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  1. Article: The Pathophysiology, Diagnosis and Treatment of Corona Virus Disease 2019 (COVID-19).

    Das, Subir Kumar

    Indian journal of clinical biochemistry : IJCB

    2020  Volume 35, Issue 4, Page(s) 385–396

    Abstract: Since the beginning of this century, beta coronaviruses (CoV) have caused three zoonotic outbreaks. However, little is currently known about the biology of the newly emerged SARS-CoV-2 in late 2019. There is a spectrum of clinical features from mild to ... ...

    Abstract Since the beginning of this century, beta coronaviruses (CoV) have caused three zoonotic outbreaks. However, little is currently known about the biology of the newly emerged SARS-CoV-2 in late 2019. There is a spectrum of clinical features from mild to severe life threatening disease with major complications like severe pneumonia, acute respiratory distress syndrome, acute cardiac injury and septic shock. The genome of SARS-CoV-2 encodes polyproteins, four structural proteins and six accessory proteins. SARS-CoV-2 tends to utilize Angiotensin-converting enzyme 2 (ACE2) of various mammals. The imbalance between ACE/Ang II/AT1R pathway and ACE2/Ang(1-7)/Mas receptor pathway in the renin-angiotensin system leads to multi-system inflammation. The early symptoms of COVID-19 pneumonia are low to midgrade fever, dry cough and fatigue. Vigilant screening is important. The diagnosis of COVID-19 should be based on imaging findings along with epidemiological history and nucleic acid detection. Isolation and quarantine of suspected cases is recommended. Management is primarily supportive, with newer antiviral drugs/vaccines under investigation.
    Keywords covid19
    Language English
    Publishing date 2020-08-13
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-020-00919-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Retraction Note: Protein kinase catalytic subunit (PKAcat) from bovine lens: purification, characterization and phosphorylation of lens crystallins.

    Samanta, Bhaswati / Nagdas, Subir Kumar / Das, Kalipada / Sen, Parimal Chandra

    Molecular and cellular biochemistry

    2023  Volume 479, Issue 1, Page(s) 187

    Language English
    Publishing date 2023-11-23
    Publishing country Netherlands
    Document type Retraction of Publication
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-023-04896-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Pathophysiology, Diagnosis and Treatment of Corona Virus Disease 2019 (COVID-19)

    Das, Subir Kumar

    Indian Journal of Clinical Biochemistry

    2020  Volume 35, Issue 4, Page(s) 385–396

    Keywords Clinical Biochemistry ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-020-00919-0
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Antioxidant Properties of

    Das, Uttam / Saha, Tanmay / Das, Subir Kumar

    Indian journal of clinical biochemistry : IJCB

    2021  Volume 37, Issue 2, Page(s) 192–198

    Abstract: Antioxidants in fruits and vegetables protect cells against radiation induced damage. ...

    Abstract Antioxidants in fruits and vegetables protect cells against radiation induced damage.
    Language English
    Publishing date 2021-03-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-021-00964-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical Characteristics of Paediatric Hyperinflammatory Syndrome in the Era of Corona Virus Disease 2019 (COVID-19).

    Basu, Manjari / Das, Subir Kumar

    Indian journal of clinical biochemistry : IJCB

    2021  Volume 36, Issue 4, Page(s) 404–415

    Abstract: The pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome- ... ...

    Abstract The pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2 (PIMS-TS) with a phenotype resembling Kawasaki disease (KD) ('Kawa-COVID-19'). Features of this newly recognized condition may include fever, hypotension, severe abdominal pain and cardiac dysfunction, evidence of inflammation, and single or multi organ dysfunction in the absence of other known infections. Children emerge to have mild symptoms compared to adults, perhaps due to reduced expression of the angiotensin converting enzyme (ACE)-2 receptor (the target of SARS-CoV-2) gene, trained innate immunity, and a young and fit immune system. Some of these children may share features of Kawasaki disease, toxic shock syndrome or cytokine storm syndrome. They can deteriorate rapidly and may need intensive care support as well. The PCR test is more often negative although most of the children have antibodies to SARS-CoV-2. Although the pathogenesis is not clearly known, immune-mediated injury has been implicated.
    Language English
    Publishing date 2021-03-06
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-021-00963-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Authors and Contributors in Scientific and Medical Publications.

    Das, Subir Kumar

    Indian journal of clinical biochemistry : IJCB

    2016  Volume 31, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2016-01-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-015-0547-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Pathophysiology, Diagnosis and Treatment of Corona Virus Disease 2019 (COVID-19)

    Das, Subir Kumar

    Indian J Clin Biochem

    Abstract: Since the beginning of this century, beta coronaviruses (CoV) have caused three zoonotic outbreaks. However, little is currently known about the biology of the newly emerged SARS-CoV-2 in late 2019. There is a spectrum of clinical features from mild to ... ...

    Abstract Since the beginning of this century, beta coronaviruses (CoV) have caused three zoonotic outbreaks. However, little is currently known about the biology of the newly emerged SARS-CoV-2 in late 2019. There is a spectrum of clinical features from mild to severe life threatening disease with major complications like severe pneumonia, acute respiratory distress syndrome, acute cardiac injury and septic shock. The genome of SARS-CoV-2 encodes polyproteins, four structural proteins and six accessory proteins. SARS-CoV-2 tends to utilize Angiotensin-converting enzyme 2 (ACE2) of various mammals. The imbalance between ACE/Ang II/AT1R pathway and ACE2/Ang(1-7)/Mas receptor pathway in the renin-angiotensin system leads to multi-system inflammation. The early symptoms of COVID-19 pneumonia are low to midgrade fever, dry cough and fatigue. Vigilant screening is important. The diagnosis of COVID-19 should be based on imaging findings along with epidemiological history and nucleic acid detection. Isolation and quarantine of suspected cases is recommended. Management is primarily supportive, with newer antiviral drugs/vaccines under investigation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #713186
    Database COVID19

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  8. Article: Emerging contaminant triclosan incites endocrine disruption, reproductive impairments and oxidative stress in the commercially important carp, Catla (Labeo catla): An insight through molecular, histopathological and bioinformatic approach.

    Adhikari, Anupam / Das, Basanta Kumar / Ganguly, Satabdi / Nag, Subir Kumar / Sadhukhan, Debalina / Raut, Subhashree Subhasmita

    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

    2023  Volume 268, Page(s) 109605

    Abstract: ... In this context, Labeo catla were subjected to sub-lethal doses of TCS for 30 days and variations in expression ...

    Abstract Triclosan (TCS), a broad-spectrum antimicrobial agent is ubiquitous in aquatic ecosystems; however, the mechanisms regarding TCS-induced reproductive toxicity in the teleost still remains uncertain. In this context, Labeo catla were subjected to sub-lethal doses of TCS for 30 days and variations in expression of genes and hormones comprising the hypothalamic-pituitary-gonadal (HPG) axis along with alterations in sex steroids were evaluated. Moreover, manifestation of oxidative stress, histopathological alterations, in silico docking and the potential to bioaccumulate were also investigated. Exposure to TCS may lead to an inevitable onset of the steroidogenic pathway through its interaction at several loci along the reproductive axis: TCS stimulated synthesis of kisspeptin 2 (Kiss 2) mRNAs which in turn prompts the hypothalamus to secrete gonadotropin-releasing hormone (GnRH), resulting in elevated serum 17β-estradiol (E
    MeSH term(s) Animals ; Triclosan/toxicity ; Carps/metabolism ; Ecosystem ; Molecular Docking Simulation ; Gonadotropin-Releasing Hormone/metabolism ; Oxidative Stress
    Chemical Substances Triclosan (4NM5039Y5X) ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189285-x
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    ISSN 1532-0456 ; 0306-4492 ; 0742-8413
    DOI 10.1016/j.cbpc.2023.109605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Conference proceedings: Research Workshop on Diagnostics and Therapeutic Immunology: Report.

    Das, Subir Kumar

    Indian journal of biochemistry & biophysics

    2015  Volume 52, Issue 2, Page(s) 213–214

    MeSH term(s) Diagnosis ; Humans ; Immunotherapy
    Language English
    Publishing date 2015-04
    Publishing country India
    Document type Congresses
    ZDB-ID 121689-2
    ISSN 0975-0959 ; 0301-1208
    ISSN (online) 0975-0959
    ISSN 0301-1208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Preface. Diagnostic and Therapeutic Immunology.

    Das, Subir Kumar

    Indian journal of experimental biology

    2015  Volume 53, Issue 11, Page(s) 687–688

    MeSH term(s) Allergy and Immunology ; Diagnosis ; Humans ; Therapeutics
    Language English
    Publishing date 2015-11
    Publishing country India
    Document type Introductory Journal Article
    ZDB-ID 416061-7
    ISSN 0975-1009 ; 0019-5189
    ISSN (online) 0975-1009
    ISSN 0019-5189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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