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Article ; Online: Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans.

Zou, Jiaxi / Xu, Weiming / Li, Ziyun / Gao, Ping / Zhang, Fangyuan / Cui, Yuting / Hu, Jingqing

2023 Volume 55, Issue 1, Page(s) 2218105

Abstract: Background: Si-Miao-Yong-An decoction (SMYAD) is a conventional therapeutic formula for treat ...

Abstract	Background: Si-Miao-Yong-An decoction (SMYAD) is a conventional therapeutic formula for treat thromboangiitis obliterans (TAO), consisting of four Chinese herbs: Methods: Components, as well as potential targets of SMYAD in TAO therapy, were downloaded from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Subsequently, with the Database for Annotation, Visualization, and Integrated Discovery (DAVID) server, the gene ontology (GO) biological processes and the Kyoto encyclopedia of genes and genomes (KEGG) signalling pathways of the targets enrichment were performed. Next, based on STRING online database, the protein interaction network of vital targets was built and analysed. Molecular docking and calculation of the binding affinity were performed using AutoDock. The PyMOL software was employed to observe docking outcomes of active compounds and protein targets. Based on the predicted outcomes of network pharmacology, Results: In the network pharmacology analysis, we obtained 105 chemical components in SMYAD and 24 therapeutic targets. We found that the mechanism SMYAD in TAO therapy was primarily associated with inflammation and angiogenesis by constructing multiple networks. Quercetin, vestitol and beta-sitosterol were important compounds, and interleukin-6 (IL6), MMP9, and VEGFA were key targets. According to molecular docking, active compounds (quercetin, vestitol and beta-sitosterol) and targets (IL6, MMP9 and VEGFA) showed good binding interactions. In Conclusions: This study showed that SMYAD improves TAO symptoms and inhibits the development of TAO. The mechanism could be associated with anti-inflammatory and therapeutic angiogenesis.
MeSH term(s)	Humans ; Animals ; Rats ; Thromboangiitis Obliterans/drug therapy ; Matrix Metalloproteinase 9 ; Network Pharmacology ; Quercetin ; Endothelial Cells ; Interleukin-6 ; Lipopolysaccharides ; Molecular Docking Simulation
Chemical Substances	si-miao-yong-an decoction ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Quercetin (9IKM0I5T1E) ; Interleukin-6 ; Lipopolysaccharides
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2023.2218105
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Article ; Online: Correction: Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.

Cui, Yuting / Zhang, Fangyuan / Xu, Weiming / Li, Ziyun / Zou, Jiaxi / Gao, Ping / Hu, Jingqing

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 220

Language	English
Publishing date	2023-07-01
Publishing country	England
Document type	Published Erratum
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-04057-x
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Article ; Online: Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway.

Cui, Yuting / Zhang, Fangyuan / Xu, Weiming / Li, Ziyun / Zou, Jiaxi / Gao, Ping / Hu, Jingqing

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 180

Abstract: ... linked to the gut microbiota. Si-Miao-Yong-An (SMYA) decoction is a traditional Chinese herbal formula ...

Abstract	Background: Coronary Artery Disease (CAD) is primarily caused by inflammation which is closely linked to the gut microbiota. Si-Miao-Yong-An (SMYA) decoction is a traditional Chinese herbal formula with anti-inflammatory properties that found to be effective against CAD. However, it is still unclear whether SMYA can modulate gut microbiota and whether it contributes to the improvement of CAD by reducing inflammation and regulating the gut microbiota. Methods: The identification of components in the SMYA extract was conducted using the HPLC method. A total of four groups of SD rats were orally administered with SMYA for 28 days. The levels of inflammatory biomarkers and myocardial damage biomarkers were measured through ELISA, while echocardiography was used to assess heart function. Histological alterations in the myocardial and colonic tissues were examined following H&E staining. Western blotting was performed to evaluate protein expression, whereas alterations in gut microbiota were determined by 16 s rDNA sequencing. Results: SMYA was found to enhance cardiac function and decrease the expression of serum CK-MB and LDH. SMYA was also observed to inhibit the TLR4/NF-κB signaling pathway by downregulating the protein expression of myocardial TLR4, MyD88, and p-P65, leading to a reduction in serum pro-inflammatory factors. SMYA modified the composition of gut microbiota by decreasing the Firmicutes/Bacteroidetes ratio, modulating Prevotellaceae_Ga6A1 and Prevotellaceae_NK3B3 linked to the LPS/TLR4/NF-κB pathway, and increasing beneficial microbiota such as Bacteroidetes, Alloprevotella, and other bacterial species. Moreover, SMYA was found to safeguard the intestinal mucosal and villi structures, elevate the expression of tight junction protein (ZO-1, occludin), and reduce intestinal permeability and inflammation. Conclusions: The results indicate that SMYA has the potential to modulate the gut microbiota and protect the intestinal barrier, thereby reducing the translocation of LPS into circulation. SMYA was also found to inhibit the LPS-induced TLR4/NF-κB signaling pathway, leading to a decrease in the release of inflammatory factors, which ultimately mitigated myocardial injury. Hence, SMYA holds promise as a therapeutic agent for the management of CAD.
MeSH term(s)	Rats ; Animals ; NF-kappa B/metabolism ; Toll-Like Receptor 4/metabolism ; Lipopolysaccharides/pharmacology ; Gastrointestinal Microbiome ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/metabolism ; Signal Transduction ; Inflammation
Chemical Substances	NF-kappa B ; si-miao-yong-an decoction ; Toll-Like Receptor 4 ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Tlr4 protein, rat
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-04013-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Anti-Inflammatory and Uric Acid Lowering Effects of Si-Miao-San on Gout.

Cao, Ling / Zhao, Tianyi / Xue, Yu / Xue, Luan / Chen, Yueying / Quan, Feng / Xiao, Yu / Wan, Weiguo / Han, Man / Jiang, Quan / Lu, Liwei / Zou, Hejian / Zhu, Xiaoxia

Frontiers in immunology

2022 Volume 12, Page(s) 777522

Abstract: Background: Si-Miao-San (SMS) is a well-known traditional Chinese medicine. This study aims ...

Abstract	Background: Si-Miao-San (SMS) is a well-known traditional Chinese medicine. This study aims to evaluate the anti-inflammatory effects of SMS on gouty arthritis and its potential mechanism of action. Methods: The effects and mechanism of SMS were evaluated in monosodium urate (MSU)-treated mice or macrophages. The expression of cytokines and PI3K/Akt was analyzed using real-time PCR and Western blotting analyses. Macrophage polarization was assessed with immunofluorescence assays, real-time PCR, and Western blotting. Mass spectrometry was used to screen the active ingredients of SMS. Results: Pretreatment with SMS ameliorated MSU-induced acute gouty arthritis in mice with increased PI3K/Akt activation and M2 macrophage polarization in the joint tissues. Conclusion: SMS ameliorated MSU-induced gouty arthritis and inhibited hyperuricemia. The anti-inflammatory mechanism of SMS may exert anti-inflammatory effects by promoting M2 polarization
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Chromones/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Gout/drug therapy ; Gout/immunology ; Gout/metabolism ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice ; Morpholines/pharmacology ; Phosphatidylinositol 3-Kinases/immunology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/immunology ; Proto-Oncogene Proteins c-akt/metabolism ; THP-1 Cells ; Uric Acid/immunology ; Uric Acid/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Chromones ; Drugs, Chinese Herbal ; Morpholines ; Uric Acid (268B43MJ25) ; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (31M2U1DVID) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.777522
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Article ; Online: Network pharmacology-based approach to research the effect and mechanism of Si-Miao-Yong-An decoction against thromboangiitis obliterans

Jiaxi Zou / Weiming Xu / Ziyun Li / Ping Gao / Fangyuan Zhang / Yuting Cui / Jingqing Hu

Annals of Medicine, Vol 55, Iss

2023 Volume 1

Abstract: AbstractBackground Si-Miao-Yong-An decoction (SMYAD) is a conventional therapeutic formula ...

Abstract	AbstractBackground Si-Miao-Yong-An decoction (SMYAD) is a conventional therapeutic formula for treat thromboangiitis obliterans (TAO), consisting of four Chinese herbs: Lonicerae japonicae Thunb. (Jinyinhua), Scrophularia ningpoensis Hemsl. (Xuanshen), Angelica sinensis (Oliv.) Diels (Danggui) and Glycyrrhiza uralensis Fisch. (Gancao). However, the mechanism of SMYAD in TAO treatment remains unclear.Methods Components, as well as potential targets of SMYAD in TAO therapy, were downloaded from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Subsequently, with the Database for Annotation, Visualization, and Integrated Discovery (DAVID) server, the gene ontology (GO) biological processes and the Kyoto encyclopedia of genes and genomes (KEGG) signalling pathways of the targets enrichment were performed. Next, based on STRING online database, the protein interaction network of vital targets was built and analysed. Molecular docking and calculation of the binding affinity were performed using AutoDock. The PyMOL software was employed to observe docking outcomes of active compounds and protein targets. Based on the predicted outcomes of network pharmacology, in vivo and in vitro tests were performed for validation. In vivo experiment, the TAO rats model was established using sodium laurate injection into the femoral artery. The symptoms as well as pathological changes of the femoral artery were observed. Besides, the predicted targets were verified by the RT-qPCR, in vitro experiment. The cell viability in LPS-induced human umbilical vein endothelial cells (HUVECs) was detected using CCK-8 kit, and the predicted targets were also verified by the RT-qPCR.Results In the network pharmacology analysis, we obtained 105 chemical components in SMYAD and 24 therapeutic targets. We found that the mechanism SMYAD in TAO therapy was primarily associated with inflammation and angiogenesis by constructing multiple networks. Quercetin, vestitol and beta-sitosterol were important compounds, ...
Keywords	Si-Miao-Yong-An decoction ; thromboangiitis obliterans ; network pharmacology ; mechanism ; molecular docking ; Medicine ; R
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Si-Miao-Yong-An decoction on myocardial I/R rats by regulating gut microbiota to inhibit LPS-induced TLR4/NF-κB signaling pathway

Yuting Cui / Fangyuan Zhang / Weiming Xu / Ziyun Li / Jiaxi Zou / Ping Gao / Jingqing Hu

BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-

2023 Volume 16

Abstract: ... closely linked to the gut microbiota. Si-Miao-Yong-An (SMYA) decoction is a traditional Chinese herbal ...

Abstract	Abstract Background Coronary Artery Disease (CAD) is primarily caused by inflammation which is closely linked to the gut microbiota. Si-Miao-Yong-An (SMYA) decoction is a traditional Chinese herbal formula with anti-inflammatory properties that found to be effective against CAD. However, it is still unclear whether SMYA can modulate gut microbiota and whether it contributes to the improvement of CAD by reducing inflammation and regulating the gut microbiota. Methods The identification of components in the SMYA extract was conducted using the HPLC method. A total of four groups of SD rats were orally administered with SMYA for 28 days. The levels of inflammatory biomarkers and myocardial damage biomarkers were measured through ELISA, while echocardiography was used to assess heart function. Histological alterations in the myocardial and colonic tissues were examined following H&E staining. Western blotting was performed to evaluate protein expression, whereas alterations in gut microbiota were determined by 16 s rDNA sequencing. Results SMYA was found to enhance cardiac function and decrease the expression of serum CK-MB and LDH. SMYA was also observed to inhibit the TLR4/NF-κB signaling pathway by downregulating the protein expression of myocardial TLR4, MyD88, and p-P65, leading to a reduction in serum pro-inflammatory factors. SMYA modified the composition of gut microbiota by decreasing the Firmicutes/Bacteroidetes ratio, modulating Prevotellaceae_Ga6A1 and Prevotellaceae_NK3B3 linked to the LPS/TLR4/NF-κB pathway, and increasing beneficial microbiota such as Bacteroidetes, Alloprevotella, and other bacterial species. Moreover, SMYA was found to safeguard the intestinal mucosal and villi structures, elevate the expression of tight junction protein (ZO-1, occludin), and reduce intestinal permeability and inflammation. Conclusions The results indicate that SMYA has the potential to modulate the gut microbiota and protect the intestinal barrier, thereby reducing the translocation of LPS into circulation. ...
Keywords	Ischemia/Reperfusion ; Si-Miao-Yong-an ; Gut microbiota ; Intestinal permeability ; TLR4/NF-κB ; Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Study on fat-soluble components in different parts of miao ethnomedicine Pileostegia viburnoides by the herbal blitzkrieg extractor].

Yuan, Yan / Liu, Xiang-Qian / Liu, Zu-Zhen / Zou, Qin-Peng / Liu, Heng-Yan / Dai, Ling

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2011 Volume 34, Issue 12, Page(s) 1894–1897

Abstract: ... for ex-ploiting resources of Miao ethnomedicine Pileostegia viburnoides. ...

Abstract	Objective: To study the fat-soluble components in different parts of Pileostegia viburnoides. Methods: The fat-soluble components in different parts of Pileostegia viburnoides were extracted by Herbal Blitzkrieg Extractor (HBE), and its constituents were analyzed by GC-MS. Results: 37 compounds from the stems, 14 compounds from the leaves were separated and identified. The ratios of identification of total compounds were 90. 63% and 81.61%, respectively. Conclusion: This result provides the scientific basis for ex-ploiting resources of Miao ethnomedicine Pileostegia viburnoides.
MeSH term(s)	Esters/analysis ; Fats/analysis ; Fatty Acids/analysis ; Gas Chromatography-Mass Spectrometry/methods ; Linoleic Acid/analysis ; Medicine, Traditional ; Oils, Volatile/chemistry ; Oils, Volatile/isolation & purification ; Palmitic Acid/analysis ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Saxifragaceae/chemistry ; Technology, Pharmaceutical/methods
Chemical Substances	Esters ; Fats ; Fatty Acids ; Oils, Volatile ; Plant Extracts ; Palmitic Acid (2V16EO95H1) ; Linoleic Acid (9KJL21T0QJ)
Language	Chinese
Publishing date	2011-12
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1001-4454
ISSN	1001-4454
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Article: [Detection of mtDNA coding region variants using mAPLP in Han, Miao and Tujia populations from Hunan Province].

Zhou, Hai-Yan / Ni, Bin / Zou, Yong-Hua / Zhang, Rui

Yi chuan = Hereditas

2008 Volume 30, Issue 6, Page(s) 716–722

Abstract: ... mtDNA) coding regions, we genotyped 16 SNP loci in the mitochondrial DNA coding region in Han, Miao and ... significantly different from that of in the Miao population (P0.01). The allelic frequency of 8020A in Han ... population was 6% , which was different from that of in the Miao and Tujia populations (P0.05 ...

Abstract	To find a rapid single nucleotide polymorphism (SNP) loci typing method in the mitochondrial DNA (mtDNA) coding regions, we genotyped 16 SNP loci in the mitochondrial DNA coding region in Han, Miao and Tujia populations by the multiplex-amplified product-length polymorphism (mAPLP) technique. This method generates allele-specific fragments that are different in length through PCR amplification using allele-specific forward (or reverse) primers different in size and a common reverse (or forward) primer. Results showed that both of the allelic frequency of 3970T in Han and Tujia populations were 17%, which were significantly different from that of in the Miao population (P0.01). The allelic frequency of 8020A in Han population was 6% , which was different from that of in the Miao and Tujia populations (P0.05) . In all of 300 samples, a total of 45 different haplotypes were identified, 12 of which were found in all the three populations, 10 were shared by two populations and 23 haplotypes existed only in one of the populations. Among these 23 haplotypes, 8, 6 and 12 haplotypes were exclusively observed in the Han, Miao and Tujia populations, respectively.
MeSH term(s)	Asian Continental Ancestry Group/genetics ; China ; DNA, Mitochondrial/genetics ; Haplotypes/genetics ; Humans ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	DNA, Mitochondrial
Language	Chinese
Publishing date	2008-05-23
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0253-9772
ISSN	0253-9772
DOI	10.3724/sp.j.1005.2008.00716
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Article: UPLC-MS coupled with a dynamic multiple data processing method for the comprehensive detection of the chemical constituents of the herbal formula San-Miao-Wan

Zou, Di / Zhang, Ai-hua / Yan, Guang-li / Tan, Yun-long / Sun, Hui / Wang, Xi-jun

Analytical methods. 2014 Apr. 10, v. 6, no. 9

2014

Abstract: San-Miao-Wan (SMW) is a combination prescription of Cortex Phellodendri Chinensis, Rhizoma ...

Abstract	San-Miao-Wan (SMW) is a combination prescription of Cortex Phellodendri Chinensis, Rhizoma Atractylodis, and Radix Achyranthis Bidentatae commonly used to treat arthritis and hyperuricemia, described in the State Pharmacopoeia of the People's Republic of China. However, despite numerous pharmacological studies, the phytochemical constituents of SMW have not been conclusively identified. In the present study, a universally applicable UPLC-ESI-Q-TOF-MS technique coupled with a multiple data processing approach (Mdpa) was developed to carry out comprehensive detection of the chemical constituents of SMW. The Mdpa method can efficiently deal with the large volumes of mass data collected via the use of spectral and chromatographic search algorithms that detect ions at low concentrations. Using an UPLC system, the total analysis time for separation was less than 20 min without the loss of any resolution. In the principal component analysis VIP-plot, 77 ions of interest (36 ions in positive mode, 43 ions in negative mode, and 2 ions in both modes) were extracted. Based on the MS fragmentation patterns of the reference standards, a total of 71 components were identified or tentatively characterized by comparing their retention times, UV and MS spectra with those of reference standards, or through the matching of empirical information with those of the published components in the in-house library. Our results indicated that the developed method could be used as a rapid and effective technique for the structural characterization of phytochemical constituents in SMW. This work is also expected to provide comprehensive information for the quality evaluation study of SMW.
Keywords	algorithms ; arthritis ; chemical composition ; chemical constituents of plants ; data collection ; hyperuricemia ; information processing ; ions ; mass spectrometry ; principal component analysis ; reference standards ; rhizomes ; ultra-performance liquid chromatography ; China
Language	English
Dates of publication	2014-0410
Size	p. 2848-2854.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/c3ay41814f
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Orthopedic manifestations in children with Prader-Willi syndrome.

Miao, Miao / Zhao, Guo-Qiang / Zhou, Qiong / Chao, Yun-Qi / Zou, Chao-Chun

BMC pediatrics

2024 Volume 24, Issue 1, Page(s) 118

Abstract: Background: Prader-Willi syndrome (PWS) is a rare genetic disease often associated with bone problems, mainly scoliosis and hip dysplasia (HD). This study aimed to analyze the clinical characteristics of orthopedic deformities in patients with PWS.: ... ...

Abstract	Background: Prader-Willi syndrome (PWS) is a rare genetic disease often associated with bone problems, mainly scoliosis and hip dysplasia (HD). This study aimed to analyze the clinical characteristics of orthopedic deformities in patients with PWS. Methods: A retrospective study was conducted on 175 patients up to March 2023. The Cobb angle(CA) of the spine, the alpha angle of the hip joint, and the acetabular index (AI) were measured. This study aimed to evaluate the relationship between demographic parameters and bone deformities. Results: Scoliosis was found in 66 patients (43.7%), including 52 (78.8%) with mild scoliosis, 10 (15.2%) with moderate scoliosis, and 4 (6.1%) with severe scoliosis. Only seven patients received orthopedic treatment (10.6%). The median age of scoliosis was 4.5 years old, and the prevalence of scoliosis increased rapidly at the age of 5 years and adolescence. The mean CA in this study increased gradually with age. HD was found in 47 patients (38.2%), and 6 patients received orthopedic treatment (12.7%). The median age at HD was 1.8 years old. The mean AI of the study population decreased with age. The prevalence of HD treated with recombinant human growth hormone (rhGH) was low. No significant differences were observed in sex, genotype, body mass index (BMI), obesity rate, or onset of scoliosis and HD. Conclusion: The prevalence of scoliosis and HD was higher in patients with PWS. The onset age and developmental trends of the different skeletal malformations were different. Early diagnosis and treatment are important for the prognosis and treatment of orthopedic diseases in patients with PWS.
MeSH term(s)	Child ; Adolescent ; Humans ; Child, Preschool ; Infant ; Prader-Willi Syndrome/complications ; Prader-Willi Syndrome/diagnosis ; Prader-Willi Syndrome/drug therapy ; Scoliosis/etiology ; Retrospective Studies ; Human Growth Hormone/therapeutic use ; Obesity/complications
Chemical Substances	Human Growth Hormone (12629-01-5)
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-024-04603-7
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