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Article ; Online: A framework to identify functional interactors that contribute to disrupted early retinal development in Vsx2 ocular retardation J mice.

Leung, Amanda M / Rao, Mahesh B / Raju, Nathan / Chung, Minh / Klinger, Allison / Rowe, DiAnna J / Li, Xiaodong / Levine, Edward M

Developmental dynamics : an official publication of the American Association of Anatomists

2023 Volume 252, Issue 11, Page(s) 1338–1362

Abstract: ... disrupts early retinal development. We utilized the Vsx2 loss-of-function mouse, ocular retardation J (orJ ...

Abstract	Background: A goal of developmental genetics is to identify functional interactions that underlie phenotypes caused by mutations. We sought to identify functional interactors of Vsx2, which when mutated, disrupts early retinal development. We utilized the Vsx2 loss-of-function mouse, ocular retardation J (orJ), to assess interactions based on principles of positive and negative epistasis as applied to bulk transcriptome data. This was first tested in vivo with Mitf, a target of Vsx2 repression, and then to cultures of orJ retina treated with inhibitors of Retinoid-X Receptors (RXR) to target Rxrg, an up-regulated gene in the orJ retina, and gamma-Secretase, an enzyme required for Notch signaling, a key mediator of retinal proliferation and neurogenesis. Results: Whereas Mitf exhibited robust positive epistasis with Vsx2, it only partially accounts for the orJ phenotype, suggesting other functional interactors. RXR inhibition yielded minimal evidence for epistasis between Vsx2 and Rxrg. In contrast, gamma-Secretase inhibition caused hundreds of Vsx2-dependent genes associated with proliferation to deviate further from wild-type, providing evidence for convergent negative epistasis with Vsx2 in regulating tissue growth. Conclusions: Combining in vivo and ex vivo testing with transcriptome analysis revealed quantitative and qualitative characteristics of functional interaction between Vsx2, Mitf, RXR, and gamma-Secretase activities.
MeSH term(s)	Mice ; Animals ; Transcription Factors/genetics ; Homeodomain Proteins/genetics ; Amyloid Precursor Protein Secretases/genetics ; Retina ; Neurogenesis/physiology
Chemical Substances	Transcription Factors ; Homeodomain Proteins ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Vsx2 protein, mouse
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1102541-4
ISSN	1097-0177 ; 1058-8388
ISSN (online)	1097-0177
ISSN	1058-8388
DOI	10.1002/dvdy.629
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Article ; Online: Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities.

Russell, Magdalena L / Souquette, Aisha / Levine, David M / Schattgen, Stefan A / Allen, E Kaitlynn / Kuan, Guillermina / Simon, Noah / Balmaseda, Angel / Gordon, Aubree / Thomas, Paul G / Matsen, Frederick A / Bradley, Philip

eLife

2022 Volume 11

Abstract: ... determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection ... from a large human cohort, we infer specific genetic loci associated with V(D)J recombination probabilities ... using genome-wide association inference. We show that V(D)J gene usage profiles are associated ...

Abstract	Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and functional TCRs. The extent to which an individual's genetic background is associated with their resulting TCR repertoire diversity has yet to be fully explored. Using a previously published repertoire sequencing dataset paired with high-resolution genome-wide genotyping from a large human cohort, we infer specific genetic loci associated with V(D)J recombination probabilities using genome-wide association inference. We show that V(D)J gene usage profiles are associated with variation in the
MeSH term(s)	Genetic Loci ; Genome-Wide Association Study ; Genotype ; Humans ; Probability ; Receptors, Antigen, T-Cell/genetics ; V(D)J Recombination/genetics
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.73475
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Article ; Online: Conceptualizing life via non-equilibrium physics; is it enough?: Comment on "Unified representation of life's basic properties by a 3-species stochastic cubic autocatalytic reaction-diffusion system of equations" by A.P. Muñuzuri and J. Pérez-Mercader.

Levine, Herbert

Physics of life reviews

2023 Volume 45, Page(s) 71–73

MeSH term(s)	Life ; Physics
Language	English
Publishing date	2023-04-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2148883-6
ISSN	1873-1457 ; 1571-0645
ISSN (online)	1873-1457
ISSN	1571-0645
DOI	10.1016/j.plrev.2023.04.007
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Article ; Online: Historical Perspective on Pressure Injury Classification: The Legacy of J. Darrell Shea.

Levine, Jeffrey M

Advances in skin & wound care

2019 Volume 32, Issue 3, Page(s) 103–106

MeSH term(s)	Classification ; Clinical Competence ; History, 20th Century ; Humans ; Pressure Ulcer/classification ; Pressure Ulcer/history ; Risk Assessment ; Terminology as Topic
Language	English
Publishing date	2019-02-05
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	2012792-3
ISSN	1538-8654 ; 1527-7941
ISSN (online)	1538-8654
ISSN	1527-7941
DOI	10.1097/01.ASW.0000553113.63128.a5
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Article ; Online: Response to Ok S-H, Wiedmer SK, Sohn J-T. Comment on "Lipid emulsion therapy during management of the critically-ill poisoned patient: a prospective cohort study".

Levine, Michael / Beuhler, Michael / Brent, Jeffrey / Finkelstein, Yaron

Clinical toxicology (Philadelphia, Pa.)

2023 Volume 61, Issue 9, Page(s) 711–712

MeSH term(s)	Humans ; Poisons ; Critical Illness/therapy ; Prospective Studies ; Fat Emulsions, Intravenous/therapeutic use ; Lipids
Chemical Substances	Poisons ; Fat Emulsions, Intravenous ; Lipids
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2023.2276669
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Article ; Online: Corrigendum to "Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice" Redox Biol; 32 (2020): 101504, doi: 10.1016/j.redox.2020.101504, PMID: 32182573.

Li, Feng / Bahnson, Edward M / Wilder, Jennifer / Siletzky, Robin / Hagaman, John / Nickekeit, Volker / Hiller, Sylvia / Ayesha, Azraa / Feng, Lanfei / Levine, Jerrold S / Takahashi, Nobuyuki / Maeda-Smithies, Nobuyo

Redox biology

2021 Volume 44, Page(s) 102023

Language	English
Publishing date	2021-05-31
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2021.102023
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Article ; Online: Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

Magdalena L Russell / Aisha Souquette / David M Levine / Stefan A Schattgen / E Kaitlynn Allen / Guillermina Kuan / Noah Simon / Angel Balmaseda / Aubree Gordon / Paul G Thomas / Frederick A Matsen IV / Philip Bradley

eLife, Vol

2022 Volume 11

Abstract	Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of genetically determined biases and immune exposures. T cells combine a random V(D)J recombination process with a selection process to generate highly diverse and functional TCRs. The extent to which an individual’s genetic background is associated with their resulting TCR repertoire diversity has yet to be fully explored. Using a previously published repertoire sequencing dataset paired with high-resolution genome-wide genotyping from a large human cohort, we infer specific genetic loci associated with V(D)J recombination probabilities using genome-wide association inference. We show that V(D)J gene usage profiles are associated with variation in the TCRB locus and, specifically for the functional TCR repertoire, variation in the major histocompatibility complex locus. Further, we identify specific variations in the genes encoding the Artemis protein and the TdT protein to be associated with biasing junctional nucleotide deletion and N-insertion, respectively. These results refine our understanding of genetically-determined TCR repertoire biases by confirming and extending previous studies on the genetic determinants of V(D)J gene usage and providing the first examples of trans genetic variants which are associated with modifying junctional diversity. Together, these insights lay the groundwork for further explorations into how immune responses vary between individuals.
Keywords	t cell receptor repertoire ; VDJ recombination probabilities ; GWAS ; Artemis ; TdT ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
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Article ; Online: Relative Modification of Prompt ψ(2S) and J/ψ Yields from pp to PbPb Collisions at sqrt[s_{NN}]=5.02 TeV.

Sirunyan, A M / Tumasyan, A / Adam, W / Asilar, E / Bergauer, T / Brandstetter, J / Brondolin, E / Dragicevic, M / Erö, J / Flechl, M / Friedl, M / Frühwirth, R / Ghete, V M / Hartl, C / Hörmann, N / Hrubec, J / Jeitler, M / König, A / Krätschmer, I /

Liko, D / Matsushita, T / Mikulec, I / Rabady, D / Rad, N / Rahbaran, B / Rohringer, H / Schieck, J / Strauss, J / Waltenberger, W / Wulz, C-E / Chekhovsky, V / Dvornikov, O / Dydyshka, Y / Emeliantchik, I / Litomin, A / Makarenko, V / Mossolov, V / Stefanovitch, R / Suarez Gonzalez, J / Zykunov, V / Shumeiko, N / Alderweireldt, S / De Wolf, E A / Janssen, X / Lauwers, J / Van De Klundert, M / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Van Spilbeeck, A / Abu Zeid, S / Blekman, F / D'Hondt, J / Daci, N / De Bruyn, I / Deroover, K / Lowette, S / Moortgat, S / Moreels, L / Olbrechts, A / Python, Q / Skovpen, K / Tavernier, S / Van Doninck, W / Van Mulders, P / Van Parijs, I / Brun, H / Clerbaux, B / De Lentdecker, G / Delannoy, H / Fasanella, G / Favart, L / Goldouzian, R / Grebenyuk, A / Karapostoli, G / Lenzi, T / Léonard, A / Luetic, J / Maerschalk, T / Marinov, A / Randle-Conde, A / Seva, T / Vander Velde, C / Vanlaer, P / Vannerom, D / Yonamine, R / Zenoni, F / Zhang, F / Cimmino, A / Cornelis, T / Dobur, D / Fagot, A / Garcia, G / Gul, M / Khvastunov, I / Poyraz, D / Salva, S / Schöfbeck, R / Tytgat, M / Van Driessche, W / Yazgan, E / Zaganidis, N / Bakhshiansohi, H / Beluffi, C / Bondu, O / Brochet, S / Bruno, G / Caudron, A / De Visscher, S / Delaere, C / Delcourt, M / Francois, B / Giammanco, A / Jafari, A / Jez, P / Komm, M / Krintiras, G / Lemaitre, V / Magitteri, A / Mertens, A / Musich, M / Nuttens, C / Piotrzkowski, K / Quertenmont, L / Selvaggi, M / Vidal Marono, M / Wertz, S / Beliy, N / Aldá Júnior, W L / Alves, F L / Alves, G A / Brito, L / Hensel, C / Moraes, A / Pol, M E / Rebello Teles, P / Belchior Batista Das Chagas, E / Carvalho, W / Chinellato, J / Custódio, A / Da Costa, E M / Da Silveira, G G / De Jesus Damiao, D / De Oliveira Martins, C / Fonseca De Souza, S / Huertas Guativa, L M / Malbouisson, H / Matos Figueiredo, D / Mora Herrera, C / Mundim, L / Nogima, H / Prado Da Silva, W L / Santoro, A / Sznajder, A / Tonelli Manganote, E J / Vilela Pereira, A / Ahuja, S / Bernardes, C A / Dogra, S / Tomei, T R Fernandez Perez / Gregores, E M / Mercadante, P G / Moon, C S / Novaes, S F / Padula, Sandra S / Romero Abad, D / Ruiz Vargas, J C / Aleksandrov, A / Hadjiiska, R / Iaydjiev, P / Rodozov, M / Stoykova, S / Sultanov, G / Vutova, M / Dimitrov, A / Glushkov, I / Litov, L / Pavlov, B / Petkov, P / Fang, W / Ahmad, M / Bian, J G / Chen, G M / Chen, H S / Chen, M / Chen, Y / Cheng, T / Jiang, C H / Leggat, D / Liu, Z / Romeo, F / Shaheen, S M / Spiezia, A / Tao, J / Wang, C / Wang, Z / Zhang, H / Zhao, J / Ban, Y / Chen, G / Li, Q / Liu, S / Mao, Y / Qian, S J / Wang, D / Xu, Z / Avila, C / Cabrera, A / Chaparro Sierra, L F / Florez, C / Gomez, J P / González Hernández, C F / Ruiz Alvarez, J D / Sanabria, J C / Godinovic, N / Lelas, D / Puljak, I / Ribeiro Cipriano, P M / Sculac, T / Antunovic, Z / Kovac, M / Brigljevic, V / Ferencek, D / Kadija, K / Mesic, B / Micanovic, S / Sudic, L / Susa, T / Attikis, A / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Tsiakkouri, D / Finger, M / Carrera Jarrin, E / Ellithi Kamel, A / Mahmoud, M A / Radi, A / Kadastik, M / Perrini, L / Raidal, M / Tiko, A / Veelken, C / Eerola, P / Pekkanen, J / Voutilainen, M / Härkönen, J / Järvinen, T / Karimäki, V / Kinnunen, R / Lampén, T / Lassila-Perini, K / Lehti, S / Lindén, T / Luukka, P / Tuominiemi, J / Tuovinen, E / Wendland, L / Talvitie, J / Tuuva, T / Besancon, M / Couderc, F / Dejardin, M / Denegri, D / Fabbro, B / Faure, J L / Favaro, C / Ferri, F / Ganjour, S / Ghosh, S / Givernaud, A / Gras, P / Hamel de Monchenault, G / Jarry, P / Kucher, I / Locci, E / Machet, M / Malcles, J / Rander, J / Rosowsky, A / Titov, M / Zghiche, A / Abdulsalam, A / Antropov, I / Arleo, F / Baffioni, S / Beaudette, F / Busson, P / Cadamuro, L / Chapon, E / Charlot, C / Davignon, O / Granier de Cassagnac, R / Jo, M / Lisniak, S / Martin Blanco, J / Miné, P / Nguyen, M / Ochando, C / 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R / Giffels, M / Gilbert, A / Goldenzweig, P / Haitz, D / Hartmann, F / Heindl, S M / Husemann, U / Katkov, I / Kudella, S / Mildner, H / Mozer, M U / Müller, Th / Plagge, M / Quast, G / Rabbertz, K / Röcker, S / Roscher, F / Schröder, M / Shvetsov, I / Sieber, G / Simonis, H J / Ulrich, R / Wayand, S / Weber, M / Weiler, T / Williamson, S / Wöhrmann, C / Wolf, R / Anagnostou, G / Daskalakis, G / Geralis, T / Giakoumopoulou, V A / Kyriakis, A / Loukas, D / Topsis-Giotis, I / Kesisoglou, S / Panagiotou, A / Saoulidou, N / Tziaferi, E / Evangelou, I / Flouris, G / Foudas, C / Kokkas, P / Loukas, N / Manthos, N / Papadopoulos, I / Paradas, E / Filipovic, N / Bencze, G / Hajdu, C / Horvath, D / Sikler, F / Veszpremi, V / Vesztergombi, G / Zsigmond, A J / Beni, N / Czellar, S / Karancsi, J / Makovec, A / Molnar, J / Szillasi, Z / Bartók, M / Raics, P / Trocsanyi, Z L / Ujvari, B / Bahinipati, S / Choudhury, S / Mal, P / Mandal, K / Nayak, A / Sahoo, D K / Sahoo, N / Swain, S K / Bansal, S / Beri, S B / Bhatnagar, V / Chawla, R / Bhawandeep, U / Kalsi, A K / Kaur, A / Kaur, M / Kumar, R / Kumari, P / Mehta, A / Mittal, M / Singh, J B / Walia, G / Kumar, Ashok / Bhardwaj, A / Choudhary, B C / Garg, R B / Keshri, S / Malhotra, S / Naimuddin, M / Nishu, N / Ranjan, K / Sharma, R / Sharma, V / Bhattacharya, R / Bhattacharya, S / Chatterjee, K / Dey, S / Dutt, S / Dutta, S / Majumdar, N / Modak, A / Mondal, K / Mukhopadhyay, S / Nandan, S / Purohit, A / Roy, A / Roy, D / Roy Chowdhury, S / Sarkar, S / Sharan, M / Thakur, S / Behera, P K / Chudasama, R / Dutta, D / Jha, V / Kumar, V / Mohanty, A K / Netrakanti, P K / Pant, L M / Shukla, P / Topkar, A / Aziz, T / Dugad, S / Kole, G / Mahakud, B / Mitra, S / Mohanty, G B / Parida, B / Sur, N / Sutar, B / Banerjee, S / Bhowmik, S / Dewanjee, R K / Ganguly, S / Guchait, M / Jain, Sa / Kumar, S / Maity, M / Majumder, G / Mazumdar, K / Sarkar, T / Wickramage, N / Chauhan, S / Dube, S / Hegde, V / Kapoor, A / Kothekar, K / Pandey, S / 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/ Barbieri, R / Baty, A / Bi, R / Bierwagen, K / Brandt, S / Busza, W / Cali, I A / D'Alfonso, M / Demiragli, Z / Di Matteo, L / Gomez Ceballos, G / Goncharov, M / Hsu, D / Iiyama, Y / Innocenti, G M / Klute, M / Kovalskyi, D / Krajczar, K / Lai, Y S / Lee, Y-J / Levin, A / Luckey, P D / Maier, B / Marini, A C / Mcginn, C / Mironov, C / Narayanan, S / Niu, X / Paus, C / Roland, C / Roland, G / Salfeld-Nebgen, J / Stephans, G S F / Tatar, K / Varma, M / Velicanu, D / Veverka, J / Wang, T W / Wyslouch, B / Yang, M / Zhukova, V / Benvenuti, A C / Chatterjee, R M / Evans, A / Finkel, A / Gude, A / Hansen, P / Kalafut, S / Kao, S C / Kubota, Y / Lesko, Z / Mans, J / Nourbakhsh, S / Ruckstuhl, N / Rusack, R / Tambe, N / Turkewitz, J / Acosta, J G / Oliveros, S / Avdeeva, E / Bartek, R / Bloom, K / Claes, D R / Dominguez, A / Fangmeier, C / Gonzalez Suarez, R / Kamalieddin, R / Kravchenko, I / Malta Rodrigues, A / Meier, F / Monroy, J / Siado, J E / Snow, G R / Stieger, B / Alyari, M / Dolen, J / George, J / Godshalk, A / Harrington, C / Iashvili, I / Kaisen, J / Kharchilava, A / Kumar, A / Parker, A / Rappoccio, S / Roozbahani, B / Alverson, G / Barberis, E / Hortiangtham, A / Massironi, A / Morse, D M / Nash, D / Orimoto, T / Teixeira De Lima, R / Trocino, D / Wang, R-J / Wood, D / Charaf, O / Hahn, K A / Kubik, A / Mucia, N / Odell, N / Pollack, B / Schmitt, M H / Sung, K / Trovato, M / Velasco, M / Dev, N / Hildreth, M / Hurtado Anampa, K / Jessop, C / Karmgard, D J / Kellams, N / Lannon, K / Marinelli, N / Meng, F / Mueller, C / Musienko, Y / Planer, M / Reinsvold, A / Ruchti, R / Smith, G / Taroni, S / Wayne, M / Wolf, M / Woodard, A / Alimena, J / Antonelli, L / Bylsma, B / Durkin, L S / Flowers, S / Francis, B / Hart, A / Hill, C / Hughes, R / Ji, W / Liu, B / Luo, W / Puigh, D / Winer, B L / Wulsin, H W / Cooperstein, S / Driga, O / Elmer, P / Hardenbrook, J / Hebda, P / Lange, D / Luo, J / Marlow, D / Medvedeva, T / Mei, K / Mooney, M / Olsen, J / Palmer, C / Piroué, P / Stickland, D / Svyatkovskiy, A / Tully, C / Zuranski, A / Barker, A / Barnes, V E / Folgueras, S / Gutay, L / Jha, M K / Jones, M / Jung, A W / Khatiwada, A / Miller, D H / Neumeister, N / Schulte, J F / Shi, X / Sun, J / Wang, F / Xie, W / Parashar, N / Stupak, J / Adair, A / Akgun, B / Chen, Z / Ecklund, K M / Geurts, F J M / Guilbaud, M / Li, W / Michlin, B / Northup, M / Padley, B P / Redjimi, R / Roberts, J / Rorie, J / Tu, Z / Zabel, J / Betchart, B / Bodek, A / de Barbaro, P / Demina, R / Duh, Y T / Ferbel, T / Galanti, M / Garcia-Bellido, A / Han, J / Hindrichs, O / Khukhunaishvili, A / Lo, K H / Tan, P / Verzetti, M / Agapitos, A / Chou, J P / Contreras-Campana, E / Gershtein, Y / Gómez Espinosa, T A / Halkiadakis, E / Heindl, M / Hidas, D / Hughes, E / Kaplan, S / Kunnawalkam Elayavalli, R / Kyriacou, S / Lath, A / Nash, K / Saka, H / Salur, S / Schnetzer, S / Sheffield, D / Somalwar, S / Stone, R / Thomas, S / Thomassen, P / Walker, M / Delannoy, A G / Foerster, M / Heideman, J / Riley, G / Rose, K / Spanier, S / Thapa, K / Bouhali, O / Celik, A / Dalchenko, M / De Mattia, M / Delgado, A / Dildick, S / Eusebi, R / Gilmore, J / Huang, T / Juska, E / Kamon, T / Mueller, R / Pakhotin, Y / Patel, R / Perloff, A / Perniè, L / Rathjens, D / Safonov, A / Tatarinov, A / Ulmer, K A / Akchurin, N / Cowden, C / Damgov, J / De Guio, F / Dragoiu, C / Dudero, P R / Faulkner, J / Gurpinar, E / Kunori, S / Lamichhane, K / Libeiro, T / Peltola, T / Undleeb, S / Volobouev, I / Greene, S / Gurrola, A / Janjam, R / Johns, W / Maguire, C / Melo, A / Ni, H / Sheldon, P / Tuo, S / Velkovska, J / Xu, Q / Arenton, M W / Barria, P / Cox, B / Goodell, J / Hirosky, R / Ledovskoy, A / Li, H / Neu, C / Sinthuprasith, T / Sun, X / Wang, Y / Wolfe, E / Xia, F / Clarke, C / Harr, R / Karchin, P E / Sturdy, J / Belknap, D A / Buchanan, J / Caillol, C / Dasu, S / Dodd, L / Duric, S / Gomber, B / Grothe, M / Herndon, M / Hervé, A / Klabbers, P / Lanaro, A / Levine, A / Long, K / Loveless, R / Ojalvo, I / Perry, T / Pierro, G A / Polese, G / Ruggles, T / Savin, A / Smith, N / Smith, W H / Taylor, D / Woods, N

Physical review letters

2017 Volume 118, Issue 16, Page(s) 162301

Abstract: The relative modification of the prompt ψ(2S) and J/ψ yields from pp to PbPb collisions ... charmonia reconstructed through their decays into muon pairs, (N_{ψ(2S)}/N_{J/ψ})_{PbPb}/(N_{ψ(2S)}/N_{J/ψ ... bins, suggesting that the ψ(2S) yield is more suppressed than the J/ψ yield in the explored phase space. ...

Abstract	The relative modification of the prompt ψ(2S) and J/ψ yields from pp to PbPb collisions, at the center-of-mass energy of 5.02 TeV per nucleon pair, is presented. The analysis is based on pp and PbPb data samples collected by the CMS experiment at the LHC in 2015, corresponding to integrated luminosities of 28.0 pb^{-1} and 464 μb^{-1}, respectively. The double ratio of measured yields of prompt charmonia reconstructed through their decays into muon pairs, (N_{ψ(2S)}/N_{J/ψ})_{PbPb}/(N_{ψ(2S)}/N_{J/ψ})_{pp}, is determined as a function of PbPb collision centrality and charmonium transverse momentum p_{T}, in two kinematic intervals: \|y\|<1.6 covering 6.5<p_{T}<30 GeV/c and 1.6<\|y\|<2.4 covering 3<p_{T}<30 GeV/c. The centrality-integrated double ratios are 0.36±0.08(stat)±0.05(syst) in the first interval and 0.24±0.22(stat)±0.09(syst) in the second. The double ratio is lower than unity in all the measured bins, suggesting that the ψ(2S) yield is more suppressed than the <mark>J/ψ yield in the explored phase space.
Language	English
Publishing date	2017-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.118.162301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Measurement of J/ψ azimuthal anisotropy in Au+Au collisions at sqrt[s(NN)]=200 GeV.

Adamczyk, L / Adkins, J K / Agakishiev, G / Aggarwal, M M / Ahammed, Z / Alekseev, I / Alford, J / Anson, C D / Aparin, A / Arkhipkin, D / Aschenauer, E / Averichev, G S / Balewski, J / Banerjee, A / Barnovska, Z / Beavis, D R / Bellwied, R / Betancourt, M J / Betts, R R /

Bhasin, A / Bhati, A K / Bhattarai, P / Bichsel, H / Bielcik, J / Bielcikova, J / Bland, L C / Bordyuzhin, I G / Borowski, W / Bouchet, J / Brandin, A V / Brovko, S G / Bruna, E / Bültmann, S / Bunzarov, I / Burton, T P / Butterworth, J / Cai, X Z / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Cendejas, R / Cervantes, M C / Chaloupka, P / Chang, Z / Chattopadhyay, S / Chen, H F / Chen, J H / Chen, J Y / Chen, L / Cheng, J / Cherney, M / Chikanian, A / Christie, W / Chung, P / Chwastowski, J / Codrington, M J M / Corliss, R / Cramer, J G / Crawford, H J / Cui, X / Das, S / Davila Leyva, A / De Silva, L C / Debbe, R R / Dedovich, T G / Deng, J / Derradi de Souza, R / Dhamija, S / di Ruzza, B / Didenko, L / Ding, F / Dion, A / Djawotho, P / Dong, X / Drachenberg, J L / Draper, J E / Du, C M / Dunkelberger, L E / Dunlop, J C / Efimov, L G / Elnimr, M / Engelage, J / Eppley, G / Eun, L / Evdokimov, O / Fatemi, R / Fazio, S / Fedorisin, J / Fersch, R G / Filip, P / Finch, E / Fisyak, Y / Flores, E / Gagliardi, C A / Gangadharan, D R / Garand, D / Geurts, F / Gibson, A / Gliske, S / Grebenyuk, O G / Grosnick, D / Gupta, A / Gupta, S / Guryn, W / Haag, B / Hajkova, O / Hamed, A / Han, L-X / Harris, J W / Hays-Wehle, J P / Heppelmann, S / Hirsch, A / Hoffmann, G W / Hofman, D J / Horvat, S / Huang, B / Huang, H Z / Huck, P / Humanic, T J / Igo, G / Jacobs, W W / Jena, C / Judd, E G / Kabana, S / Kang, K / Kapitan, J / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kesich, A / Kikola, D P / Kiryluk, J / Kisel, I / Kisiel, A / Klein, S R / Koetke, D D / Kollegger, T / Konzer, J / Koralt, I / Korsch, W / Kotchenda, L / Kravtsov, P / Krueger, K / Kulakov, I / Kumar, L / Lamont, M A C / Landgraf, J M / Landry, K D / Lapointe, S / Lauret, J / Lebedev, A / Lednicky, R / Lee, J H / Leight, W / LeVine, M J / Li, C / Li, W / Li, X / Li, Y / Li, Z M / Lima, L M / Lisa, M A / Liu, F / Ljubicic, T / Llope, W J / Longacre, R S / Lu, Y / Luo, X / Luszczak, A / Ma, G L / Ma, Y G / Madagodagettige Don, D M M D / Mahapatra, D P / Majka, R / Margetis, S / Markert, C / Masui, H / Matis, H S / McDonald, D / McShane, T S / Mioduszewski, S / Mitrovski, M K / Mohammed, Y / Mohanty, B / Mondal, M M / Munhoz, M G / Mustafa, M K / Naglis, M / Nandi, B K / Nasim, Md / Nayak, T K / Nelson, J M / Nogach, L V / Novak, J / Odyniec, G / Ogawa, A / Oh, K / Ohlson, A / Okorokov, V / Oldag, E W / Oliveira, R A N / Olson, D / Pachr, M / Page, B S / Pal, S K / Pan, Y X / Pandit, Y / Panebratsev, Y / Pawlak, T / Pawlik, B / Pei, H / Perkins, C / Peryt, W / Pile, P / Planinic, M / Pluta, J / Poljak, N / Porter, J / Poskanzer, A M / Powell, C B / Pruneau, C / Pruthi, N K / Przybycien, M / Pujahari, P R / Putschke, J / Qiu, H / Ramachandran, S / Raniwala, R / Raniwala, S / Ray, R L / Riley, C K / Ritter, H G / Roberts, J B / Rogachevskiy, O V / Romero, J L / Ross, J F / Ruan, L / Rusnak, J / Sahoo, N R / Sahu, P K / Sakrejda, I / Salur, S / Sandacz, A / Sandweiss, J / Sangaline, E / Sarkar, A / Schambach, J / Scharenberg, R P / Schmah, A M / Schmidke, B / Schmitz, N / Schuster, T R / Seger, J / Seyboth, P / Shah, N / Shahaliev, E / Shao, M / Sharma, B / Sharma, M / Shi, S S / Shou, Q Y / Sichtermann, E P / Singaraju, R N / Skoby, M J / Smirnov, D / Smirnov, N / Solanki, D / Sorensen, P / Desouza, U G / Spinka, H M / Srivastava, B / Stanislaus, T D S / Stevens, J R / Stock, R / Strikhanov, M / Stringfellow, B / Suaide, A A P / Suarez, M C / Sumbera, M / Sun, X M / Sun, Y / Sun, Z / Surrow, B / Svirida, D N / Symons, T J M / Szanto de Toledo, A / Takahashi, J / Tang, A H / Tang, Z / Tarini, L H / Tarnowsky, T / Thomas, J H / Tian, J / Timmins, A R / Tlusty, D / Tokarev, M / Trentalange, S / Tribble, R E / Tribedy, P / Trzeciak, B A / Tsai, O D / Turnau, J / Ullrich, T / Underwood, D G / Van Buren, G / van Nieuwenhuizen, G / Vanfossen, J A / Varma, R / Vasconcelos, G M S / Videbæk, F / Viyogi, Y P / Vokal, S / Voloshin, S A / Vossen, A / Wada, M / Wang, F / Wang, G / Wang, H / Wang, J S / Wang, Q / Wang, X L / Wang, Y / Webb, G / Webb, J C / Westfall, G D / Whitten, C / Wieman, H / Wissink, S W / Witt, R / Wu, Y F / Xiao, Z / Xie, W / Xin, K / Xu, H / Xu, N / Xu, Q H / Xu, W / Xu, Y / Xu, Z / Xue, L / Yang, Y / Yepes, P / Yi, L / Yip, K / Yoo, I-K / Zawisza, M / Zbroszczyk, H / Zhang, J B / Zhang, S / Zhang, X P / Zhang, Y / Zhang, Z P / Zhao, F / Zhao, J / Zhong, C / Zhu, X / Zhu, Y H / Zoulkarneeva, Y / Zyzak, M

Physical review letters

2013 Volume 111, Issue 5, Page(s) 52301

Abstract: The measurement of J/ψ azimuthal anisotropy is presented as a function of transverse momentum ... for different centralities in Au+Au collisions at sqrt[s(NN)]=200 GeV. The measured J/ψ elliptic flow is ... that J/ψ particles with relatively large transverse momenta are not dominantly produced by coalescence ...

Abstract	The measurement of J/ψ azimuthal anisotropy is presented as a function of transverse momentum for different centralities in Au+Au collisions at sqrt[s(NN)]=200 GeV. The measured J/ψ elliptic flow is consistent with zero within errors for transverse momentum between 2 and 10 GeV/c. Our measurement suggests that J/ψ particles with relatively large transverse momenta are not dominantly produced by coalescence from thermalized charm quarks, when comparing to model calculations.
MeSH term(s)	Anisotropy ; Elementary Particles ; Gold/chemistry ; Quantum Theory
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2013-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.111.052301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Measurement of J/ψ and ψ(2S) Prompt Double-Differential Cross Sections in pp Collisions at sqrt[s]=7 TeV.

Khachatryan, V / Sirunyan, A M / Tumasyan, A / Adam, W / Bergauer, T / Dragicevic, M / Erö, J / Friedl, M / Frühwirth, R / Ghete, V M / Hartl, C / Hörmann, N / Hrubec, J / Jeitler, M / Kiesenhofer, W / Knünz, V / Krammer, M / Krätschmer, I / Liko, D /

Mikulec, I / Rabady, D / Rahbaran, B / Rohringer, H / Schöfbeck, R / Strauss, J / Treberer-Treberspurg, W / Waltenberger, W / Wulz, C-E / Mossolov, V / Shumeiko, N / Suarez Gonzalez, J / Alderweireldt, S / Bansal, S / Cornelis, T / De Wolf, E A / Janssen, X / Knutsson, A / Lauwers, J / Luyckx, S / Ochesanu, S / Rougny, R / Van De Klundert, M / Van Haevermaet, H / Van Mechelen, P / Van Remortel, N / Van Spilbeeck, A / Blekman, F / Blyweert, S / D'Hondt, J / Daci, N / Heracleous, N / Keaveney, J / Lowette, S / Maes, M / Olbrechts, A / Python, Q / Strom, D / Tavernier, S / Van Doninck, W / Van Mulders, P / Van Onsem, G P / Villella, I / Caillol, C / Clerbaux, B / De Lentdecker, G / Dobur, D / Favart, L / Gay, A P R / Grebenyuk, A / Léonard, A / Mohammadi, A / Perniè, L / Randle-Conde, A / Reis, T / Seva, T / Thomas, L / Vander Velde, C / Vanlaer, P / Wang, J / Zenoni, F / Adler, V / Beernaert, K / Benucci, L / Cimmino, A / Costantini, S / Crucy, S / Fagot, A / Garcia, G / Mccartin, J / Ocampo Rios, A A / Poyraz, D / Ryckbosch, D / Salva Diblen, S / Sigamani, M / Strobbe, N / Thyssen, F / Tytgat, M / Yazgan, E / Zaganidis, N / Basegmez, S / Beluffi, C / Bruno, G / Castello, R / Caudron, A / Ceard, L / Da Silveira, G G / Delaere, C / du Pree, T / Favart, D / Forthomme, L / Giammanco, A / Hollar, J / Jafari, A / Jez, P / Komm, M / Lemaitre, V / Nuttens, C / Pagano, D / Perrini, L / Pin, A / Piotrzkowski, K / Popov, A / Quertenmont, L / Selvaggi, M / Vidal Marono, M / Vizan Garcia, J M / Beliy, N / Caebergs, T / Daubie, E / Hammad, G H / Aldá Júnior, W L / Alves, G A / Brito, L / Correa Martins Junior, M / Dos Reis Martins, T / Molina, J / Mora Herrera, C / Pol, M E / Rebello Teles, P / Carvalho, W / Chinellato, J / Custódio, A / Da Costa, E M / De Jesus Damiao, D / De Oliveira Martins, C / Fonseca De Souza, S / Malbouisson, H / Matos Figueiredo, D / Mundim, L / Nogima, H / Prado Da Silva, W L / Santaolalla, J / Santoro, A / Sznajder, A / Tonelli Manganote, E J / Vilela Pereira, A / Bernardes, C A / Dogra, S / Tomei, T R Fernandez Perez / Gregores, E M / Mercadante, P G / Novaes, S F / Padula, Sandra S / Aleksandrov, A / Genchev, V / Hadjiiska, R / Iaydjiev, P / Marinov, A / Piperov, S / Rodozov, M / Stoykova, S / Sultanov, G / Vutova, M / Dimitrov, A / Glushkov, I / Litov, L / Pavlov, B / Petkov, P / Bian, J G / Chen, G M / Chen, H S / Chen, M / Cheng, T / Du, R / Jiang, C H / Plestina, R / Romeo, F / Tao, J / Wang, Z / Asawatangtrakuldee, C / Ban, Y / Guo, W / Liu, S / Mao, Y / Qian, S J / Wang, D / Xu, Z / Zhang, F / Zhang, L / Zou, W / Avila, C / Cabrera, A / Chaparro Sierra, L F / Florez, C / Gomez, J P / Gomez Moreno, B / Sanabria, J C / Godinovic, N / Lelas, D / Polic, D / Puljak, I / Antunovic, Z / Kovac, M / Brigljevic, V / Kadija, K / Luetic, J / Mekterovic, D / Sudic, L / Attikis, A / Mavromanolakis, G / Mousa, J / Nicolaou, C / Ptochos, F / Razis, P A / Rykaczewski, H / Bodlak, M / Finger, M / Assran, Y / Ellithi Kamel, A / Mahmoud, M A / 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Physical review letters

2015 Volume 114, Issue 19, Page(s) 191802

Abstract: The double-differential cross sections of promptly produced J/ψ and ψ(2S) mesons are measured in pp ... The analysis uses J/ψ and ψ(2S) dimuon samples collected by the CMS experiment, corresponding to integrated ... of the dimuon invariant mass and decay length, and extend to p_{T}=120 and 100 GeV for the J/ψ and ψ(2S ...

Abstract	The double-differential cross sections of promptly produced J/ψ and ψ(2S) mesons are measured in pp collisions at sqrt[s]=7 TeV, as a function of transverse momentum p_{T} and absolute rapidity \|y\|. The analysis uses J/ψ and ψ(2S) dimuon samples collected by the CMS experiment, corresponding to integrated luminosities of 4.55 and 4.90 fb^{-1}, respectively. The results are based on a two-dimensional analysis of the dimuon invariant mass and decay length, and extend to p_{T}=120 and 100 GeV for the J/ψ and ψ(2S), respectively, when integrated over the interval \|y\|<1.2. The ratio of the ψ(2S) to J/ψ cross sections is also reported for \|y\|<1.2, over the range 10<p_{T}<100 GeV. These are the highest p_{T} values for which the cross sections and ratio have been measured.<br />
Language	English
Publishing date	2015-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.114.191802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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