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Article ; Online: Sustainable dispersive liquid-liquid microextraction method utilizing a natural deep eutectic solvent for determination of chloramphenicol in honey: assessment of the environmental impact of the developed method.

Shaaban, Heba

RSC advances

2023 Volume 13, Issue 8, Page(s) 5058–5069

Abstract: The greening of pharmaceutical analysis is gaining interest, and different approaches have been proposed, such as minimizing the consumption of hazardous reagents, replacing toxic solvents with safer alternatives, and reducing waste generation. In this ... ...

Abstract	The greening of pharmaceutical analysis is gaining interest, and different approaches have been proposed, such as minimizing the consumption of hazardous reagents, replacing toxic solvents with safer alternatives, and reducing waste generation. In this work, a natural deep eutectic solvent (NADES) was synthesized and utilized as a green alternative in dispersive liquid-liquid microextraction (DLLME) for the determination of chloramphenicol in honey. Different deep eutectic solvents composed of monoterpenoids and acids were tested. The NADES system composed of menthol and acetic acid at a molar ratio of 1 : 1 was found to be the most appropriate in terms of extraction recovery. Different DLLME parameters including vortex time, centrifugation time, sample volume, and deep eutectic solvent volume were optimized. A determination coefficient of 0.9997 was achieved. Satisfactory recovery ranged from 98.8 to 101.5 with % RSD ≤4.5. The chromatographic performance of the presented method compared with other previously documented methods for determination of chloramphenicol in honey was highlighted. Additionally, the ecological impact of the developed method was assessed employing three tools: the Analytical Eco-scale, the Green Analytical Procedure Index, and the Analytical GREEnness metric. The presented method can be regarded as a green substitute for the traditional methods used for the determination of chloramphenicol in honey.
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra08221g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The ecological impact of liquid chromatographic methods reported for bioanalysis of COVID-19 drug, hydroxychloroquine: Insights on greenness assessment.

Shaaban, Heba

Microchemical journal : devoted to the application of microtechniques in all branches of science

2022 Volume 184, Page(s) 108145

Abstract: Hydroxychloroquine is a drug that has been widely used during the early stages of COVID-19 pandemic. Different liquid chromatographic methods have been reported for the analysis of hydroxychloroquine in various biological matrices such as human plasma, ... ...

Abstract	Hydroxychloroquine is a drug that has been widely used during the early stages of COVID-19 pandemic. Different liquid chromatographic methods have been reported for the analysis of hydroxychloroquine in various biological matrices such as human plasma, serum, whole blood, oral fluid, rat plasma and tissues. In this comparative study, the most popular tools used for assessing the greenness profile: National Environmental Methods Index (NEMI), Eco-Scale Assessment (ESA), Green Analytical Procedure Index (GAPI) and Analytical Greenness metric (AGREE) were utilized to evaluate the ecological impact of eighteen liquid chromatographic methods developed for the bioanalysis of COVID-19 drug; hydroxychloroquine. NEMI is the simplest tool for evaluating the greenness profile of developed methods, but it is the least informative approach as all the reported methods had the same NEMI pictograms. On the other hand, GAPI is a dependable tool providing a complete picture about the method greenness starting from sampling until the final determination. ESA and AGREE tools are digitally presented and more easily applied. Therefore, their utilization for greenness assessment is highly recommended. Selection of the highest eco-friendly analytical procedure is of a paramount importance for protecting human health and the environment. Considering the greenness of the analytical procedures is highly recommended before proceeding to routine use in order to minimize the chemical hazards to the environment. The most eco-friendly analytical procedures for the analysis of hydroxychloroquine in biological samples according to ESA, GAPI and AGREE tools will be highlighted and discussed.
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Journal Article
ISSN	0026-265X
ISSN	0026-265X
DOI	10.1016/j.microc.2022.108145
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Article ; Online: GC-MS Determination of Undeclared Phthalate Esters in Commercial Fragrances: Occurrence, Profiles and Assessment of Carcinogenic and Non-Carcinogenic Risk Associated with Their Consumption among Adult Consumers.

Mostafa, Ahmed / Shaaban, Heba

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 4

Abstract: Phthalates are chemicals that are extensively used in the manufacturing of cosmetic products. The occurrence of phthalate esters in personal care products may pose adverse effects on consumers' health. In this work, a simple, fast and reliable GC-MS ... ...

Abstract	Phthalates are chemicals that are extensively used in the manufacturing of cosmetic products. The occurrence of phthalate esters in personal care products may pose adverse effects on consumers' health. In this work, a simple, fast and reliable GC-MS method was developed and validated for concurrent determination of phthalate esters in fragrances. Simple procedures were employed for sample preparation and clean up. The recoveries achieved were in the range of 94.9% to 105.6% with RSD ≤ 4.06. The detection limits were in the range of 0.0010 to 0.0021 µg/mL. The GC-MS method was utilized to investigate the occurrence of phthalate esters in different brands of perfumes sold in the Saudi Arabian market. Diethyl phthalate was detected in all analyzed samples, with a maximum concentration of 5766 µg/mL, and di (2-ethylhexyl) phthalate was detected in the majority of the analyzed samples (95%), with a mean concentration of 55.9 µg/mL and a highest concentration of 377.7 µg/mL. Additionally, the exposure to phthalate esters due to the consumption of perfumes was investigated among the adult Saudi population for the first time. It was found that the systemic exposure dose, measured at mean concentrations, ranged from 4.59 × 10
MeSH term(s)	Female ; Male ; Humans ; Gas Chromatography-Mass Spectrometry ; Carcinogens ; Esters/analysis ; Diethylhexyl Phthalate ; Odorants ; Saudi Arabia ; Phthalic Acids/analysis ; Perfume ; Cosmetics/analysis
Chemical Substances	phthalic acid (6O7F7IX66E) ; Carcinogens ; Esters ; Diethylhexyl Phthalate (C42K0PH13C) ; Phthalic Acids ; Perfume ; Cosmetics
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041689
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Article ; Online: Simultaneous determination of antibiotics residues in edible fish muscle using eco-friendly SPE-UPLC-MS/MS: Occurrence, human dietary exposure and health risk assessment for consumer safety

Shaaban, Heba / Mostafa, Ahmed

Toxicology Reports. 2023, v. 10 p.1-10

2023

Abstract: Occurrence of multi-class antibiotics in edible fish species from the Saudi market was investigated. A fast and sensitive UPLC-MS/MS method for simultaneous determination of selected fluoroquinolones, sulfonamides and macrolides in fish muscle was ... ...

Abstract	Occurrence of multi-class antibiotics in edible fish species from the Saudi market was investigated. A fast and sensitive UPLC-MS/MS method for simultaneous determination of selected fluoroquinolones, sulfonamides and macrolides in fish muscle was developed and validated. Sample clean up was performed using solid-phase extraction on Oasis HLB cartridges. The greenness profile of the developed method was evaluated using three assessment tools: analytical Eco-scale assessment method, green analytical procedure index and analytical greenness metric. Detection limits ranged from 0.008 to 0.35 μg/kg. The recovery ranged from 80.1 % to 98.6 % with RSDs ≤ 12.1 %. The mean and maximum concentrations of the detected antibiotics in fish samples ranged between 0.28 and 19.15 and 3.50–112.00 µg/kg, respectively. Human antibiotics (clarithromycin and roxithromycin) were detected in 50 % and 27.5 % of the samples, respectively. The estimated daily intake for the detected antibiotics ranged from 0.10 to 6.61 ng/kg/ BW/day for Saudi adults. The health risk associated with fish consumption was evaluated. The results suggested that fish consumption may not pose a serious risk to consumers in Saudi Arabia. The developed method was fast, sensitive, cost-effective and environmentally friendly.
Keywords	average daily intake ; clarithromycin ; cost effectiveness ; dietary exposure ; fish ; fish consumption ; fluoroquinolones ; health effects assessments ; humans ; markets ; muscles ; product safety ; risk ; roxithromycin ; solid phase extraction ; toxicology ; Saudi Arabia ; UPLC-MS/MS ; Aquaculture ; Antibiotics ; Greenness assessment ; Human health risk ; Estimated daily intake
Language	English
Size	p. 1-10.
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2805786-7
ISSN	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.11.010
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Simultaneous determination of antibiotics residues in edible fish muscle using eco-friendly SPE-UPLC-MS/MS: Occurrence, human dietary exposure and health risk assessment for consumer safety.

Shaaban, Heba / Mostafa, Ahmed

Toxicology reports

2022 Volume 10, Page(s) 1–10

Abstract	Occurrence of multi-class antibiotics in edible fish species from the Saudi market was investigated. A fast and sensitive UPLC-MS/MS method for simultaneous determination of selected fluoroquinolones, sulfonamides and macrolides in fish muscle was developed and validated. Sample clean up was performed using solid-phase extraction on Oasis HLB cartridges. The greenness profile of the developed method was evaluated using three assessment tools: analytical Eco-scale assessment method, green analytical procedure index and analytical greenness metric. Detection limits ranged from 0.008 to 0.35 μg/kg. The recovery ranged from 80.1 % to 98.6 % with RSDs ≤ 12.1 %. The mean and maximum concentrations of the detected antibiotics in fish samples ranged between 0.28 and 19.15 and 3.50-112.00 µg/kg, respectively. Human antibiotics (clarithromycin and roxithromycin) were detected in 50 % and 27.5 % of the samples, respectively. The estimated daily intake for the detected antibiotics ranged from 0.10 to 6.61 ng/kg/ BW/day for Saudi adults. The health risk associated with fish consumption was evaluated. The results suggested that fish consumption may not pose a serious risk to consumers in Saudi Arabia. The developed method was fast, sensitive, cost-effective and environmentally friendly.
Language	English
Publishing date	2022-11-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.11.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Inhibition of Erythromycin and Erythromycin-Induced Resistance among

Mahfouz, Aya A / Said, Heba S / Elfeky, Sherin M / Shaaban, Mona I

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: The increasing incidence of erythromycin and erythromycin-induced resistance to clindamycin ... ...

Abstract	The increasing incidence of erythromycin and erythromycin-induced resistance to clindamycin among
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12030503
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Article ; Online: New insights into liquid chromatography for more eco-friendly analysis of pharmaceuticals.

Shaaban, Heba

Analytical and bioanalytical chemistry

2016 Volume 408, Issue 25, Page(s) 6929–6944

Abstract: Greening the analytical methods used for analysis of pharmaceuticals has been receiving great interest aimed at eliminating or minimizing the amount of organic solvents consumed daily worldwide without loss in chromatographic performance. Traditional ... ...

Abstract	Greening the analytical methods used for analysis of pharmaceuticals has been receiving great interest aimed at eliminating or minimizing the amount of organic solvents consumed daily worldwide without loss in chromatographic performance. Traditional analytical LC techniques employed in pharmaceutical analysis consume tremendous amounts of hazardous solvents and consequently generate large amounts of waste. The monetary and ecological impact of using large amounts of solvents and waste disposal motivated the analytical community to search for alternatives to replace polluting analytical methodologies with clean ones. In this context, implementing the principles of green analytical chemistry (GAC) in analytical laboratories is highly desired. This review gives a comprehensive overview on different green LC pathways for implementing GAC principles in analytical laboratories and focuses on evaluating the greenness of LC analytical procedures. This review presents green LC approaches for eco-friendly analysis of pharmaceuticals in industrial, biological, and environmental matrices. Graphical Abstract Green pathways of liquid chromatography for more eco-friendly analysis of pharmaceuticals.
Language	English
Publishing date	2016-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-016-9726-2
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Article ; Online: Usage Patterns of Cosmetic and Personal Care Products among Female Population in Saudi Arabia: Important Factors for Exposure and Risk Assessment.

Shaaban, Heba / Alhajri, Wejdan

Journal of environmental and public health

2020 Volume 2020, Page(s) 8434508

Abstract: Reliable data regarding the usage patterns of personal care products (PCPs) are needed to determine the health risks posed by the ingredients of these products such as parabens, phthalates, and bisphenol A. There are no published data regarding the ... ...

Abstract	Reliable data regarding the usage patterns of personal care products (PCPs) are needed to determine the health risks posed by the ingredients of these products such as parabens, phthalates, and bisphenol A. There are no published data regarding the consumption patterns of PCPs in the Middle East in general and in Saudi Arabia in particular. To fill this gap, this study aimed to assess important factors such as the percentage of users and the frequency of use and co-use of twenty-three cosmetic and PCPs among the female population in Saudi Arabia. Additionally, this study aimed to assess the common cosmetic-related adverse events among the participants. The studied products included general hygiene, hair care, skin care, makeup, fragrances, and other products. The data were collected from 709 female participants of different age groups through a digital questionnaire. It was found that eighteen of the investigated products are consumed by at least 50% of the respondents. The frequency of use of PCPs varied over a wide range. Cosmetic-related adverse events were experienced by 16.1% of the participants. Use frequencies of many hygiene and makeup products were correlated with each other. This study provides, for the first time, baseline data on the usage patterns of a large number of widely consumed PCPs among female population pertaining to several sociodemographic strata. Such information is crucial for exposure and risk assessment and also needed for updating the current knowledge on usage of PCPs in Saudi Arabia.
MeSH term(s)	Adolescent ; Adult ; Aged ; Consumer Product Safety ; Cosmetics/adverse effects ; Cosmetics/analysis ; Female ; Humans ; Middle Aged ; Risk Assessment ; Saudi Arabia/epidemiology ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Cosmetics
Language	English
Publishing date	2020-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2020/8434508
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Usage Patterns of Cosmetic and Personal Care Products among Female Population in Saudi Arabia

Heba Shaaban / Wejdan Alhajri

Journal of Environmental and Public Health, Vol

Important Factors for Exposure and Risk Assessment

2020 Volume 2020

Abstract	Reliable data regarding the usage patterns of personal care products (PCPs) are needed to determine the health risks posed by the ingredients of these products such as parabens, phthalates, and bisphenol A. There are no published data regarding the consumption patterns of PCPs in the Middle East in general and in Saudi Arabia in particular. To fill this gap, this study aimed to assess important factors such as the percentage of users and the frequency of use and co-use of twenty-three cosmetic and PCPs among the female population in Saudi Arabia. Additionally, this study aimed to assess the common cosmetic-related adverse events among the participants. The studied products included general hygiene, hair care, skin care, makeup, fragrances, and other products. The data were collected from 709 female participants of different age groups through a digital questionnaire. It was found that eighteen of the investigated products are consumed by at least 50% of the respondents. The frequency of use of PCPs varied over a wide range. Cosmetic-related adverse events were experienced by 16.1% of the participants. Use frequencies of many hygiene and makeup products were correlated with each other. This study provides, for the first time, baseline data on the usage patterns of a large number of widely consumed PCPs among female population pertaining to several sociodemographic strata. Such information is crucial for exposure and risk assessment and also needed for updating the current knowledge on usage of PCPs in Saudi Arabia.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	650
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Quantitative analysis and resolution of pharmaceuticals in the environment using multivariate curve resolution-alternating least squares (MCR-ALS).

Mostafa, Ahmed / Shaaban, Heba

Acta pharmaceutica (Zagreb, Croatia)

2019 Volume 69, Issue 2, Page(s) 217–231

Abstract: The study presents the application of multivariate curve resolution alternating least squares (MCR-ALS) with a correlation constraint for simultaneous resolution and quantification of ketoprofen, naproxen, paracetamol and caffeine as target analytes and ... ...

Abstract	The study presents the application of multivariate curve resolution alternating least squares (MCR-ALS) with a correlation constraint for simultaneous resolution and quantification of ketoprofen, naproxen, paracetamol and caffeine as target analytes and triclosan as an interfering component in different water samples using UV-Vis spectrophotometric data. A multivariate regression model using the partial least squares regression (PLSR) algorithm was developed and calculated. The MCR-ALS results were compared with the PLSR obtained results. Both models were validated on external sample sets and were applied to the analysis of real water samples. Both models showed comparable and satisfactory results with the relative error of prediction of real water samples in the range of 1.70-9.75 % and 1.64-9.43 % for MCR-ALS and PLSR, resp. The obtained results show the potential of MCR-ALS with correlation constraint to be applied for the determination of different pharmaceuticals in complex environmental matrices.
MeSH term(s)	Environmental Monitoring/methods ; Least-Squares Analysis ; Multivariate Analysis ; Pharmaceutical Preparations/analysis ; Spectrophotometry/methods ; Water Pollutants, Chemical/analysis
Chemical Substances	Pharmaceutical Preparations ; Water Pollutants, Chemical
Language	English
Publishing date	2019-11-09
Publishing country	Croatia
Document type	Comparative Study ; Journal Article ; Validation Studies
ZDB-ID	1111806-4
ISSN	1846-9558 ; 1330-0075
ISSN (online)	1846-9558
ISSN	1330-0075
DOI	10.2478/acph-2019-0011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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