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Book ; Online ; E-Book: Place-based Learning for the Plate

Pontius, Joel B. / Mueller, Michael P. / Greenwood, David

Hunting, Foraging and Fishing for Food

(Environmental Discourses in Science Education, ; 6)

2020

Abstract: This edited volume explores 21st century stories of hunting, foraging, and fishing for food as unique forms of place-based learning. Through the authors’ narratives, it reveals complex social and ecological relationships while readers sample the flavors ... ...

Author's details	edited by Joel B. Pontius, Michael P. Mueller, David Greenwood
Series title	Environmental Discourses in Science Education, ; 6
Abstract	This edited volume explores 21st century stories of hunting, foraging, and fishing for food as unique forms of place-based learning. Through the authors’ narratives, it reveals complex social and ecological relationships while readers sample the flavors of foraging in Portland, Oregon; feel some of what it’s like to grow up hunting and gathering as a person of Oglala Lakota and Shoshone-Bannock descent; track the immersive process of learning to communicate with rocky mountain elk; encounter a road-killed deer as a spontaneous source of local meat, and more. Other topics in the collection connect place, food, and learning to issues of identity, activism, spirituality, food movements, conservation, traditional and elder knowledge, and the ethics related to eating the more-than-human world. This volume will bring lively discussion to courses on place-based learning, food studies, environmental education, outdoor recreation, experiential education, holistic learning, human dimensions of natural resource management, sustainability, food systems, environmental ethics, and others. .
Keywords	Environmental education ; Science education ; Civilization—History ; Learning ; Instruction ; Environmental and Sustainability Education ; Science Education ; Cultural History ; Learning & Instruction
Subject code	370.115
Language	English
Size	1 online resource (206 pages).
Edition	1st ed. 2020.
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-030-42814-1 ; 3-030-42813-3 ; 978-3-030-42814-3 ; 978-3-030-42813-6
DOI	10.1007/978-3-030-42814-3
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Male rat hypothalamic extraretinal photoreceptor Opsin3 is sensitive to osmotic stimuli and light.

Bárez-López, Soledad / Bishop, Paul / Searby, Daniel / Murphy, David / Greenwood, Michael P

Journal of neuroendocrinology

2024 Volume 36, Issue 2, Page(s) e13363

Abstract: The light-sensitive protein Opsin 3 (Opn3) is present throughout the mammalian brain; however, the role of Opn3 in this organ remains unknown. Since Opn3 encoded mRNA is modulated in the supraoptic and paraventricular nucleus of the hypothalamus in ... ...

Abstract	The light-sensitive protein Opsin 3 (Opn3) is present throughout the mammalian brain; however, the role of Opn3 in this organ remains unknown. Since Opn3 encoded mRNA is modulated in the supraoptic and paraventricular nucleus of the hypothalamus in response to osmotic stimuli, we have explored by in situ hybridization the expression of Opn3 in these nuclei. We have demonstrated that Opn3 is present in the male rat magnocellular neurones expressing either the arginine vasopressin or oxytocin neuropeptides and that Opn3 increases in both neuronal types in response to osmotic stimuli, suggesting that Opn3 functions in both cell types and that it might be involved in regulating water balance. Using rat hypothalamic organotypic cultures, we have demonstrated that the hypothalamus is sensitive to light and that the observed light sensitivity is mediated, at least in part, by Opn3. The data suggests that hypothalamic Opn3 can mediate a light-sensitive role to regulate circadian homeostatic processes.
MeSH term(s)	Animals ; Male ; Rats ; Arginine Vasopressin/metabolism ; Hypothalamus/metabolism ; In Situ Hybridization ; Mammals ; Oxytocin/metabolism ; Paraventricular Hypothalamic Nucleus/metabolism ; Vasopressins/metabolism
Chemical Substances	Arginine Vasopressin (113-79-1) ; Oxytocin (50-56-6) ; Vasopressins (11000-17-2)
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1007517-3
ISSN	1365-2826 ; 0953-8194
ISSN (online)	1365-2826
ISSN	0953-8194
DOI	10.1111/jne.13363
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Article ; Online: Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release.

Greenwood, Michael P / Greenwood, Mingkwan / Bárez-López, Soledad / Hawkins, Joe W / Short, Katherine / Tatovic, Danijela / Murphy, David

Molecular metabolism

2023 Volume 70, Page(s) 101692

Abstract: Objectives: The excessive release of the antidiuretic hormone vasopressin is implicated in many diseases including cardiovascular disease, diabetes, obesity, and metabolic syndrome. Once thought to be elevated as a consequence of diseases, data now ... ...

Abstract	Objectives: The excessive release of the antidiuretic hormone vasopressin is implicated in many diseases including cardiovascular disease, diabetes, obesity, and metabolic syndrome. Once thought to be elevated as a consequence of diseases, data now supports a more causative role. We have previously identified CREB3L1 as a transcription factor that co-ordinates vasopressin synthesis and release in the hypothalamus. The objective here was to identify mechanisms orchestrated by CREB3L1 that co-ordinate vasopressin release. Methods: We mined Creb3l1 knockdown SON RNA-seq data to identify downstream target genes. We proceeded to investigate the expression of these genes and associated pathways in the supraoptic nucleus of the hypothalamus in response to physiological and pharmacological stimulation. We used viruses to selectively knockdown gene expression in the supraoptic nucleus and assessed physiological and metabolic parameters. We adopted a phosphoproteomics strategy to investigate mechanisms that facilitate hormone release by the pituitary gland. Results: We discovered glucagon like peptide 1 receptor (Glp1r) as a downstream target gene and found increased expression in stimulated vasopressin neurones. Selective knockdown of supraoptic nucleus Glp1rs resulted in decreased food intake and body weight. Treatment with GLP-1R agonist liraglutide decreased vasopressin synthesis and release. Quantitative phosphoproteomics of the pituitary neurointermediate lobe revealed that liraglutide initiates hyperphosphorylation of presynapse active zone proteins that control vasopressin exocytosis. Conclusion: In summary, we show that GLP-1R signalling inhibits the vasopressin system. Our data advises that hydration status may influence the pharmacodynamics of GLP-1R agonists so should be considered in current therapeutic strategies.
MeSH term(s)	Liraglutide/pharmacology ; Hypothalamus/metabolism ; Neurons/metabolism ; Vasopressins/genetics ; Vasopressins/metabolism
Chemical Substances	Liraglutide (839I73S42A) ; Vasopressins (11000-17-2)
Language	English
Publishing date	2023-02-10
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2023.101692
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Article ; Online: Isoflurane Rapidly Modifies Synaptic and Cytoskeletal Phosphoproteomes of the Supraoptic Nucleus of the Hypothalamus and the Cortex.

Bárez-López, Soledad / Gadd, George J / Pauža, Audrys G / Murphy, David / Greenwood, Michael P

Neuroendocrinology

2023 Volume 113, Issue 10, Page(s) 1008–1023

Abstract: Introduction: Despite the widespread use of general anaesthetics, the mechanisms mediating their effects are still not understood. Although suppressed in most parts of the brain, neuronal activity, as measured by FOS activation, is increased in the ... ...

Abstract	Introduction: Despite the widespread use of general anaesthetics, the mechanisms mediating their effects are still not understood. Although suppressed in most parts of the brain, neuronal activity, as measured by FOS activation, is increased in the hypothalamic supraoptic nucleus (SON) by numerous general anaesthetics, and evidence points to this brain region being involved in the induction of general anaesthesia (GA) and natural sleep. Posttranslational modifications of proteins, including changes in phosphorylation, enable fast modulation of protein function which could be underlying the rapid effects of GA. In order to identify potential phosphorylation events in the brain-mediating GA effects, we have explored the phosphoproteome responses in the rat SON and compared these to cingulate cortex (CC) which displays no FOS activation in response to general anaesthetics. Methods: Adult Sprague-Dawley rats were treated with isoflurane for 15 min. Proteins from the CC and SON were extracted and processed for nano-LC mass spectrometry (LC-MS/MS). Phosphoproteomic determinations were performed by LC-MS/MS. Results: We found many changes in the phosphoproteomes of both the CC and SON in response to 15 min of isoflurane exposure. Pathway analysis indicated that proteins undergoing phosphorylation adaptations are involved in cytoskeleton remodelling and synaptic signalling events. Importantly, changes in protein phosphorylation appeared to be brain region specific suggesting that differential phosphorylation adaptations might underlie the different neuronal activity responses to GA between the CC and SON. Conclusion: In summary, these data suggest that rapid posttranslational modifications in proteins involved in cytoskeleton remodelling and synaptic signalling events might mediate the central mechanisms mediating GA.
MeSH term(s)	Rats ; Animals ; Supraoptic Nucleus/metabolism ; Isoflurane/pharmacology ; Isoflurane/metabolism ; Chromatography, Liquid ; Rats, Sprague-Dawley ; Proto-Oncogene Proteins c-fos/metabolism ; Tandem Mass Spectrometry ; Hypothalamus/metabolism ; Anesthetics, General/metabolism ; Anesthetics, General/pharmacology ; Paraventricular Hypothalamic Nucleus/metabolism
Chemical Substances	Isoflurane (CYS9AKD70P) ; Proto-Oncogene Proteins c-fos ; Anesthetics, General
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	123303-8
ISSN	1423-0194 ; 0028-3835
ISSN (online)	1423-0194
ISSN	0028-3835
DOI	10.1159/000531352
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Article ; Online: Society for Cardiovascular Magnetic Resonance perspective on the 2021 AHA/ACC Chest Pain Guidelines.

Arai, Andrew E / Kwong, Raymond Y / Salerno, Michael / Greenwood, John P / Bucciarelli-Ducci, Chiara

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2022 Volume 24, Issue 1, Page(s) 8

MeSH term(s)	American Heart Association ; Cardiovascular Diseases ; Chest Pain ; Humans ; Magnetic Resonance Spectroscopy ; Predictive Value of Tests ; United States
Language	English
Publishing date	2022-01-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/s12968-021-00835-z
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Article ; Online: Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration.

Gillard, Benjamin T / Amor, Nabil / Iraizoz, Fernando Alvira / Pauža, Audrys G / Campbell, Colin / Greenwood, Michael P / Alagaili, Abdulaziz N / Murphy, David

iScience

2023 Volume 26, Issue 9, Page(s) 107574

Abstract: Desert animals have evolved systems that enable them to thrive under dry conditions. Focusing on the kidney, we have investigated the transcriptomic adaptations that enable a desert rodent, the Lesser Egyptian Jerboa ( ...

Abstract	Desert animals have evolved systems that enable them to thrive under dry conditions. Focusing on the kidney, we have investigated the transcriptomic adaptations that enable a desert rodent, the Lesser Egyptian Jerboa (
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107574
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Article ; Online: Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release

Michael P. Greenwood / Mingkwan Greenwood / Soledad Bárez-López / Joe W. Hawkins / Katherine Short / Danijela Tatovic / David Murphy

Molecular Metabolism, Vol 70, Iss , Pp 101692- (2023)

2023

Abstract	Objectives: The excessive release of the antidiuretic hormone vasopressin is implicated in many diseases including cardiovascular disease, diabetes, obesity, and metabolic syndrome. Once thought to be elevated as a consequence of diseases, data now supports a more causative role. We have previously identified CREB3L1 as a transcription factor that co-ordinates vasopressin synthesis and release in the hypothalamus. The objective here was to identify mechanisms orchestrated by CREB3L1 that co-ordinate vasopressin release. Methods: We mined Creb3l1 knockdown SON RNA-seq data to identify downstream target genes. We proceeded to investigate the expression of these genes and associated pathways in the supraoptic nucleus of the hypothalamus in response to physiological and pharmacological stimulation. We used viruses to selectively knockdown gene expression in the supraoptic nucleus and assessed physiological and metabolic parameters. We adopted a phosphoproteomics strategy to investigate mechanisms that facilitate hormone release by the pituitary gland. Results: We discovered glucagon like peptide 1 receptor (Glp1r) as a downstream target gene and found increased expression in stimulated vasopressin neurones. Selective knockdown of supraoptic nucleus Glp1rs resulted in decreased food intake and body weight. Treatment with GLP-1R agonist liraglutide decreased vasopressin synthesis and release. Quantitative phosphoproteomics of the pituitary neurointermediate lobe revealed that liraglutide initiates hyperphosphorylation of presynapse active zone proteins that control vasopressin exocytosis. Conclusion: In summary, we show that GLP-1R signalling inhibits the vasopressin system. Our data advises that hydration status may influence the pharmacodynamics of GLP-1R agonists so should be considered in current therapeutic strategies.
Keywords	Liraglutide ; Hypothalamus ; Hydration ; Vasopressin ; Oxytocin ; Glucagon like peptide 1 ; Internal medicine ; RC31-1245
Subject code	570
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transcription factor Creb3l1 maintains proteostasis in neuroendocrine cells.

Greenwood, Mingkwan / Gillard, Benjamin T / Farrukh, Rizwan / Paterson, Alex / Althammer, Ferdinand / Grinevich, Valery / Murphy, David / Greenwood, Michael P

Molecular metabolism

2022 Volume 63, Page(s) 101542

Abstract: Objectives: Dynamic changes to neuropeptide hormone synthesis and secretion by hypothalamic neuroendocrine cells is essential to ensure metabolic homeostasis. The specialised molecular mechanisms that allow neuroendocrine cells to synthesise and secrete ...

Abstract	Objectives: Dynamic changes to neuropeptide hormone synthesis and secretion by hypothalamic neuroendocrine cells is essential to ensure metabolic homeostasis. The specialised molecular mechanisms that allow neuroendocrine cells to synthesise and secrete vast quantities of neuropeptides remain ill defined. The objective of this study was to identify novel genes and pathways controlled by transcription factor and endoplasmic reticulum stress sensor Creb3l1 which is robustly activated in hypothalamic magnocellular neurones in response to increased demand for protein synthesis. Methods: We adopted a multiomic strategy to investigate specific roles of Creb3l1 in rat magnocellular neurones. We first performed chromatin immunoprecipitation followed by genome sequencing (ChIP-seq) to identify Creb3l1 genomic targets and then integrated this data with RNA sequencing data from physiologically stimulated and Creb3l1 knockdown magnocellular neurones. Results: The data converged on Creb3l1 targets that code for ribosomal proteins and endoplasmic reticulum proteins crucial for the maintenance of cellular proteostasis. We validated genes that compose the PERK arm of the unfolded protein response pathway including Eif2ak3, Eif2s1, Atf4 and Ddit3 as direct Creb3l1 targets. Importantly, knockdown of Creb3l1 in the hypothalamus led to a dramatic depletion in neuropeptide synthesis and secretion. The physiological outcomes from studies of paraventricular and supraoptic nuclei Creb3l1 knockdown animals were changes to food and water consumption. Conclusion: Collectively, our data identify Creb3l1 as a comprehensive controller of the PERK signalling pathway in magnocellular neurones in response to physiological stimulation. The broad regulation of neuropeptide synthesis and secretion by Creb3l1 presents a new therapeutic strategy for metabolic diseases.
MeSH term(s)	Animals ; Gene Expression Regulation ; Neuroendocrine Cells ; Proteostasis ; Rats ; Rats, Sprague-Dawley ; Supraoptic Nucleus/metabolism
Language	English
Publishing date	2022-07-06
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2022.101542
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Article ; Online: Transcriptional and Post-Transcriptional Regulation of Oxytocin and Vasopressin Gene Expression by CREB3L1 and CAPRIN2.

Bárez-López, Soledad / Konopacka, Agnieszka / Cross, Stephen J / Greenwood, Mingkwan / Skarveli, Marina / Murphy, David / Greenwood, Michael P

Neuroendocrinology

2022 Volume 112, Issue 11, Page(s) 1058–1077

Abstract: Introduction: Water homoeostasis is achieved by secretion of the peptide hormones arginine vasopressin (AVP) and oxytocin (OXT) that are synthesized by separate populations of magnocellular neurones (MCNs) in the supraoptic and paraventricular (PVN) ... ...

Abstract	Introduction: Water homoeostasis is achieved by secretion of the peptide hormones arginine vasopressin (AVP) and oxytocin (OXT) that are synthesized by separate populations of magnocellular neurones (MCNs) in the supraoptic and paraventricular (PVN) nuclei of the hypothalamus. To further understand the molecular mechanisms that facilitate biosynthesis of AVP and OXT by MCNs, we have explored the spatiotemporal dynamic, both mRNA and protein expression, of two genes identified by our group as being important components of the osmotic defence response: Caprin2 and Creb3l1. Methods: By RNA in situ hybridization and immunohistochemistry, we have characterized the expression of Caprin2 and Creb3l1 in MCNs in the basal state, in response to dehydration, and during rehydration in the rat. Results: We found that Caprin2 and Creb3l1 are expressed in AVP and OXT MCNs and in response to dehydration expression increases in both MCN populations. Protein levels mirror the increase in transcript levels for both CREB3L1 and CAPRIN2. In view of increased CREB3L1 and CAPRIN2 expression in OXT neurones by dehydration, we explored OXT-specific functions for these genes. By luciferase assays, we demonstrate that CREB3L1 may be a transcription factor regulating Oxt gene expression. By RNA immunoprecipitation assays and Northern blot analysis of Oxt mRNA poly(A) tails, we have found that CAPRIN2 binds to Oxt mRNA and regulates its poly(A) tail length. Moreover, in response to dehydration, Caprin2 mRNA is subjected to nuclear retention, possibly to regulate Caprin2 mRNA availability in the cytoplasm. Conclusion: The exploration of the spatiotemporal dynamics of Creb3l1- and Caprin2-encoded mRNAs and proteins has provided novel insights beyond the AVP-ergic system, revealing novel OXT-ergic system roles of these genes in the osmotic defence response.
MeSH term(s)	Animals ; Rats ; Arginine Vasopressin/genetics ; Arginine Vasopressin/metabolism ; Dehydration/metabolism ; Gene Expression ; Gene Expression Regulation ; Oxytocin/genetics ; Oxytocin/metabolism ; Paraventricular Hypothalamic Nucleus/metabolism ; RNA, Messenger/metabolism ; Supraoptic Nucleus/metabolism ; Water/metabolism ; Cyclic AMP Response Element-Binding Protein/genetics ; RNA-Binding Proteins/genetics
Chemical Substances	Arginine Vasopressin (113-79-1) ; Oxytocin (50-56-6) ; RNA, Messenger ; Water (059QF0KO0R) ; CREB3L1 protein, rat ; Caprin2 protein, rat ; Cyclic AMP Response Element-Binding Protein ; RNA-Binding Proteins
Language	English
Publishing date	2022-01-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123303-8
ISSN	1423-0194 ; 0028-3835
ISSN (online)	1423-0194
ISSN	0028-3835
DOI	10.1159/000522088
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Article ; Online: Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration.

Elsamad, Ghadir / Mecawi, André Souza / Pauža, Audrys G / Gillard, Benjamin / Paterson, Alex / Duque, Victor J / Šarenac, Olivera / Žigon, Nina Japundžić / Greenwood, Mingkwan / Greenwood, Michael P / Murphy, David

npj aging

2023 Volume 9, Issue 1, Page(s) 12

Abstract: Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering the elderly more susceptible ...

Abstract	Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic hormone vasopressin, ageing alters acute responses to hyperosmotic cues, rendering the elderly more susceptible to dehydration. Chronically, vasopressin has been associated with numerous diseases of old age, including type 2 diabetes and metabolic syndrome. Bulk RNAseq transcriptome analysis has been used to catalogue the polyadenylated supraoptic nucleus transcriptomes of adult (3 months) and aged (18 months) rats in basal euhydrated and stimulated dehydrated conditions. Gene ontology and Weighted Correlation Network Analysis revealed that ageing is associated with alterations in the expression of extracellular matrix genes. Interestingly, whilst the transcriptomic response to dehydration is overall blunted in aged animals compared to adults, there is a specific enrichment of differentially expressed genes related to neurodegenerative processes in the aged cohort, suggesting that dehydration itself may provoke degenerative consequences in aged rats.
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Journal Article
ISSN	2731-6068
ISSN (online)	2731-6068
DOI	10.1038/s41514-023-00108-2
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