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  1. Article ; Online: Nephrology education and training in Africa.

    Naicker, Saraladevi

    Nature reviews. Nephrology

    2022  Volume 17, Issue 12, Page(s) 784

    MeSH term(s) Africa ; Humans ; Nephrology
    Language English
    Publishing date 2022-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00486-4
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  2. Article ; Online: The changing landscape of HIV-associated kidney disease.

    Diana, Nina E / Naicker, Saraladevi

    Nature reviews. Nephrology

    2024  Volume 20, Issue 5, Page(s) 330–346

    Abstract: The HIV epidemic has devastated millions of people globally, with approximately 40 million deaths since its start. The availability of antiretroviral therapy (ART) has transformed the prognosis of millions of individuals infected with HIV such that a ... ...

    Abstract The HIV epidemic has devastated millions of people globally, with approximately 40 million deaths since its start. The availability of antiretroviral therapy (ART) has transformed the prognosis of millions of individuals infected with HIV such that a diagnosis of HIV infection no longer automatically confers death. However, morbidity and mortality remain substantial among people living with HIV. HIV can directly infect the kidney to cause HIV-associated nephropathy (HIVAN) - a disease characterized by podocyte and tubular damage and associated with an increased risk of kidney failure. The reports of HIVAN occurring primarily in those of African ancestry led to the discovery of its association with APOL1 risk alleles. The advent of ART has led to a substantial decrease in the prevalence of HIVAN; however, reports have emerged of an increase in the prevalence of other kidney pathology, such as focal segmental glomerulosclerosis and pathological conditions associated with co-morbidities of ageing, such as hypertension and diabetes mellitus. Early initiation of ART also results in a longer cumulative exposure to medications, increasing the likelihood of nephrotoxicity. A substantial body of literature supports the use of kidney transplantation in people living with HIV, demonstrating significant survival benefits compared with that of people undergoing chronic dialysis, and similar long-term allograft and patient survival compared with that of HIV-negative kidney transplant recipients.
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-023-00801-1
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  3. Article ; Online: Introduction: ISN Frontiers Meeting on "Infections and the Kidney".

    Naicker, Saraladevi / Yang, Chih-Wei / Jha, Vivekanand

    Seminars in nephrology

    2023  Volume 43, Issue 5, Page(s) 151464

    MeSH term(s) Humans ; Kidney
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Editorial
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2023.151464
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  4. Article: HIV/AIDS and chronic kidney disease.

    Naicker, Saraladevi

    Clinical nephrology

    2019  Volume 93, Issue 1, Page(s) 87–93

    Abstract: Chronic kidney disease (CKD) is a frequent complication of HIV infection. The classic involvement of the kidney by HIV infection is HIV-associated nephropathy (HIVAN), occurring typically in young adults of African ancestry with advanced HIV disease in ... ...

    Abstract Chronic kidney disease (CKD) is a frequent complication of HIV infection. The classic involvement of the kidney by HIV infection is HIV-associated nephropathy (HIVAN), occurring typically in young adults of African ancestry with advanced HIV disease in association with
    MeSH term(s) AIDS-Associated Nephropathy/epidemiology ; AIDS-Associated Nephropathy/therapy ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; Female ; Humans ; Kidney/drug effects ; Kidney Transplantation ; Male ; Renal Dialysis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Young Adult
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2019-08-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CNP92S115
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  5. Article ; Online: HIV and Associated TB: A Lethal Association for Kidney Health?

    Kalyesubula, Robert / Wearne, Nicola / Kubo, Mary / Hussey, Nadia / Naicker, Saraladevi

    Seminars in nephrology

    2024  Volume 43, Issue 5, Page(s) 151470

    Abstract: Human immunodeficiency virus (HIV) and tuberculosis (TB) are the leading infectious causes of death globally. The combined brunt of these diseases is experienced mainly in low-income and lower-middle-income countries. HIV/TB have devastating effects on ... ...

    Abstract Human immunodeficiency virus (HIV) and tuberculosis (TB) are the leading infectious causes of death globally. The combined brunt of these diseases is experienced mainly in low-income and lower-middle-income countries. HIV/TB have devastating effects on the kidneys, leading to accelerated decline of kidney function as well as mortality. Managing the triad of TB/HIV and kidney disease is challenging. We discuss the epidemiology of HIV/TB coinfection and the kidney and the key mechanisms of kidney disease including genetic susceptibility. The clinical presentation and pathology, as well as the challenges of diagnosing CKD in these patients, also are discussed. The strategies to prevent and manage HIV/TB-related kidney disease such as proper assessment, avoiding nephrotoxic regimens, drug dose adjustments, kidney function monitoring, avoidance of drug-drug interactions, and other interventions are explored. We also briefly discuss the complexities around HIV/TB patients on dialysis and kidney transplantation. HIV/TB coinfection presents an increased risk for kidney-related morbidity and mortality; patients with this triad need to be given special consideration for future research and management.
    MeSH term(s) Humans ; HIV ; Coinfection/epidemiology ; Tuberculosis/complications ; Tuberculosis/epidemiology ; HIV Infections/complications ; HIV Infections/epidemiology ; Kidney ; Kidney Diseases
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2023.151470
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  6. Article ; Online: Nephrology in Africa: forgotten no more.

    Naicker, Saraladevi / Jha, Vivekanand

    Kidney international

    2020  Volume 98, Issue 4, Page(s) 804–806

    MeSH term(s) Acute Kidney Injury ; Africa/epidemiology ; Humans ; Kidney Failure, Chronic ; Nephrology ; Renal Insufficiency, Chronic
    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.07.016
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  7. Article ; Online: Acute Interstitial Nephritis in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

    Do Vale, Claudia L / Naicker, Saraladevi / Lippincott, Christopher K

    Kidney international reports

    2021  Volume 7, Issue 4, Page(s) 920–923

    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.12.008
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  8. Article ; Online: Reform of research funding processes could pave the way for progress in global health.

    Ashuntantang, Gloria / Luyckx, Valerie / Naicker, Saraladevi / Venkatapuram, Sridhar

    The Lancet. Global health

    2021  Volume 9, Issue 8, Page(s) e1053–e1054

    MeSH term(s) Global Health/statistics & numerical data ; Humans ; Research Support as Topic/organization & administration
    Language English
    Publishing date 2021-07-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(21)00207-2
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  9. Article: Nephrology in Africa - challenges of practice in resource-limited environment.

    Naicker, Saraladevi

    Clinical nephrology

    2016  Volume 86 2016, Issue 13, Page(s) 84–89

    Abstract: Chronic kidney disease (CKD), a major public health problem, is especially challenging for patients and healthcare personnel in Africa, a region with poor economic resources and a massive shortage of health-care workers. The burden of kidney disease is ... ...

    Abstract Chronic kidney disease (CKD), a major public health problem, is especially challenging for patients and healthcare personnel in Africa, a region with poor economic resources and a massive shortage of health-care workers. The burden of kidney disease is increased in poorly-resourced regions due to increased exposure to infections, poverty, poor access to healthcare, and genetic predisposition to kidney disease, contributing further to the problems when managing CKD and acute kidney injury. The vast majority of patients do not have access to renal replacement therapy. Urgent attention to cost of dialysis is required for wider expansion of services so that renal replacement therapy is affordable for the governments and populations of Africa. Priority needs to be given to prevention and treatment of acute kidney injury. Lack of resources has hampered the widespread utilization of prevention strategies; these are optimally delivered in a primary healthcare setting by doctors, nurses, and other healthcare workers with access to protocols for screening, disease management, achievement of treatment goals (with availability of therapy to retard progression), and criteria for referral to specialist and nephrology expertise. A regional or national renal registry is an important initiative to obtain accurate data on the burden of disease and outcomes of therapeutic interventions.
    MeSH term(s) Acute Kidney Injury/therapy ; Africa ; Health Resources ; Humans ; Nephrology/trends ; Professional Practice/trends ; Referral and Consultation ; Renal Insufficiency, Chronic/therapy ; Renal Replacement Therapy/trends
    Language English
    Publishing date 2016
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CNP86S112
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  10. Article ; Online: Progression of chronic kidney disease among black patients attending a tertiary hospital in Johannesburg, South Africa.

    Alfred Meremo / Graham Paget / Raquel Duarte / Deogratius Bintabara / Saraladevi Naicker

    PLoS ONE, Vol 18, Iss 2, p e

    2023  Volume 0276356

    Abstract: Background Chronic kidney disease (CKD) is a major public health issue worldwide and is an important contributor to the overall non-communicable disease burden. Chronic kidney disease is usually asymptomatic, and insidiously and silently progresses to ... ...

    Abstract Background Chronic kidney disease (CKD) is a major public health issue worldwide and is an important contributor to the overall non-communicable disease burden. Chronic kidney disease is usually asymptomatic, and insidiously and silently progresses to advanced stages in resource limited settings. Methodology A prospective longitudinal study was carried out on black patients with CKD attending the kidney outpatient clinic at Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) in South Africa, between September 2019 to March 2022. Demographic and clinical data were extracted from the ongoing continuous clinic records, as well as measurements of vital signs and interviews at baseline and at follow up. Patients provided urine and blood samples for laboratory investigations as standard of care at study entry (0) and at 24 months, and were followed up prospectively for two (2) years. Data were descriptively and inferentially entered into REDcap and analysed using STATA version 17, and multivariable logistic regression analysis was used to identify predictors of CKD progression. Results A total of 312 patients were enrolled into the study, 297 (95.2%) patients completed the study, 10 (3.2%) patients were lost to follow and 5 (1.6%) patients died during the study period. The prevalence of CKD progression was 49.5%, while that of CKD remission was 33% and CKD regression was 17.5%. For patients with CKD progression the median age at baseline was 58 (46-67) years, the median eGFR was 37 (32-51) mL/min/1.73 m2, median urine protein creatinine ratio (uPCR) was 0.038 (0.016-0.82) g/mmol and the median haemoglobin (Hb) was 13.1 (11.7-14.4) g/dl; 95.2% had hypertension, 40.1% patients had diabetes mellitus and 39.5% had both hypertension and diabetes mellitus. Almost half (48.3%) of patients with CKD progression had severely increased proteinuria and 45.6% had anaemia. Variables associated with higher odds for CKD progression after multivariable logistic regression analysis were severely increased proteinuria (OR 32.3, 95% ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 616 ; 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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