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  1. Article ; Online: The Nation-State after the Virus.

    Manghi, Nicola

    Social anthropology : the journal of the European Association of Social Anthropologists = Anthropologie sociale

    2020  Volume 28, Issue 2, Page(s) 315–316

    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001972-5
    ISSN 1469-8676 ; 0964-0282
    ISSN (online) 1469-8676
    ISSN 0964-0282
    DOI 10.1111/1469-8676.12877
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  2. Article ; Online: L’autolesionismo nel CPR Brunelleschi di Torino

    Nicola Manghi

    Anuac, Vol 10, Iss

    Campo, agency, soggettivazione

    2021  Volume 1

    Abstract: I Centri di Permanenza per il Rimpatrio (CPR) sono luoghi che hanno ricevuto poca attenzione da parte delle scienze sociali. Questo contributo si focalizza sul tema delle condotte autolesionistiche, unanimemente riferite come assai frequenti dagli ... ...

    Abstract I Centri di Permanenza per il Rimpatrio (CPR) sono luoghi che hanno ricevuto poca attenzione da parte delle scienze sociali. Questo contributo si focalizza sul tema delle condotte autolesionistiche, unanimemente riferite come assai frequenti dagli osservatori, e si propone d’individuare le condizioni che permettano di metterne in risalto la politicità. Tali condizioni saranno delineate, da un lato, tramite l’analisi del sistema CPR, e, dall’altro, per mezzo di un riesame critico dei concetti di “campo” e “agency”, con riferimento obbligato ai lavori di Giorgio Agamben e Michel Foucault. Se questi luoghi – quanto mai “d’eccezione” – sembrano costringere massimamente le possibilità delle persone che vi sono trattenute, abolendo in apparenza il campo del politico, la condotta autolesionistica, qualunque siano le motivazioni che soggettivamente la sostengono, individua il cuore biopolitico di tali istituzioni, rivelando così la propria intrinseca e “oggettiva” politicità.
    Keywords Ethnology. Social and cultural anthropology ; GN301-674
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Università degli Studi di Cagliari
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Translating the Microbiome: What's the Target?

    O'Toole, Paul W / Ghosh, Tarini Shankar / Goswami, Sourav / Manghi, Paolo / Segata, Nicola / Shanahan, Fergus

    Gastroenterology

    2023  Volume 165, Issue 2, Page(s) 317–319

    MeSH term(s) Humans ; Microbiota
    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.04.008
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  5. Article: Impact of Single-Walled Carbon Nanotube Functionalization on Ion and Water Molecule Transport at the Nanoscale.

    Mejri, Alia / Arroyo, Nicolas / Herlem, Guillaume / Palmeri, John / Manghi, Manoel / Henn, François / Picaud, Fabien

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 1

    Abstract: Nanofluidics has a very promising future owing to its numerous applications in many domains. It remains, however, very difficult to understand the basic physico-chemical principles that control the behavior of solvents confined in nanometric channels. ... ...

    Abstract Nanofluidics has a very promising future owing to its numerous applications in many domains. It remains, however, very difficult to understand the basic physico-chemical principles that control the behavior of solvents confined in nanometric channels. Here, water and ion transport in carbon nanotubes is investigated using classical force field molecular dynamics simulations. By combining one single walled carbon nanotube (uniformly charged or not) with two perforated graphene sheets, we mimic single nanopore devices similar to experimental ones. The graphitic edges delimit two reservoirs of water and ions in the simulation cell from which a voltage is imposed through the application of an external electric field. By analyzing the evolution of the electrolyte conductivity, the role of the carbon nanotube geometric parameters (radius and chirality) and of the functionalization of the carbon nanotube entrances with OH or COO
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14010117
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  6. Article ; Online: Favorable subgingival plaque microbiome shifts are associated with clinical treatment for peri-implant diseases.

    Bazzani, Davide / Heidrich, Vitor / Manghi, Paolo / Blanco-Miguez, Aitor / Asnicar, Francesco / Armanini, Federica / Cavaliere, Sara / Bertelle, Alberto / Dell'Acqua, Federico / Dellasega, Ester / Waldner, Romina / Vicentini, Daniela / Bolzan, Mattia / Tomasi, Cristiano / Segata, Nicola / Pasolli, Edoardo / Ghensi, Paolo

    NPJ biofilms and microbiomes

    2024  Volume 10, Issue 1, Page(s) 12

    Abstract: We performed a longitudinal shotgun metagenomic investigation of the plaque microbiome associated with peri-implant diseases in a cohort of 91 subjects with 320 quality-controlled metagenomes. Through recently improved taxonomic profiling methods, we ... ...

    Abstract We performed a longitudinal shotgun metagenomic investigation of the plaque microbiome associated with peri-implant diseases in a cohort of 91 subjects with 320 quality-controlled metagenomes. Through recently improved taxonomic profiling methods, we identified the most discriminative species between healthy and diseased subjects at baseline, evaluated their change over time, and provided evidence that clinical treatment had a positive effect on plaque microbiome composition in patients affected by mucositis and peri-implantitis.
    MeSH term(s) Humans ; Peri-Implantitis/therapy ; Microbiota
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2817021-0
    ISSN 2055-5008 ; 2055-5008
    ISSN (online) 2055-5008
    ISSN 2055-5008
    DOI 10.1038/s41522-024-00482-z
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  7. Article: Discovering and exploring the hidden diversity of human gut viruses using highly enriched virome samples.

    Zolfo, Moreno / Silverj, Andrea / Blanco-Míguez, Aitor / Manghi, Paolo / Rota-Stabelli, Omar / Heidrich, Vitor / Jensen, Jordan / Maharjan, Sagun / Franzosa, Eric / Menni, Cristina / Visconti, Alessia / Pinto, Federica / Ciciani, Matteo / Huttenhower, Curtis / Cereseto, Anna / Asnicar, Francesco / Kitano, Hiroaki / Yamada, Takuji / Segata, Nicola

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Viruses are an abundant and crucial component of the human microbiome, but accurately discovering them via metagenomics is still challenging. Currently, the available viral reference genomes poorly represent the diversity in microbiome samples, and ... ...

    Abstract Viruses are an abundant and crucial component of the human microbiome, but accurately discovering them via metagenomics is still challenging. Currently, the available viral reference genomes poorly represent the diversity in microbiome samples, and expanding such a set of viral references is difficult. As a result, many viruses are still undetectable through metagenomics even when considering the power of
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.19.580813
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  8. Article ; Online: Neuroblastoma is associated with alterations in gut microbiome composition subsequent to maternal microbial seedingResearch in context

    Mireia Valles-Colomer / Paolo Manghi / Fabio Cumbo / Giulia Masetti / Federica Armanini / Francesco Asnicar / Aitor Blanco-Miguez / Federica Pinto / Michal Punčochář / Alberto Garaventa / Loredana Amoroso / Mirco Ponzoni / Maria Valeria Corrias / Nicola Segata

    EBioMedicine, Vol 99, Iss , Pp 104917- (2024)

    1481  

    Abstract: Summary: Background: Neuroblastoma is the most frequent extracranial solid tumour in children, accounting for ∼15% of deaths due to cancer in childhood. The most common clinical presentation are abdominal tumours. An altered gut microbiome composition ... ...

    Abstract Summary: Background: Neuroblastoma is the most frequent extracranial solid tumour in children, accounting for ∼15% of deaths due to cancer in childhood. The most common clinical presentation are abdominal tumours. An altered gut microbiome composition has been linked to multiple cancer types, and reported in murine models of neuroblastoma. Whether children with neuroblastoma display alterations in gut microbiome composition remains unexplored. Methods: We assessed gut microbiome composition by shotgun metagenomic profiling in an observational cross-sectional study on 288 individuals, consisting of patients with a diagnosis of neuroblastoma at disease onset (N = 63), healthy controls matching the patients on the main covariates of microbiome composition (N = 94), healthy siblings of the patients (N = 13), mothers of patients (N = 59), and mothers of the controls (N = 59). We examined taxonomic and functional microbiome composition and mother-infant strain transmission patterns. Findings: Patients with neuroblastoma displayed alterations in gut microbiome composition characterised by reduced microbiome richness, decreased relative abundances of 18 species (including Phocaeicola dorei and Bifidobacterium bifidum), enriched protein fermentation and reduced carbohydrate fermentation potential. Using machine learning, we could successfully discriminate patients from controls (AUC = 82%). Healthy siblings did not display such alterations but resembled the healthy control group. No significant differences in maternal microbiome composition nor mother-to-offspring transmission were detected. Interpretation: Patients with neuroblastoma display alterations in taxonomic and functional gut microbiome composition, which cannot be traced to differential maternal seeding. Follow-up research should include investigating potential causal links. Funding: Italian Ministry of Health Ricerca Corrente and Ricerca Finalizzata 5 per mille (to MPonzoni); Fondazione Italiana Neuroblastoma (to MPonzoni); European Research Council (ERC-StG ...
    Keywords Neuroblastoma ; Paediatric cancer ; Gut microbiome ; Metagenomics ; Mother-infant transmission ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610 ; 616
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Neuroblastoma is associated with alterations in gut microbiome composition subsequent to maternal microbial seeding.

    Valles-Colomer, Mireia / Manghi, Paolo / Cumbo, Fabio / Masetti, Giulia / Armanini, Federica / Asnicar, Francesco / Blanco-Miguez, Aitor / Pinto, Federica / Punčochář, Michal / Garaventa, Alberto / Amoroso, Loredana / Ponzoni, Mirco / Corrias, Maria Valeria / Segata, Nicola

    EBioMedicine

    2023  Volume 99, Page(s) 104917

    Abstract: Background: Neuroblastoma is the most frequent extracranial solid tumour in children, accounting for ∼15% of deaths due to cancer in childhood. The most common clinical presentation are abdominal tumours. An altered gut microbiome composition has been ... ...

    Abstract Background: Neuroblastoma is the most frequent extracranial solid tumour in children, accounting for ∼15% of deaths due to cancer in childhood. The most common clinical presentation are abdominal tumours. An altered gut microbiome composition has been linked to multiple cancer types, and reported in murine models of neuroblastoma. Whether children with neuroblastoma display alterations in gut microbiome composition remains unexplored.
    Methods: We assessed gut microbiome composition by shotgun metagenomic profiling in an observational cross-sectional study on 288 individuals, consisting of patients with a diagnosis of neuroblastoma at disease onset (N = 63), healthy controls matching the patients on the main covariates of microbiome composition (N = 94), healthy siblings of the patients (N = 13), mothers of patients (N = 59), and mothers of the controls (N = 59). We examined taxonomic and functional microbiome composition and mother-infant strain transmission patterns.
    Findings: Patients with neuroblastoma displayed alterations in gut microbiome composition characterised by reduced microbiome richness, decreased relative abundances of 18 species (including Phocaeicola dorei and Bifidobacterium bifidum), enriched protein fermentation and reduced carbohydrate fermentation potential. Using machine learning, we could successfully discriminate patients from controls (AUC = 82%). Healthy siblings did not display such alterations but resembled the healthy control group. No significant differences in maternal microbiome composition nor mother-to-offspring transmission were detected.
    Interpretation: Patients with neuroblastoma display alterations in taxonomic and functional gut microbiome composition, which cannot be traced to differential maternal seeding. Follow-up research should include investigating potential causal links.
    Funding: Italian Ministry of Health Ricerca Corrente and Ricerca Finalizzata 5 per mille (to MPonzoni); Fondazione Italiana Neuroblastoma (to MPonzoni); European Research Council (ERC-StG project MetaPG-716575 and ERC-CoG microTOUCH-101045015 to NS); the European H2020 program ONCOBIOME-825410 project (to NS); the National Cancer Institute of the National Institutes of Health 1U01CA230551 (to NS); the Premio Internazionale Lombardia e Ricerca 2019 (to NS); the MIUR Progetti di Ricerca di Rilevante Interesse Nazionale (PRIN) Bando 2017 Grant 2017J3E2W2 (to NS); EMBO ALTF 593-2020 and Knowledge Generation Project from the Spanish Ministry of Science and Innovation (PID2022-139328OA-I00) (to MV-C).
    MeSH term(s) Infant ; Child ; Female ; Humans ; Animals ; Mice ; Gastrointestinal Microbiome ; Cross-Sectional Studies ; Microbiota ; Metagenome ; Neuroblastoma/etiology
    Language English
    Publishing date 2023-12-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104917
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  10. Article ; Online: Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer.

    Blanco-Míguez, Aitor / Carloni, Sara / Cardenas, Cindy / Dioguardi, Carola Conca / Lambroia, Luca / Capretti, Giovanni / Nappo, Gennaro / Fugazza, Alessandro / Capogreco, Antonio / Armanini, Federica / Asnicar, Francesco / Dubois, Leonard / Golzato, Davide / Manghi, Paolo / Pinto, Federica / Scuderi, Cristina / Casari, Erminia / Montorsi, Marco / Anderloni, Andrea /
    Rescigno, Maria / Repici, Alessandro / Zerbi, Alessandro / Peano, Clelia / Tamburini, Sabrina / Rusconi, Roberto / Segata, Nicola

    NPJ biofilms and microbiomes

    2024  Volume 10, Issue 1, Page(s) 35

    Abstract: Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. ... ...

    Abstract Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.
    MeSH term(s) Humans ; Bacterial Infections ; Biofilms ; Cholestasis/surgery ; Neoplasms ; Stents/adverse effects ; Stents/microbiology
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2817021-0
    ISSN 2055-5008 ; 2055-5008
    ISSN (online) 2055-5008
    ISSN 2055-5008
    DOI 10.1038/s41522-024-00506-8
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