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  1. AU=Hascalovici Jacob
  2. AU="Spagnolo, Jennifer B"
  3. AU="Anderloni, Giulia"
  4. AU="Ahmad, Shoaib"
  5. AU="Du, Roujia"
  6. AU="Colmenero-Repiso, Ana"
  7. AU="Alvarez-Carbonell, David"
  8. AU="Phelippeau, Michael"
  9. AU="Lunghi, Laura"
  10. AU=Giersiepen Klaus
  11. AU="Drobyshev, Sergey"
  12. AU="Timme, Kathleen H"
  13. AU=Sfriso Paolo
  14. AU="Kim, John S"
  15. AU=Farkash Evan A AU=Farkash Evan A
  16. AU="Xia, Xueqian"

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  1. Artikel ; Online: Radiotracers in the Diagnosis of Pain: A Mini Review.

    Hascalovici, Jacob / Babb, Anthony / Norwood, Braxton A

    Seminars in musculoskeletal radiology

    2023  Band 27, Heft 6, Seite(n) 655–660

    Abstract: The diagnosis and understanding of pain is challenging in clinical practice. Assessing pain relies heavily on self-reporting by patients, rendering it inherently subjective. Traditional clinical imaging methods such as computed tomography and magnetic ... ...

    Abstract The diagnosis and understanding of pain is challenging in clinical practice. Assessing pain relies heavily on self-reporting by patients, rendering it inherently subjective. Traditional clinical imaging methods such as computed tomography and magnetic resonance imaging can only detect anatomical abnormalities, offering limited sensitivity and specificity in identifying pain-causing conditions. Radiotracers play a vital role in molecular imaging that aims to identify abnormal biological processes at the cellular level, even in apparently normal anatomical structures. Therefore, molecular imaging is an important area of research as a prospective diagnostic modality for pain-causing pathophysiology. We present a mini review of the current knowledge base regarding radiotracers for identification of pain in vivo. We also describe radiocaine, a novel positron emission tomography imaging agent for sodium channels that has shown great potential for identifying/labeling pain-producing nerves and producing an objectively measurable pain intensity signal.
    Mesh-Begriff(e) Humans ; Prospective Studies ; Positron-Emission Tomography/methods ; Tomography, X-Ray Computed ; Radiopharmaceuticals ; Pain/diagnostic imaging
    Chemische Substanzen Radiopharmaceuticals
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Erscheinungsland United States
    Dokumenttyp Review ; Journal Article
    ZDB-ID 1360919-1
    ISSN 1098-898X ; 1089-7860
    ISSN (online) 1098-898X
    ISSN 1089-7860
    DOI 10.1055/s-0043-1775743
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The Other Side of the COVID-19 Curve: A Model for the Safe Reintegration of Elective Interventional Pain Procedures.

    Hascalovici, Jacob / Shaparin, Naum

    Pain physician

    2020  Band 23, Heft 4S, Seite(n) S449–S451

    Abstract: Background: Throughout the COVID-19 pandemic, clinicians have had to think quickly, adapt to changing recommendations sometimes on a daily basis, and have often had to rely on trial-and-error-based treatment protocols under various conditions. As we ... ...

    Abstract Background: Throughout the COVID-19 pandemic, clinicians have had to think quickly, adapt to changing recommendations sometimes on a daily basis, and have often had to rely on trial-and-error-based treatment protocols under various conditions. As we move on past the apex of the COVID-19 curve, new treatment protocols for the safe reintegration of elective interventional pain procedures into chronic pain practice are needed.
    Methods: Literature review and description of a model for the safe reintegration of interventional pain procedures.
    Limitations: A narrative review with paucity of literature.
    Discussion: Herein we describe one such model in the hopes that through similar knowledge sharing, we can draw on others experiences to reach a collective conclusion on the safest, most effective, and efficient way(s) to move forward.
    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Chronic Pain/therapy ; Clinical Protocols ; Coronavirus Infections ; Humans ; Pain Management/methods ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2146393-1
    ISSN 2150-1149 ; 1533-3159
    ISSN (online) 2150-1149
    ISSN 1533-3159
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Radiotracers in the Diagnosis of Pain: A Mini Review

    Hascalovici, Jacob / Babb, Anthony / Norwood, Braxton A.

    Seminars in Musculoskeletal Radiology

    (Molecular and Functional Imaging of Musculoskeletal Pain, Inflammation and Arthritis)

    2023  Band 27, Heft 06, Seite(n) 655–660

    Abstract: The diagnosis and understanding of pain is challenging in clinical practice. Assessing pain relies heavily on self-reporting by patients, rendering it inherently subjective. Traditional clinical imaging methods such as computed tomography and magnetic ... ...

    Serientitel Molecular and Functional Imaging of Musculoskeletal Pain, Inflammation and Arthritis
    Abstract The diagnosis and understanding of pain is challenging in clinical practice. Assessing pain relies heavily on self-reporting by patients, rendering it inherently subjective. Traditional clinical imaging methods such as computed tomography and magnetic resonance imaging can only detect anatomical abnormalities, offering limited sensitivity and specificity in identifying pain-causing conditions. Radiotracers play a vital role in molecular imaging that aims to identify abnormal biological processes at the cellular level, even in apparently normal anatomical structures. Therefore, molecular imaging is an important area of research as a prospective diagnostic modality for pain-causing pathophysiology. We present a mini review of the current knowledge base regarding radiotracers for identification of pain in vivo. We also describe radiocaine, a novel positron emission tomography imaging agent for sodium channels that has shown great potential for identifying/labeling pain-producing nerves and producing an objectively measurable pain intensity signal.
    Schlagwörter radiotracers ; pain ; positron emission tomography imaging ; single-photon emission computed tomography imaging
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Verlag Thieme Medical Publishers, Inc.
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 1360919-1
    ISSN 1098-898X ; 1089-7860
    ISSN (online) 1098-898X
    ISSN 1089-7860
    DOI 10.1055/s-0043-1775743
    Datenquelle Thieme Verlag

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  4. Artikel: Defining Personas of People Living with Chronic Pain: An Ethnographic Research Study.

    Cullens, Melissa / James, Cyan / Liu, Meran / Vydyanathan, Amaresh / Shaparin, Naum / Schatman, Michael / Hascalovici, Jacob

    Journal of pain research

    2023  Band 16, Seite(n) 2803–2816

    Abstract: Introduction: Pain is the leading reason for which people seek medical care in the United States, and chronic pain (CP) affects approximately 50 million people in the US Pain perception is deeply personal, is highly correlated with behavioral and ... ...

    Abstract Introduction: Pain is the leading reason for which people seek medical care in the United States, and chronic pain (CP) affects approximately 50 million people in the US Pain perception is deeply personal, is highly correlated with behavioral and emotional disorders, and is greatly influenced by physiological and environmental factors. The patient-provider relationship can have profound implications for clinical outcomes within the context of treating CP. However, limited access to pain specialists, the complex nature of many CP-causing conditions, the absence of instruments for objective pain measurement, and the need to foster a trust-based patient-provider relationship throughout treatment pose unique challenges.
    Objective: To support a more optimal CP care delivery system that leverages a healthy therapeutic patient-provider relationship, we systematically gathered deeper knowledge of the behaviors, interpersonal dynamics, home environment, values, and mindsets of people who experience CP.
    Methods: We employed ethnographic research methods to collect and analyze data on views, habits, strategies, attitudes, and life circumstances of a range of participants living with CP. We aggregated, analyzed, and summarized participant data to identify trends and similarities.
    Results: Our findings suggest that patients can be broadly categorized into five predominant pain typologies, or "personas", which are characterized by respective symptom durations, care management preferences, values, communication styles, and behaviors.
    Conclusion: Identifying CP personas may enhance the ability to personalize CP care and help foster more robust therapeutic relationships, which may lead to greater trust, improved patient satisfaction, and better clinical outcomes.
    Sprache Englisch
    Erscheinungsdatum 2023-08-14
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S420742
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Emerging Subspecialties in Neurology: Pain medicine.

    Schuster, Nathaniel M / Hascalovici, Jacob R

    Neurology

    2018  Band 91, Heft 22, Seite(n) 1025–1028

    Mesh-Begriff(e) Humans ; Neurology ; Pain ; Specialization
    Sprache Englisch
    Erscheinungsdatum 2018-11-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000006580
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Soft Tissue Infection After Lumbar Epidural Steroid Injection.

    Isakov, Aleksandr / Shaparin, Naum / Hascalovici, Jacob

    Pain medicine (Malden, Mass.)

    2020  Band 21, Heft 10, Seite(n) 2593–2594

    Mesh-Begriff(e) Humans ; Injections, Epidural/adverse effects ; Lumbar Vertebrae ; Soft Tissue Infections ; Steroids/adverse effects ; Treatment Outcome
    Chemische Substanzen Steroids
    Sprache Englisch
    Erscheinungsdatum 2020-08-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnaa225
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Expanding frontiers in telehealth: Video assisted at-home application of capsaicin 8% patch.

    Shaparin, Naum / Nair, Singh / Vydyanathan, Amaresh / Hascalovici, Jacob R

    European journal of pain (London, England)

    2021  Band 25, Heft 7, Seite(n) 1564–1567

    Abstract: In recent years, the delivery of health services has undergone a major paradigm shift towards expanded outpatient services and widespread use of telemedicine. Post-herpetic neuralgia (PHN) is a treatment recalcitrant neuropathic pain condition referring ... ...

    Abstract In recent years, the delivery of health services has undergone a major paradigm shift towards expanded outpatient services and widespread use of telemedicine. Post-herpetic neuralgia (PHN) is a treatment recalcitrant neuropathic pain condition referring to pain persisting more than three months from the initial onset of an acute herpes zoster. QUTENZA® (capsaicin 8% patch) is a single 1-hr localized treatment for PHN and can provide several months of pain relief per application. However, patient access to capsaicin 8% patch is limited due to sensitive handling protocols that require the patch application to occur under physicians or healthcare professionals under the close supervision of a physician. Herein, we describe a successful treatment of PHN at-home, using capsaicin 8% patch, performed under full supervision and instruction from a physician using video telehealth services. SIGNIFICANCE: This is a case report of the successful treatment of post-herpetic neuralgia at-home using Capsaicin 8% patch. The procedure was performed under full supervision and instruction from a physician using video telehealth services. Not only did the patient tolerate the procedure and have significant efficacy, she voiced preference to repeat treatment in this manner versus going back to the office.
    Mesh-Begriff(e) Capsaicin ; Female ; Humans ; Neuralgia, Postherpetic/drug therapy ; Pain Measurement ; Sensory System Agents ; Telemedicine ; Transdermal Patch
    Chemische Substanzen Sensory System Agents ; Capsaicin (S07O44R1ZM)
    Sprache Englisch
    Erscheinungsdatum 2021-04-06
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1390424-3
    ISSN 1532-2149 ; 1090-3801
    ISSN (online) 1532-2149
    ISSN 1090-3801
    DOI 10.1002/ejp.1769
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Acute Cauda Equina Syndrome Due to Spondylolisthesis in the Midst of a Pandemic: A Case Report.

    Isakov, Aleksandr / Yanamadala, Vijay / Yassari, Reza / Udemba, Adaobi / Shaparin, Naum / Hascalovici, Jacob R

    JBJS case connector

    2022  Band 12, Heft 1

    Abstract: Case: A 54-year-old woman with chronic lumbar radiculopathy due to grade II spondylolisthesis at lumbar 4 to 5 developed acute cauda equina syndrome (CES) after an elective lumbar decompression, and fusion was delayed because of statewide bans on ... ...

    Abstract Case: A 54-year-old woman with chronic lumbar radiculopathy due to grade II spondylolisthesis at lumbar 4 to 5 developed acute cauda equina syndrome (CES) after an elective lumbar decompression, and fusion was delayed because of statewide bans on elective procedures during the pandemic. The diagnosis was made largely through telehealth consultation and eventually prompted urgent neurosurgical intervention.
    Conclusion: This case report illustrates a rare presentation of acute CES and highlights some of the challenges of practicing clinical medicine in the midst of a pandemic.
    Mesh-Begriff(e) Cauda Equina Syndrome/diagnosis ; Cauda Equina Syndrome/etiology ; Cauda Equina Syndrome/surgery ; Female ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Middle Aged ; Pandemics ; Radiculopathy/etiology ; Spondylolisthesis/complications ; Spondylolisthesis/surgery
    Sprache Englisch
    Erscheinungsdatum 2022-02-10
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e20.00546
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Peripheral Nerve Blocks for the Treatment of Headache in Older Adults: A Retrospective Study.

    Hascalovici, Jacob R / Robbins, Matthew S

    Headache

    2017  Band 57, Heft 1, Seite(n) 80–86

    Abstract: Objective: The objective of this study is to provide demographical and clinical descriptions of patients age 65 years old and older who were treated with peripheral nerve blocks (PNBs) at our institution and evaluate the safety and efficacy of this ... ...

    Abstract Objective: The objective of this study is to provide demographical and clinical descriptions of patients age 65 years old and older who were treated with peripheral nerve blocks (PNBs) at our institution and evaluate the safety and efficacy of this treatment.
    Background: Headache disorders are common, disabling chronic neurological diseases that often persist with advancing age. Geriatric headache management poses unique therapeutic challenges because of considerations of comorbidity, drug interactions, and adverse effects. Peripheral nerve blocks are commonly used for acute and short-term prophylactic treatment for headache disorders and may be a safer alternative to standard pharmacotherapy in this demographic.
    Design: We performed a single center, retrospective chart review of patients at least 65 years of age who received peripheral nerve blocks for headache management over a 6 year period.
    Results: Sixty-four patients were mostly female (78%) with an average age of 71 years (range 65-94). Representative headache diagnoses were chronic migraine 50%, episodic migraine 12.5%, trigeminal autonomic cephalalgia 9.4%, and occipital neuralgia 7.8%. Average number of headache days/month was 23. Common comorbidities were hypertension 48%, hyperlipidemia 42%, arthritis 27%, depression 47%, and anxiety 33%. Eighty-nine percent were prescribed at least 1 medication fulfilling the Beers criteria. The average number of peripheral nerve blocks per patient was 4. Peripheral nerve blocks were felt to be effective in 73% for all headaches, 81% for chronic migraine, 75% for episodic migraine, 67% for chronic tension type headache, 67% for new daily persistent headache, and 60% for occipital neuralgia. There were no adverse events related to PNBs reported.
    Conclusions: PNBs might be a safe and effective alternative headache management strategy for older adults. Medical and psychiatric comorbidities, medication overuse, and Beers list medication rates were extraordinarily high, giving credence to the use of peripherally administered therapies in the geriatric population that may be better tolerated and safer.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Comorbidity ; Female ; Headache/drug therapy ; Headache/epidemiology ; Headache Disorders/drug therapy ; Headache Disorders/epidemiology ; Humans ; Male ; Nerve Block/methods ; Peripheral Nerves/drug effects ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2017-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.12992
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Diffuse Symmetric Cerebral Calcifications: An Emerging Clinical Pivot.

    Hascalovici, Jacob R / Farmakidis, Constantine

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2016  Band 44, Heft 2, Seite(n) 190–191

    Mesh-Begriff(e) Brain/diagnostic imaging ; Calcinosis/diagnostic imaging ; Humans ; Male ; Middle Aged ; Pseudohypoparathyroidism/blood ; Pseudohypoparathyroidism/diagnosis ; Pseudohypoparathyroidism/diagnostic imaging
    Sprache Englisch
    Erscheinungsdatum 2016-12-14
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2016.407
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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