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Article ; Online: A comparison of the isostructural [Co(NH

Kalinina, Polina P / Marchuk, Alexander S / Sahoo, Subash / Zakharov, Boris A / Boldyreva, Elena V

Acta crystallographica Section B, Structural science, crystal engineering and materials

2024

Abstract: A new photoactive cobalt coordination compound, [Co( ... ...

Abstract	A new photoactive cobalt coordination compound, [Co(NH
Language	English
Publishing date	2024-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2020841-8
ISSN	2052-5206 ; 1600-5740 ; 1600-8650 ; 2052-5192
ISSN (online)	2052-5206 ; 1600-5740 ; 1600-8650
ISSN	2052-5192
DOI	10.1107/S2052520624002816
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Article ; Online: Subjective factors of travel activity for the purpose of cultural support of biological diversity for individuals with different success levels

Shcherbakova Tatyana / Zvezdina Galina / Kalinina Elena

BIO Web of Conferences, Vol 84, p

2024 Volume 04040

Abstract: It is shown that the activity of a person’s travels is associated with his psychological characteristics, ideological attitudes, needs for new connections and knowledge. Travel is endowed with a psychological resource that allows you to actualize the ... ...

Abstract	It is shown that the activity of a person’s travels is associated with his psychological characteristics, ideological attitudes, needs for new connections and knowledge. Travel is endowed with a psychological resource that allows you to actualize the motivation for positive personality transformations. A system of internal factors for personal travel activity is identified and described: direction, tolerance for uncertainty, interests, tendency to accept novelty and test one’s capabilities. The factors that determine the specificity of travel trajectory choice and tourist programs’ types in the conditions of modern realities are described. The content of external and internal factors that can enhance the psychological resource of travel as a platform for self-development and personal improvement is shown. The role of travel in cognitive, communicative and personal transformations, in the development of the subject’s ability to productively solve complex situations and effective activity in conditions of uncertainty is shown. The novelty of the study lies in the identification and subjective factors’ description of travel activity for individuals with different success levels. Empirically, studies have identified severity indicators of tolerance and intolerance to uncertainty among participants in tourism programs with different statuses of success and self-efficacy.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Subject code	380
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article: Inflammatory and Anti-Inflammatory Parameters in PCOS Patients Depending on Body Mass Index: A Case-Control Study.

Vasyukova, Elena / Zaikova, Ekaterina / Kalinina, Olga / Gorelova, Inga / Pyanova, Irina / Bogatyreva, Elena / Vasilieva, Elena / Grineva, Elena / Popova, Polina

Biomedicines

2023 Volume 11, Issue 10

Abstract: Background: it has been suggested that chronic low-grade inflammation plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS). According to previous studies, it remains unclear which cytokines influence the development of this ... ...

Abstract	Background: it has been suggested that chronic low-grade inflammation plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS). According to previous studies, it remains unclear which cytokines influence the development of this syndrome and whether their increase is associated with the presence of excess weight/obesity or is an independent factor. The aim of our research was to determine the parameters of chronic inflammation in women with PCOS in comparison with healthy women in the normal weight and the overweight subgroups. Methods: This case-control study included 44 patients with PCOS (19 women with a body mass index (BMI) < 25 kg/m² and 25 women with a BMI ≥ 25 kg/m²) and 45 women without symptoms of PCOS (22 women with a BMI < 25 kg/m² and 23 women with a BMI ≥ 25 kg/m²). Thirty-two cytokines were analyzed in the plasma of the participants using Immunology multiplex assay HCYTA-60K-PX48 (Merck Life Science, LLC, Germany). Results: Cytokines: interleukin-1 receptor antagonist (IL-1 RA), IL-2, IL-6, IL-17 E, IL-17 A, IL-18, and macrophage inflammatory protein-1 alpha (MIP-1 α) were increased in women with PCOS compared to controls, both in lean and overweight/obese subgroups ( Conclusion: Chronic low-grade inflammation is an independent factor affecting the occurrence of PCOS and does not depend on the presence of excess weight/obesity. For the first time, we obtained data on the increase in such inflammatory parameters as IL-9, MCP-3, and MIP-1α in women with PCOS.
Language	English
Publishing date	2023-10-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11102791
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Article: Clinical Relevance of Secreted Small Noncoding RNAs in an Embryo Implantation Potential Prediction at Morula and Blastocyst Development Stages.

Timofeeva, Angelika V / Fedorov, Ivan S / Shamina, Maria A / Chagovets, Vitaliy V / Makarova, Nataliya P / Kalinina, Elena A / Nazarenko, Tatiana A / Sukhikh, Gennady T

Life (Basel, Switzerland)

2021 Volume 11, Issue 12

Abstract: Despite the improvements in biotechnological approaches and the selection of controlled ovarian hyperstimulation protocols, the resulting pregnancy rate from in vitro fertilization (IVF) protocols still does not exceed 30-40%. In this connection, there ... ...

Abstract	Despite the improvements in biotechnological approaches and the selection of controlled ovarian hyperstimulation protocols, the resulting pregnancy rate from in vitro fertilization (IVF) protocols still does not exceed 30-40%. In this connection, there is an acute question of the development of a non-invasive, sensitive, and specific method for assessing the implantation potential of an embryo. A total of 110 subfertile couples were included in the study to undergo the IVF/ICSI program. Obtained embryos for transfer into the uterine cavity of patient cohort 1 (
Language	English
Publishing date	2021-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life11121328
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Article ; Online: Assessment of the digital transformation impact on the structural changes dynamics in the Russian economy

Petrova Elena / Buyanova Marina / Kalinina Vera

E3S Web of Conferences, Vol 389, p

2023 Volume 09052

Abstract: The purpose of this study is a quantitative assessment of the structural changes dynamics; the authors propose to assess these shifts based on an analysis of changes occurring within the economy sectoral structure and the gross value added in recent ... ...

Abstract	The purpose of this study is a quantitative assessment of the structural changes dynamics; the authors propose to assess these shifts based on an analysis of changes occurring within the economy sectoral structure and the gross value added in recent years. Another purpose is to identify the relations between economic development and the digital technologies use in the Russian economy in general, which allow to evaluate the effectiveness of the strategy implementation as part of the development of the Digital Economy in the country in general. The Gatev’s coefficient is the most effective tool for calculating the magnitude of structural changes, it allows to evaluate the dynamics of changes, as well as to identify structural changes based on the effectiveness. The empirical base of the study consists of statistical materials on the gross value added reflected in the industry structure, statistical publications on the use of various types of digital technologies and on digital technology expenses from 2005 to 2022. The study identified the trends of the Gatev’s structural changes coefficients dynamics and provided their quantitative assessment according to the selected indicators for Russia. An analysis of the comparability of economical structural changes both in terms of the use and the costs of digital technologies was carried out. The obtained results of the quantitative assessment served as the basis for substantiating the identified dynamics for the quantitative assessment of the structural changes taking place in the country's economy and the dynamics of the use of digital technologies.
Keywords	Environmental sciences ; GE1-350
Subject code	330
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Glutathione in Protein Redox Modulation through S-Glutathionylation and S-Nitrosylation

Elena Kalinina / Maria Novichkova

Molecules, Vol 26, Iss 2, p

2021 Volume 435

Abstract: S-glutathionylation and S-nitrosylation are reversible post-translational modifications on the cysteine thiol groups of proteins, which occur in cells under physiological conditions and oxidative/nitrosative stress both spontaneously and enzymatically. ... ...

Abstract	S-glutathionylation and S-nitrosylation are reversible post-translational modifications on the cysteine thiol groups of proteins, which occur in cells under physiological conditions and oxidative/nitrosative stress both spontaneously and enzymatically. They are important for the regulation of the functional activity of proteins and intracellular processes. Connecting link and “switch” functions between S-glutathionylation and S-nitrosylation may be performed by GSNO, the generation of which depends on the GSH content, the GSH/GSSG ratio, and the cellular redox state. An important role in the regulation of these processes is played by Trx family enzymes (Trx, Grx, PDI), the activity of which is determined by the cellular redox status and depends on the GSH/GSSG ratio. In this review, we analyze data concerning the role of GSH/GSSG in the modulation of S-glutathionylation and S-nitrosylation and their relationship for the maintenance of cell viability.
Keywords	S-glutathionylation ; S-nitrosylation ; GSH ; nitrosoglutathione ; redox-regulation ; Organic chemistry ; QD241-441
Subject code	500
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The role of load-dependent sensory input in the control of balance during gait in rats.

Popov, Alexander / Lyakhovetskii, Vsevolod / Bazhenova, Elena / Gorskii, Oleg / Kalinina, Daria / Merkulyeva, Natalia / Musienko, Pavel

The Journal of experimental biology

2021 Volume 224, Issue 15

Abstract: Locomotor activity requires fine balance control that strongly depends on the afferent input from the load receptors. Following hindlimb unloading (HU), the kinematic and EMG activity of the hindlimbs is known to change significantly. However, the ... ...

Abstract	Locomotor activity requires fine balance control that strongly depends on the afferent input from the load receptors. Following hindlimb unloading (HU), the kinematic and EMG activity of the hindlimbs is known to change significantly. However, the effects of HU on the integrative control mechanisms of posture and locomotion are not clear. The goal of the present study was to evaluate the center of mass (CoM) dynamic stabilization and associated adaptive changes in the trunk and hindlimb muscle activity during locomotion after 7 days of HU. The EMG signals from the muscles of the low lumbar trunk [m. longissimus dorsi (VERT)] and the hind limb [m. tibialis anterior (TA), m. semitendinosus (ST), m. soleus (SOL)] were recorded together with the hindquarter kinematics during locomotion on a treadmill in six rats before and after HU. The CoM lateral shift in the step cycle significantly increased after HU and coincided with the enhanced activity of the VERT. The mean EMG of the TA and the ST flexor activity increased significantly with reduction of their burst duration. These data demonstrate the disturbances of body balance after HU that can influence the basic parameters of locomotor activity. The load-dependent mechanisms resulted in compensatory adjustments of flexor activity toward a faster gait strategy, such as a trot or gallop, which presumably have supraspinal origin. The neuronal underpinnings of these integrative posture and locomotion mechanisms and their possible reorganization after HU are discussed.
MeSH term(s)	Animals ; Electromyography ; Gait ; Hindlimb ; Locomotion ; Muscle, Skeletal ; Rats
Language	English
Publishing date	2021-08-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218085-6
ISSN	1477-9145 ; 0022-0949
ISSN (online)	1477-9145
ISSN	0022-0949
DOI	10.1242/jeb.242138
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Article ; Online: Prognostic value of Doppler echocardiographic coronary flow velocity assessment at rest in elderly patients.

Zagatina, Angela / Kalinina, Elena / Caprnda, Martin / Gaspar, Ludovit / Gazdikova, Katarina / Ullrich, David / Prosecky, Robert / Rodrigo, Luis / Kruzliak, Peter

Acta cardiologica

2022 Volume 78, Issue 4, Page(s) 409–416

Abstract: Background: Atherosclerosis and coronary artery disease (CAD) are a common condition and cause of death in the elderly population. There are difficulties with risk assessment in the elderly as the objectification of their symptomatic status can be ... ...

Abstract	Background: Atherosclerosis and coronary artery disease (CAD) are a common condition and cause of death in the elderly population. There are difficulties with risk assessment in the elderly as the objectification of their symptomatic status can be challenging due to neuromuscular weakness, physical deconditioning or neurological, orthopaedic, peripheral vascular, or respiratory limitations. Non-invasive coronary artery velocity assessment by Doppler method at rest could be helpful in the elderly population. To evaluate the prognostic role of coronary artery ultrasound assessment in a non-selected elderly population in everyday clinical practice. Methods: One hundred forty-five patients, aged ≥75years (99 women; 80 ± 4 years), formed the study group. Left coronary artery flows were scanned in addition to conventional echocardiography. During a median follow-up of 26 months, 16 deaths and 2 non-fatal MI occurred. Results: In multivariable analysis, maximal coronary velocity was the only independent predictor for mortality (heart rate [HR]: 1.02, 95%, CI: 1.01-1.04, Conclusion: Doppler CFL scanning during routine echocardiography is a feasible and valuable tool for assessment of short-term prognosis in elderly patients.
MeSH term(s)	Humans ; Aged ; Female ; Prognosis ; Echocardiography, Doppler/methods ; Coronary Artery Disease ; Echocardiography ; Blood Flow Velocity/physiology ; Coronary Circulation/physiology
Language	English
Publishing date	2022-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	390197-x
ISSN	1784-973X ; 0001-5385
ISSN (online)	1784-973X
ISSN	0001-5385
DOI	10.1080/00015385.2022.2121538
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Article ; Online: Newborn Screening for Severe T and B Cell Lymphopenia Using TREC/KREC Detection: A Large-Scale Pilot Study of 202,908 Newborns.

Marakhonov, Andrey V / Efimova, Irina Yu / Mukhina, Anna A / Zinchenko, Rena A / Balinova, Natalya V / Rodina, Yulia / Pershin, Dmitry / Ryzhkova, Oxana P / Orlova, Anna A / Zabnenkova, Viktoriia V / Cherevatova, Tatiana B / Beskorovainaya, Tatiana S / Shchagina, Olga A / Polyakov, Alexander V / Markova, Zhanna G / Minzhenkova, Marina E / Shilova, Nadezhda V / Larin, Sergey S / Khadzhieva, Maryam B /

Dudina, Ekaterina S / Kalinina, Ekaterina V / Mudaeva, Dzhaina A / Saydaeva, Djamila H / Matulevich, Svetlana A / Belyashova, Elena Yu / Yakubovskiy, Grigoriy I / Tebieva, Inna S / Gabisova, Yulia V / Irinina, Nataliya A / Nurgalieva, Liya R / Saifullina, Elena V / Belyaeva, Tatiana I / Romanova, Olga S / Voronin, Sergey V / Shcherbina, Anna / Kutsev, Sergey I

Journal of clinical immunology

2024 Volume 44, Issue 4, Page(s) 93

Abstract: Newborn screening (NBS) for severe inborn errors of immunity (IEI), affecting T lymphocytes, and implementing measurements of T cell receptor excision circles (TREC) has been shown to be effective in early diagnosis and improved prognosis of patients ... ...

Abstract	Newborn screening (NBS) for severe inborn errors of immunity (IEI), affecting T lymphocytes, and implementing measurements of T cell receptor excision circles (TREC) has been shown to be effective in early diagnosis and improved prognosis of patients with these genetic disorders. Few studies conducted on smaller groups of newborns report results of NBS that also include measurement of kappa-deleting recombination excision circles (KREC) for IEI affecting B lymphocytes. A pilot NBS study utilizing TREC/KREC detection was conducted on 202,908 infants born in 8 regions of Russia over a 14-month period. One hundred thirty-four newborns (0.66‰) were NBS positive after the first test and subsequent retest, 41% of whom were born preterm. After lymphocyte subsets were assessed via flow cytometry, samples of 18 infants (0.09‰) were sent for whole exome sequencing. Confirmed genetic defects were consistent with autosomal recessive agammaglobulinemia in 1/18, severe combined immunodeficiency - in 7/18, 22q11.2DS syndrome - in 4/18, combined immunodeficiency - in 1/18 and trisomy 21 syndrome - in 1/18. Two patients in whom no genetic defect was found met criteria of (severe) combined immunodeficiency with syndromic features. Three patients appeared to have transient lymphopenia. Our findings demonstrate the value of implementing combined TREC/KREC NBS screening and inform the development of policies and guidelines for its integration into routine newborn screening programs.
MeSH term(s)	Infant ; Infant, Newborn ; Humans ; Neonatal Screening/methods ; Pilot Projects ; Lymphopenia/diagnosis ; T-Lymphocytes ; Severe Combined Immunodeficiency/diagnosis ; Severe Combined Immunodeficiency/genetics ; DNA ; Receptors, Antigen, T-Cell/genetics
Chemical Substances	DNA (9007-49-2) ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2024-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-024-01691-z
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Article ; Online: Lime soil conditioner based on soda production sludge for reclamation of industry-disturbed soils in the impact zone of an oil refinery

Kalinina Elena / Rudakova Larisa

E3S Web of Conferences, Vol 217, p

2020 Volume 10003

Abstract: The paper presents the results of a study on the use of soda production sludge (SPS) as a lime soil conditioner. SPS with a less than 0.1 mm fraction is the most suitable in terms of physical, chemical, and toxicological properties and meets the ... ...

Abstract	The paper presents the results of a study on the use of soda production sludge (SPS) as a lime soil conditioner. SPS with a less than 0.1 mm fraction is the most suitable in terms of physical, chemical, and toxicological properties and meets the requirements of GOST-14050-93 «Limestone (dolomite) dust. Specifications» on the content of the active substance, the mass fraction of calcium and magnesium carbonates. Reclamative properties of SPS were studied on soil samples taken in the territory removed from the sanitary protection zone of the oil refinery. It was found that all soil samples have a phytotoxic effect on pea seedlings. The introduction of SPS in amount of 1-3 g per kg of soil stimulates the development of the ground part and roots of oats and peas, and also increases the germination energy of oat and pea seeds in the initial soil samples by 2÷10 times. The introduction of SPS into the samples of the studied soils at a dose of 1-3 g/kg stimulates the development of colonies of Azotobacter bacteria and leads to an increase in the total number of soil microorganisms. The introduction of SPS in an amount of 3 g per kilo of soil leads to a slight increase in the environment reaction and an increase in the content of water-soluble salts in the soil up to 2 times. In view of this, it is necessary to control that the content of water-soluble salts does not exceed the established standards. Based on the results obtained, we consider it expedient to use soda production sludge as a lime soil conditioner and for the reclamation of industry-disturbed soils.
Keywords	Environmental sciences ; GE1-350
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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