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  1. Article ; Online: Mental health outcomes before psychotropic medications: a retrospective case series of one state hospital records from 1945 to 1954.

    Chapleau, Ann / Harrison, Jennifer / Love, Stephen / Sherman, David

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 257

    Abstract: ... in favor of medication focused treatment. The majority of large U.S. state hospitals have closed ... to examine discharge outcomes in relation to length of stay and diagnosis in one U.S. state hospital ...

    Abstract Background: Current outcomes for mental illness are widely regarded as poor. Since the introduction of psychotropic medications in the mid 1950's, previous psychosocial practices were minimized in favor of medication focused treatment. The majority of large U.S. state hospitals have closed with records destroyed or in storage, inaccessible to researchers. This creates barriers to studying and comparing outcomes before and after this shift in treatment practices.
    Aims: The study aim was to examine discharge outcomes in relation to length of stay and diagnosis in one U.S. state hospital.
    Methods: This case series study examined 5618 medical records of participants admitted to one state hospital from 1945 to 1954, the decade prior to adoption of psychotropic medications.
    Results: Of the 3332 individuals who left the facility, over half (59.87%) of first episode hospitalizations were discharged within 1 year, and 16.95% were hospitalized for more than 5 years. 46.17% of all admissions were discharged from hospital with no readmission. The most common diagnoses included schizophrenia, other forms of psychosis, and alcoholism. In the decade before the introduction of psychotropic medications, participants were often admitted for a single episode and returned to their homes within several years.
    Conclusions: Although limited to one site, findings suggest that discharge outcomes prior to psychotropic medication as a primary treatment for mental illness may be more positive than previously understood.
    MeSH term(s) Humans ; Hospitals, State ; Retrospective Studies ; Hospital Records ; Psychotropic Drugs/therapeutic use ; Mental Disorders/drug therapy ; Mental Disorders/diagnosis ; Outcome Assessment, Health Care
    Chemical Substances Psychotropic Drugs
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-09235-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Women's professional development programs for emergency physicians: A scoping review.

    Frisch, Stacey / Desai, Riddhi / Chung, Arlene S / Love, Jennifer S / Adair White, Bobbie Ann

    AEM education and training

    2024  Volume 8, Issue 2, Page(s) e10971

    Abstract: Background: Gender disparities in emergency medicine (EM) persist, with women underrepresented in leadership positions and faced with unique challenges, such as gender discrimination and harassment. To address these issues, professional development ... ...

    Abstract Background: Gender disparities in emergency medicine (EM) persist, with women underrepresented in leadership positions and faced with unique challenges, such as gender discrimination and harassment. To address these issues, professional development programs for women have been recommended.
    Objectives: The purpose of this scoping review was to examine current women's professional development programs for EM and develop a collection of program characteristics, meeting topics, and tips for success that can be useful to new or existing women's professional development programs.
    Methods: The authors systematically searched research databases for literature detailing current women's professional development programs for EM physicians. Studies detailing professional development programs for female physicians in EM were included.
    Results: After 149 unique articles were screened, 11 studies met inclusion criteria, describing 10 professional development programs for women in EM. The most commonly cited program objectives included providing mentors and role models (
    Conclusions: The study's findings can inform the development of programs that promote gender equity and support the advancement of women in EM.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2472-5390
    ISSN (online) 2472-5390
    DOI 10.1002/aet2.10971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of proton pump inhibitors and other commonly prescribed drugs on rescanning of patients undergoing myocardial perfusion imaging: a case-control study.

    Rose, David S / Rowe, Jennifer M / Love, Aimee E

    Nuclear medicine communications

    2022  Volume 43, Issue 5, Page(s) 494–501

    Abstract: Objectives: Proton pump inhibitor use is associated with increased gastric wall activity on myocardial perfusion imaging; however, the clinical impact is unknown. We sought to determine the association of the use of proton pump inhibitors and nine other ...

    Abstract Objectives: Proton pump inhibitor use is associated with increased gastric wall activity on myocardial perfusion imaging; however, the clinical impact is unknown. We sought to determine the association of the use of proton pump inhibitors and nine other commonly prescribed classes of medications on the risk of rescanning patients undergoing myocardial perfusion imaging.
    Methods: A matched case-control study was performed including 337 rescanned cases and 337 same-day controls from a total of 5432 patients undergoing myocardial perfusion imaging (MPI) over a 4-year period.
    Results: The odds of rescanning was higher in patients taking a proton pump inhibitor than those not [adjusted odds ratio (OR), 1.6; 95% confidence interval (CI), 1.1-2.2] and in those taking an angiotensin-converting enzyme inhibitor than those not (adjusted OR, 1.5; 95% CI, 1.0-2.2) adjusted for age, sex and BMI category. Eight other commonly prescribed medications showed no associations with rescanning. Among the cases of rescanning, the culprit organ site of extracardiac activity was the left lobe of the liver, 48%; gastric wall, 31%; gastric lumen, 12%; spleen, 7% and bowel <1%. Proton pump inhibitor use was strongly associated with rescanning due to gastric wall uptake (adjusted OR, 6.3; 95% CI, 2.8-14.1) but not the other causes of rescanning.
    Conclusions: Proton pump inhibitor use and angiotensin-converting enzyme inhibitor use are associated with an increased risk of rescanning of patients undergoing MPI. Gastric wall activity is likely to account for the excess cases of rescanning in those taking a proton pump inhibitor.
    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Case-Control Studies ; Humans ; Myocardial Perfusion Imaging ; Perfusion ; Proton Pump Inhibitors/adverse effects
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Proton Pump Inhibitors
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: "Pressed" Etizolam.

    Love, Jennifer S / Thompson, John A / Horowitz, B Zane

    The Journal of pediatrics

    2021  Volume 232, Page(s) 303–304

    MeSH term(s) Candy ; Child ; Diazepam/analogs & derivatives ; Diazepam/poisoning ; Humans ; Illicit Drugs/poisoning ; Male ; Tablets ; Tranquilizing Agents/poisoning
    Chemical Substances Illicit Drugs ; Tablets ; Tranquilizing Agents ; etizolam (A76XI0HL37) ; Diazepam (Q3JTX2Q7TU)
    Language English
    Publishing date 2021-01-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.12.075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pediatric opioid-related emergency visits offer critical opportunities for opioid safety screening and planning.

    Love, Jennifer S / Hughes, Adrienne / Hendrickson, Robert G

    The American journal of emergency medicine

    2021  Volume 55, Page(s) 199–200

    MeSH term(s) Analgesics, Opioid/adverse effects ; Child ; Drug Overdose/drug therapy ; Emergency Service, Hospital ; Humans ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; Opioid-Related Disorders/drug therapy
    Chemical Substances Analgesics, Opioid ; Narcotic Antagonists ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2021.06.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Methotrexate Toxicity from Unintentional Dosing Errors: Calls to a Poison Center and Death Descriptions.

    Thompson, John A / Love, Jennifer S / Hendrickson, Robert G

    Journal of the American Board of Family Medicine : JABFM

    2021  Volume 34, Issue 6, Page(s) 1246–1248

    Abstract: Background: Methotrexate is a folate analog prescribed for varying disease with weekly administration as opposed to daily. Dosing errors can prove clinically significant and sometimes fatal.: Methods: We performed a retrospective poison center review ...

    Abstract Background: Methotrexate is a folate analog prescribed for varying disease with weekly administration as opposed to daily. Dosing errors can prove clinically significant and sometimes fatal.
    Methods: We performed a retrospective poison center review of methotrexate calls between 2009 and 2019.
    Results: Of 111 human-related poison center calls, most patients taking methotrexate were women ages 41 to 80 years old and were prescribed methotrexate for rheumatoid arthritis. Eighty-eight (79%), and 41 (36%) were admitted to the hospital. Thirty-one (75%) of hospitalized patients received leukovorin treatment for their exposure. Two patients died from methotrexate dosing errors.
    Discussion: Most methotrexate accidental ingestions reported to poison centers result from dose frequency errors. However, we note a higher incidence of unintentional therapeutic errors (79% vs 13.7%) than reported in the National Poison Data System in 2019. Patients are often hospitalized for lab monitoring, and many receive leucovorin.
    Conclusions: Most methotrexate calls to our poison center resulted from taking the drug more often than prescribed. Efforts may focus on patient education, physician or pharmacist monitoring during initiation, improved dispensing devices, or weekly drug dispensing.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Medication Errors ; Methotrexate/adverse effects ; Middle Aged ; Poison Control Centers ; Poisons ; Retrospective Studies
    Chemical Substances Poisons ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2239939-2
    ISSN 1558-7118 ; 1557-2625
    ISSN (online) 1558-7118
    ISSN 1557-2625
    DOI 10.3122/jabfm.2021.06.210120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Parallel Pandemic: Medical Misinformation and COVID-19 : Primum non nocere.

    Love, Jennifer S / Blumenberg, Adam / Horowitz, Zane

    Journal of general internal medicine

    2020  Volume 35, Issue 8, Page(s) 2435–2436

    MeSH term(s) Betacoronavirus ; COVID-19 ; Communication ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/psychology ; Ethics, Medical ; Harm Reduction ; Humans ; Information Dissemination/ethics ; Information Literacy ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/psychology ; Psychology ; SARS-CoV-2 ; Social Media/ethics ; Social Media/standards
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-05897-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fluorogenic Cyclopropenones for Multicomponent, Real-Time Imaging.

    Heiss, Tyler K / Dorn, Robert S / Ferreira, Andrew J / Love, Anna C / Prescher, Jennifer A

    Journal of the American Chemical Society

    2022  Volume 144, Issue 17, Page(s) 7871–7880

    Abstract: Fluorogenic bioorthogonal reactions enable biomolecule visualization in real time. These reactions comprise reporters that "light up" upon reaction with complementary partners. While the spectrum of fluorogenic chemistries is expanding, few ... ...

    Abstract Fluorogenic bioorthogonal reactions enable biomolecule visualization in real time. These reactions comprise reporters that "light up" upon reaction with complementary partners. While the spectrum of fluorogenic chemistries is expanding, few transformations are compatible with live cells due to cross-reactivities or insufficient signal turn-on. To address the need for more suitable chemistries for cellular imaging, we developed a fluorogenic reaction featuring cyclopropenone reporters and phosphines. The transformation involves regioselective activation and cyclization of cyclopropenones to form coumarin products. With optimal probes, the reaction provides >1600-fold signal turn-on, one of the highest fluorescence enhancements reported to date. The bioorthogonal motifs were evaluated in vitro and in cells. The reaction was also found to be compatible with other common fluorogenic transformations, enabling multicomponent, real-time imaging. Collectively, these data suggest that the cyclopropenone-phosphine reaction will bolster efforts to track biomolecule targets in their native settings.
    MeSH term(s) Cyclopropanes ; Fluorescent Dyes
    Chemical Substances Cyclopropanes ; Fluorescent Dyes ; cyclopropenone
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c02058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Self-reported Xylazine Experiences: A Mixed Methods Study of Reddit Subscribers.

    Spadaro, Anthony / Connor, Karen O' / Lakamana, Sahithi / Sarker, Abeed / Wightman, Rachel / Love, Jennifer S / Perrone, Jeanmarie

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Objectives: Xylazine is an alpha-2 agonist increasingly prevalent in the illicit drug supply. Our objectives were to curate information about xylazine through social media from People Who Use Drugs (PWUDs). Specifically, we sought to answer the ... ...

    Abstract Objectives: Xylazine is an alpha-2 agonist increasingly prevalent in the illicit drug supply. Our objectives were to curate information about xylazine through social media from People Who Use Drugs (PWUDs). Specifically, we sought to answer the following: 1) what are the demographics of Reddit subscribers reporting exposure to xylazine? 2) is xylazine a desired additive? and 3) what adverse effects of xylazine are PWUDs experiencing?
    Methods: Natural Language Processing (NLP) was used to identify mentions of "xylazine" from posts by Reddit subscribers who also posted on drug-related subreddits. Posts were qualitatively evaluated for xylazine-related themes. A survey was developed to gather additional information about the Reddit subscribers. This survey was posted on subreddits that were identified by NLP to contain xylazine-related discussions from March 2022 to October 2022.
    Results: 76 posts mentioning xylazine were extracted via NLP from 765,616 posts by 16,131 Reddit subscribers (January 2018 to August 2021). People on Reddit described xylazine as an unwanted adulterant in their opioid supply. 61 participants completed the survey. Of those that disclosed their location, 25/50 (50%) participants reported locations in the Northeastern United States. The most common eoute of xylazine use was intranasal use (57%). 31/59 (53%) reported experiencing xylazine withdrawal. Frequent adverse events reported were prolonged sedation (81%) and increased skin wounds (43%).
    Conclusions: Among respondents on these Reddit forums, xylazine appears to be an unwanted adulterant. PWUDs may be experiencing adverse effects such as prolonged sedation and xylazine withdrawal. This appeared to be more common in the Northeast.
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.13.23287215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Self-reported Xylazine Experiences: A Mixed-methods Study of Reddit Subscribers.

    Spadaro, Anthony / O'Connor, Karen / Lakamana, Sahithi / Sarker, Abeed / Wightman, Rachel / Love, Jennifer S / Perrone, Jeanmarie

    Journal of addiction medicine

    2023  Volume 17, Issue 6, Page(s) 691–694

    Abstract: Objectives: Xylazine is an α 2 -agonist increasingly prevalent in the illicit drug supply. Our objectives were to curate information about xylazine through social media from people who use drugs (PWUDs). Specifically, we sought to answer the following: ( ...

    Abstract Objectives: Xylazine is an α 2 -agonist increasingly prevalent in the illicit drug supply. Our objectives were to curate information about xylazine through social media from people who use drugs (PWUDs). Specifically, we sought to answer the following: (1) What are the demographics of Reddit subscribers reporting exposure to xylazine? (2) Is xylazine a desired additive? And (3) what adverse effects of xylazine are PWUDs experiencing?
    Methods: Natural language processing (NLP) was used to identify mentions of "xylazine" from posts by Reddit subscribers who also posted on drug-related subreddits. Posts were qualitatively evaluated for xylazine-related themes. A survey was developed to gather additional information about the Reddit subscribers. This survey was posted on subreddits that were identified by NLP to contain xylazine-related discussions from March 2022 to October 2022.
    Results: Seventy-six posts were extracted via NLP from 765,616 posts by 16,131 Reddit subscribers (January 2018 to August 2021). People on Reddit described xylazine as an unwanted adulterant in their opioid supply. Sixty-one participants completed the survey. Of those who disclosed their location, 25 of 50 participants (50%) reported locations in the Northeastern United States. The most common route of xylazine use was intranasal use (57%). Thirty-one of 59 (53%) reported experiencing xylazine withdrawal. Frequent adverse events reported were prolonged sedation (81%) and increased skin wounds (43%).
    Conclusions: Among respondents on these Reddit forums, xylazine seems to be an unwanted adulterant. People who use drugs may be experiencing adverse effects such as prolonged sedation and xylazine withdrawal. This seemed to be more common in the Northeast.
    MeSH term(s) Humans ; Self Report ; Xylazine ; Analgesics, Opioid ; Antisocial Personality Disorder ; Illicit Drugs
    Chemical Substances Xylazine (2KFG9TP5V8) ; Analgesics, Opioid ; Illicit Drugs
    Language English
    Publishing date 2023-08-10
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1935-3227
    ISSN (online) 1935-3227
    DOI 10.1097/ADM.0000000000001216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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