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  1. Article ; Online: The ability of supercritical CO

    Frattaruolo, Luca / Durante, Miriana / Cappello, Maria Stella / Montefusco, Anna / Mita, Giovanni / Cappello, Anna Rita / Lenucci, Marcello Salvatore

    Food & function

    2023  Volume 14, Issue 22, Page(s) 10083–10096

    Abstract: Supercritical fluid extraction with ... ...

    Abstract Supercritical fluid extraction with CO
    MeSH term(s) Animals ; Mice ; Lipopolysaccharides/pharmacology ; Cucurbita ; Carbon Dioxide/pharmacology ; Culture Media, Conditioned/pharmacology ; Daucus carota ; Reactive Oxygen Species ; MDA-MB-231 Cells ; Plant Extracts/pharmacology ; Macrophages ; Oxidative Stress ; Inflammation/drug therapy ; Carotenoids/pharmacology ; RAW 264.7 Cells
    Chemical Substances Lipopolysaccharides ; Carbon Dioxide (142M471B3J) ; Culture Media, Conditioned ; Reactive Oxygen Species ; Plant Extracts ; Carotenoids (36-88-4)
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo03159d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  2. Article: Chemical Profile and Bioactivity of

    La Torre, Chiara / Loizzo, Monica Rosa / Frattaruolo, Luca / Plastina, Pierluigi / Grisolia, Antonio / Armentano, Biagio / Cappello, Maria Stella / Cappello, Anna Rita / Tundis, Rosa

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 8

    Abstract: Raspberry ( ...

    Abstract Raspberry (
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13081115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Enhancing the Anticancer and Anti-Inflammatory Properties of Curcumin in Combination with Quercetin, for the Prevention and Treatment of Prostate Cancer.

    Pellegrino, Michele / Bevacqua, Emilia / Frattaruolo, Luca / Cappello, Anna Rita / Aquaro, Stefano / Tucci, Paola

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: Prostate cancer is the second most common cancer in men. Although epidemiologic studies show that a higher intake of polyphenols, curcumin (CUR), and quercetin (QRT), in particular, result in lower prostate cancer risk, the chemopreventive mechanisms ... ...

    Abstract Prostate cancer is the second most common cancer in men. Although epidemiologic studies show that a higher intake of polyphenols, curcumin (CUR), and quercetin (QRT), in particular, result in lower prostate cancer risk, the chemopreventive mechanisms underlying the effects of CUR and QRT have not been fully understood yet, and most investigations were conducted with individual compounds. Here, we investigated the anticancer and anti-inflammatory effects of CUR in combination with QRT, respectively, in a human prostate cancer cell line, PC-3, and in LPS-stimulated RAW 264.7 cells, and found that their combination significantly inhibited proliferation and arrested the cell cycle, inducing apoptosis, so exhibiting synergic activities stronger than single drug use. Moreover, via their antioxidant effects, the combination of CUR and QRT modulated several inflammation-mediated signaling pathways (ROS, nitric oxide, and pro-inflammatory cytokines) thus helping protect cells from undergoing molecular changes that trigger carcinogenesis. Although additional studies, including in vivo experiments and translational studies, are required, this study raises the possibility of their use as a safe, effective, and affordable therapeutic approach to prostate cancer.
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11072023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Iridoid- and flavonoid-enriched fractions of

    Tenuta, Maria Concetta / Loizzo, Monica Rosa / Tundis, Rosa / Dugay, Annabelle / Bouzidi, Chouaha / Marie, Arul / Acquaviva, Rosaria / Cappello, Anna Rita / Deguin, Brigitte

    Food & function

    2023  Volume 14, Issue 19, Page(s) 8838–8853

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Flavonoids/chemistry ; Antioxidants/chemistry ; Kaempferols ; Cornus/chemistry ; Quercetin/analysis ; alpha-Glucosidases/analysis ; Iridoids/pharmacology ; Plant Extracts/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Lipase ; Galactosides ; Metabolic Diseases ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/analysis ; Fruit/chemistry
    Chemical Substances Flavonoids ; Antioxidants ; Kaempferols ; Quercetin (9IKM0I5T1E) ; alpha-Glucosidases (EC 3.2.1.20) ; Iridoids ; Plant Extracts ; Lipase (EC 3.1.1.3) ; Galactosides ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo02987e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  5. Article ; Online: Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications-A Comprehensive Review.

    Iaconisi, Giorgia Natalia / Lunetti, Paola / Gallo, Nunzia / Cappello, Anna Rita / Fiermonte, Giuseppe / Dolce, Vincenza / Capobianco, Loredana

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only in maintaining tissue hydration but also in cellular processes such as ... ...

    Abstract Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only in maintaining tissue hydration but also in cellular processes such as proliferation, differentiation, and the inflammatory response. HA has demonstrated its efficacy as a powerful bioactive molecule not only for skin antiaging but also in atherosclerosis, cancer, and other pathological conditions. Due to its biocompatibility, biodegradability, non-toxicity, and non-immunogenicity, several HA-based biomedical products have been developed. There is an increasing focus on optimizing HA production processes to achieve high-quality, efficient, and cost-effective products. This review discusses HA's structure, properties, and production through microbial fermentation. Furthermore, it highlights the bioactive applications of HA in emerging sectors of biomedicine.
    MeSH term(s) Humans ; Hyaluronic Acid/chemistry ; Chemical Phenomena ; Skin ; Extracellular Matrix ; Hydrogels
    Chemical Substances Hyaluronic Acid (9004-61-9) ; Hydrogels
    Language English
    Publishing date 2023-06-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hyaluronic Acid

    Giorgia Natalia Iaconisi / Paola Lunetti / Nunzia Gallo / Anna Rita Cappello / Giuseppe Fiermonte / Vincenza Dolce / Loredana Capobianco

    International Journal of Molecular Sciences, Vol 24, Iss 10296, p

    A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review

    2023  Volume 10296

    Abstract: Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only in maintaining tissue hydration but also in cellular processes such as ... ...

    Abstract Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only in maintaining tissue hydration but also in cellular processes such as proliferation, differentiation, and the inflammatory response. HA has demonstrated its efficacy as a powerful bioactive molecule not only for skin antiaging but also in atherosclerosis, cancer, and other pathological conditions. Due to its biocompatibility, biodegradability, non-toxicity, and non-immunogenicity, several HA-based biomedical products have been developed. There is an increasing focus on optimizing HA production processes to achieve high-quality, efficient, and cost-effective products. This review discusses HA’s structure, properties, and production through microbial fermentation. Furthermore, it highlights the bioactive applications of HA in emerging sectors of biomedicine.
    Keywords hyaluronic acid ; biomaterial ; bioactive molecule ; metabolic pathways ; bioproduction ; fermentation processes ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: A Picrocrocin-Enriched Fraction from a Saffron Extract Affects Lipid Homeostasis in HepG2 Cells through a Non-Statin-like Mode.

    Frattaruolo, Luca / Marra, Federica / Lauria, Graziantonio / Siciliano, Carlo / Curcio, Rosita / Muto, Luigina / Brindisi, Matteo / Aiello, Donatella / Napoli, Anna / Fiermonte, Giuseppe / Cappello, Anna Rita / Fiorillo, Marco / Ahmed, Amer / Dolce, Vincenza

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Dyslipidemia is a lipid metabolism disorder associated with the loss of the physiological homeostasis that ensures safe levels of lipids in the organism. This metabolic disorder can trigger pathological conditions such as atherosclerosis and ... ...

    Abstract Dyslipidemia is a lipid metabolism disorder associated with the loss of the physiological homeostasis that ensures safe levels of lipids in the organism. This metabolic disorder can trigger pathological conditions such as atherosclerosis and cardiovascular diseases. In this regard, statins currently represent the main pharmacological therapy, but their contraindications and side effects limit their use. This is stimulating the search for new therapeutic strategies. In this work, we investigated in HepG2 cells the hypolipidemic potential of a picrocrocin-enriched fraction, analyzed by high-resolution
    MeSH term(s) Humans ; Crocus/chemistry ; Hep G2 Cells ; Plant Extracts/pharmacology ; Terpenes/pharmacology ; Cyclohexenes/pharmacology
    Chemical Substances picrocrocin (ON5B022511) ; Plant Extracts ; Terpenes ; Cyclohexenes
    Language English
    Publishing date 2023-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New insights into cholesterol‐mediated ERRα activation in breast cancer progression and pro‐tumoral microenvironment orchestration

    Brindisi, Matteo / Frattaruolo, Luca / Fiorillo, Marco / Dolce, Vincenza / Sotgia, Federica / Lisanti, Michael P. / Cappello, Anna Rita

    The FEBS Journal. 2023 Mar., v. 290, no. 6 p.1481-1501

    2023  

    Abstract: Breast cancer remains the greatest cause of cancer‐related death in women worldwide. Its aggressiveness and progression derive from intricate processes that occur simultaneously both within the tumour itself and in the neighbouring cells that make up its ...

    Abstract Breast cancer remains the greatest cause of cancer‐related death in women worldwide. Its aggressiveness and progression derive from intricate processes that occur simultaneously both within the tumour itself and in the neighbouring cells that make up its microenvironment. The aim of the present work was firstly to study how elevated cholesterol levels increase tumour aggressiveness. Herein, we demonstrate that cholesterol, by activating ERRα pathway, promotes epithelium‐mesenchymal transition (EMT) in breast cancer cells (MCF‐7 and MDA‐MB‐231) as well as the release of pro‐inflammatory factors able to orchestrate the tumour microenvironment. A further objective of this work was to study the close symbiosis between tumour cells and the microenvironment. Our results allow us to highlight, for the first time, that breast cancer cells exposed to high cholesterol levels promote (a) greater macrophages infiltration with induction of an M2 phenotype, (b) angiogenesis and endothelial branching, as well as (c) a cancer‐associated fibroblasts (CAFs) phenotype. The effects observed could be due to direct activation of the ERRα pathway by high cholesterol levels, since the simultaneous inhibition of this pathway subverts such effects. Overall, these findings enable us to identify the cholesterol‐ERRα synergy as an interesting target for breast cancer treatment.
    Keywords angiogenesis ; breast neoplasms ; cancer therapy ; cholesterol ; death ; fibroblasts ; macrophages ; neoplasm progression ; phenotype ; symbiosis
    Language English
    Dates of publication 2023-03
    Size p. 1481-1501.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16651
    Database NAL-Catalogue (AGRICOLA)

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    Z 2006/704: Show issues

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  9. Article ; Online: Two functionally different mitochondrial phosphate carriers support Drosophila melanogaster OXPHOS throughout distinct developmental stages.

    Curcio, Rosita / Frattaruolo, Luca / Marra, Federica / Pesole, Graziano / Vozza, Angelo / Cappello, Anna Rita / Fiorillo, Marco / Lauria, Graziantonio / Ahmed, Amer / Fiermonte, Giuseppe / Capobianco, Loredana / Dolce, Vincenza

    Biochimica et biophysica acta. Molecular cell research

    2023  Volume 1871, Issue 1, Page(s) 119615

    MeSH term(s) Animals ; Drosophila melanogaster/genetics ; Mitochondria/genetics ; Mitochondrial Membrane Transport Proteins ; Biological Phenomena ; Phosphate Transport Proteins
    Chemical Substances Mitochondrial Membrane Transport Proteins ; Phosphate Transport Proteins
    Language English
    Publishing date 2023-10-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2023.119615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Santolina pinnata

    Brindisi, Matteo / Frattaruolo, Luca / Sicari, Vincenzo / Loizzo, Monica Rosa / Bedini, Gianni / Rago, Vittoria / Tundis, Rosa / Cappello, Anna Rita

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: Cancer is one of the largest causes of mortality in the world, and due to its incidence, the discovery of novel anticancer drugs is of great importance. Many successful anticancer drugs used in clinical practices are derived from natural products. The ... ...

    Abstract Cancer is one of the largest causes of mortality in the world, and due to its incidence, the discovery of novel anticancer drugs is of great importance. Many successful anticancer drugs used in clinical practices are derived from natural products. The genus
    MeSH term(s) Mice ; Animals ; Humans ; Female ; RAW 264.7 Cells ; Lipopolysaccharides/pharmacology ; NF-kappa B/metabolism ; Breast Neoplasms/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Gas Chromatography-Mass Spectrometry ; Asteraceae/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Antineoplastic Agents/pharmacology
    Chemical Substances Lipopolysaccharides ; NF-kappa B ; Plant Extracts ; Anti-Inflammatory Agents ; Antineoplastic Agents
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232112885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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