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Article: An insight into the potent medicinal plant

Bose Mazumdar Ghosh, Aparupa / Banerjee, Anindita / Chattopadhyay, Sharmila

The Nucleus : an international journal of cytology and allied topics

2022 Volume 65, Issue 3, Page(s) 437–472

Abstract: Phyllanthus amarus: Supplementary information: The online version contains supplementary material available at 10.1007/s13237-022-00409-z. ...

Abstract	Phyllanthus amarus Supplementary information: The online version contains supplementary material available at 10.1007/s13237-022-00409-z.
Language	English
Publishing date	2022-11-12
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2589081-5
ISSN	0976-7975 ; 0029-568X
ISSN (online)	0976-7975
ISSN	0029-568X
DOI	10.1007/s13237-022-00409-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mycobacterium abscessus

Sur, Saubashya / Patra, Tanushree / Karmakar, Mistu / Banerjee, Anindita

Critical reviews in microbiology

2022 Volume 49, Issue 4, Page(s) 499–514

Abstract: Mycobacterium ... ...

Abstract	Mycobacterium abscessus
MeSH term(s)	Humans ; Mycobacterium abscessus/genetics ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/epidemiology ; Mycobacterium Infections, Nontuberculous/microbiology ; Nontuberculous Mycobacteria/genetics ; Cystic Fibrosis/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-06-13
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1053620-6
ISSN	1549-7828 ; 1040-841X
ISSN (online)	1549-7828
ISSN	1040-841X
DOI	10.1080/1040841X.2022.2082268
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Article ; Online: Phytochemical analysis and bioactivity reports of ethnomedicinal plants from West Bengal, India.

Pal, Asmita / Banerjee, Anindita / Kundu, Rita

Natural product research

2022 Volume 37, Issue 6, Page(s) 1036–1041

Abstract: The biodiversity-rich forests of the Jhargram subdivision of West Bengal, India houses many lesser-known prospective plants. Four ethnomedicinal plants from this locality- ...

Abstract	The biodiversity-rich forests of the Jhargram subdivision of West Bengal, India houses many lesser-known prospective plants. Four ethnomedicinal plants from this locality-
MeSH term(s)	Female ; Humans ; Medicine, Traditional ; Plants, Medicinal/chemistry ; Plant Extracts/pharmacology ; Alkaloids ; Anti-Bacterial Agents/pharmacology ; Uterine Cervical Neoplasms ; Antioxidants/pharmacology ; Menispermaceae ; Phytochemicals/pharmacology ; India
Chemical Substances	Plant Extracts ; Alkaloids ; Anti-Bacterial Agents ; Antioxidants ; Phytochemicals
Language	English
Publishing date	2022-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2099388
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Article ; Online: Role of hydroxyurea therapy in the prevention of organ damage in sickle cell disease: a systematic review and meta-analysis.

Khargekar, Naveen / Banerjee, Anindita / Athalye, Shreyasi / Mahajan, Namrata / Kargutkar, Neha / Tapase, Prashant / Madkaikar, Manisha

Systematic reviews

2024 Volume 13, Issue 1, Page(s) 60

Abstract: Background: Hydroxyurea is an affordable drug that reduces vaso-occlusive crises and transfusion requirements in sickle cell disease. However, its effectiveness in preventing chronic organ damage is still unclear. This systematic review and meta- ... ...

Abstract	Background: Hydroxyurea is an affordable drug that reduces vaso-occlusive crises and transfusion requirements in sickle cell disease. However, its effectiveness in preventing chronic organ damage is still unclear. This systematic review and meta-analysis aimed to evaluate the role of hydroxyurea in preventing organ morbidity. Method: We included original articles published in English from 1st January 1990 to 31st January 2023, reporting hydroxyurea therapy and organ damage from PubMed, Google Scholar, Scopus, and CrossRef databases. A total of 45 studies with 4681 sickle cell disease patients were evaluated for organ damage. Results: Our analysis showed that hydroxyurea intervention significantly lowered transcranial Doppler and tricuspid regurgitant velocity, with a standardized mean difference of - 1.03 (- 1.49; - 0.58); I Conclusion: Our study found that a hydroxyurea dose above 20 mg/kg/day with a mean rise in HbF by 18.46% post-hydroxyurea therapy had a beneficial role in reducing transcranial doppler velocity, tricuspid regurgitant velocity, albuminuria, and splenic abnormality. Systematic review registration: PROSPERO CRD42023401187.
MeSH term(s)	Humans ; Hydroxyurea/therapeutic use ; Antisickling Agents/therapeutic use ; Albuminuria/drug therapy ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/drug therapy ; Blood Transfusion
Chemical Substances	Hydroxyurea (X6Q56QN5QC) ; Antisickling Agents
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-024-02461-z
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Article ; Online: Antileishmanial activity of cathelicidin and its modulation by Leishmania donovani in a CREM-dependent manner for establishing infection.

Roy, Shalini / Roy, Souravi / Banerjee, Madhurima / Madbhagat, Pratibha / Chande, Ajit / Ukil, Anindita

The Journal of infectious diseases

2024

Abstract: Concerns regarding toxicity and resistance of current drugs have been reported in visceral leishmaniasis. Anti-microbial peptides are considered as new promising candidates and amongst them, human cathelicidin hCAP18/LL-37 showed significant parasite ... ...

Abstract	Concerns regarding toxicity and resistance of current drugs have been reported in visceral leishmaniasis. Anti-microbial peptides are considered as new promising candidates and amongst them, human cathelicidin hCAP18/LL-37 showed significant parasite killing on drug-sensitive and resistant Leishmania promastigotes, coupled with its apoptosis-inducing role. Administration of hCAP18/LL-37 in infected macrophages also decreased parasite survival and increased the host favorable cytokine IL-12. However, 1,25-dihydroxyvitamin D3 (VitD3)-induced endogenous hCAP18/LL-37 production was hampered in infected THP-1 cells. Infection also suppressed the VitD3-receptor (VDR), transcription factor of hCAP18/LL-37. cAMP response element modulator (CREM), the repressor of VDR, was induced in infection resulting in suppression of both VDR and cathelicidin expression. PGE2/cAMP/PKA axis was found to regulate CREM induction during infection and silencing CREM in infected cells and BALB/c mice led to decreased parasite survival. Present study thus documents the anti-leishmanial potential of cathelicidin and further identifies CREM as a repressor of cathelicidin in Leishmania infection.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiae158
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Article ; Online: Master protocols and other innovative trial designs in inflammation and immunology to expedite clinical drug development.

Peeva, Elena / Banerjee, Anindita / Banfield, Christopher / Soma, Koshika / Christensen, Jared / Menon, Sandeep / Vincent, Michael S / Dolsten, Mikael

Drug discovery today

2024 Volume 29, Issue 5, Page(s) 103948

Abstract: Master protocol designs, such as umbrella and basket studies, allow multiple compounds or multiple target populations to be evaluated simultaneously within a single protocol, and have been widely adopted in oncology clinical trials. These novel designs ... ...

Abstract	Master protocol designs, such as umbrella and basket studies, allow multiple compounds or multiple target populations to be evaluated simultaneously within a single protocol, and have been widely adopted in oncology clinical trials. These novel designs can also be applied in other therapeutic areas, where they could have several benefits over conducting traditional randomized controlled trials. Here, we detail Pfizer's recent implementations of master protocol designs in inflammation and immunology clinical studies, focusing on the opportunities for cost and resource savings and how these designs can expedite the time required to bring new treatments to patients in need.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2024.103948
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Article: Chronic Hepatitis B and Related Liver Diseases Are Associated with Reduced 25-Hydroxy-Vitamin D Levels: A Systematic Review and Meta-Analysis.

Banerjee, Anindita / Athalye, Shreyasi / Khargekar, Naveen / Shingade, Poonam / Madkaikar, Manisha

Biomedicines

2023 Volume 11, Issue 1

Abstract: Hepatitis B infection is a major public health problem globally leading to chronic liver disease and death, which are influenced by various environmental and host factors including serum 25-hydroxy-vitamin D levels. There is no comprehensive systematic ... ...

Abstract	Hepatitis B infection is a major public health problem globally leading to chronic liver disease and death, which are influenced by various environmental and host factors including serum 25-hydroxy-vitamin D levels. There is no comprehensive systematic review reporting the association of serum 25-hydroxy-vitamin D levels and different stages of chronic hepatitis B. This study aimed to analyze the association of 25-hydroxy-vitamin D levels in chronic hepatitis B with various determinants and outcomes. A bibliographic search in PubMed, Google Scholar, and Scopus was conducted using the search terms “Vitamin D”, “cholecalciferol”, “calcitriol”, “Hepatitis B”, and “HBV”, which were published until September 2022. Meta-analysis using the “metafor” package in R was conducted with a random effect model. This analysis included 33 studies with 6360 chronic hepatitis B patients. The pooled estimates of serum 25-hydroxy-vitamin D level among CHB cases was 21.05 ng/mL and was significantly lower compared to healthy controls. (p < 0.005). Reduced serum 25-hydroxy-vitamin D level was significantly associated with the severity of liver fibrosis as well as HBe positivity. This analysis suggests that serum 25-hydroxy-vitamin D levels are associated with disease activity and pathobiology, although the exact nature of the cause−effect relationship cannot be discerned from this study.
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11010135
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Article: Impact of COVID-19 infection among indian sickle cell disease patients.

Khargekar, Naveen / Shinde, Nikhil / Banerjee, Anindita / Madkaikar, Manisha / Nadkarni, Anita

Indian journal of public health

2023 Volume 67, Issue 1, Page(s) 112–116

Abstract: Background: Sickle cell disease (SCD) is one of the most common hemoglobinopathy disorders and is widely prevalent in India, especially in the tribal population. SCD patients are prone to develop recurrent respiratory infections and related ... ...

Abstract	Background: Sickle cell disease (SCD) is one of the most common hemoglobinopathy disorders and is widely prevalent in India, especially in the tribal population. SCD patients are prone to develop recurrent respiratory infections and related complications owing to the microvascular occlusion and impaired immunological response. Objectives: We aimed to determine the prevalence and impact of COVID-19 in SCD patients from India. Methodology: We conducted a cross-sectional study in Chandrapur district of Maharashtra, India, between August and October 2021. After taking informed consent, details of 300 SCD patients' demographic data, history of COVID-19 testing, infection, symptoms related to COVID-19 in the past 1 year, hospitalization, complications, mortality, COVID-19 vaccination, and side effects were recorded. Results: We found that 93 (31%) of SCD patients had influenza-like symptoms during the COVID-19 pandemic with symptoms of fever (81.72%), cough (35.48%), sore throat (18.27%), headache (15.05%), and breathlessness (7.52%). A total of 13 (4.33%) SCD among 300 SCD were tested as COVID positive. Majority of them were mild cases and the 1 Conclusion: Low incidence of COVID-19 and milder disease spectrum in our study cohort suggests that there is no increased risk of COVID-19 mortality and morbidity in SCD patients compared to general population. However, the reason for low COVID vaccination in our study could be due to the fear of complications of COVID vaccine.
MeSH term(s)	Humans ; COVID-19 Vaccines ; COVID-19/epidemiology ; COVID-19 Testing ; Pandemics ; Cross-Sectional Studies ; India/epidemiology ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/diagnosis
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-01-10
Publishing country	India
Document type	Journal Article
ZDB-ID	800737-8
ISSN	2229-7693 ; 0019-557X
ISSN (online)	2229-7693
ISSN	0019-557X
DOI	10.4103/ijph.ijph_1230_22
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Article ; Online: Mycobacterium abscessus: insights from a bioinformatic perspective

Sur, Saubashya / Patra, Tanushree / Karmakar, Mistu / Banerjee, Anindita

Critical Reviews in Microbiology. 2023 July 4, v. 49, no. 4 p.499-514

2023

Abstract: Mycobacterium abscessus is a nontuberculous mycobacterium, associated with broncho-pulmonary infections in individuals suffering from cystic fibrosis, bronchiectasis, and pulmonary diseases. The risk factors for transmission include biofilms, ... ...

Abstract	Mycobacterium abscessus is a nontuberculous mycobacterium, associated with broncho-pulmonary infections in individuals suffering from cystic fibrosis, bronchiectasis, and pulmonary diseases. The risk factors for transmission include biofilms, contaminated water resources, fomites, and infected individuals. M. abscessus is extensively resistant to antibiotics. To date, there is no vaccine and combination antibiotic therapy is followed. However, drug toxicities, low cure rates, and high cost of treatment make it imperfect. Over the last 20 years, bioinformatic studies on M. abscessus have advanced our understanding of the pathogen. This review integrates knowledge from the analysis of genomes, microbiomes, genomic variations, phylogeny, proteome, transcriptome, secretome, antibiotic resistance, and vaccine design to further our understanding. The utility of genome-based studies in comprehending disease progression, surveillance, tracing transmission routes, and epidemiological outbreaks on a global scale has been highlighted. Furthermore, this review underlined the importance of using computational methodologies for pinpointing factors responsible for pathogen survival and resistance. We reiterate the significance of interdisciplinary research to fight M. abscessus. In a nutshell, the outcome of computational studies can go a long way in creating novel therapeutic avenues to control M. abscessus mediated pulmonary infections.
Keywords	Mycobacterium abscessus ; antibiotic resistance ; antibiotics ; biofilm ; bioinformatics ; cystic fibrosis ; disease progression ; fomites ; genome ; genomics ; interdisciplinary research ; microbiology ; microbiome ; monitoring ; pathogen survival ; pathogens ; phylogeny ; proteome ; risk ; therapeutics ; transcriptome ; vaccine development ; vaccines ; pulmonary infections ; nontuberculous mycobacteria (NTM) ; infectious diseases
Language	English
Dates of publication	2023-0704
Size	p. 499-514.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1053620-6
ISSN	1549-7828 ; 1040-841X
ISSN (online)	1549-7828
ISSN	1040-841X
DOI	10.1080/1040841X.2022.2082268
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Phytochemical analysis and bioactivity reports of ethnomedicinal plants from West Bengal, India

Pal, Asmita / Banerjee, Anindita / Kundu, Rita

Natural Product Research. 2023 Mar. 19, v. 37, no. 6 p.1036-1041

2023

Abstract: The biodiversity-rich forests of the Jhargram subdivision of West Bengal, India houses many lesser-known prospective plants. Four ethnomedicinal plants from this locality—Cleistanthus collinus, Tiliacora racemosa, Eupatorium odoratum, and Sida acuta ... ...

Abstract	The biodiversity-rich forests of the Jhargram subdivision of West Bengal, India houses many lesser-known prospective plants. Four ethnomedicinal plants from this locality—Cleistanthus collinus, Tiliacora racemosa, Eupatorium odoratum, and Sida acuta reported for traditional medical uses by local forest tribes have been analyzed for phytochemical constituents and bioactivity potential, viz., antioxidant, antibacterial and antitumor activity. Cleistanthus and Tiliacora plants were rich in alkaloids while Eupatorium and Sida showed tannin abundance. Tiliacora showed maximum alkaloid content, that is, 711 mg strychnine equivalent/gm dry weight. Consequently, these plant extracts showed decent antioxidant activity which is reflected in their antibacterial and antitumor potencies. Cleistanthus showed strong bactericidal activity against Gram-negative bacteria, particularly against Klebsiella pneumoniae and Pseudomonas aeruginosa, while Tiliacora showed robust antitumor activity against cervical cancer cells SiHa at a 50% inhibitory concentration (IC₅₀) of 86 µg/ml. Hence, the biodiversity-rich Jhargram forest should be conserved to protect the potential repertoire for ethnomedicinal plants.
Keywords	Chromolaena odorata ; Cleistanthus ; Eupatorium ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; Sida acuta ; Tiliacora ; antibacterial properties ; antineoplastic activity ; antioxidant activity ; antioxidants ; forests ; inhibitory concentration 50 ; phytochemicals ; research ; strychnine ; uterine cervical neoplasms ; India ; Phytochemical ; antibacterial ; anticancer ; West Bengal ; ethnomedicine
Language	English
Dates of publication	2023-0319
Size	p. 1036-1041.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2099388
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