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  1. Book ; Online ; E-Book: NK cells in cancer immunotherapy

    Jewett, Anahid / Fong, Yuman

    successes and challenges

    (Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy ; v.Volume 4)

    2023  

    Abstract: NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in ... ...

    Author's details edited by Anahid Jewett, Yuman Fong
    Series title Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy ; v.Volume 4
    Abstract NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients.
    MeSH term(s) Killer Cells, Natural ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy
    Keywords Cancer/Immunotherapy ; Killer cells
    Subject code 616.99406
    Language English
    Size 1 online resource (496 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-822626-9 ; 9780128226209 ; 978-0-12-822626-1 ; 012822620X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Successes and challenges of NK immunotherapy

    Bonavida, Benjamin / Jewett, Anahid

    breaking tolerance to cancer resistance

    2021  

    Author's details Benjamin Bonavida and Anahid Jewett
    Keywords Cancer/Immunotherapy ; Cancer/Immunotherapy/Research
    Subject code 616.994061
    Language English
    Size 1 online resource :, illustrations
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-824396-1 ; 0-12-824375-9 ; 978-0-12-824396-1 ; 978-0-12-824375-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro.

    Kaur, Kawaljit / Jewett, Anahid

    Critical reviews in immunology

    2024  Volume 44, Issue 5, Page(s) 87–98

    Abstract: Despite advancements in the field of cancer therapeutics, the five-year survival rate remains low in oral cancer patients. Therefore, the effective therapeutics are needed against oral cancer. Also, several studies including ours, have shown severely ... ...

    Abstract Despite advancements in the field of cancer therapeutics, the five-year survival rate remains low in oral cancer patients. Therefore, the effective therapeutics are needed against oral cancer. Also, several studies including ours, have shown severely suppressed function and number of NK cells in oral cancer patients. In this review, we discuss the approach to inhibit the tumor growth and metastasis by direct killing or NK cell-mediated tumor differentiation. This review also provides an overview on supercharging NK cells using osteoclasts and probiotic bacteria, and their efficacy as cancer immunotherapeutic in humanized-BLT mice.
    MeSH term(s) Humans ; Animals ; Mice ; Mouth Neoplasms/therapy ; Immunotherapy ; Cell Differentiation ; Killer Cells, Natural ; Lymphocyte Activation
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1353116-5
    ISSN 1040-8401
    ISSN 1040-8401
    DOI 10.1615/CritRevImmunol.2024052389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1699: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Article: Similarities and Differences between Osteoclast-Mediated Functional Activation of NK, CD3+ T, and γδ T Cells from Humans, Humanized-BLT Mice, and WT Mice.

    Kaur, Kawaljit / Jewett, Anahid

    Critical reviews in immunology

    2024  Volume 44, Issue 2, Page(s) 61–75

    Abstract: This study is focused on assessing the activation in NK, CD3+ T, and γδ T cells when they interact with osteoclasts (OCs) and monocytes in the presence or absence of zoledronate (ZOL), both in humans and WT mice. OCs resulted in increased IFN-γ secretion ...

    Abstract This study is focused on assessing the activation in NK, CD3+ T, and γδ T cells when they interact with osteoclasts (OCs) and monocytes in the presence or absence of zoledronate (ZOL), both in humans and WT mice. OCs resulted in increased IFN-γ secretion in NK, CD3+ T, and γδ T cells, however, the significantly highest increase was seen when cells were co-cultured with ZOL-treated OCs. Our previous studies have demonstrated increased IFN-γ secretion in the peripheral blood-derived immune cells of bisphosphonate-related osteonecrosis of the jaw (BRONJ) mice model. This could be due to increased OCs-induced activation of immune cells with ZOL treatment. We also observed increased IFN-γ secretion in humanized-BLT (hu-BLT) mice NK cells when were co-cultured with OCs or monocytes, and higher IFN-γ secretion levels were seen in the presence of OCs or ZOL-treated OCs. In addition, similar effects on IFN-γ secretion levels of NK, CD3+ T, and γδ T cells were seen whether cells were co-cultured with allogeneic OCs or autologous OCs.
    MeSH term(s) Humans ; Mice ; Animals ; Osteoclasts ; Receptors, Antigen, T-Cell, gamma-delta ; Zoledronic Acid/pharmacology ; Monocytes ; T-Lymphocytes
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta ; Zoledronic Acid (6XC1PAD3KF)
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1353116-5
    ISSN 1040-8401
    ISSN 1040-8401
    DOI 10.1615/CritRevImmunol.2023051091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1699: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Osteoclasts and Probiotics Mediate Significant Expansion, Functional Activation and Supercharging in NK, γδ T, and CD3+ T Cells: Use in Cancer Immunotherapy.

    Kaur, Kawaljit / Jewett, Anahid

    Cells

    2024  Volume 13, Issue 3

    Abstract: Our previous studies have introduced osteoclasts (OCs) as major activators of NK cells. It was found that OCs exhibit the capabilities of inducing cell expansion as well as increasing the cytotoxic activity of NK cells by granule release and increasing ... ...

    Abstract Our previous studies have introduced osteoclasts (OCs) as major activators of NK cells. It was found that OCs exhibit the capabilities of inducing cell expansion as well as increasing the cytotoxic activity of NK cells by granule release and increasing the secretion of TNF-α and TRAIL, leading to increased lysis of tumors in short-term as well as long-term periods, respectively. OC- induced expanded NK cells were named supercharged NK cells (sNK) due to their significantly high functional activity as well as their significantly higher cell expansion rate. It is, however, unclear whether the OC-mediated effect in NK cells is specific or whether other cytotoxic immune cells can also be expanded and activated by OCs. We chose to focus on γδ T cells and pan T cells, which also include CD8+ T cells. In this paper, we report that OCs are capable of expanding and functionally activating both γδ T cells and pan T cells. Expanded γδ T and pan T cells were capable of secreting high levels of INF-γ, albeit with different dynamics to those of NK cells, and, moreover, they are unable to kill NK-specific targets. Since we used humanized-BLT (hu-BLT) mice as a model of human disease, we next determined whether NK and T cell activation through OCs is also evident in cells obtained from hu-BLT mice. Similar to humans, OCs were capable of increasing the cell expansion and secretion of IFN-γ in the culture of either NK or T cells from hu-BLT mice, providing yet further evidence that these mice are appropriate models to study human disease. Therefore, these studies indicated that CD3+ T or γδ T cells can proliferate and be supercharged by OCs similar to the NK cells; thus, they can be used individually or in combination in the cell therapy of cancers.
    MeSH term(s) Humans ; Animals ; Mice ; Osteoclasts ; Killer Cells, Natural ; Immunotherapy ; Neoplasms/therapy ; Antineoplastic Agents ; Probiotics
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13030213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions

    Anahid Jewett

    Frontiers in Immunology, Vol

    2020  Volume 11

    Abstract: Coronavirus-induced disease-2019 (COVID-19) continues to cause significant morbidity and mortality worldwide. While studies on SARS-CoV-2 effects on immune cell function continue to progress, we know very little about the significance of depletion of key ...

    Abstract Coronavirus-induced disease-2019 (COVID-19) continues to cause significant morbidity and mortality worldwide. While studies on SARS-CoV-2 effects on immune cell function continue to progress, we know very little about the significance of depletion of key immune effectors by the virus in the mortality and morbidity of the disease. This commentary outlines what is the reported literature thus far on the effect of virus on NK cells known to kill virally infected cells. It also underscores the necessity for the future comprehensive studies of NK cells in SARS-CoV-2 infected individuals and animal models to better understand the role and significance of reported NK cell depletion and functional inactivation in disease morbidity and mortality, in hope to design effective therapeutic interventions for the disease.
    Keywords COVID-19 ; NK cells ; virus ; immune cell ; SARS-CoV-2 ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Novel Coronavirus SARS-CoV-2 Target and Disable Natural Killer Cells: Core Immune Effectors for Fighting the Disease.

    Jewett, Anahid

    Critical reviews in immunology

    2020  Volume 40, Issue 2, Page(s) 167–171

    Abstract: Coronavirus disease 2019 (COVID-19) poses a great public health challenge worldwide. While studies on the effects of SARS-CoV-2 on immune cell function continue to progress, we know very little about the significance of depletion of key immune effectors ... ...

    Abstract Coronavirus disease 2019 (COVID-19) poses a great public health challenge worldwide. While studies on the effects of SARS-CoV-2 on immune cell function continue to progress, we know very little about the significance of depletion of key immune effectors by the virus in the mortality and morbidity of the disease. This commentary reviews what is known thus far about the effects of the virus on natural killer (NK) cells, the major cell type responsible for the destruction and removal of virally infected cells. It also highlights the necessity of comprehensive studies of NK cells in COVID-19 patients and animal models to better understand the role and significance of reported NK depletion and functional inactivation in disease morbidity and mortality, in the hopes of designing effective therapeutic interventions for the disease.
    MeSH term(s) Antibody-Dependent Cell Cytotoxicity/immunology ; Betacoronavirus/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/therapy ; Humans ; Interferon-gamma/immunology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/virology ; Neutrophils/immunology ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Tumor Necrosis Factor-alpha/immunology
    Chemical Substances IFNG protein, human ; Tumor Necrosis Factor-alpha ; Interferon-gamma (82115-62-6)
    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1353116-5
    ISSN 1040-8401
    ISSN 1040-8401
    DOI 10.1615/CritRevImmunol.2020034441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1699: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: The Potential Effect of Novel Coronavirus SARS-CoV-2 on NK Cells; A Perspective on Potential Therapeutic Interventions.

    Jewett, Anahid

    Frontiers in immunology

    2020  Volume 11, Page(s) 1692

    Abstract: Coronavirus-induced disease-2019 (COVID-19) continues to cause significant morbidity and mortality worldwide. While studies on SARS-CoV-2 effects on immune cell function continue to progress, we know very little about the significance of depletion of key ...

    Abstract Coronavirus-induced disease-2019 (COVID-19) continues to cause significant morbidity and mortality worldwide. While studies on SARS-CoV-2 effects on immune cell function continue to progress, we know very little about the significance of depletion of key immune effectors by the virus in the mortality and morbidity of the disease. This commentary outlines what is the reported literature thus far on the effect of virus on NK cells known to kill virally infected cells. It also underscores the necessity for the future comprehensive studies of NK cells in SARS-CoV-2 infected individuals and animal models to better understand the role and significance of reported NK cell depletion and functional inactivation in disease morbidity and mortality, in hope to design effective therapeutic interventions for the disease.
    MeSH term(s) Adult ; Aged ; Animals ; Betacoronavirus/immunology ; CD8-Positive T-Lymphocytes/immunology ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Cytokines/blood ; Disease Progression ; Female ; Humans ; Immunotherapy/methods ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Male ; Middle Aged ; Middle East Respiratory Syndrome Coronavirus/immunology ; NK Cell Lectin-Like Receptor Subfamily C/metabolism ; Neutrophils/immunology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Cytokines ; KLRC1 protein, human ; NK Cell Lectin-Like Receptor Subfamily C
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Supercharged NK Cell-Based Immuotherapy in Humanized Bone Marrow Liver and Thymus (Hu-BLT) Mice Model of Oral, Pancreatic, Glioblastoma, Hepatic, Melanoma and Ovarian Cancers.

    Kaur, Kawaljit / Jewett, Anahid

    Critical reviews in immunology

    2023  Volume 43, Issue 2, Page(s) 13–25

    Abstract: In this paper, we review a number of in vitro and in vivo studies regarding the efficacy of supercharged NK (sNK) cell therapy in elimination or treatment of cancer. We have performed studies using six different types of cancer models of oral, pancreatic, ...

    Abstract In this paper, we review a number of in vitro and in vivo studies regarding the efficacy of supercharged NK (sNK) cell therapy in elimination or treatment of cancer. We have performed studies using six different types of cancer models of oral, pancreatic, glioblastoma, melanoma, hepatic and ovarian cancers using hu-BLT mice. Our in vitro studies demonstrated that primary NK cells preferentially target cancer stem-like cells (CSCs)/poorly differentiated tumors whereas sNK cells target both CSCs/poorly-differentiated and well-differentiated tumors significantly higher than primary activated NK cells. Our in vivo studies in humanized-BLT mice showed that sNK cells alone or in combination with other cancer therapeutics prevented tumor growth and metastasis. In addition, sNK cells were able to increase IFN-γ secretion and cytotoxic function by the immune cells in bone marrow, spleen, gingiva, pancreas and peripheral blood. Furthermore, sNK cells were able to increase the expansion and function of CD8+ T cells both in in vitro and in vivo studies. Overall, our studies demonstrated that sNK cells alone or in combination with other cancer therapeutics were not only effective against eliminating aggressive cancers, but were also able to increase the expansion and function of CD8+ T cells to further target cancer cells, providing a successful approach to eradicate and cure cancer.
    MeSH term(s) Animals ; Female ; Mice ; Bone Marrow ; Disease Models, Animal ; Glioblastoma ; Killer Cells, Natural ; Liver ; Melanoma ; Ovarian Neoplasms/therapy ; Pancreas
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1353116-5
    ISSN 1040-8401
    ISSN 1040-8401
    DOI 10.1615/CritRevImmunol.2023050618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Editorial: Lysosomal peptidases in tumor immunity.

    Perišić Nanut, Milica / Božić Nedeljković, Biljana / Jewett, Anahid

    Frontiers in immunology

    2023  Volume 14, Page(s) 1176736

    MeSH term(s) Humans ; Peptide Hydrolases ; Lysosomes/pathology ; Neoplasms/pathology
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1176736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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