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  1. Article: The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy.

    Bacyinski, Andrew / Xu, Maosheng / Wang, Wei / Hu, Jiani

    Frontiers in neuroanatomy

    2017  Volume 11, Page(s) 101

    Abstract: The paravascular pathway, also known as the "glymphatic" pathway, is a recently described system for waste clearance in the brain. According to this model, cerebrospinal fluid (CSF) enters the paravascular spaces surrounding penetrating arteries of the ... ...

    Abstract The paravascular pathway, also known as the "glymphatic" pathway, is a recently described system for waste clearance in the brain. According to this model, cerebrospinal fluid (CSF) enters the paravascular spaces surrounding penetrating arteries of the brain, mixes with interstitial fluid (ISF) and solutes in the parenchyma, and exits along paravascular spaces of draining veins. Studies have shown that metabolic waste products and solutes, including proteins involved in the pathogenesis of neurodegenerative diseases such as amyloid-beta, may be cleared by this pathway. Consequently, a growing body of research has begun to explore the association between glymphatic dysfunction and various disease states. However, significant controversy exists in the literature regarding both the direction of waste clearance as well as the anatomical space in which the waste-fluid mixture is contained. Some studies have found no evidence of interstitial solute clearance along the paravascular space of veins. Rather, they demonstrate a perivascular pathway in which waste is cleared from the brain along an anatomically distinct perivascular space in a direction opposite to that of paravascular flow. Although possible explanations have been offered, none have been able to fully reconcile the discrepancies in the literature, and many questions remain. Given the therapeutic potential that a comprehensive understanding of brain waste clearance pathways might offer, further research and clarification is highly warranted.
    Language English
    Publishing date 2017-11-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452969-2
    ISSN 1662-5129
    ISSN 1662-5129
    DOI 10.3389/fnana.2017.00101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aneroid Blood Pressure Manometer Calibration Rates of Devices Used in Home Health.

    Arena, Sara K / Bacyinski, Andrew / Simon, Lee / Peterson, Edward L

    Home healthcare now

    2016  Volume 34, Issue 1, Page(s) 23–28

    Abstract: Hypertension is associated with cardiovascular disease, stroke, and a range of other medical sequelae. Accurate blood pressure (BP) readings, which depend on the integrity and calibration of the measuring device, are essential to identifying suboptimal ... ...

    Abstract Hypertension is associated with cardiovascular disease, stroke, and a range of other medical sequelae. Accurate blood pressure (BP) readings, which depend on the integrity and calibration of the measuring device, are essential to identifying suboptimal BP. This study describes calibration rates of aneroid BP devices (a) utilized in home healthcare (HHC) and (b) having the needle resting within the zero accuracy indicator. BP devices from one branch of a home care agency were inspected and checked for calibration according to the protocol set forth by the European Society of Hypertension. Of the 125 devices measured, 78.4% were in calibration. Of the 94 devices with the gauge needle resting in the zero accuracy indicator, 11.7% were not in calibration; whereas, 51.6% of the 31 devices with the gauge needle resting outside the zero accuracy indicator were found not in calibration. Twenty-one devices were not checked for calibration due to inflation bulb malfunction, tubing tears, or excessive wear. Furthermore, visual inspection of the needle placement did not confirm a device as being in or out of calibration. Proper maintenance and routine calibration of BP equipment is foundational to assuring accuracy of BP readings obtained by HHC providers.
    MeSH term(s) Blood Pressure Determination/instrumentation ; Calibration ; Equipment Design ; Equipment Safety ; Female ; Home Care Services ; Humans ; Hypertension/diagnosis ; Male ; Prospective Studies ; Sampling Studies ; Sensitivity and Specificity ; Sphygmomanometers
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2814267-6
    ISSN 2374-4537 ; 2374-4529
    ISSN (online) 2374-4537
    ISSN 2374-4529
    DOI 10.1097/NHH.0000000000000321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2710: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Histogram Analysis of Native T

    Wu, Chong-Wen / Wu, Rui / Shi, Ruo-Yang / An, Dong-Aolei / Chen, Bing-Hua / Jiang, Meng / Bacyinski, Andrew / Rahim, Ali / Deen, James M / Hu, Jiani / Han, Tong-Tong / Xu, Jian-Rong / Wu, Lian-Ming

    Journal of magnetic resonance imaging : JMRI

    2018  Volume 49, Issue 3, Page(s) 668–677

    Abstract: Background: The use of native T: Purpose: To investigate the relationship of segmental left ventricular wall thickness (LVWT), myocardial fibrosis, and strain parameters with segmental histogram parameters of native T: Study type: Retrospective.!## ...

    Abstract Background: The use of native T
    Purpose: To investigate the relationship of segmental left ventricular wall thickness (LVWT), myocardial fibrosis, and strain parameters with segmental histogram parameters of native T
    Study type: Retrospective.
    Subjects: Ninety-three HCM patients without previous cardiovascular diseases were included.
    Field strength/sequence: 3.0T cardiac MR. Steady-state free precession cine imaging, modified Look-Locker inversion recovery, phase-sensitive inversion recovery.
    Assessment: Images were assessed by three experienced radiologists.
    Statistical tests: Mann-Whitney U-tests, area under the curve (AUC), Spearman's rank correlation, intraclass correlation coefficient, and Bland-Altman test were used for statistical analysis.
    Results: A higher LVWT value correlated with higher means, minimums, 10
    Data conclusion: Histogram parameters of native T
    Level of evidence: 2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;49:668-677.
    MeSH term(s) Aged ; Area Under Curve ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Contrast Media/chemistry ; Electronic Health Records ; Female ; Fibrosis ; Gadolinium/chemistry ; Heart Ventricles/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Myocardium/pathology ; Observer Variation ; ROC Curve ; Reproducibility of Results ; Retrospective Studies
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2018-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.26272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3648: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 236: Show issues

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  4. Article ; Online: Myocardial fibrosis evaluated by diffusion-weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy.

    Wu, Rui / An, Dong-Aolei / Shi, Ruo-Yang / Chen, Bing-Hua / Jiang, Meng / Bacyinski, Andrew / Han, Tong-Tong / Hu, Jiani / Xu, Jian-Rong / Wu, Lian-Ming

    Journal of magnetic resonance imaging : JMRI

    2018  Volume 48, Issue 4, Page(s) 1139–1146

    Abstract: Background: Previous studies have shown that diffusion-weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy.: Purpose: To explore the prognostic value of apparent diffusion coefficient (ADC) for ... ...

    Abstract Background: Previous studies have shown that diffusion-weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy.
    Purpose: To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the contractile function in hypertrophic cardiomyopathy (HCM).
    Study type: Prospective.
    Population: A total of 45 HCM patients and 20 controls.
    Field strength/sequence: 3.0T cardiac MRI. The cardiac MR sequences included cine, T
    Assessment: According to the presence of late gadolinium enhancement (LGE) and the extracellular volume (ECV) values (+2 SD of control subjects), respectively, reader W and reader J assessed the value of ADC of each segment for detecting myocardial fibrosis and its relationship to impaired contractile function in HCM patients.
    Statistical tests: Independent sample t-test, Pearson analysis, and intraclass correlation (ICC).
    Results: The value of ECV was 23.6 ± 3.0% for control. ECV ≥ 29.6% and ECV < 29.6% groups were classified. ADC values in the ECV ≥ 29.6% group were significantly increased compared to the ECV < 29.6% group, (2.41 ± 0.23 μm
    Data conclusion: Contractile dysfunction in HCM is predominantly associated with ADC, which is a feasible alternative to ECV and LGE for detecting myocardial fibrosis.
    Level of evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;48:1139-1146.
    MeSH term(s) Adult ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Contrast Media ; Diffusion Magnetic Resonance Imaging ; Female ; Fibrosis ; Heart/diagnostic imaging ; Humans ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Myocardial Contraction ; Myocardium/pathology ; Prognosis ; Prospective Studies ; Reproducibility of Results
    Chemical Substances Contrast Media
    Language English
    Publishing date 2018-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.26016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3648: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 236: Show issues

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