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  1. Article ; Online: Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol

    Haruka Kemmoku / Kanoko Takahashi / Kojiro Mukai / Toshiki Mori / Koichiro M. Hirosawa / Fumika Kiku / Yasunori Uchida / Yoshihiko Kuchitsu / Yu Nishioka / Masaaki Sawa / Takuma Kishimoto / Kazuma Tanaka / Yasunari Yokota / Hiroyuki Arai / Kenichi G. N. Suzuki / Tomohiko Taguchi

    Nature Communications, Vol 15, Iss 1, Pp 1-

    2024  Volume 17

    Abstract: Abstract Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence ... ...

    Abstract Abstract Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence remains lacking. Here we show, using single-molecule imaging of STING with enhanced time resolutions down to 5 ms, that STING becomes clustered at the trans-Golgi network (about 20 STING molecules per cluster). The clustering requires STING palmitoylation and the Golgi lipid order defined by cholesterol. Single-molecule imaging of TBK1 reveals that STING clustering enhances the association with TBK1. We thus provide quantitative proof-of-principle for the signaling STING scaffold, reveal the mechanistic role of STING palmitoylation in the STING activation, and resolve the long-standing question of the requirement of STING translocation for triggering the innate immune signaling.
    Keywords Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol.

    Kemmoku, Haruka / Takahashi, Kanoko / Mukai, Kojiro / Mori, Toshiki / Hirosawa, Koichiro M / Kiku, Fumika / Uchida, Yasunori / Kuchitsu, Yoshihiko / Nishioka, Yu / Sawa, Masaaki / Kishimoto, Takuma / Tanaka, Kazuma / Yokota, Yasunari / Arai, Hiroyuki / Suzuki, Kenichi G N / Taguchi, Tomohiko

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 220

    Abstract: Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence remains lacking. ...

    Abstract Stimulator of interferon genes (STING) is critical for the type I interferon response to pathogen- or self-derived DNA in the cytosol. STING may function as a scaffold to activate TANK-binding kinase 1 (TBK1), but direct cellular evidence remains lacking. Here we show, using single-molecule imaging of STING with enhanced time resolutions down to 5 ms, that STING becomes clustered at the trans-Golgi network (about 20 STING molecules per cluster). The clustering requires STING palmitoylation and the Golgi lipid order defined by cholesterol. Single-molecule imaging of TBK1 reveals that STING clustering enhances the association with TBK1. We thus provide quantitative proof-of-principle for the signaling STING scaffold, reveal the mechanistic role of STING palmitoylation in the STING activation, and resolve the long-standing question of the requirement of STING translocation for triggering the innate immune signaling.
    MeSH term(s) trans-Golgi Network/metabolism ; Lipoylation ; Microscopy ; Single Molecule Imaging ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Cholesterol ; Cluster Analysis ; Immunity, Innate
    Chemical Substances Membrane Proteins ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44317-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence of Health Care Worker Burnout During the Coronavirus Disease 2019 (COVID-19) Pandemic in Japan.

    Matsuo, Takahiro / Kobayashi, Daiki / Taki, Fumika / Sakamoto, Fumie / Uehara, Yuki / Mori, Nobuyoshi / Fukui, Tsuguya

    JAMA network open

    2020  Volume 3, Issue 8, Page(s) e2017271

    MeSH term(s) Adult ; Betacoronavirus ; Burnout, Professional/diagnosis ; Burnout, Professional/etiology ; Burnout, Professional/prevention & control ; Burnout, Professional/psychology ; COVID-19 ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Cross-Sectional Studies ; Female ; Health Personnel/classification ; Health Personnel/psychology ; Humans ; Male ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Prevalence ; Risk Factors ; SARS-CoV-2 ; Sex Factors
    Keywords covid19
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2020.17271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Discordance of light chain isotypes between serum and glomerular deposits in proliferative glomerulonephritis with monoclonal IgG deposits: a case report and review of the literature.

    Miura, Shoko / Katayama, Kan / Sugimoto, Yuka / Tanaka, Fumika / Mori, Mutsuki / Takahashi, Daisuke / Saiki, Ryosuke / Hirabayashi, Yosuke / Murata, Tomohiro / Tawara, Isao / Dohi, Kaoru

    BMC nephrology

    2023  Volume 24, Issue 1, Page(s) 199

    Abstract: Background: Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a disease entity with nonorganized granular glomerular deposition with monoclonal proteins of both heavy and light chains. Dysproteinemia was ... ...

    Abstract Background: Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a disease entity with nonorganized granular glomerular deposition with monoclonal proteins of both heavy and light chains. Dysproteinemia was observed in only 30% of the patients with PGNMID. We herein report a case of PGNMID with discrepancy between serum and glomerular deposits.
    Case presentation: The patient was a 50-year-old man who had been followed at a local clinic due to hypertension, type 2 diabetes, hyperlipidemia, hyperuricemia, fatty liver, and obesity. Proteinuria had been noted five years previously, and he had been referred to a hematology department due to hyperproteinemia, high gamma globulin, and κ Bence-Jones protein (BJP) positivity one year previously. Bone marrow aspiration showed 5% plasma cells, and he was referred to the nephrology department to evaluate persistent proteinuria. He was hypertensive, and his estimated glomerular filtration rate was 54.2 ml/min/1.73 m
    Conclusions: We experienced a case of membranous nephropathy-type PGNMID with discrepancy in light chains between serum and kidney that was successfully treated with oral prednisolone.
    MeSH term(s) Male ; Humans ; Middle Aged ; Glomerulonephritis, Membranous ; Diabetes Mellitus, Type 2 ; Immunoglobulin G ; Glomerulonephritis/diagnosis ; Glomerulonephritis/drug therapy ; Kidney Diseases ; Proteinuria ; Hypertension ; Antibodies, Monoclonal
    Chemical Substances Immunoglobulin G ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-023-03256-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Prevalence of Health Care Worker Burnout During the Coronavirus Disease 2019 (COVID-19) Pandemic in Japan

    Matsuo, Takahiro / Kobayashi, Daiki / Taki, Fumika / Sakamoto, Fumie / Uehara, Yuki / Mori, Nobuyoshi / Fukui, Tsuguya

    JAMA Netw Open

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #694378
    Database COVID19

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  6. Article ; Online: Prevalence of Health Care Worker Burnout During the Coronavirus Disease 2019 (COVID-19) Pandemic in Japan

    Matsuo, Takahiro / Kobayashi, Daiki / Taki, Fumika / Sakamoto, Fumie / Uehara, Yuki / Mori, Nobuyoshi / Fukui, Tsuguya

    JAMA Network Open

    2020  Volume 3, Issue 8, Page(s) e2017271

    Keywords covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ISSN 2574-3805
    DOI 10.1001/jamanetworkopen.2020.17271
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Roles of Early Mobilization Program in Preventing Muscle Weakness and Decreasing Psychiatric Disorders in Patients with Coronavirus Disease 2019 Pneumonia: A Retrospective Observational Cohort Study.

    Kotani, Toru / Sugiyama, Mizuki / Matsuzaki, Fumika / Kubodera, Kota / Saito, Jin / Kaneki, Mika / Shono, Atsuko / Maruo, Hiroko / Mori, Maiko / Ohta, Shin / Kasai, Fumihito

    Journal of clinical medicine

    2021  Volume 10, Issue 13

    Abstract: Although many coronavirus 2019 patients have experienced persistent symptoms and a long-term decline in quality of life after discharge, the details of these persistent symptoms and the effect of early rehabilitation are still unclear. We conducted a ... ...

    Abstract Although many coronavirus 2019 patients have experienced persistent symptoms and a long-term decline in quality of life after discharge, the details of these persistent symptoms and the effect of early rehabilitation are still unclear. We conducted a single-center, retrospective observational study to investigate the prevalence of persistent symptoms three months after discharge from the intensive care unit by checking the medical records. All patients received an early mobilization program. Four out of 13 patients (31%) had postintensive care syndrome. No patients had muscle weakness, and 11 patients (85%) returned to their previous work. However, psychiatric disorder, such as anxiety (23%) and posttraumatic stress disorder (15%), were observed. Eleven patients claimed persistent symptoms, including fatigue and numbness in the extremities. Our results suggest that the implementation of an early rehabilitation program plays some role in preventing muscle weakness and that decreasing psychiatric disorders should be a next target of patient care in the intensive care unit.
    Language English
    Publishing date 2021-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10132941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Erratum to: Glutamate functions in stomatal closure in Arabidopsis and fava bean.

    Yoshida, Riichiro / Mori, Izumi C / Kamizono, Nobuto / Shichiri, Yudai / Shimatani, Tetsuo / Miyata, Fumika / Honda, Kenji / Iwai, Sumio

    Journal of plant research

    2017  Volume 130, Issue 6, Page(s) 1095

    Language English
    Publishing date 2017-07-18
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 2077362-6
    ISSN 1618-0860 ; 0918-9440
    ISSN (online) 1618-0860
    ISSN 0918-9440
    DOI 10.1007/s10265-017-0969-6
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  9. Article ; Online: Retrospective evaluation of the symptom-based work restriction strategy of healthcare providers in the first epidemic of COVID-19 at a tertiary care hospital in Tokyo, Japan.

    Shikano, Hiroki / Uehara, Yuki / Kuboki, Rino / Tashino, Erika / Nakahara, Fumiko / Matsumoto, Yumi / Kusakabe, Satomi / Fukazawa, Chizumi / Matsuo, Takahiro / Mori, Nobuyoshi / Ayabe, Akiko / Jinta, Torahiko / Taki, Fumika / Sakamoto, Fumie / Takahashi, Osamu / Fukui, Tsuguya

    American journal of infection control

    2021  Volume 50, Issue 6, Page(s) 645–650

    Abstract: Background: Effectiveness of restricting healthcare providers (HCPs) from working based on the coronavirus disease 2019 (COVID-19)-like symptoms should be evaluated.: Methods: A total of 495 HCPs in a tertiary care hospital in Tokyo, Japan, ... ...

    Abstract Background: Effectiveness of restricting healthcare providers (HCPs) from working based on the coronavirus disease 2019 (COVID-19)-like symptoms should be evaluated.
    Methods: A total of 495 HCPs in a tertiary care hospital in Tokyo, Japan, participated in this study between June and July in 2020. Analysis of serum anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody to identify infected HCPs, questionnaire surveys, and medical record reviews were conducted to evaluate the appropriateness of symptom-based work restriction for 10 days.
    Results: Five participants (1.0%) were identified as infected. Forty-six participants (9.3%) experienced work restriction and all 5 infected participants (10.8%) restricted working, even though the real-time reverse transcription-polymerase chain reaction was positive only in 4 participants (80.0%). There were no unexpectedly infected participants among those who did not experience work restriction. However, only 46 of 110 HCPs with COVID-19-like symptoms (41.8%) restricted themselves from working.
    Discussion: Symptom-based work restriction strategy successfully prevented infected HCPs to work, but showed low specificity to identify truly infected HCPs, and their low adherence to the strategy was revealed.
    Conclusions: HCPs with COVID-19-like symptoms should restrict working as the first step of infection prevention, but the strategy to identify truly infected HCPs is necessary.
    MeSH term(s) COVID-19 ; Health Personnel ; Humans ; Japan/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Tertiary Care Centers ; Tokyo/epidemiology
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2021.11.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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  10. Article ; Online: Roles of Early Mobilization Program in Preventing Muscle Weakness and Decreasing Psychiatric Disorders in Patients with Coronavirus Disease 2019 Pneumonia

    Toru Kotani / Mizuki Sugiyama / Fumika Matsuzaki / Kota Kubodera / Jin Saito / Mika Kaneki / Atsuko Shono / Hiroko Maruo / Maiko Mori / Shin Ohta / Fumihito Kasai

    Journal of Clinical Medicine, Vol 10, Iss 2941, p

    A Retrospective Observational Cohort Study

    2021  Volume 2941

    Abstract: Although many coronavirus 2019 patients have experienced persistent symptoms and a long-term decline in quality of life after discharge, the details of these persistent symptoms and the effect of early rehabilitation are still unclear. We conducted a ... ...

    Abstract Although many coronavirus 2019 patients have experienced persistent symptoms and a long-term decline in quality of life after discharge, the details of these persistent symptoms and the effect of early rehabilitation are still unclear. We conducted a single-center, retrospective observational study to investigate the prevalence of persistent symptoms three months after discharge from the intensive care unit by checking the medical records. All patients received an early mobilization program. Four out of 13 patients (31%) had postintensive care syndrome. No patients had muscle weakness, and 11 patients (85%) returned to their previous work. However, psychiatric disorder, such as anxiety (23%) and posttraumatic stress disorder (15%), were observed. Eleven patients claimed persistent symptoms, including fatigue and numbness in the extremities. Our results suggest that the implementation of an early rehabilitation program plays some role in preventing muscle weakness and that decreasing psychiatric disorders should be a next target of patient care in the intensive care unit.
    Keywords postintensive care syndrome ; coronavirus disease 2019 ; acute respiratory failure ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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