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  1. Article ; Online: The cckOMA syndrome and its relation to the Zollinger-Ellison syndrome: a diagnostic challenge.

    Rehfeld, Jens F

    Scandinavian journal of gastroenterology

    2024  Volume 59, Issue 5, Page(s) 533–542

    Abstract: Objective: Among patients with enteropancreatic neuroendocrine tumor syndromes only one case with a cholecystokinin (CCK) secreting tumor has been reported. She had significant hyperCCKemia leading to a specific syndrome of severe diarrheas, weight loss, ...

    Abstract Objective: Among patients with enteropancreatic neuroendocrine tumor syndromes only one case with a cholecystokinin (CCK) secreting tumor has been reported. She had significant hyperCCKemia leading to a specific syndrome of severe diarrheas, weight loss, repeated duodenal ulcers and a permanently contracted gallbladder with gallstones. There are, however, reasons to believe that further CCKomas exist, for instance among Zollinger-Ellison patients with normal plasma gastrin concentrations. The present review is a call to gastroenterologists for awareness of such CCKoma patients.
    Method: After a short case report, the normal endocrine and oncological biology of CCK is described. Subsequently, the CCKoma symptoms are discussed with particular reference to the partly overlapping symptoms of the Zollinger-Ellison syndrome. In this context, the diagnostic use of truly specific CCK and gastrin assays are emphasized. The discussion also entails the problem of access to accurate CCK measurements.
    Conclusion: Obviously, the clinical awareness about the CCKoma syndrome is limited. Moreover, it is also likely that the knowledge about the necessary specificity demands of diagnostic gastrin and CCK assays have obscured proper diagnosis of the CCKoma syndromes in man.
    MeSH term(s) Humans ; Zollinger-Ellison Syndrome/diagnosis ; Cholecystokinin/blood ; Pancreatic Neoplasms/diagnosis ; Gastrins/blood ; Female ; Neuroendocrine Tumors/diagnosis ; Male ; Middle Aged ; Diagnosis, Differential ; Syndrome
    Chemical Substances Cholecystokinin (9011-97-6) ; Gastrins
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review ; Case Reports
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2024.2308532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Natriuretic Peptides and Metabolic Hypertension: A Match Made in Heaven?

    Goetze, Jens P / Rehfeld, Jens F

    JACC. Basic to translational science

    2024  Volume 9, Issue 1, Page(s) 30–32

    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2023.11.007
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  3. Article ; Online: Gastrointestinal hormones: History, biology, and measurement.

    Rehfeld, Jens F / Goetze, Jens P

    Advances in clinical chemistry

    2024  Volume 118, Page(s) 111–154

    Abstract: This chapter attempts to provide an all-round picture of a dynamic and major branch of modern endocrinology, i.e. the gastrointestinal endocrinology. The advances during the last half century in our understanding of the dimensions and diversity of gut ... ...

    Abstract This chapter attempts to provide an all-round picture of a dynamic and major branch of modern endocrinology, i.e. the gastrointestinal endocrinology. The advances during the last half century in our understanding of the dimensions and diversity of gut hormone biology - inside as well as outside the digestive tract - are astounding. Among major milestones are the dual brain-gut relationship, i.e. the comprehensive expression of gastrointestinal hormones as potent transmitters in central and peripheral neurons; the hormonal signaling from the enteroendocrine cells to the brain and other extraintestinal targets; the role of gut hormones as growth and fertility factors; and the new era of gut hormone-derived drugs. Accordingly, gastrointestinal hormones have pathogenetic roles in major metabolic disorders (diabetes mellitus and obesity); in tumor development (common cancers, sarcomas, and neuroendocrine tumors); and in cerebral diseases (anxiety, panic attacks, and probably eating disorders). Such clinical aspects require accurate pathogenetic and diagnostic measurements of gastrointestinal hormones - an obvious responsibility for clinical chemistry/biochemistry. In order to obtain a necessary insight into today's gastrointestinal endocrinology, the chapter will first describe the advances in gastrointestinal endocrinology in a historical context. The history provides a background for the subsequent description of the present biology of gastrointestinal hormones, and its biomedical consequences - not least for clinical chemistry/biochemistry with its specific responsibility for selection of appropriate assays and reliable measurements.
    MeSH term(s) Humans ; Gastrointestinal Hormones/history ; Gastrointestinal Hormones/metabolism ; Gastrointestinal Tract/metabolism ; Endocrinology/history ; Signal Transduction ; Biology
    Chemical Substances Gastrointestinal Hormones
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 210505-6
    ISSN 2162-9471 ; 0065-2423
    ISSN (online) 2162-9471
    ISSN 0065-2423
    DOI 10.1016/bs.acc.2023.11.004
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  4. Article ; Online: Four sidenotes about glucagon peptides.

    Rehfeld, Jens F

    Peptides

    2022  Volume 159, Page(s) 170924

    Abstract: Century old glucagon is a classic pancreatic hormone. But today we also know that the glucagon gene is expressed at high levels at extrapancreatic sites - particularly so in the gut. Major hormonal glucagon gene products in the digestive tract are the ... ...

    Abstract Century old glucagon is a classic pancreatic hormone. But today we also know that the glucagon gene is expressed at high levels at extrapancreatic sites - particularly so in the gut. Major hormonal glucagon gene products in the digestive tract are the two glucagon-like peptides (GLP-1 and -2). Of these, truncated GLP-1 has in recent decades attracted massive interest due to its incretin effect, and the subsequent GLP-1 derived design of potent diabetes and obesity drugs. Truncated GLP-1 has consequently become an important contributor to gastrointestinal endocrinology. The gastrointestinal branch of endocrinology today includes more than 100 bioactive peptides encoded by some 30 different hormone genes. Therefore, the gut is the largest endocrine organ in the body. In addition to a general discussion of glucagon peptides in the hierarchy of gut hormones, this review also includes three short notes about glucagon studies from the 1970s. These studies dealt with reactive hypoglycemia, chronic liver disease, and the secretory response of pancreatic glucagon to gastrin/cholecystokinin stimulation. Considering today's possibilities in molecular endocrinology, revisits to the questions raised by these studies might be worthwhile.
    MeSH term(s) Glucagon ; Peptides ; Glucagon-Like Peptide 1/genetics ; Gastrointestinal Hormones/physiology ; Incretins
    Chemical Substances Glucagon (9007-92-5) ; Peptides ; Glucagon-Like Peptide 1 (89750-14-1) ; Gastrointestinal Hormones ; Incretins
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2022.170924
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    Zs.A 1649: Show issues Location:
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  5. Article ; Online: Cholecystokinin and Panic Disorder: Reflections on the History and Some Unsolved Questions.

    Rehfeld, Jens F

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 18

    Abstract: The classic gut hormone cholecystokinin (CCK) and its ... ...

    Abstract The classic gut hormone cholecystokinin (CCK) and its CCK
    MeSH term(s) Adult ; Cholecystokinin ; Humans ; Panic Disorder
    Chemical Substances Cholecystokinin (9011-97-6)
    Language English
    Publishing date 2021-09-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26185657
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    Zs.MO 81: Show issues

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  6. Book: Cellular peptide hormone synthesis and secretory pathways

    Rehfeld, Jens F.

    (Results and problems in cell differentiation ; 50)

    2010  

    Author's details Jens F. Rehfeld ... (ed.)
    Series title Results and problems in cell differentiation ; 50
    Collection
    Keywords Peptidhormon ; Endokrine Regulation
    Subject Proteohormon ; Peptidhormone ; Polypeptidhormone ; Hormonale Regulation ; Hormonelle Regulation ; Hormonregulation ; Innersekretorische Regulation ; Hormonsystem
    Language English
    Size VIII, 239 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016300450
    ISBN 978-3-642-11834-0 ; 9783642118364 ; 3-642-11834-8 ; 3642118364
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 2096 order for loan Magazin

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  7. Article: Cholecystokinin and the hormone concept.

    Rehfeld, Jens F

    Endocrine connections

    2021  Volume 10, Issue 3, Page(s) R139–R150

    Abstract: The birth certificate for endocrinology was Bayliss' and Starling's demonstration in 1902 that regulation of bodily functions is not only neuronal but also due to blood-borne messengers. Starling named these messengers hormones. Since then transport via ... ...

    Abstract The birth certificate for endocrinology was Bayliss' and Starling's demonstration in 1902 that regulation of bodily functions is not only neuronal but also due to blood-borne messengers. Starling named these messengers hormones. Since then transport via blood has defined hormones. This definition, however, may be too narrow. Thus, today we know that several peptide hormones are not only produced and released to blood from endocrine cells but also released from neurons, myocytes, immune cells, endothelial cells, spermatogenic cells, fat cells, etc. And they are often secreted in cell-specific molecular forms with more or less different spectra of activity. The present review depicts this development with the story about cholecystokinin which was discovered in 1928 as a hormone and still in 1976 was conceived as a single blood-borne peptide. Today's multifaceted picture of cholecystokinin suggests that time may be ripe for expansion of the hormone concept to all messenger molecules, which activate their target cells - irrespective of their road to the target (endocrine, neurocrine, neuronal, paracrine, autocrine, etc.) and irrespective of their kind of activity as classical hormone, growth factor, neurotransmitter, adipokine, cytokine, myokine, or fertility factor.
    Language English
    Publishing date 2021-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2668428-7
    ISSN 2049-3614
    ISSN 2049-3614
    DOI 10.1530/EC-21-0025
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  8. Article ; Online: Gastrin and the Moderate Hypergastrinemias.

    Rehfeld, Jens F

    International journal of molecular sciences

    2021  Volume 22, Issue 13

    Abstract: The antral hormone gastrin potently regulates gastric acid secretion and fundic mucosal growth. Consequently, appropriate gastrin secretion and plasma concentrations are important for the early phases of digestion. This review describes as the first ... ...

    Abstract The antral hormone gastrin potently regulates gastric acid secretion and fundic mucosal growth. Consequently, appropriate gastrin secretion and plasma concentrations are important for the early phases of digestion. This review describes as the first premise the normal biogenesis of gastrin in the antral mucosa, but also mentions the extraantral expression. Subsequently, the molecular nature and concentration levels of gastrin in serum or plasma are overviewed. Third, assays for accurate measurements of plasma or serum concentrations are commented. Finally, the problem of moderate hypergastrinemia due to
    MeSH term(s) Animals ; Biomarkers ; Disease Susceptibility/blood ; Disease Susceptibility/etiology ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Gastrin-Secreting Cells/metabolism ; Gastrins/blood ; Gastrins/chemistry ; Gastrins/genetics ; Gastrins/metabolism ; Gene Expression Regulation ; Helicobacter Infections/complications ; Helicobacter Infections/microbiology ; Helicobacter pylori/physiology ; Humans ; Molecular Diagnostic Techniques ; Organ Specificity/genetics ; Proton Pump Inhibitors/adverse effects ; Proton Pump Inhibitors/therapeutic use ; Reagent Kits, Diagnostic
    Chemical Substances Biomarkers ; Gastrins ; Proton Pump Inhibitors ; Reagent Kits, Diagnostic
    Language English
    Publishing date 2021-06-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22136977
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  9. Article ; Online: Measurement of cholecystokinin in plasma with reference to nutrition related obesity studies.

    Rehfeld, Jens F

    Nutrition research (New York, N.Y.)

    2020  Volume 76, Page(s) 1–8

    Abstract: This review describes the premises for accurate measurement of the gut hormone and satiety factor cholecystokinin (CCK) in circulation. Such a description is useful for nutrition and obesity research in which CCK in its satiety role has evoked ... ...

    Abstract This review describes the premises for accurate measurement of the gut hormone and satiety factor cholecystokinin (CCK) in circulation. Such a description is useful for nutrition and obesity research in which CCK in its satiety role has evoked considerable interest during the last decades. The background for the review is two sorts of considerations or concerns. First, CCK is a complex peptide system that in several ways challenges plasma measurements because the concentrations in plasma are very low (in the femtomolar to low picomolar range), and the bioactive CCK circulates in different molecular forms (CCK-58, -33, -22, and -8). Furthermore, there are major specificity problems because the structurally similar gastrin hormone circulates in 10- to 20-fold higher concentrations, and in addition, plasma proteins may, due to their high concentration, interfere in an unspecific way with immunoassay measurements. The second concern is that several obesity studies in recent decades have been based on commercial CCK kits with often inadequate documentation of the reliability in plasma measurement. Consequently, many plasma CCK results in today's obesity studies are difficult to compare. Moreover, the use of even fairly reliable commercial CCK kits has recently suffered from sudden discontinuation of the kit production, which has endangered several projects in nutrition and obesity research.
    MeSH term(s) Animals ; Appetite Regulation ; Bias ; Biomedical Research/methods ; Biomedical Research/standards ; Blood Chemical Analysis/standards ; Blood Proteins/metabolism ; Cholecystokinin/blood ; Gastrins/blood ; Humans ; Nutritional Sciences ; Nutritional Status ; Obesity/blood ; Peptide Fragments/blood ; Plasma/metabolism ; Satiety Response/physiology
    Chemical Substances Blood Proteins ; Gastrins ; Peptide Fragments ; cholecystokinin 8 ; Cholecystokinin (9011-97-6)
    Language English
    Publishing date 2020-01-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 582432-1
    ISSN 1879-0739 ; 0271-5317
    ISSN (online) 1879-0739
    ISSN 0271-5317
    DOI 10.1016/j.nutres.2020.01.003
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    Zs.A 1686: Show issues Location:
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  10. Article: Premises for Cholecystokinin and Gastrin Peptides in Diabetes Therapy.

    Rehfeld, Jens F

    Clinical medicine insights. Endocrinology and diabetes

    2019  Volume 12, Page(s) 1179551419883608

    Abstract: Gastrin and cholecystokinin (CCK) are classical gastrointestinal peptide hormones. Their biogenesis, structures, and intestinal secretory patterns are well-known with the striking feature that their receptor-bound 'active sites' are highly homologous and ...

    Abstract Gastrin and cholecystokinin (CCK) are classical gastrointestinal peptide hormones. Their biogenesis, structures, and intestinal secretory patterns are well-known with the striking feature that their receptor-bound 'active sites' are highly homologous and that this structure is conserved for more than 500 million years during evolution. Consequently, gastrin and CCK are agonists for the same receptor (the CCK
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2628990-8
    ISSN 1179-5514
    ISSN 1179-5514
    DOI 10.1177/1179551419883608
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