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  1. Article: Opening new vista for rapid detection of antimicrobial resistant genes via film array multiplex PCR.

    Zafar, Humaira / Mirza, Irfan Ali

    Pakistan journal of medical sciences

    2023  Volume 39, Issue 6, Page(s) 1555–1556

    Language English
    Publishing date 2023-01-14
    Publishing country Pakistan
    Document type Editorial
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.39.6.8635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3948: Show issues Location:
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  2. Article: The Microbiology of Coronaviruses.

    Zafar, Humaira

    JPMA. The Journal of the Pakistan Medical Association

    2020  Volume 70Suppl 3, Issue 5, Page(s) S44–S47

    Abstract: The end of 2019 marked the start of coronavirus disease (COVID-19) pandemic from China, which went on to envelope more than 190 countries and territories across the globe. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from a group of ... ...

    Abstract The end of 2019 marked the start of coronavirus disease (COVID-19) pandemic from China, which went on to envelope more than 190 countries and territories across the globe. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from a group of betacoronaviruses, is responsible for COVID-19. The virulent factors include the presence of envelope and spike proteins having receptor bonding domains (RBD). Clinical manifestations can range from mild respiratory infections to fatal outcomes. The viability of virus ranges from 3 to 72 hours. Polymerase chain reaction (PCR) is the diagnostic test of choice in this pandemic situation. Due to the absence of specific antivirals and vaccine, adoption of preventive option can help to combat the specific life-threatening outcomes.
    MeSH term(s) Animals ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Chiroptera ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Viral Vaccines
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.5455/JPMA.08
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  3. Article: The Microbiology of Coronaviruses

    Zafar, Humaira

    J Pak Med Assoc

    Abstract: The end of 2019 marked the start of coronavirus disease (COVID-19) pandemic from China, which went on to envelope more than 190 countries and territories across the globe. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from a group of ... ...

    Abstract The end of 2019 marked the start of coronavirus disease (COVID-19) pandemic from China, which went on to envelope more than 190 countries and territories across the globe. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from a group of betacoronaviruses, is responsible for COVID-19. The virulent factors include the presence of envelope and spike proteins having receptor bonding domains (RBD). Clinical manifestations can range from mild respiratory infections to fatal outcomes. The viability of virus ranges from 3 to 72 hours. Polymerase chain reaction (PCR) is the diagnostic test of choice in this pandemic situation. Due to the absence of specific antivirals and vaccine, adoption of preventive option can help to combat the specific life-threatening outcomes.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #609351
    Database COVID19

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  4. Article ; Online: The Ever-Worsening Antimicrobial Resistance in Enterobacterales; A wakeup call

    Fatima Ali / Irfan Mirza / Hafsa Waseem / Humaira Zafar

    Pakistan Armed Forces Medical Journal, Vol 73, Iss

    2023  Volume 2

    Abstract: Objective: To determine the comprehensive antibiotic susceptibility profile of carbapenem-resistant Enterobacterales among clinical samples received at the Armed Forces Institute of Pathology (AFIP), Rawalpindi. Study Design: Cross-sectional study. Place ...

    Abstract Objective: To determine the comprehensive antibiotic susceptibility profile of carbapenem-resistant Enterobacterales among clinical samples received at the Armed Forces Institute of Pathology (AFIP), Rawalpindi. Study Design: Cross-sectional study. Place and Duration of Study: Department of Microbiology, Armed Forces Institute of Pathology (AFIP), Rawalpindi Pakistan, from Apr to Sep 2020 Methodology: Over six months, 150 carbapenem-resistant Enterobacterales were isolated at the Armed Forces Institute ofPathology, Rawalpindi Pakistan. The antimicrobial susceptibility testing was performed using the Kirby-Bauer Disk-Diffusion technique, and their susceptibility was interpreted according to the CLSI 2020 and EUCAST 2020 guidelines. Results: Out of 150 clinical isolates resistant to Carbapenems, 99(66%) were identified as Klebsiella Pneumoniae, followed by Escherichia Coli 38(25.7%), Proteus Mirabilis 7(4.6%), Enterobacter Cloacae, Serratia Marcescens, Citrobacter Freundii, Providencia retgerii 1(0.6%) each. The isolates were highly resistant to the following categories of antibiotics tested. For Penicillins/Cephalosporins and their combinations, the resistance range was between 94 to 100%, and it was and >79% for Aminoglycosides, >97% for Fluoroquinolones and >48% for Tetracyclines. Isolates showed the highest susceptibility to Colistin, 94(92%) out of 102 then to Tigecycline 81(81%) out of 100, followed by Fosfomycin 60(78.9%) out of 76, Minocycline 41(52%) out of 79 and Doxycycline 33(50%) out of 66. Conclusion: Extensively drug-resistant Enterobacterales ‘Superbugs’ with ever-worsening antimicrobial resistance threaten the human race back to the pre-antibiotic era. This real menace cautions against the lack of antimicrobials for treating lethal and hazardous infections caused by such difficult-to-treat bacteria in times to come.
    Keywords Enterobacterales ; Carbapenems ; Klebsiella pneumonia ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 630
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
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  5. Article: Characterization and comparative evaluation of wound healing potential of Ajugarin I and

    Wasti, Yusra / Muntaqua, Durdana / Majid, Muhammad / Naz, Iffat / Zafar, Aroosa / Khan, Safir Ullah / Kazmi, Syeda Tayyaba Batool / Rehman, Tofeeq Ur / Irshad, Nadeem / Fatima, Humaira

    Frontiers in chemistry

    2024  Volume 11, Page(s) 1325578

    Abstract: ... Ajuga ... ...

    Abstract Ajuga bracteosa
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1325578
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  6. Article ; Online: Antibiotic Sensitivity Pattern of Carbapenem-Resistant Pseudomonas Aeruginosa

    Fatima Ali / Ifran Ali Mirza / Hafsa Waseem / Humaira Zafar

    Pakistan Armed Forces Medical Journal, Vol 73, Iss

    2023  Volume 1

    Abstract: Objective: To determine the sensitivity of Carbapenem-resistant Pseudomonas aeruginosa (CARP) with the panel of antibiotics according to Clinical and Laboratory Standards Institute (CLSI) 2020 guidelines. Study Design: Cross-sectional study. Duration and ...

    Abstract Objective: To determine the sensitivity of Carbapenem-resistant Pseudomonas aeruginosa (CARP) with the panel of antibiotics according to Clinical and Laboratory Standards Institute (CLSI) 2020 guidelines. Study Design: Cross-sectional study. Duration and Place of Study: Armed Forces Institute of Pathology, Rawalpindi from Pakistan, Apr to Sep 2020. Methodology: All samples received at the Microbiology Department during the study period were included. Various samples such as blood, pus, sputum, Endobronchial washing (EBW), non-directed bronchial lavage (NBL), tissue and urine were processed in the laboratory. Samples were inoculated on appropriate culture media, and bacteria were identified according to their colony morphology, Gram staining characteristics and biochemical tests. Antibiotic susceptibility testing was performed using the Kirby Bauer Disk Diffusion technique according to Clinical and Laboratory Standards Institute (CLSI) 2020 guidelines. However, for susceptibility to Colistin, the agar dilution method was performed. Results: In our study, fifty-five Carbapenem-resistant Pseudomonas aeruginosa were isolated. Out of these fifty-five isolates,thirteen (23.6%) were sensitive to Tazocin, seven (12.7%) were sensitive to Ceftazidime, fourteen (25.4%) were sensitive to Gentamicin, 7(12.7%) were sensitive to Cefepime, (12.7%) to Aztreonam, 10(18.2%) were sensitive to Amikacin, 7(12.7%) to Ciprofloxacin, 6(11%) to Levofloxacin and forty-two (76.4%) were sensitive to Colistin. Conclusion: The susceptibility of Carbapenem-resistant Pseudomonas aeruginosa to all the antibiotics tested in this study was low. Isolates displayed the highest susceptibility to Colistin. Keywords: Antibiotic susceptibility profile, Carbapenems, Carbapenem-resistant Pseudomonas aeruginosa (CRPA), Disk diffusion technique.
    Keywords Antibiotic susceptibility profile ; Carbapenems ; Carbapenem-resistant Pseudomonas aeruginosa (CRPA) ; Disk diffusion technique ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7).

    Zadi, Seema / Javaid, Sumaira / Atia-Tul-Wahab / Zafar, Humaira / Awais, Muhammad / Maslennikov, Innokentiy / Choudhary, M Iqbal

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e26345

    Abstract: Ubiquitin-specific protease7 (USP7) regulates the stability of the p53 tumor suppressor protein and several other proteins critical for tumor cell survival. Aberrant expression of USP7 facilitates human malignancies by altering the activity of proto- ... ...

    Abstract Ubiquitin-specific protease7 (USP7) regulates the stability of the p53 tumor suppressor protein and several other proteins critical for tumor cell survival. Aberrant expression of USP7 facilitates human malignancies by altering the activity of proto-oncogenes/proteins, and tumor suppressor genes. Therefore, USP7 is a validated anti-cancer drug target. In this study, a drug repurposing approach was used to identify new hits against the USP7 enzyme. It is one of the most strategic approaches to find new uses for drugs in a cost- and time-effective way. Nuclear Magnetic Resonance-based screening of 172 drugs identified 11 compounds that bind to the catalytic domain of USP7 with dissociation constant (
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26345
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  8. Article ; Online: Partial syntheses of aromatic amides: their anti-urease potential and docking studies.

    Onocha, Patricia Akpomedaye / Okpala, Ejike Onwudiegwu / Ali, Muhammad Shaiq / Rahman, Noor / Zafar, Humaira / Oloyede, Ganiyat Kehinde / Nwozo, Sarah Oyenibe / Lateef, Mehreen

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–12

    Abstract: The aromatic amide: ...

    Abstract The aromatic amide:
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2263876
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    Zs.A 2093: Show issues Location:
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  9. Article: Mechanistic insight into the synergistic antimicrobial potential of

    Abrar, Anum / Zafar, Aroosa / Fatima, Mahvish / Muntaqua, Durdana / Naz, Iffat / Fatima, Humaira / Ul Haq, Ihsan

    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

    2023  Volume 32, Issue 1, Page(s) 101893

    Abstract: ... Fagonia ... ...

    Abstract Fagonia indica
    Language English
    Publishing date 2023-12-05
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1378024-4
    ISSN 1319-0164
    ISSN 1319-0164
    DOI 10.1016/j.jsps.2023.101893
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    Zs.A 4758: Show issues Location:
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  10. Article ; Online: O-band TE- and TM-mode densely packed adiabatically bent waveguide arrays on the silicon-on-insulator platform.

    Zafar, Humaira / Paredes, Bruna / Villegas, Juan / Rasras, Mahmoud / Fernandes Pereira, Mauro

    Optics express

    2023  Volume 31, Issue 13, Page(s) 21389–21398

    Abstract: An efficient, dual-polarization silicon waveguide array with low insertion losses and negligible crosstalks for both TE and TM polarizations has been reported using S-shaped adiabatically bent waveguides. Simulation results for a single S-shaped bend ... ...

    Abstract An efficient, dual-polarization silicon waveguide array with low insertion losses and negligible crosstalks for both TE and TM polarizations has been reported using S-shaped adiabatically bent waveguides. Simulation results for a single S-shaped bend show an insertion loss (IL) of ≤ 0.03 dB and ≤ 0.1 dB for the TE and TM polarizations, respectively, and TE and TM crosstalk values in the first neighboring waveguides at either side of the input waveguide are lower than -39 dB and -24 dB, respectively, over the wavelength range of 1.24 µm to 1.38 µm. The bent waveguide arrays exhibit a measured average TE IL of ≈ 0.1 dB, measured TE crosstalks in the first neighboring waveguides are ≤ -35 dB, at the 1310 nm communication wavelength. The proposed bent array can be made by using multiple cascaded S-shaped bends to transmit signals to all optical components in integrated chips.
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.493077
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