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  1. Article ; Online: Treating Acute Covid-19 - Final Chapters Still Unwritten.

    Gandhi, Rajesh T / Hirsch, Martin

    The New England journal of medicine

    2024  Volume 390, Issue 13, Page(s) 1234–1236

    MeSH term(s) Humans ; COVID-19
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2402224
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  2. Article ; Online: The severity of COVID-19 across the spectrum of HIV.

    Miller, Kathleen W / Gandhi, Rajesh T

    Current opinion in HIV and AIDS

    2023  Volume 18, Issue 3, Page(s) 119–125

    Abstract: Purpose of review: We review the intersection between the HIV and COVID-19 pandemics, particularly the impact of HIV infection on the development of severe COVID-19.: Recent findings: Studies early in the COVID-19 pandemic did not find a clear link ... ...

    Abstract Purpose of review: We review the intersection between the HIV and COVID-19 pandemics, particularly the impact of HIV infection on the development of severe COVID-19.
    Recent findings: Studies early in the COVID-19 pandemic did not find a clear link between HIV infection and increased COVID-19 severity or mortality. People with HIV (PWH) were more likely to have severe COVID-19, but much of the risk for worse outcomes was related to high rates of comorbidities and social determinants of health. Although comorbidities and social determinants of health are certainly critically important reasons for severe COVID-19 among PWH, recent large studies have found HIV infection - particularly when the CD4 cell count is low or HIV RNA is not suppressed - is an independent risk factor for COVID-19 severity. The link between HIV and severe COVID-19 highlights the need to diagnose and treat HIV as well as the importance of COVID-19 vaccination and treatment among PWH.
    Summary: People with HIV have faced increased challenges during the COVID-19 pandemic because of high rates of comorbidities and social determinants of health as well as the impact of HIV on COVID-19 severity. Information on the intersection of the two pandemics has been crucial to improving care for people with HIV.
    MeSH term(s) Humans ; HIV Infections/complications ; COVID-19/epidemiology ; COVID-19 Vaccines ; Pandemics ; Risk Factors
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-03-17
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000791
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  3. Article ; Online: COVID-19 Therapeutics for Nonhospitalized Patients-Updates and Future Directions.

    Chew, Kara W / Malani, Preeti N / Gandhi, Rajesh T

    JAMA

    2023  Volume 330, Issue 16, Page(s) 1519–1520

    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.19542
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  4. Article ; Online: The Multidimensional Challenge of Treating Coronavirus Disease 2019 (COVID-19): Remdesivir Is a Foot in the Door.

    Gandhi, Rajesh T

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 11, Page(s) e4175–e4178

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
    Chemical Substances remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-08-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1132
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  5. Article ; Online: Realizing the Potential of Anti-SARS-CoV-2 Monoclonal Antibodies for COVID-19 Management.

    Li, Jonathan Z / Gandhi, Rajesh T

    JAMA

    2022  Volume 327, Issue 5, Page(s) 427–429

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.19994
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  6. Article ; Online: Treatments for COVID-19.

    Andrews, Hayden S / Herman, Jonathan D / Gandhi, Rajesh T

    Annual review of medicine

    2023  Volume 75, Page(s) 145–157

    Abstract: The treatment for COVID-19 has evolved rapidly since the start of the pandemic and now consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir and nirmatrelvir-ritonavir, have proved to be most useful earlier in illness ( ... ...

    Abstract The treatment for COVID-19 has evolved rapidly since the start of the pandemic and now consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir and nirmatrelvir-ritonavir, have proved to be most useful earlier in illness (e.g., as outpatient therapy) and for less severe disease. Immunomodulatory therapies, such as dexamethasone and interleukin-6 or Janus kinase inhibitors, are most useful in severe disease or critical illness. The role of anti-SARS-CoV-2 monoclonal antibodies has diminished because of the emergence of viral variants that are not anticipated to be susceptible to these treatments, and there still is not a consensus on the use of convalescent plasma. COVID-19 has been associated with increased rates of venous thromboembolism, but the role of antithrombotic therapy is limited. Multiple investigational agents continue to be studied, which will alter current treatment paradigms as new data are released.
    MeSH term(s) Humans ; COVID-19 ; COVID-19 Serotherapy ; Immunomodulation ; Interleukin-6 ; Janus Kinase Inhibitors/therapeutic use
    Chemical Substances Interleukin-6 ; Janus Kinase Inhibitors
    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-052422-020316
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  7. Article ; Online: COVID-19: Where We Are, Where We Need to Be.

    Bender Ignacio, Rachel A / Gandhi, Rajesh T

    Infectious disease clinics of North America

    2022  Volume 36, Issue 2, Page(s) xiii–xv

    MeSH term(s) COVID-19 ; Humans
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2022.02.003
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  8. Article ; Online: COVID-19 Treatments for Nonhospitalized Patients-Reply.

    Gandhi, Rajesh T / Malani, Preeti N / Del Rio, Carlos

    JAMA

    2022  Volume 327, Issue 22, Page(s) 2248

    MeSH term(s) Ambulatory Care ; COVID-19/drug therapy ; Hospitalization ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.6173
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  10. Article ; Online: The Multidimensional Challenge of Treating Coronavirus Disease 2019 (COVID-19)

    Gandhi, Rajesh T

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    Remdesivir Is a Foot in the Door

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa1132
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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