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Article ; Online: Central neuropathic pain.

Rosner, Jan / de Andrade, Daniel C / Davis, Karen D / Gustin, Sylvia M / Kramer, John L K / Seal, Rebecca P / Finnerup, Nanna B

Nature reviews. Disease primers

2023 Volume 9, Issue 1, Page(s) 73

Abstract: Central neuropathic pain arises from a lesion or disease of the central somatosensory nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related neuroinflammatory conditions. The incidence of central neuropathic pain ... ...

Abstract	Central neuropathic pain arises from a lesion or disease of the central somatosensory nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related neuroinflammatory conditions. The incidence of central neuropathic pain differs based on its underlying cause. Individuals with spinal cord injury are at the highest risk; however, central post-stroke pain is the most prevalent form of central neuropathic pain worldwide. The mechanisms that underlie central neuropathic pain are not fully understood, but the pathophysiology likely involves intricate interactions and maladaptive plasticity within spinal circuits and brain circuits associated with nociception and antinociception coupled with neuronal hyperexcitability. Modulation of neuronal activity, neuron-glia and neuro-immune interactions and targeting pain-related alterations in brain connectivity, represent potential therapeutic approaches. Current evidence-based pharmacological treatments include antidepressants and gabapentinoids as first-line options. Non-pharmacological pain management options include self-management strategies, exercise and neuromodulation. A comprehensive pain history and clinical examination form the foundation of central neuropathic pain classification, identification of potential risk factors and stratification of patients for clinical trials. Advanced neurophysiological and neuroimaging techniques hold promise to improve the understanding of mechanisms that underlie central neuropathic pain and as predictive biomarkers of treatment outcome.
MeSH term(s)	Humans ; Neuralgia/etiology ; Pain Management ; Spinal Cord Injuries/complications ; Antidepressive Agents/therapeutic use ; Multiple Sclerosis
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article ; Review
ISSN	2056-676X
ISSN (online)	2056-676X
DOI	10.1038/s41572-023-00484-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of the Effectiveness of a Novel Brain-Computer Interface Neuromodulative Intervention to Relieve Neuropathic Pain Following Spinal Cord Injury: Protocol for a Single-Case Experimental Design With Multiple Baselines.

Hesam-Shariati, Negin / Newton-John, Toby / Singh, Avinash K / Tirado Cortes, Carlos A / Do, Tien-Thong Nguyen / Craig, Ashley / Middleton, James W / Jensen, Mark P / Trost, Zina / Lin, Chin-Teng / Gustin, Sylvia M

JMIR research protocols

2020 Volume 9, Issue 9, Page(s) e20979

Abstract: Background: Neuropathic pain is a debilitating secondary condition for many individuals with spinal cord injury. Spinal cord injury neuropathic pain often is poorly responsive to existing pharmacological and nonpharmacological treatments. A growing body ...

Abstract	Background: Neuropathic pain is a debilitating secondary condition for many individuals with spinal cord injury. Spinal cord injury neuropathic pain often is poorly responsive to existing pharmacological and nonpharmacological treatments. A growing body of evidence supports the potential for brain-computer interface systems to reduce spinal cord injury neuropathic pain via electroencephalographic neurofeedback. However, further studies are needed to provide more definitive evidence regarding the effectiveness of this intervention. Objective: The primary objective of this study is to evaluate the effectiveness of a multiday course of a brain-computer interface neuromodulative intervention in a gaming environment to provide pain relief for individuals with neuropathic pain following spinal cord injury. Methods: We have developed a novel brain-computer interface-based neuromodulative intervention for spinal cord injury neuropathic pain. Our brain-computer interface neuromodulative treatment includes an interactive gaming interface, and a neuromodulation protocol targeted to suppress theta (4-8 Hz) and high beta (20-30 Hz) frequency powers, and enhance alpha (9-12 Hz) power. We will use a single-case experimental design with multiple baselines to examine the effectiveness of our self-developed brain-computer interface neuromodulative intervention for the treatment of spinal cord injury neuropathic pain. We will recruit 3 participants with spinal cord injury neuropathic pain. Each participant will be randomly allocated to a different baseline phase (ie, 7, 10, or 14 days), which will then be followed by 20 sessions of a 30-minute brain-computer interface neuromodulative intervention over a 4-week period. The visual analog scale assessing average pain intensity will serve as the primary outcome measure. We will also assess pain interference as a secondary outcome domain. Generalization measures will assess quality of life, sleep quality, and anxiety and depressive symptoms, as well as resting-state electroencephalography and thalamic γ-aminobutyric acid concentration. Results: This study was approved by the Human Research Committees of the University of New South Wales in July 2019 and the University of Technology Sydney in January 2020. We plan to begin the trial in October 2020 and expect to publish the results by the end of 2021. Conclusions: This clinical trial using single-case experimental design methodology has been designed to evaluate the effectiveness of a novel brain-computer interface neuromodulative treatment for people with neuropathic pain after spinal cord injury. Single-case experimental designs are considered a viable alternative approach to randomized clinical trials to identify evidence-based practices in the field of technology-based health interventions when recruitment of large samples is not feasible. Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12620000556943; https://bit.ly/2RY1jRx. International registered report identifier (irrid): PRR1-10.2196/20979.
Language	English
Publishing date	2020-09-29
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/20979
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Article ; Online: GATA3

Gustin, John P / Miller, Jernelle / Farag, Mina / Rosen, D Marc / Thomas, Matthew / Scharpf, Robert B / Lauring, Josh

Oncotarget

2017 Volume 8, Issue 61, Page(s) 103415–103427

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2017-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.21910
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Article ; Online: The PIK3CA gene as a mutated target for cancer therapy.

Gustin, John P / Cosgrove, David P / Park, Ben Ho

Current cancer drug targets

2008 Volume 8, Issue 8, Page(s) 733–740

Abstract: The development of targeted therapies with true specificity for cancer relies upon exploiting differences between cancerous and normal cells. Genetic and genomic alterations including somatic mutations, translocations, and amplifications have served as ... ...

Abstract	The development of targeted therapies with true specificity for cancer relies upon exploiting differences between cancerous and normal cells. Genetic and genomic alterations including somatic mutations, translocations, and amplifications have served as recent examples of how such differences can be exploited as effective drug targets. Small molecule inhibitors and monoclonal antibodies directed against the protein products of these genetic anomalies have led to cancer therapies with high specificity and relatively low toxicity. Recently, our group and others have demonstrated that somatic mutations in the PIK3CA gene occur at high frequency in breast and other cancers. Moreover, the majority of mutations occur at three hotspots, making these ideal targets for therapeutic development. Here we review the literature on PIK3CA mutations in cancer, as well as existing data on PIK3CA inhibitors and inhibitors of downstream effectors for potential use as targeted cancer therapeutics.
MeSH term(s)	Class I Phosphatidylinositol 3-Kinases ; Enzyme Inhibitors/therapeutic use ; Humans ; Mutation ; Neoplasms/drug therapy ; Neoplasms/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphoinositide-3 Kinase Inhibitors ; Protein Kinases/drug effects ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; TOR Serine-Threonine Kinases
Chemical Substances	Enzyme Inhibitors ; Phosphoinositide-3 Kinase Inhibitors ; Protein Kinases (EC 2.7.-) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CA protein, human (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2008-12-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2064824-8
ISSN	1873-5576 ; 1568-0096
ISSN (online)	1873-5576
ISSN	1568-0096
DOI	10.2174/156800908786733504
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Article ; Online: Hydrophobically modified chitosan gauze: a novel topical hemostat.

Chaturvedi, Apurva / Dowling, Matthew B / Gustin, John P / Scalea, Thomas M / Raghavan, Srinivasa R / Pasley, Jason D / Narayan, Mayur

The Journal of surgical research

2016 Volume 207, Page(s) 45–52

Abstract: Background: Currently, the standard of care for treating severe hemorrhage in a military setting is Combat Gauze (CG). Previous work has shown that hydrophobically modified chitosan (hm-C) has significant hemostatic capability relative to its native ... ...

Abstract	Background: Currently, the standard of care for treating severe hemorrhage in a military setting is Combat Gauze (CG). Previous work has shown that hydrophobically modified chitosan (hm-C) has significant hemostatic capability relative to its native chitosan counterpart. This work aims to evaluate gauze coated in hm-C relative to CG as well as ChitoGauze (ChG) in a lethal in vivo hemorrhage model. Methods: Twelve Yorkshire swine were randomized to receive either hm-C gauze (n = 4), ChG (n = 4), or CG (n = 4). A standard hemorrhage model was used in which animals underwent a splenectomy before a 6-mm punch arterial puncture of the femoral artery. Thirty seconds of free bleeding was allowed before dressings were applied and compressed for 3 min. Baseline mean arterial pressure was preserved via fluid resuscitation. Experiments were conducted for 3 h after which any surviving animal was euthanized. Results: hm-C gauze was found to be at least equivalent to both CG and ChG in terms of overall survival (100% versus 75%), number of dressing used (6 versus 7), and duration of hemostasis (3 h versus 2.25 h). Total post-treatment blood loss was lower in the hm-C gauze treatment group (4.7 mL/kg) when compared to CG (13.4 mL/kg) and ChG (12.1 mL/kg) groups. Conclusions: hm-C gauze outperformed both CG and ChG in a lethal hemorrhage model but without statistical significance for key endpoints. Future comparison of hm-C gauze to CG and ChG will be performed on a hypothermic, coagulopathic model that should allow for outcome significance to be differentiated under small treatment groups.
MeSH term(s)	Administration, Topical ; Animals ; Bandages ; Chitosan/administration & dosage ; Chitosan/chemistry ; Chitosan/therapeutic use ; Female ; Hemorrhage/etiology ; Hemorrhage/therapy ; Hemostatic Techniques/instrumentation ; Hemostatics/administration & dosage ; Hemostatics/chemistry ; Hemostatics/therapeutic use ; Hydrophobic and Hydrophilic Interactions ; Random Allocation ; Swine ; Treatment Outcome ; Wounds and Injuries/complications
Chemical Substances	Hemostatics ; Chitosan (9012-76-4)
Language	English
Publishing date	2016-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2016.04.052
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Article ; Online: Evaluation of the Effectiveness of a Novel Brain-Computer Interface Neuromodulative Intervention to Relieve Neuropathic Pain Following Spinal Cord Injury

JMIR Research Protocols, Vol 9, Iss 9, p e

Protocol for a Single-Case Experimental Design With Multiple Baselines

2020 Volume 20979

Abstract: BackgroundNeuropathic pain is a debilitating secondary condition for many individuals with spinal cord injury. Spinal cord injury neuropathic pain often is poorly responsive to existing pharmacological and nonpharmacological treatments. A growing body of ...

Abstract	BackgroundNeuropathic pain is a debilitating secondary condition for many individuals with spinal cord injury. Spinal cord injury neuropathic pain often is poorly responsive to existing pharmacological and nonpharmacological treatments. A growing body of evidence supports the potential for brain-computer interface systems to reduce spinal cord injury neuropathic pain via electroencephalographic neurofeedback. However, further studies are needed to provide more definitive evidence regarding the effectiveness of this intervention. ObjectiveThe primary objective of this study is to evaluate the effectiveness of a multiday course of a brain-computer interface neuromodulative intervention in a gaming environment to provide pain relief for individuals with neuropathic pain following spinal cord injury. MethodsWe have developed a novel brain-computer interface-based neuromodulative intervention for spinal cord injury neuropathic pain. Our brain-computer interface neuromodulative treatment includes an interactive gaming interface, and a neuromodulation protocol targeted to suppress theta (4-8 Hz) and high beta (20-30 Hz) frequency powers, and enhance alpha (9-12 Hz) power. We will use a single-case experimental design with multiple baselines to examine the effectiveness of our self-developed brain-computer interface neuromodulative intervention for the treatment of spinal cord injury neuropathic pain. We will recruit 3 participants with spinal cord injury neuropathic pain. Each participant will be randomly allocated to a different baseline phase (ie, 7, 10, or 14 days), which will then be followed by 20 sessions of a 30-minute brain-computer interface neuromodulative intervention over a 4-week period. The visual analog scale assessing average pain intensity will serve as the primary outcome measure. We will also assess pain interference as a secondary outcome domain. Generalization measures will assess quality of life, sleep quality, and anxiety and depressive symptoms, as well as resting-state electroencephalography ...
Keywords	Medicine ; R ; Computer applications to medicine. Medical informatics ; R858-859.7
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Communication skills training curriculum for pulmonary and critical care fellows.

McCallister, Jennifer W / Gustin, Jillian L / Wells-Di Gregorio, Sharla / Way, David P / Mastronarde, John G

Annals of the American Thoracic Society

2015 Volume 12, Issue 4, Page(s) 520–525

Abstract: ... with an increase in total observed skills from 51 to 65% (P ≤ 0.01; Cohen's D effect size [es], 1.13 ... who demonstrated only 49% of observed skills (P ≤ 0.01; es, 1.55). Fellows in the intervention group also showed ... P ≤ 0.01; es, 0.87) upon completion of the curriculum: Conclusions: A structured curriculum ...

Abstract	Rationale: The Accreditation Council for Graduate Medical Education requires physicians training in pulmonary and critical care medicine to demonstrate competency in interpersonal communication. Studies have shown that residency training is often insufficient to prepare physicians to provide end-of-life care and facilitate patient and family decision-making. Poor communication in the intensive care unit (ICU) can adversely affect outcomes for critically ill patients and their family members. Despite this, communication training curricula in pulmonary and critical care medicine are largely absent in the published literature. Objectives: We evaluated the effectiveness of a communication skills curriculum during the first year of a pulmonary and critical care medicine fellowship using a family meeting checklist to provide formative feedback to fellows during ICU rotations. We hypothesized that fellows would demonstrate increased competence and confidence in the behavioral skills necessary for facilitating family meetings. Methods: We evaluated a 12-month communication skills curriculum using a pre-post, quasiexperimental design. Subjects for this study included 11 first-year fellows who participated in the new curriculum (intervention group) and a historical control group of five fellows who had completed no formal communication curriculum. Performance of communication skills and self-confidence in family meetings were assessed for the intervention group before and after the curriculum. The control group was assessed once at the beginning of their second year of fellowship. Results: Fellows in the intervention group demonstrated significantly improved communication skills as evaluated by two psychologists using the Family Meeting Behavioral Skills Checklist, with an increase in total observed skills from 51 to 65% (P ≤ 0.01; Cohen's D effect size [es], 1.13). Their performance was also rated significantly higher when compared with the historical control group, who demonstrated only 49% of observed skills (P ≤ 0.01; es, 1.55). Fellows in the intervention group also showed significantly improved self-confidence scores upon completion of the curriculum, with an increase from 77 to 89% (P ≤ 0.01; es, 0.87) upon completion of the curriculum Conclusions: A structured curriculum that includes abundant opportunities for fellows to practice and receive feedback using a behavioral checklist during their ICU rotations helps to develop physicians with advanced communication skills.
MeSH term(s)	Adult ; Clinical Competence ; Communication ; Critical Care ; Curriculum ; Decision Making ; Fellowships and Scholarships/methods ; Female ; Humans ; Male ; Palliative Medicine/education ; Patient Participation ; Physician-Patient Relations ; Professional-Family Relations ; Pulmonary Medicine/education ; Self Efficacy ; Terminal Care
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.201501-039OC
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Zs.A 5828: Show issues

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Article ; Online: Edge Effects along a Seagrass Margin Result in an Increased Grazing Risk on Posidonia australis Transplants.

Statton, John / Gustin-Craig, Samuel / Dixon, Kingsley W / Kendrick, Gary A

PloS one

2015 Volume 10, Issue 10, Page(s) e0137778

Abstract: ... that other environmental filters are also affecting survival of P. australis transplants within the study area. We found ...

Abstract	A key issue in habitat restoration are the changes in ecological processes that occur when fragments of habitat are lost, resulting in the persistence of habitat-degraded margins. Margins often create or enhance opportunities for negative plant-herbivore interactions, preventing natural or assisted re-establishment of native vegetation into the degraded area. However, at some distance from the habitat margin these negative interactions may relax. Here, we posit that the intensity of species interactions in a fragmented Posidonia australis seagrass meadow may be spatially dependent on proximity to the seagrass habitat edge, whereby the risk of grazing is high and the probability of survival of seagrass transplants is low. To test this, transplants were planted 2 m within the meadow, on the meadow edge at 0m, and at 2m, 10m, 30m, 50m and 100m distance from the edge of the seagrass meadow into the unvegetated sand sheet. There was an enhanced grazing risk 0-10m from the edge, but decreased sharply with increasing distances (>30m). Yet, the risk of grazing was minimal inside the seagrass meadow, indicating that grazers may use the seagrass meadow for refuge but are not actively grazing within it. The relationship between short-term herbivory risk and long-term survival was not straightforward, suggesting that other environmental filters are also affecting survival of P. australis transplants within the study area. We found that daily probability of herbivory was predictable and operating over a small spatial scale at the edge of a large, intact seagrass meadow. These findings highlight the risk from herbivory can be high, and a potential contributing factor to seagrass establishment in restoration programs.
MeSH term(s)	Alismatales ; Animals ; Conservation of Natural Resources ; Ecology ; Fishes ; Grassland ; Herbivory ; Plant Leaves ; Poaceae/physiology ; Probability ; Western Australia ; Wetlands
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0137778
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine.

Yi, Kyung H / Axtmayer, Jossette / Gustin, John P / Rajpurohit, Anandita / Lauring, Josh

Oncotarget

2012 Volume 4, Issue 1, Page(s) 29–34

Abstract: The phosphatidylinositol 3-kinase (PI3-kinase)-Akt-mTOR pathway is mutated at high frequency in human breast cancer, and this pathway is the focus of active drug discovery and clinical investigation. Trials of personalized cancer therapy seek to leverage ...

Abstract	The phosphatidylinositol 3-kinase (PI3-kinase)-Akt-mTOR pathway is mutated at high frequency in human breast cancer, and this pathway is the focus of active drug discovery and clinical investigation. Trials of personalized cancer therapy seek to leverage knowledge of cancer gene mutations by using mutations to guide the choice of targeted therapies. At the same time, cancer genome sequencing studies are identifying low frequency variants of unknown significance in known cancer genes, as well as genes of unknown function. We have performed functional analysis of six non-hotspot AKT1 pleckstrin homology domain mutants identified in recent large-scale breast cancer sequencing studies. Three of these mutants cause constitutive activation of Akt1 in the absence of growth factors, leading to phosphorylation of downstream target proteins. Like the hotspot E17K mutation, these mutants confer constitutive membrane localization of Akt1. Finally, the same three mutants showed oncogenic activity in a cellular transformation assay. The other three mutants were inactive in all assays. These findings validate novel driver mutations in AKT1, and extend the number and type of mutations that activate the PI3-kinase pathway in human breast cancers.
MeSH term(s)	Amino Acid Substitution ; Animals ; Binding Sites/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line ; Cell Membrane/metabolism ; Cell Transformation, Neoplastic/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Immunoblotting ; MCF-7 Cells ; Microscopy, Confocal ; Mutation ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Green Fluorescent Proteins (147336-22-9) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2012-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.755
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Article ; Online: Heart Rate Variability Biofeedback in Adults with a Spinal Cord Injury

Jacob Schoffl / Mohit Arora / Ilaria Pozzato / Candice McBain / Dianah Rodrigues / Elham Vafa / James Middleton / Glen M. Davis / Sylvia Maria Gustin / John Bourke / Annette Kifley / Andrei V. Krassioukov / Ian D. Cameron / Ashley Craig

Journal of Clinical Medicine, Vol 12, Iss 24, p

A Laboratory Framework and Case Series

2023 Volume 7664

Abstract: Heart rate variability biofeedback (HRV-F) is a neurocardiac self-regulation therapy that aims to regulate cardiac autonomic nervous system activity and improve cardiac balance. Despite benefits in various clinical populations, no study has reported the ... ...

Abstract	Heart rate variability biofeedback (HRV-F) is a neurocardiac self-regulation therapy that aims to regulate cardiac autonomic nervous system activity and improve cardiac balance. Despite benefits in various clinical populations, no study has reported the effects of HRV-F in adults with a spinal cord injury (SCI). This article provides an overview of a neuropsychophysiological laboratory framework and reports the impact of an HRV-F training program on two adults with chronic SCI (T1 AIS A and T3 AIS C) with different degrees of remaining cardiac autonomic function. The HRV-F intervention involved 10 weeks of face-to-face and telehealth sessions with daily HRV-F home practice. Physiological (HRV, blood pressure variability (BPV), baroreflex sensitivity (BRS)), and self-reported assessments (Fatigue Severity Scale, Generalised Anxiety Disorder Scale, Patient Health Questionnaire, Appraisal of Disability and Participation Scale, EuroQol Visual Analogue Scale) were conducted at baseline and 10 weeks. Participants also completed weekly diaries capturing mood, anxiety, pain, sleep quality, fatigue, and adverse events. Results showed some improvement in HRV, BPV, and BRS. Additionally, participants self-reported some improvements in mood, fatigue, pain, quality of life, and self-perception. A 10-week HRV-F intervention was feasible in two participants with chronic SCI, warranting further investigation into its autonomic and psychosocial effects.
Keywords	autonomic nervous system ; psychophysiology ; biofeedback ; heart rate ; spinal cord injuries ; case reports ; Medicine ; R
Subject code	796
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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