; quaternary ammonium compounds ; disinfectants ; nanoprophylaxis ; viral inhibition ; human papillomavirus ; HPV ; pseudovirus ; viral infection inhibition ; nanocomplex formation ; photodynamic therapy ; photosensitizer ; upconversion nanoparticles ; graphene quantum dots ; reactive oxygen species ; green synthesis ; carbon nanomaterials ; biomass ; sustainability ; nanomaterials ; machine learning ; antioxidant ; biopolymers ; therapeutic substances ; incorporation ; biocompatibility ; healthcare ; biomedical applications ; surface characterization ; quantum yield ; label-free detection ; zinc oxide nanostructure ; surface functionalization ; mesoporous polydopamine ; ferric ions ; doxorubicin (DOX) ; hyaluronic acid target modification
Language	English
Size	1 electronic resource (482 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030645650
ISBN	9783036591025 ; 3036591028
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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