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  1. Article: A Quantitative Study of the Hypophysis of the Human Anencephalic Fetus.

    Covell, W P

    The American journal of pathology

    2009  Volume 3, Issue 1, Page(s) 17–28

    Language English
    Publishing date 2009-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
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  2. Article: The Occurrence of Intranuclear Inclusions in Monkeys Unaccompanied by Specific Signs of Disease.

    Covell, W P

    The American journal of pathology

    2009  Volume 8, Issue 2, Page(s) 151–158.1

    Language English
    Publishing date 2009-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
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  3. Article ; Online: Low Intensity Epicardial Pacing During the Absolute Refractory Period Augments Left Ventricular Function Mediated by Local Catecholamine Release.

    Ito, Bruce R / Covell, James W / Curtis, Guy P

    Journal of cardiovascular electrophysiology

    2016  Volume 27, Issue 9, Page(s) 1102–1109

    Abstract: Background: Biventricular epicardial (Epi) pacing can augment left ventricular (LV) function in heart failure. We postulated that these effects might involve catecholamine release from local autonomic nerve activation. To evaluate this hypothesis we ... ...

    Abstract Background: Biventricular epicardial (Epi) pacing can augment left ventricular (LV) function in heart failure. We postulated that these effects might involve catecholamine release from local autonomic nerve activation. To evaluate this hypothesis we applied low intensity Epi electrical stimuli during the absolute refractory period (ARP), thus avoiding altered activation sequence.
    Methods: Anesthetized pigs (n = 6) were instrumented with an LV pressure (LVP) transducer, left atrial (LA) and LV Epi pacing electrodes, and sonomicrometer segment length (SL) gauges placed proximal and remote to the LV stimulation site. A catheter was placed into the great cardiac vein adjacent to the LV pacing site for norepinephrine (NE) analysis. During LA pacing at constant rate, 3 pulses (0.8 milliseconds, 2-3x threshold) were applied to the LV Epi electrodes during the ARP. An experimental run consisted of baseline, stimulation (10 minutes), and recovery (5 minutes), repeated 3 times before and after β1 - receptor blockade (BB, metoprolol).
    Results: ARP stimulation produced significant increases in cardiac function reflected by elevated LVP, LV, dP/dtmax , and reduced time to LV dP/dtmax . This was accompanied by increased coronary NE levels and increases in LVP versus SL loop area in the remote myocardial segment. In contrast, the proximal segment exhibited early shortening and decreased loop area. BB abolished the changes in SL and LV function despite continued NE release.
    Conclusion: These results demonstrate that ARP EPI stimulation induces NE release mediating augmented global LV function. This effect may contribute to the beneficial effect of biventricular Epi pacing in heart failure in some patients.
    MeSH term(s) Action Potentials ; Adrenergic beta-1 Receptor Antagonists/pharmacology ; Animals ; Autonomic Nervous System/drug effects ; Autonomic Nervous System/physiopathology ; Autonomic Nervous System/secretion ; Cardiac Pacing, Artificial/methods ; Heart Conduction System/physiopathology ; Heart Rate ; Heart Ventricles/drug effects ; Heart Ventricles/innervation ; Models, Animal ; Myocardial Contraction ; Norepinephrine/secretion ; Pericardium/innervation ; Refractory Period, Electrophysiological ; Sus scrofa ; Time Factors ; Ventricular Function, Left/drug effects ; Ventricular Pressure
    Chemical Substances Adrenergic beta-1 Receptor Antagonists ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.13027
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  4. Article: Histologic changes in the aging cochlea.

    COVELL, W P

    Journal of gerontology

    2004  Volume 7, Issue 2, Page(s) 173–177

    MeSH term(s) Aging ; Cochlea/anatomy & histology ; Ear, Inner ; Histological Techniques
    Language English
    Publishing date 2004-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80138-0
    ISSN 0022-1422
    ISSN 0022-1422
    DOI 10.1093/geronj/7.2.173
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  5. Article: Studies on the Nature of the Negri Body.

    Covell, W P / Danks, W B

    The American journal of pathology

    2009  Volume 8, Issue 5, Page(s) 557–572.3

    Language English
    Publishing date 2009-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
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  6. Article: Histologic changes in the organ of Corti with intense sound.

    COVELL, W P

    The Journal of comparative neurology

    2003  Volume 99, Issue 1, Page(s) 43–59

    MeSH term(s) Ear, Inner ; Humans ; Noise ; Organ of Corti ; Sound
    Language English
    Publishing date 2003-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.900990104
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  7. Article: Bayesian Calibration of a Natural State Geothermal Reservoir Model, Krafla, North Iceland

    Scott, S. W. / O’Sullivan, J. P. / Maclaren, O. J. / Nicholson, R. / Covell, C. / Newson, J. / Guðjónsdóttir, M. S.

    Water resources research. 2022 Feb., v. 58, no. 2

    2022  

    Abstract: The Krafla area in north Iceland hosts a high‐temperature geothermal system within a volcanic caldera. Temperature measurements from boreholes drilled for power generation reveal enigmatic contrasts throughout the drilled area. While wells in the western ...

    Abstract The Krafla area in north Iceland hosts a high‐temperature geothermal system within a volcanic caldera. Temperature measurements from boreholes drilled for power generation reveal enigmatic contrasts throughout the drilled area. While wells in the western part of the production field indicate a 0.5–1 km thick near‐isothermal (∼210°C) liquid‐dominated reservoir underlain by a deeper boiling reservoir, wells in the east indicate boiling conditions extending from the surface to the maximum depth of drilled wells (∼2 km). Understanding these systematic temperature contrasts in terms of the subsurface permeability structure has remained challenging. Here, we present a new numerical model of the natural, pre‐exploitation state of the Krafla system, incorporating a new geologic/conceptual model and a version of TOUGH2 extending to supercritical conditions. The model shows how the characteristic temperature distribution results from structural partitioning of the system by a rift‐parallel eruptive fissure and an aquitard at the transition between deeper basement intrusions and high‐permeability extrusive volcanic rocks. As model calibration is performed using a Bayesian framework, the posterior results reveal significant uncertainty in the inferred permeability values for the different rock types, often exceeding two orders of magnitude. While the model shows how zones of single‐phase supercritical vapor develop above the deep intrusive heat source, more data from deep wells is needed to better constrain the extent and temperature of the deep supercritical zones. However, the model suggests the presence of a significant untapped resource at Krafla.
    Keywords Bayesian theory ; heat ; mathematical models ; permeability ; power generation ; research ; temperature ; uncertainty ; vapors ; water ; Iceland
    Language English
    Dates of publication 2022-02
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 5564-5
    ISSN 1944-7973 ; 0043-1397
    ISSN (online) 1944-7973
    ISSN 0043-1397
    DOI 10.1029/2021WR031254
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: A laboratory method for the study of acoustic trauma.

    ELDREDGE, D H / COVELL, W P

    The Laryngoscope

    2003  Volume 68, Issue 3, Page(s) 465–477

    MeSH term(s) Ear Diseases ; Hearing Loss, Noise-Induced ; Humans ; Noise/adverse effects
    Language English
    Publishing date 2003-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.5540680328
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  9. Article: Paludrine in prophylaxis and treatment of malarial infections caused by a West African strain of P. falciparum.

    COVELL, G / NICOL, W D / SHUTE, P G

    British medical journal

    2007  Volume 1, Issue 4593, Page(s) 88–91

    MeSH term(s) African Continental Ancestry Group ; Humans ; Malaria/therapy ; Malaria, Falciparum ; Proguanil
    Chemical Substances Proguanil (S61K3P7B2V)
    Language English
    Publishing date 2007-11-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 80088-0
    ISSN 0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
    ISSN 0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
    DOI 10.1136/bmj.1.4593.88
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  10. Article: Congestive heart failure. Biochemical and physiological considerations. Combined clinical staff conference at the National Institutes of Health.

    Braunwald, E / Chidsey, C A / Pool, P E / Sonnenblick, E H / Ross, J / Mason, D T / Spann, J F / Covell, J W

    Annals of internal medicine

    2013  Volume 64, Issue 4, Page(s) 904–941

    MeSH term(s) Heart/physiopathology ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Heart Failure/therapy ; Hemodynamics ; Humans ; Mitochondria, Heart/physiology ; Myocardial Contraction ; Myocardium/metabolism
    Language English
    Publishing date 2013-06-24
    Publishing country United States
    Document type Clinical Conference ; Journal Article ; Review
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-64-4-904
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