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  1. Article ; Online: Eli Robins: The grandfather of DSM-III.

    Kirkpatrick, Brian / Fernandez-Egea, Emilio

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2024  Volume 83, Page(s) 30–31

    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2024.03.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3288: Show issues Location:
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  2. Article ; Online: Assessment and the concept of negative symptoms.

    Kirkpatrick, Brian / Fernandez-Egea, Emilio

    Spanish journal of psychiatry and mental health

    2023  

    Language English
    Publishing date 2023-10-29
    Publishing country Spain
    Document type Journal Article
    ISSN 2950-2853
    ISSN (online) 2950-2853
    DOI 10.1016/j.sjpmh.2023.09.006
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  3. Article ; Online: Degree of leukochimerism with calf age in Angus-crossbred twin sets.

    Hunt, Heather L / Kirkpatrick, Brian W

    Animal genetics

    2023  Volume 54, Issue 5, Page(s) 619–622

    Abstract: Twinning in cattle is infrequent and usually undesired. It can result in an increased occurrence of abortion and dystocia, reduced calf survival and a high likelihood of freemartinism in mixed-sex twins. Twin gestations are also commonly associated with ... ...

    Abstract Twinning in cattle is infrequent and usually undesired. It can result in an increased occurrence of abortion and dystocia, reduced calf survival and a high likelihood of freemartinism in mixed-sex twins. Twin gestations are also commonly associated with the formation of placental vascular anastomoses (PVA) between twins. Through PVA they share blood, hormones (leading to freemartinism in mixed sex twins) and hematopoietic stem cells, which are the progenitors of white blood cells. The sharing of stem cells between twins can result in leukochimeric twin sets. These are twins that have white blood cells derived from both self and the co-twin owing to the fetal migration of hematopoietic stem cells from the extraembryonic mesoderm of the yolk sac to final sites like bone marrow and thymus. This study examined the degree to which this leukochimerism changes with age. DNA was extracted from hair bulbs containing mesenchymal dermal papilla to determine the individual's true genotype and blood samples were obtained at six time points from 1 week to 8 months of age to assess leukochimerism. Samples were genotyped using a medium density SNP chip, and quantitative estimates of allele frequency were determined using SNPs for which members of a twin set had alternative homozygous genotypes. The results indicate statistically significant changes in the proportion of self and co-twin with age and suggest that by 2-4 months of age the genotypic mix in white blood cells represents the hematopoetic stem cell population resident in the individual (i.e. permanently found in thymus and bone marrow).
    MeSH term(s) Pregnancy ; Animals ; Cattle/genetics ; Female ; Freemartinism ; Placenta ; Gene Frequency ; Cattle Diseases
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 632766-7
    ISSN 1365-2052 ; 0268-9146 ; 0268-9154
    ISSN (online) 1365-2052
    ISSN 0268-9146 ; 0268-9154
    DOI 10.1111/age.13349
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  4. Article ; Online: Exploring Perceptions and Approaches of Registered Managers Regarding Clinical Safety in Care Homes in the UK

    Clare Kirkpatrick / Brian Nyatanga

    Journal of Long-Term Care (2023)

    2023  

    Abstract: Context: Around 400,000 people currently live in care homes with increasing complexity of care needs and comorbidities. Despite this, there is a paucity of research that asks questions about how the care and clinical safety of this vulnerable population ... ...

    Abstract Context: Around 400,000 people currently live in care homes with increasing complexity of care needs and comorbidities. Despite this, there is a paucity of research that asks questions about how the care and clinical safety of this vulnerable population are managed. Objective: The aim of this research was to understand how registered care home managers approach clinical safety and what they feel helps or hinders them in this. Methods: The research took a Heideggerian interpretative phenomenological approach, embracing the closeness of the researcher to the participants and the subject matter to uncover rich and detailed findings. Five registered managers of care homes owned by one provider participated in semi-structured interviews between March and May 2020. Three of the interviews took place in the managers’ care homes, and, due to coronavirus restrictions, two were undertaken via video conferencing software. Findings: Thematic analysis of the data generated unexpected findings demonstrating the significant impact on clinical safety in care homes caused not by the managers themselves, but by external forces, including regulation, shortcomings in the structure of the health and social care system in the UK and complex relationships between care homes and other agencies. Limitations: The strengths (e.g., in-depth data) and limitations (e.g., only including care homes in one area) of this phenomenological qualitative study are discussed. Implications: The findings led to recommendations that further research and reviews should be undertaken urgently to understand these factors in more detail. This would provide valuable guidance to inform system-wide reform to ensure better clinical safety for care home residents.
    Keywords nursing homes ; care homes ; leadership ; social care ; social and health services ; management ; Medicine ; R ; Social Sciences ; H
    Subject code 360
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher LSE Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Identifying genetic variants and pathways influencing daughter averages for twinning in North American Holstein cattle and evaluating the potential for genomic selection.

    Lett, Beth M / Kirkpatrick, Brian W

    Journal of dairy science

    2022  Volume 105, Issue 7, Page(s) 5972–5984

    Abstract: Multiple birth in dairy cattle is a detrimental trait both economically for producers and for animal health. Genetics of twinning is complex and has led to several quantitative trait loci regions being associated with increased twinning. To identify ... ...

    Abstract Multiple birth in dairy cattle is a detrimental trait both economically for producers and for animal health. Genetics of twinning is complex and has led to several quantitative trait loci regions being associated with increased twinning. To identify variants associated with this trait, calving records from 2 time periods were used to estimate daughter averages for twinning for Holstein bulls. Multiple analyses were conducted and compared including GWAS, genomic prediction, and gene set enrichment analysis for pathway detection. Although pathway analysis did not yield many congruent pathways of interest between data sets, it did indicate two of interest. Both pathways have ties to the strong candidate region on BTA11 from the genome-wide association analysis across data sets. This region does not overlap with previously identified quantitative trait loci regions for twinning or ovulation rate in cattle. The strongest associated SNPs were upstream from 2 candidate genes LHCGR and FSHR, which are involved in folliculogenesis. Genomic prediction showed a moderate correlation accuracy (0.43) when predicting genomic breeding values for bulls with estimates from calving records from 2010 to 2016. Future analysis of the region on BTA11 and the relation of the candidate genes could improve this accuracy.
    MeSH term(s) Animals ; Cattle/genetics ; Female ; Genome-Wide Association Study/veterinary ; Genomics ; Male ; North America ; Nuclear Family ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 242499-x
    ISSN 1525-3198 ; 0022-0302
    ISSN (online) 1525-3198
    ISSN 0022-0302
    DOI 10.3168/jds.2021-21238
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    Zs.B 810: Show issues Location:
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  6. Article ; Online: Negative symptoms in the clinic: we treat what we can describe.

    Kirkpatrick, Brian / Luther, Lauren / Strauss, Gregory P

    The British journal of psychiatry : the journal of mental science

    2023  Volume 223, Issue 1, Page(s) 271–272

    Abstract: Recent research has led to important changes in the concepts and assessment of negative symptoms in schizophrenia. We review current negative symptom concepts and their clinical implications, as well as new methods of assessing these symptoms. These ... ...

    Abstract Recent research has led to important changes in the concepts and assessment of negative symptoms in schizophrenia. We review current negative symptom concepts and their clinical implications, as well as new methods of assessing these symptoms. These changes hold promise for improving our understanding and treatment of negative symptoms.
    MeSH term(s) Humans ; Psychiatric Status Rating Scales ; Schizophrenic Psychology ; Schizophrenia/diagnosis ; Schizophrenia/therapy ; Psychometrics
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2023.68
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  7. Article ; Online: A new era for the negative symptoms of schizophrenia.

    Fernandez-Egea, Emilio / Mucci, Armida / Lee, Jimmy / Kirkpatrick, Brian

    The British journal of psychiatry : the journal of mental science

    2023  Volume 223, Issue 1, Page(s) 269–270

    Abstract: Negative symptoms remain one of the major unmet needs for people with schizophrenia, and the past decade has witnessed a surge in interest in negative symptoms. In this themed issue, we present new concepts of negative symptoms and recent findings on ... ...

    Abstract Negative symptoms remain one of the major unmet needs for people with schizophrenia, and the past decade has witnessed a surge in interest in negative symptoms. In this themed issue, we present new concepts of negative symptoms and recent findings on their epidemiology and pathophysiology and on therapeutic options for their management.
    MeSH term(s) Humans ; Schizophrenia/diagnosis ; Schizophrenia/epidemiology ; Schizophrenia/therapy ; Anhedonia/physiology ; Schizophrenic Psychology
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2023.69
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  8. Article ; Online: Attentional modulation of eye blinking is altered by sex, age, and task structure.

    Pitigoi, Isabell C / Coe, Brian C / Calancie, Olivia G / Brien, Donald C / Yep, Rachel / Riek, Heidi C / Kirkpatrick, Ryan H / Noyes, Blake K / White, Brian J / Blohm, Gunnar / Munoz, Douglas P

    eNeuro

    2024  

    Abstract: Spontaneous eye blinking is gaining popularity as a proxy for higher cognitive functions, as it is readily modulated by both environmental demands and internal processes. Prior studies were impoverished in sample size, sex representation and age ... ...

    Abstract Spontaneous eye blinking is gaining popularity as a proxy for higher cognitive functions, as it is readily modulated by both environmental demands and internal processes. Prior studies were impoverished in sample size, sex representation and age distribution, making it difficult to establish a complete picture of the behavior. Here we present eye-tracking data from a large cohort of normative participants (
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0296-23.2024
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  9. Article ; Online: Degree of leukochimerism with calf age in Angus‐crossbred twin sets

    Hunt, Heather L. / Kirkpatrick, Brian W.

    Animal Genetics. 2023 Oct., v. 54, no. 5 p.619-622

    2023  

    Abstract: Twinning in cattle is infrequent and usually undesired. It can result in an increased occurrence of abortion and dystocia, reduced calf survival and a high likelihood of freemartinism in mixed‐sex twins. Twin gestations are also commonly associated with ... ...

    Abstract Twinning in cattle is infrequent and usually undesired. It can result in an increased occurrence of abortion and dystocia, reduced calf survival and a high likelihood of freemartinism in mixed‐sex twins. Twin gestations are also commonly associated with the formation of placental vascular anastomoses (PVA) between twins. Through PVA they share blood, hormones (leading to freemartinism in mixed sex twins) and hematopoietic stem cells, which are the progenitors of white blood cells. The sharing of stem cells between twins can result in leukochimeric twin sets. These are twins that have white blood cells derived from both self and the co‐twin owing to the fetal migration of hematopoietic stem cells from the extraembryonic mesoderm of the yolk sac to final sites like bone marrow and thymus. This study examined the degree to which this leukochimerism changes with age. DNA was extracted from hair bulbs containing mesenchymal dermal papilla to determine the individual's true genotype and blood samples were obtained at six time points from 1 week to 8 months of age to assess leukochimerism. Samples were genotyped using a medium density SNP chip, and quantitative estimates of allele frequency were determined using SNPs for which members of a twin set had alternative homozygous genotypes. The results indicate statistically significant changes in the proportion of self and co‐twin with age and suggest that by 2–4 months of age the genotypic mix in white blood cells represents the hematopoetic stem cell population resident in the individual (i.e. permanently found in thymus and bone marrow).
    Keywords DNA ; animal genetics ; blood ; bone marrow ; calves ; dystocia ; freemartinism ; gene frequency ; genotyping ; homozygosity ; mesoderm ; stem cells ; yolk sac
    Language English
    Dates of publication 2023-10
    Size p. 619-622.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 632766-7
    ISSN 1365-2052 ; 0268-9146 ; 0268-9154
    ISSN (online) 1365-2052
    ISSN 0268-9146 ; 0268-9154
    DOI 10.1111/age.13349
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2791: Show issues

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  10. Article ; Online: Progress in the study of negative symptoms.

    Kirkpatrick, Brian

    Schizophrenia bulletin

    2014  Volume 40 Suppl 2, Page(s) S101–6

    Abstract: A selective review of the negative symptoms of schizophrenia is an appropriate article to result from the festschrift honoring William T. Carpenter Jr, as he has made substantial contributions in this area. This review assesses progress in 3 areas in ... ...

    Abstract A selective review of the negative symptoms of schizophrenia is an appropriate article to result from the festschrift honoring William T. Carpenter Jr, as he has made substantial contributions in this area. This review assesses progress in 3 areas in which he has been an important investigator: the distinction between primary vs secondary negative symptoms; the appropriate design for treatment trials; and the nosology of negative symptoms.
    MeSH term(s) Clinical Trials as Topic/standards ; Humans ; Schizophrenia/classification ; Schizophrenia/physiopathology
    Language English
    Publishing date 2014-02-22
    Publishing country United States
    Document type Festschrift
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbt158
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    Zs.B 1323: Show issues Location:
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