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  1. Article ; Online: Glucose metabolism partially regulates β-cell function through epigenomic changes.

    Kim, Yong Kyung / Won, Kyu Chang / Sussel, Lori

    Journal of diabetes investigation

    2024  

    Abstract: ... flexibility to productively respond to shifts in environmental conditions and changes in glucose availability ... that the resulting changes in cellular metabolites can impact the epigenome, causing transient and lasting ... alterations in gene expression. This review explores the intricate interplay between metabolism and ...

    Abstract The β-cell relies predominantly on glucose utilization to generate adenosine triphosphate, which is crucial for both cell viability and insulin secretion. The β-cell has evolved remarkable metabolic flexibility to productively respond to shifts in environmental conditions and changes in glucose availability. Although these adaptive responses are important for maintaining optimal cellular function, there is emerging evidence that the resulting changes in cellular metabolites can impact the epigenome, causing transient and lasting alterations in gene expression. This review explores the intricate interplay between metabolism and the epigenome, providing valuable insights into the molecular mechanisms leading to β-cell dysfunction in diabetes. Understanding these mechanisms will be critical for developing targeted therapeutic strategies to preserve and enhance β-cell function, offering potential avenues for interventions to improve glycemic control in individuals with diabetes.
    Language English
    Publishing date 2024-03-04
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6920: Show issues Location:
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  2. Article: DMJ, Better than Yesterday, More Brilliant Tomorrow.

    Won, Kyu Chang

    Diabetes & metabolism journal

    2019  Volume 43, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2019-02-21
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6079
    ISSN (online) 2233-6087
    ISSN 2233-6079
    DOI 10.4093/dmj.2019.0030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Short but Long Journey with You.

    Won, Kyu Chang

    Diabetes & metabolism journal

    2018  Volume 42, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2018-02
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6079
    ISSN (online) 2233-6087
    ISSN 2233-6079
    DOI 10.4093/dmj.2018.42.1.1
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  4. Article: Deep Learning Super-Resolution Technique Based on Magnetic Resonance Imaging for Application of Image-Guided Diagnosis and Surgery of Trigeminal Neuralgia.

    Hwang, Jun Ho / Park, Chang Kyu / Kang, Seok Bin / Choi, Man Kyu / Lee, Won Hee

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 3

    Abstract: This study aimed to implement a deep learning-based super-resolution (SR) technique that can assist in the diagnosis and surgery of trigeminal neuralgia (TN) using magnetic resonance imaging (MRI). Experimental methods applied SR to MRI data examined ... ...

    Abstract This study aimed to implement a deep learning-based super-resolution (SR) technique that can assist in the diagnosis and surgery of trigeminal neuralgia (TN) using magnetic resonance imaging (MRI). Experimental methods applied SR to MRI data examined using five techniques, including T2-weighted imaging (T2WI), T1-weighted imaging (T1WI), contrast-enhancement T1WI (CE-T1WI), T2WI turbo spin-echo series volume isotropic turbo spin-echo acquisition (VISTA), and proton density (PD), in patients diagnosed with TN. The image quality was evaluated using the peak signal-to-noise ratio (PSNR) and structural similarity index (SSIM). High-quality reconstructed MRI images were assessed using the Leksell coordinate system in gamma knife radiosurgery (GKRS). The results showed that the PSNR and SSIM values achieved by SR were higher than those obtained by image postprocessing techniques, and the coordinates of the images reconstructed in the gamma plan showed no differences from those of the original images. Consequently, SR demonstrated remarkable effects in improving the image quality without discrepancies in the coordinate system, confirming its potential as a useful tool for the diagnosis and surgery of TN.
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14030355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluation and Management of Patients With Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement.

    Lee, Kyu-Sun / Noh, Junghyun / Park, Seong-Mi / Choi, Kyung Mook / Kang, Seok-Min / Won, Kyu-Chang / Cho, Hyun-Jai / Moon, Min Kyong

    International journal of heart failure

    2023  Volume 5, Issue 1, Page(s) 1–20

    Abstract: Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart ... ...

    Abstract Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart failure in patients with diabetes mellitus are important. This review discusses the current criteria for diagnosis and screening tools for heart failure and the currently recommended pharmacological therapies for heart failure. We also highlight the effects of anti-diabetic medications on heart failure.
    Language English
    Publishing date 2023-01-24
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ISSN 2636-1558
    ISSN (online) 2636-1558
    DOI 10.36628/ijhf.2022.0028
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  6. Article ; Online: Evaluation and Management of Patients with Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement.

    Lee, Kyu-Sun / Noh, Junghyun / Park, Seong-Mi / Choi, Kyung Mook / Kang, Seok-Min / Won, Kyu-Chang / Cho, Hyun-Jai / Moon, Min Kyong

    Diabetes & metabolism journal

    2023  Volume 47, Issue 1, Page(s) 10–26

    Abstract: Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart ... ...

    Abstract Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart failure in patients with diabetes mellitus are important. This review discusses the current criteria for diagnosis and screening tools for heart failure and the currently recommended pharmacological therapies for heart failure. We also highlight the effects of anti-diabetic medications on heart failure.
    MeSH term(s) Humans ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Heart Failure/complications ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Risk Factors ; Prognosis ; Republic of Korea/epidemiology
    Language English
    Publishing date 2023-01-26
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2022.0420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Outbreak of COVID-19 and Diabetes in Korea: "We Will Find a Way as We Have Always Done".

    Won, Kyu Chang / Yoon, Kun Ho

    Diabetes & metabolism journal

    2019  Volume 44, Issue 2, Page(s) 211–212

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus ; Disease Outbreaks ; Humans ; Pandemics ; Pneumonia, Viral ; Republic of Korea ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2019-12-19
    Publishing country Korea (South)
    Document type Editorial ; Comment
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2020.0092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enhancing Diabetes Care through a Mobile Application: A Randomized Clinical Trial on Integrating Physical and Mental Health among Disadvantaged Individuals.

    Bae, Jae Hyun / Park, Eun Hee / Lee, Hae Kyung / Yoon, Kun Ho / Won, Kyu Chang / Kim, Hyun Mi / Kim, Sin Gon

    Diabetes & metabolism journal

    2024  

    Abstract: ... with usual care or only usual care. Primary outcomes measured changes in psychological status and diabetes ...

    Abstract Background: This study examines integrating physical and mental healthcare for disadvantaged persons with type 2 diabetes mellitus and mild-to-moderate depression in the community, using a mobile application within a public-private-academic partnership.
    Methods: The Korean Diabetes Association has developed a mobile application combining behavioral activation for psychological well-being and diabetes self-management, with conventional medical therapy. Participants were randomly assigned to receive the application with usual care or only usual care. Primary outcomes measured changes in psychological status and diabetes selfmanagement through questionnaires at week 12 from the baseline. Secondary outcomes assessed glycemic and lipid control, with psychological assessments at week 16.
    Results: Thirty-nine of 73 participants completed the study (20 and 19 in the intervention and control groups, respectively) and were included in the analysis. At week 12, the intervention group showed significant reductions in depression severity and perceived stress compared to the control group. Additionally, they reported increased perceived social support and demonstrated improved diabetes self-care behavior. These positive effects persisted through week 16, with the added benefit of reduced anxiety. While fasting glucose levels in the intervention group tended to improve, no other significant differences were observed in laboratory assessments between the groups.
    Conclusion: This study provides compelling evidence for the potential efficacy of a mobile application that integrates physical and mental health components to address depressive symptoms and enhance diabetes self-management in disadvantaged individuals with type 2 diabetes mellitus and depression. Further research involving larger and more diverse populations is warranted to validate these findings and solidify their implications.
    Language English
    Publishing date 2024-02-02
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2602402-0
    ISSN 2233-6087 ; 2233-6087
    ISSN (online) 2233-6087
    ISSN 2233-6087
    DOI 10.4093/dmj.2023.0298
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  9. Article: Effects of Antimicrobial Administration Route on Growth and Antimicrobial Resistance in Weaned Piglets.

    Lee, Seong-Won / Jung, Chang-Min / Do, Kyung-Hyo / Lee, Wan-Kyu / Seo, Kwang-Won

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 20

    Abstract: This study aimed to determine how the route of antimicrobial administration affected the growth performance of weaned piglets. Additionally, we aimed to investigate potential differences between antimicrobial resistance developed by antimicrobials ... ...

    Abstract This study aimed to determine how the route of antimicrobial administration affected the growth performance of weaned piglets. Additionally, we aimed to investigate potential differences between antimicrobial resistance developed by antimicrobials administered orally through drinking water, and those administered through feed, in weaned piglets. The research was undertaken on a farm housing 500 sows and involved 150 weaned piglets at 21 days of age. These piglets were evenly distributed into three groups of equal size: water, feed, and control. Antimicrobials were administered through drinking water and feed in the water and feed groups, respectively, while the control group received no antimicrobial treatment. The observation of piglets continued until they reached 70 days of age. The feed conversion ratio in the water group (1.7 ± 0.78) was significantly higher than in the control (2.4 ± 1.77) and feed (2.7 ± 1.68) groups. Additionally, the route of administration did not affect antimicrobial resistance rates. Based on these results, it can be inferred that administering antimicrobials through drinking water is advantageous for pig farming.
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13203264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of Solitary Osteochondroma on Alignment and Length in the Lower Extremities.

    Park, Hoon / Kim, Hyun Woo / Park, Kun-Bo / Kim, Jae Hong / Chang, Won June / Park, Byoung Kyu

    Journal of pediatric orthopedics

    2024  Volume 44, Issue 4, Page(s) e351–e356

    Abstract: Background: There is a lack of information about the effects of untreated solitary osteochondroma (SO) on longitudinal growth of the lower extremities in children and adolescents. This study aimed to assess the coronal alignment and length of the lower ... ...

    Abstract Background: There is a lack of information about the effects of untreated solitary osteochondroma (SO) on longitudinal growth of the lower extremities in children and adolescents. This study aimed to assess the coronal alignment and length of the lower extremity in patients with SO around the knee and to identify the factors related to the development of deformities.
    Methods: We retrospectively reviewed 111 patients diagnosed with SO around the knee. The patients were classified into 2 groups depending on the location of the SO: 51 in the distal femur and 60 in the proximal tibia. Characteristics of the lesions, such as type, location, size, and distance from the joint line, were determined. Radiographic analysis of the lower limbs included mechanical lateral distal femoral angle, mechanical medial proximal tibial angle, whole-leg length, femoral length, and tibial length.
    Results: The mean age at the time of diagnosis was 12.3±3.4 years. No statistically significant differences were found between the affected and contralateral sides for mechanical lateral distal femoral angle and mechanical medial proximal tibial angle in either the distal femur or the proximal tibia groups. In patients with femoral lesions, the femoral and whole-leg lengths were significantly shorter on the affected side than on the unaffected side ( P <0.001 and 0.002, respectively), and the mean differences were 2.1±3.6 and 2.1±4.4 mm, respectively. Univariate logistic regression analysis did not reveal any factors associated with limb length discrepancy (LLD). In patients with tibial lesions, no statistically significant differences were found in LLD.
    Conclusions: SOs around the knee did not cause clinically significant deformity of the lower extremity. However, in contrast to proximal tibia lesions, SO in the distal femur was associated with the shortening of the affected limb. Consideration should be given to the development of LLD in skeletally immature children with SO in the distal femur.
    Level of evidence: Level III-retrospective comparative study.
    MeSH term(s) Child ; Adolescent ; Humans ; Retrospective Studies ; Lower Extremity ; Tibia/diagnostic imaging ; Tibia/abnormalities ; Femur/diagnostic imaging ; Femur/abnormalities ; Knee Joint/diagnostic imaging ; Osteochondroma/diagnostic imaging
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604642-3
    ISSN 1539-2570 ; 0271-6798
    ISSN (online) 1539-2570
    ISSN 0271-6798
    DOI 10.1097/BPO.0000000000002612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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